Optogenetic manipulation of neural and non-neural functions

Spatio-temporal control of neural activityin vivousing fluorescence microendoscopy

(2012) Yuichiro Hayashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Color-tuned Channelrhodopsins for Multiwavelength Optogenetics

(2012) Matthias Prigge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Model of Channelrhodopsin

(2012) Hiroshi C. Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hierarchical Connectivity and Connection-Specific Dynamics in the Corticospinal-Corticostriatal Microcircuit in Mouse Motor Cortex

(2012) T. Kiritani et al.   JOURNAL OF NEUROSCIENCE

Wakefulness Affects Synaptic and Network Activity by Increasing Extracellular Astrocyte-Derived Adenosine

(2012) L. I. Schmitt et al.   JOURNAL OF NEUROSCIENCE

Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release

(2012) Dongdong Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice

(2012) Ryan M Wyatt et al.   NATURE NEUROSCIENCE

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Optogenetic manipulation of neural circuits and behavior in Drosophila larvae

(2012) Ken Honjo et al.   Nature Protocols

A multispectral optical illumination system with precise spatiotemporal control for the manipulation of optogenetic reagents

(2012) Jeffrey N Stirman et al.   Nature Protocols

High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device

(2012) Peixin Zhu et al.   Nature Protocols

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Functions of microglia in the central nervous system – beyond the immune response

(2012) Hiroaki Wake et al.   Neuron Glia Biology

Involvement of glutamate 97 in ion influx through photo-activated channelrhodopsin-2

(2012) Saki Tanimoto et al.   NEUROSCIENCE RESEARCH

Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0

(2012) Itaru Imayoshi et al.   NEUROSCIENCE RESEARCH

Parallel and patterned optogenetic manipulation of neurons in the brain slice using a DMD-based projector

(2012) Seiichiro Sakai et al.   NEUROSCIENCE RESEARCH

Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light

(2012) Tomomi Tsunematsu et al.   NEUROSCIENCE RESEARCH

Development of a micro-imaging probe for functional brain imaging

(2012) Makoto Osanai et al.   NEUROSCIENCE RESEARCH

Targeted expression of a chimeric channelrhodopsin in zebrafish under regulation of Gal4-UAS system

(2012) Keiko Umeda et al.   NEUROSCIENCE RESEARCH

Organically Modified Silica Nanoparticles Are Biocompatible and Can Be Targeted to Neurons In Vivo

(2012) Farda Barandeh et al.   PLoS One

Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells

(2012) Zhi-Gang Ji et al.   PLoS One

High-Throughput Single-Cell Manipulation in Brain Tissue

(2012) Joseph D. Steinmeyer et al.   PLoS One

Magneto-Electric Nano-Particles for Non-Invasive Brain Stimulation

(2012) Kun Yue et al.   PLoS One

Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

(2012) Selina Wray et al.   PLoS One

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

(2012) D. Lovatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation

(2012) T. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

(2012) F. Wang et al.   Science Signaling

A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

(2012) Y. Shi et al.   Science Translational Medicine

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Progress on stem cell research towards the treatment of Parkinson's disease

(2012) Stuart AJ Gibson et al.   Stem Cell Research & Therapy

Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System

(2012) Kenji F. Tanaka et al.   Cell Reports

Astrocytes Mediate In Vivo Cholinergic-Induced Synaptic Plasticity

(2012) Marta Navarrete et al.   PLOS BIOLOGY

Microglial Activation – Tuning and Pruning Adult Neurogenesis

(2012) Christine T. Ekdahl   Frontiers in Pharmacology

Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2

(2011) Karelia Ruffert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiscale Computational Models for Optogenetic Control of Cardiac Function

(2011) Oscar J. Abilez et al.   BIOPHYSICAL JOURNAL

Optically controlled contraction of photosensitive skeletal muscle cells

(2011) Toshifumi Asano et al.   BIOTECHNOLOGY AND BIOENGINEERING

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

The Microbial Opsin Family of Optogenetic Tools

(2011) Feng Zhang et al.   CELL

Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells

(2011) Robert H. Newman et al.   CHEMICAL REVIEWS

Stimulating Cardiac Muscle by Light

(2011) Zhiheng Jia et al.   Circulation-Arrhythmia and Electrophysiology

Neuron-Specific Gene Transfer Through Retrograde Transport of Lentiviral Vector Pseudotyped with a Novel Type of Fusion Envelope Glycoprotein

(2011) Shigeki Kato et al.   HUMAN GENE THERAPY

Neural development in human embryonic stem cells-applications of lentiviral vectors

(2011) Mirella Dottori et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Optogenetic regulation of leg movement in midstage chick embryos through peripheral nerve stimulation

(2011) Andrew A. Sharp et al.   JOURNAL OF NEUROPHYSIOLOGY

Functional Connectome of the Striatal Medium Spiny Neuron

(2011) N. Chuhma et al.   JOURNAL OF NEUROSCIENCE

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

(2011) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins

(2011) Sonja Kleinlogel et al.   NATURE METHODS

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles

(2011) Michael M Halassa et al.   NATURE NEUROSCIENCE

Imaging Voltage in Neurons

(2011) Darcy S. Peterka et al.   NEURON

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

(2011) Ilana B. Witten et al.   NEURON

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9

(2011) Y. Masamizu et al.   NEUROSCIENCE

Diversity of Chlamydomonas Channelrhodopsins

(2011) Sing-Yi Hou et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Precise Spatiotemporal Control of Optogenetic Activation Using an Acousto-Optic Device

(2011) Kaiyu Wang et al.   PLoS One

Optical Dissection of Neural Circuits Responsible for Drosophila Larval Locomotion with Halorhodopsin

(2011) Kengo Inada et al.   PLoS One

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels

(2011) A. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Optogenetic investigation of neural circuits in vivo

(2011) Matthew E. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride

(2011) E. G. Govorunova et al.   mBio

Two Open States with Progressive Proton Selectivities in the Branched Channelrhodopsin-2 Photocycle

(2010) André Berndt et al.   BIOPHYSICAL JOURNAL

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Evolution of the Channelrhodopsin Photocycle Model

(2010) Katja Stehfest et al.   CHEMPHYSCHEM

Optogenetic experimentation on astrocytes

(2010) M. Figueiredo et al.   EXPERIMENTAL PHYSIOLOGY

A user's guide to channelrhodopsin variants: features, limitations and future developments

(2010) John Y. Lin   EXPERIMENTAL PHYSIOLOGY

Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications

(2010) Min-Hyung Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil BacteriumBeggiatoa

(2010) Manuela Stierl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substitution of 5-HT1AReceptor Signaling by a Light-activated G Protein-coupled Receptor

(2010) Eugene Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-site optical excitation using ChR2 and micro-LED array

(2010) Nir Grossman et al.   Journal of Neural Engineering

PACα- an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans

(2010) Simone Weissenberger et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Activation of Channelrhodopsin-2 Reveals That Normal Patterns of Spontaneous Activity Are Required for Motoneuron Guidance and Maintenance of Guidance Molecules

(2010) K. V. Kastanenka et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish

(2010) P. J. Schoonheim et al.   JOURNAL OF NEUROSCIENCE

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Pacing lightly: optogenetics gets to the heart

(2010) Björn C Knollmann   NATURE METHODS

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion

(2010) Martin Hägglund et al.   NATURE NEUROSCIENCE

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse

(2010) Ashesh K Dhawale et al.   NATURE NEUROSCIENCE

Multiwaveguide implantable probe for light delivery to sets of distributed brain targets

(2010) Anthony N. Zorzos et al.   OPTICS LETTERS

Opto-Current-Clamp Actuation of Cortical Neurons Using a Strategically Designed Channelrhodopsin

(2010) Lei Wen et al.   PLoS One

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Functional Control of Transplantable Human ESC-Derived Neurons Via Optogenetic Targeting

(2010) Jason P. Weick et al.   STEM CELLS

Tracking Stem Cell Differentiation in the Setting of Automated Optogenetic Stimulation

(2010) Albrecht Stroh et al.   STEM CELLS

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond

(2009) Christian Bamann et al.   BIOCHEMISTRY

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

(2009) John Y. Lin et al.   BIOPHYSICAL JOURNAL

The Gal4/UAS toolbox in zebrafish: new approaches for defining behavioral circuits

(2009) Ethan K. Scott   JOURNAL OF NEUROCHEMISTRY

Temporal Dynamics of Neuronal Activation by Channelrhodopsin-2 and TRPA1 Determine Behavioral Output in Drosophila Larvae

(2009) Stefan R. Pulver et al.   JOURNAL OF NEUROPHYSIOLOGY

Neocortical Disynaptic Inhibition Requires Somatodendritic Integration in Interneurons

(2009) C. Hull et al.   JOURNAL OF NEUROSCIENCE

Mrgprd-Expressing Polymodal Nociceptive Neurons Innervate Most Known Classes of Substantia Gelatinosa Neurons

(2009) H. Wang et al.   JOURNAL OF NEUROSCIENCE

Membrane Resonance in Bursting Pacemaker Neurons of an Oscillatory Network Is Correlated with Network Frequency

(2009) V. Tohidi et al.   JOURNAL OF NEUROSCIENCE

Ectopic Expression of Multiple Microbial Rhodopsins Restores ON and OFF Light Responses in Retinas with Photoreceptor Degeneration

(2009) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Transcranial optogenetic stimulation for functional mapping of the motor cortex

(2009) Riichiro Hira et al.   JOURNAL OF NEUROSCIENCE METHODS

Reverse engineering the mouse brain

(2009) Daniel H. O'Connor et al.   NATURE

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Optogenetic dissection of a behavioural module in the vertebrate spinal cord

(2009) Claire Wyart et al.   NATURE

Optical interrogation of neural circuits in Caenorhabditis elegans

(2009) Zengcai V Guo et al.   NATURE METHODS

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Photocurrent attenuation by a single polar-to-nonpolar point mutation of channelrhodopsin-2

(2009) Yuka Sugiyama et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Photocycles of Channelrhodopsin-2

(2009) Konstantin Nikolic et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Channelrhodopsins of Volvox carteri Are Photochromic Proteins That Are Specifically Expressed in Somatic Cells under Control of Light, Temperature, and the Sex Inducer

(2009) A. Kianianmomeni et al.   PLANT PHYSIOLOGY

PINP: A New Method of Tagging Neuronal Populations for Identification during In Vivo Electrophysiological Recording

(2009) Susana Q. Lima et al.   PLoS One

Visual Properties of Transgenic Rats Harboring the Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter

(2009) Hiroshi Tomita et al.   PLoS One

Optical control of zebrafish behavior with halorhodopsin

(2009) A. B. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system

(2009) Peixin Zhu   Frontiers in Neural Circuits

Dual transneuronal tracing in the rat entorhinal-hippocampal circuit by intracerebral injection of recombinant rabies virus vectors

(2009) Shinya Ohara   Frontiers in Neuroanatomy

Genetically Encoded Calcium Indicators

(2008) Marco Mank et al.   CHEMICAL REVIEWS

Electroporation as an efficient method of gene transfer

(2008) Noritaka Odani et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Single cell electroporation method for axon tracing in cultured slices

(2008) Naofumi Uesaka et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Neurogenesis, learning and associative strength

(2008) Jaylyn Waddell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increases in Intracellular Calcium Triggered by Channelrhodopsin-2 Potentiate the Response of Metabotropic Glutamate Receptor mGluR7

(2008) John H. Caldwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins fromChlamydomonas

(2008) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseases

(2008) Mari Dezawa   Medical Molecular Morphology

Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Channelrhodopsin-1 Initiates Phototaxis and Photophobic Responses in Chlamydomonas by Immediate Light-Induced Depolarization

(2008) P. Berthold et al.   PLANT CELL

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spectral Characteristics of the Photocycle of Channelrhodopsin-2 and Its Implication for Channel Function

(2007) Christian Bamann et al.   JOURNAL OF MOLECULAR BIOLOGY