Article
Neurosciences
Kathleen E. Mantell, Nipun D. Perera, Sina Shirinpour, Oula Puonti, Ting Xu, Jan Zimmermann, Arnaud Falchier, Sarah R. Heilbronner, Axel Thielscher, Alexander Opitz
Summary: The study examined the impact of anatomical details in NHP models on NIBS electric field calculations, highlighting the effects of muscle tissue and head field of view on TES and TMS simulation results. Opposing effects were found between TES and TMS when comparing full head models to cropped head models, with significant changes in electric field strength observed.
Review
Clinical Neurology
G. Darmani, T. O. Bergmann, K. Butts Pauly, C. F. Caskey, L. de Lecea, A. Fomenko, E. Fouragnan, W. Legon, K. R. Murphy, T. Nandi, M. A. Phipps, G. Pinton, H. Ramezanpour, J. Sallet, S. N. Yaakub, S. S. Yoo, R. Chen
Summary: Transcranial ultrasound stimulation (TUS) has the potential to alter neural circuits non-invasively in both animals and humans. Unlike other non-invasive brain stimulation methods, TUS can focus on both cortical and deep brain targets with unprecedented spatial resolution. The neuromodulatory effects of TUS are derived from the interaction of ultrasound waves with neuronal membranes, resulting in changes in excitability and firing rate. After years of research, TUS is now being applied in human studies and can be assessed using non-invasive brain mapping techniques. This review provides a comprehensive overview of the principles, mechanisms, effects, and potential applications of TUS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arkadiusz Jozefczak, Katarzyna Kaczmarek, Rafal Bielas, Jitka Prochazkova, Ivo Safarik
Summary: Magneto-responsive textiles have recently gained importance in various fields, including biomedical engineering. Most research has focused on single magnetic fibers and physical characterization of magnetic textiles. In this study, we engineered materials with magnetic properties from simple woven and non-woven textiles, which can potentially be used as a smart magnetic platform for heating treatments. Experiments showed that the temperature increase in tissue-mimicking phantoms depended on factors such as the type of textile material, concentration of magnetic nanoparticles, and number of layers covering the phantom. The achieved temperature elevation with magnetic textiles is sufficient for potential applications in magnetic hyperthermia therapies and heating patches or bandages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Y. Hong, J. Wang, J. Li, Z. Xu, X. Yang, M. Bai, P. Gong, Y. Xie, X. Zhang, P. Xu, X. Chen, R. Li, X. Liu, G. Ruan, G. Xu
Summary: This study explores an alternative strategy of non-invasive brain delivery of nanoparticles and finds that this method can enhance the neural stimulation effects of transcranial magnetic stimulation (TMS). The use of Tat-SPIONs in combination with TMS shows significant improvement in stroke recovery in rats. Mechanistic studies suggest that the neural stimulation enhancement is mediated by neuroplasticity and magnetoelectric effect, primarily through the binding of Tat-SPIONs to neurons' plasma membranes. This research provides a technological platform for the medical applications of nanoparticles in remote brain stimulation for stroke and other neurological disorders.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Psychiatry
Cletus Cheyuo, Jurgen Germann, Kazuaki Yamamoto, Artur Vetkas, Aaron Loh, Can Sarica, Vanessa Milano, Ajmal Zemmar, Oliver Flouty, Irene E. Harmsen, Mojgan Hodaie, Suneil K. Kalia, David Tang-Wai, Andres M. Lozano
Summary: Deep brain stimulation (DBS) and non-invasive neuromodulation are being investigated for treating Alzheimer's Disease (AD). This study provides evidence that DBS may improve cognitive outcomes in older AD patients, while non-invasive neuromodulation may have a favorable effect in younger patients. Brain stimulation in AD may modulate specific brain networks, such as the default mode network, salience network, central executive network, and the Papez circuit.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Alessandro Bertini, Francesco Pirone, Gessica Sala, Paola Signorelli, Carlo Ferrarese, Alberto Priori, Tommaso Bocci
Summary: Non-invasive brain stimulation techniques have shown potential in improving symptoms of neurodegenerative diseases, particularly cognitive and motor impairments in Alzheimer's Disease and Parkinson's Disease. However, their effect on disease progression is still unclear, although recent evidence suggests a possible neuroprotective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Amanda R. Arulpragasam, Mascha van 't Wout-Frank, Jennifer Barredo, Christiana R. Faucher, Benjamin D. Greenberg, Noah S. Philip
Summary: This article introduces a new emerging non-invasive neuromodulatory technology called low intensity focused ultrasound (LIFU). LIFU has the potential to deliver non-invasive and reversible deep brain neuromodulation at millimeter precision through acoustic sonication. Its spatial precision and non-invasive nature make it different from current technologies. Studies have shown that LIFU can safely modulate human brain activity. The novelty of this technique underscores the need for foundational papers to introduce it to the community.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Engineering, Biomedical
Serena Fiocchi, Emma Chiaramello, Alessandra Marrella, Marta Bonato, Marta Parazzini, Paolo Ravazzani
Summary: Computational electromagnetic techniques were used to model the behavior of magnetoelectric nanoparticles (MENPs) and their potential biomedical applications. The study found that MENPs can induce highly focused electric fields, making them a potential tool for treating neuropsychiatric disorders. In comparison, traditional transcranial magnetic stimulation (TMS) coils can only generate electric fields in specific areas, limiting their effectiveness for stimulating subcortical and deep tissues.
JOURNAL OF NEURAL ENGINEERING
(2022)
Review
Behavioral Sciences
Elisa Tatti, Angela L. Phillips, Rachel Paciorek, Sara M. Romanella, Davide Dettore, Giorgio Di Lorenzo, Giulio Ruffini, Simone Rossi, Emiliano Santarnecchi
Summary: Mental health disorders and substance use disorders pose significant challenges to public health systems. Evidence-based psychotherapy is commonly used to address mental health issues, but treatment adherence, relapses, and practical barriers hinder psychological change. Non-invasive brain stimulation techniques have emerged as promising tools to directly target dysfunctional neural circuitry and promote lasting plastic changes. Combining psychotherapy with brain stimulation may personalize treatment and provide more direct control of neuronal changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Ole Numssen, Constantijn L. van der Burght, Gesa Hartwigsen
Summary: Non-invasive brain stimulation techniques are widely used in cognitive neuroscience research, but the effectiveness of transcranial magnetic stimulation (TMS) studies is often inconclusive. To improve the results, it is suggested that the cognitive neuroscience community needs to revise the stimulation focality principle of TMS, which refers to the spatial resolution with which TMS can selectively stimulate cortical regions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Cell Biology
Alberto Benussi, Giorgi Batsikadze, Carina Franca, Rubens G. Cury, Roderick P. P. W. M. Maas
Summary: This paper comprehensively reviews the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus deep brain stimulation (DBS) in patients with hereditary ataxias, as well as the underlying mechanisms at the cellular and network level and future research perspectives.
Article
Neurosciences
Emma Acerbo, Aude Jegou, Charlotte Luff, Patrycja Dzialecka, Boris Botzanowski, Florian Missey, Ibrahima Ngom, Stanislas Lagarde, Fabrice Bartolomei, Antonino Cassara, Esra Neufeld, Viktor Jirsa, Romain Carron, Nir Grossman, Adam Williamson
Summary: This study demonstrates the effectiveness of Temporal Interference (TI) stimulation as a non-invasive deep brain stimulation (DBS) method for epilepsy treatment, showing promising results in both mouse models and human cadavers. The results suggest the potential therapeutic applications of TI stimulation in treating epilepsy by impacting specific brain rhythms without affecting surrounding tissue.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Wanting Guo, Yuchen He, Wenquan Zhang, Yiwei Sun, Junling Wang, Shuang Liu, Dong Ming
Summary: Neuromodulation technology has great potential in treating neuropsychiatric disorders, but challenges like invasiveness, energy consumption, and public acceptance need to be addressed. Temporally interfering electrical stimulation, using low-frequency envelope waveform, shows promise in targeting specific brain areas without invasive procedures. Recent studies have focused on investigating the stimulation qualities and application of this technique, aiming to provide reference for future research.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Wenshu Mai, Yuheng Wang, Tao Yin, Shunqi Zhang, Zhipeng Liu
Summary: This study proposes a non-invasive method based on the magneto-acoustic effect to detect electrical stimulation current, achieving high-precision measurement in isolated pork and pig brain samples. The method is validated through experiments and finite element analysis.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Review
Psychiatry
Hongqi Xiao, Yajing Meng, Shiyu Liu, Yuan Cao, Huan Sun, Gaoju Deng, Mei Wang, Yaozong Zheng, Changjian Qiu
Summary: This study investigated the role of non-invasive brain stimulation (NIBS) techniques in treating catatonia. The results showed that electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) were effective in improving catatonia symptoms, with rTMS and tDCS providing sustained effects.
FRONTIERS IN PSYCHIATRY
(2023)
