Article
Cell & Tissue Engineering
Mian Liu, Zhihui Liu, Yunxia Chen, Shiya Peng, Jiacai Yang, Cheng Chen, Jue Wang, Ruoyu Shang, Yuanyang Tang, Yong Huang, Xiaorong Zhang, Xiaohong Hu, Yih-Cherng Liou, Gaoxing Luo, Weifeng He
Summary: The study revealed that DETCs enhance the proliferation of EpSCs around wounds to accelerate re-epithelialization. Exosomes play a crucial role in regulating the proliferation of EpSCs, contributing to skin wound healing.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Meiyu Wu, Jinghua Ruan, Xiaogang Ye, Shuo Zhao, Xiaoli Tang, Xiaoxiao Wang, Huiping Li, Boxiong Zhong
Summary: The expression of human epidermal growth factor (hEGF) in a P25 gene knockout silkworm was reported, where the knockout of the P25 gene increased hEGF production while maintaining similar physical properties of cocoon silks compared to wild type silkworms. This suggests that P25 gene knockout silkworms could be an efficient bioreactor for producing exogenous proteins and protein-containing silk biomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kenta Nishitani, Koji Hayakawa, Satoshi Tanaka
Summary: The role of EGF signaling in mouse trophoblast differentiation was investigated using mouse trophoblast stem cells (mTSCs) in an in vitro culture system. EGF stimulation at the early stage of differentiation repressed mTSC differentiation into spongiotrophoblast cells (SpT) through the EGF-Egfr-MAPK/ERK-Mash2 axis. Inhibition of the MAPK/ERK pathway alleviated the EGF-mediated repression of SpT differentiation. These findings provide insights into the molecular mechanisms underlying trophoblast cell fate decisions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Immunology
Dapeng Cheng, Xiaochen Zhu, Shaochen Yan, Linli Shi, Zhi Liu, Xin Zhou, Xinling Bi
Summary: Inflammatory memory is a form of innate immune memory that is associated with cell epigenetic modification or metabolic transformation. Cells with inflammatory memory function show enhanced or tolerated inflammatory response when re-encountering similar stimuli. Various stem cells, including hematopoietic stem cells and fibroblasts, as well as stem cells from barrier epithelial tissues, can generate and maintain inflammatory memory. Epidermal stem cells, especially hair follicle stem cells, play a crucial role in wound healing, immune-related skin diseases, and skin cancer development. Recent research has shown that hair follicle epidermal stem cells can remember inflammatory responses and exhibit a faster response to subsequent stimuli. This review provides an update on the advances of inflammatory memory and focuses on its mechanisms in epidermal stem cells. Further research on inflammatory memory is eagerly awaited to develop precise strategies for manipulating host responses to infection, injury, and inflammatory skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Jasmin Taubenschmid-Stowers, Maria Rostovskaya, Fatima Santos, Sebastian Ljung, Ricard Argelaguet, Felix Krueger, Jennifer Nichols, Wolf Reik
Summary: This study discovered human 8-cell-like cells (8CLCs) among naive embryonic stem cells, which transcriptionally resemble the 8-cell human embryo. These cells express markers and elements associated with embryonic development, providing important insights into early events in human embryogenesis.
Article
Biology
Fangfang Liu, Shuxin Yu, Nan Chen, Chonghua Ren, Sheng Li
Summary: This review summarizes the coordinated regulation of developmental plasticity in cockroaches and termites by nutritional and hormonal signals, including metamorphosis, reproduction, appendage regeneration, and caste differentiation. The interconnection of nutritional and hormonal signals forms a complex regulatory network.
CURRENT OPINION IN INSECT SCIENCE
(2023)
Article
Cell Biology
Federica Mangione, Joshua Titlow, Catherine Maclachlan, Michel Gho, Ilan Davis, Lucy Collinson, Nicolas Tapon
Summary: By examining the differentiation of tactile bristles in Drosophila, it was found that neighboring epidermal cells are essential for touch perception.
NATURE CELL BIOLOGY
(2023)
Article
Genetics & Heredity
Yu-Qing Wang, Qi Liu, Yan Zhou, Lizhi Chen, Yue-Ming Yang, Xue Shi, Deborah M. Power, Yi-Feng Li
Summary: In this study, transcriptome analysis of different developmental stages of the mussel, Mytilus coruscus, was conducted to uncover the molecular mechanisms underlying larval settlement and metamorphosis. The results showed that highly upregulated differentially expressed genes at the pediveliger stage were enriched in immune-related genes. The findings suggest that the larvae utilize molecules of the immune system to sense and respond to external chemical cues and neuroendocrine signaling pathways. The upregulation of adhesive protein genes linked to byssal thread secretion indicates the anchoring capacity required for larval settlement arises prior to metamorphosis. The results of gene expression support the role of the immune and neuroendocrine systems in mussel metamorphosis and provide a foundation for future studies.
Article
Oncology
Hye-Young Min, Ho Jin Lee, Young-Ah Suh, Honglan Pei, Hyukjin Kwon, Hyun-Ji Jang, Hye Jeong Yun, Hyeong-Gon Moon, Ho-Young Lee
Summary: This study highlights the pivotal role of EGFR signaling-mediated G6PD expression in paclitaxel resistance and suggests that targeting EGFR could be a potential therapeutic strategy to overcome paclitaxel resistance in TNBC and NSCLC cells overexpressing G6PD.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell & Tissue Engineering
Pal Boto, Timea Beatrix Gerzsenyi, Adel Lengyel, Balint Szunyog, Istvan Szatmari
Summary: Zbtb46 suppresses myeloid development and diverts mesoderm cells toward erythroid developmental pathway in ESC-derived progenitors. Despite repressive effects, Zbtb46 overexpression enhances erythroid blood cell colony formation and increases adult hemoglobin expression, along with an elevated percentage of CD105 positive cells.
Article
Cell Biology
Sangbum Park, Catherine Matte-Martone, David G. Gonzalez, Elizabeth A. Lathrop, Dennis P. May, Cristiana M. Pineda, Jessica L. Moore, Jonathan D. Boucher, Edward Marsh, Axel Schmitter-Sanchez, Katie Cockburn, Olga Markova, Yohanns Bellaiche, Valentina Greco
Summary: LCs and DETCs actively maintain a non-random spatial distribution in the skin, coordinating with surrounding epithelial cells to maintain their positions. The density of epithelial cells regulates the composition of LCs and DETCs.
NATURE CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hua-Jun Wu, Alexandro Landshammer, Elena K. Stamenova, Adriano Bolondi, Helene Kretzmer, Alexander Meissner, Franziska Michor
Summary: The disruption of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation, and germline variations affecting such boundaries are selectively retained, leading to underrepresentation in the human population.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Millissia Ben Maamar, Daniel Beck, Eric Nilsson, John R. McCarrey, Michael K. Skinner
Summary: This study aimed to investigate the dynamic changes in DNA methylation during gametogenesis and identify the associated genes and functions. The results revealed complex epigenetic alterations during the early developmental stages, which are essential for regulating genome biology and gene expression during gametogenesis.
Article
Dermatology
Maximilian E. Pickup, Anhua Hu, Hetal J. Patel, Mohammed I. Ahmed
Summary: Skin and hair development are regulated by complex gene activation and silencing programs, as well as microRNA-dependent gene expression modulation. MiR-148a plays a crucial role in the regulation of skin homeostasis and hair follicle cycling through its gene targets. It controls stem/progenitor cell functions and influences key processes such as colony-forming abilities of hair follicle bulge stem cells and keratinocyte proliferation/differentiation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell & Tissue Engineering
Kai Kretzschmar, Kim E. Boonekamp, Margit Bleijs, Priyanca Asra, Mandy Koomen, Susana M. Chuva de Sousa Lopes, Barbara Giovannone, Hans Clevers
Summary: Research has identified Troy as a marker of epidermal basal cells that play a role in the long-term renewal and cornification of the skin. Single-cell transcriptomics and organoid assays confirmed their stem cell identity and ability to generate differentiating daughter cells.
Article
Biology
Yuto Sakane, Midori Iida, Takashi Hasebe, Satoshi Fujii, Daniel R. Buchholz, Atsuko Ishizuya-Oka, Takashi Yamamoto, Ken-ichi T. Suzuki
Article
Peripheral Vascular Disease
Mutsumi Araki, Takashi Hisamitsu, Yumi Kinugasa-Katayama, Toru Tanaka, Yukihiro Harada, Shu Nakao, Sanshiro Hanada, Shuhei Ishii, Masahide Fujita, Teruhisa Kawamura, Yoshihiko Saito, Koichi Nishiyama, Yusuke Watanabe, Osamu Nakagawa
Article
Developmental Biology
Miyuki Suzuki, Toshinori Hayashi, Takeshi Inoue, Kiyokazu Agata, Miki Hirayama, Miyuzu Suzuki, Shuji Shigenobu, Takashi Takeuchi, Takashi Yamamoto, Ken-ichi T. Suzuki
DEVELOPMENTAL BIOLOGY
(2018)
Article
Genetics & Heredity
Masatoshi Matsunami, Miyuki Suzuki, Yoshikazu Haramoto, Akimasa Fukui, Takeshi Inoue, Katsushi Yamaguchi, Ikuo Uchiyama, Kazuki Mori, Kosuke Tashiro, Yuzuru Ito, Takashi Takeuchi, Ken-ichi T. Suzuki, Kiyokazu Agata, Shuji Shigenobu, Toshinori Hayashi
Article
Environmental Sciences
Yuka Yoshinouchi, Sachiko Shimizu, Jin-Seon Lee, Masashi Hirano, Ken-ichi T. Suzuki, Eun-Young Kim, Hisato Iwata
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Developmental Biology
Dai Ihara, Yusuke Watanabe, Daiki Seya, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Atsushi Kubo, Toshihiko Ogura, Teruhisa Kawamura, Osamu Nakagawa
DEVELOPMENTAL BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Takekazu Miyoshi, Takashi Hisamitsu, Hatsue Ishibashi-Ueda, Kenji Ikemura, Tomoaki Ikeda, Mikiya Miyazato, Kenji Kangawa, Yusuke Watanabe, Osamu Nakagawa, Hiroshi Hosoda
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cell Biology
Midori Iida, Miyuki Suzuki, Yuto Sakane, Hiroyo Nishide, Ikuo Uchiyama, Takashi Yamamoto, Ken-ichi T. Suzuki, Satoshi Fujii
Article
Biochemistry & Molecular Biology
Yusuke Watanabe, Daiki Seya, Dai Ihara, Shuhei Ishii, Taiki Uemoto, Atsushi Kubo, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Takaya Abe, Mayo Shigeta, Teruhisa Kawamura, Yoshihiko Saito, Toshihiko Ogura, Osamu Nakagawa
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Cell Biology
Daiki Seya, Dai Ihara, Teruhisa Kawamura, Yusuke Watanabe, Osamu Nakagawa
Summary: The transcription factor Hey2 plays a crucial role in right ventricle development during cardiac morphogenesis by mitigating Tbx2-dependent inhibition of Mycn expression. This was evidenced in Hey2 conditional knockout mice where anomalies commonly observed in Hey2 null mice were reproduced, including underdevelopment of the right ventricle due to ectopic induction of Tbx2 in the chamber myocardium.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2021)
Article
Developmental Biology
Yumi Kinugasa-Katayama, Yusuke Watanabe, Takashi Hisamitsu, Yuichiro Arima, Norika M. Liu, Ayaka Tomimatsu, Yukihiro Harada, Yuji Arai, Akihiro Urasaki, Teruhisa Kawamura, Yoshihiko Saito, Osamu Nakagawa
Summary: The study highlights the significance of Tmem100 gene in embryonic vascular development and successfully replicates its expression profile using a novel EGFP reporter mouse line. The Tmem100-BAC-EGFP mice serve as a valuable tool for further research and comparative analysis of endothelial cell subgroups in embryonic vascular development.
Article
Cell Biology
Yukihiro Harada, Toru Tanaka, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Shu Nakao, Akihiro Urasaki, Yusuke Watanabe, Teruhisa Kawamura, Osamu Nakagawa
Summary: SGK1 is predominantly expressed in endothelial cells of mouse embryos, and its expression is maintained through at least two ETS-regulated enhancers, located in the proximal and distal regions. The presence of these enhancers is essential for the responsiveness to ERG, FLI1, and ETS1 proteins.
Article
Cardiac & Cardiovascular Systems
Yu Yoshida, Keiko Uchida, Kazuki Kodo, Reina Ishizaki-Asami, Jun Maeda, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda, Kenjiro Kosaki, Yusuke Watanabe, Osamu Nakagawa, Hiroyuki Yamagishi
Summary: This study used next-generation sequencing to analyze the genes of a familial case with complex congenital heart disease (CHD). Two rare variants in the NODAL and TBX20 genes were identified and found to affect downstream signaling pathways involved in heart development. These findings suggest that loss-of-function mutations in NODAL and TBX20 may contribute to the etiology of complex CHD associated with single ventricle defects in this family.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Developmental Biology
Akira Satoh, Kazumasa Mitogawa, Nanami Saito, Miyuki Suzuki, Ken-ichi T. Suzuki, Haruki Ochi, Aki Makanae
DEVELOPMENTAL BIOLOGY
(2017)
Article
Toxicology
Junpei Mori, Seigo Sanoh, Keiko Kashiwagi, Hideki Hanada, Mitsuki Shigeta, Ken-ichi T. Suzuki, Takashi Yamamoto, Yaichiro Kotake, Kazumi Sugihara, Shigeyuki Kitamura, Akihiko Kashiwagi, Shigeru Ohta
JOURNAL OF TOXICOLOGICAL SCIENCES
(2017)