Article
Plant Sciences
Devesh Tewari, Pawan Gupta, Sweta Bawari, Archana N. Sah, Davide Barreca, Maryam Khayatkashani, Hamid Reza Khayat Kashani
Summary: The study demonstrated for the first time the significant analgesic activity of Ficus palmata L. fruit extract, and highlighted the potential of the plant chemicals rutin and psoralen in ameliorating painful conditions.
Article
Nutrition & Dietetics
Xiong Zhang, Ke Wang, Xiao-Li Ren, Meng-Di Zhang, Kai-Nian Wu, Han Wu, Zhong-Wei Chu, Shu-Shu Liu, Xiao-Xia Jiang, Jian-Hong Zhu, Hong-Mei Wu
Summary: This study investigated the effects of zinc deficiency on behavior and dopaminergic neurons in a mouse model of Parkinson's disease. The results showed that zinc deficiency worsened movement disorders and affected the degeneration of dopaminergic neurons. These findings suggest that appropriate zinc supplementation may be beneficial for patients with Parkinson's disease.
JOURNAL OF NUTRITION
(2023)
Article
Developmental Biology
Manal T. Hussein, Abdelraheim Attaai, Gamal Kamel, Doaa M. Mokhtar
Summary: The study investigated the potential role of SHH signaling components in the development of mDA neurons, revealing that Ptch1 and Gli1 were only expressed in the ventrolateral midbrain at E12 and E14, while no SHH signaling molecules were detected in the mDA area. Experimental results suggest that the differentiation and survival of mDA neurons may not depend on SHH in the late developmental stages.
GENE EXPRESSION PATTERNS
(2021)
Article
Biology
Weizhao Chen, Qiongping Zheng, Qiaoying Huang, Shanshan Ma, Mingtao Li, Serge Przedborski
Summary: This study confirms that repressing PTBP1 does not convert astrocytes to dopaminergic neurons (DAns), regardless of physiological or Parkinson's disease-related pathological conditions.
Article
Cell Biology
Lieke L. van de Haar, Danai Riga, Juliska E. Boer, Oxana Garritsen, Youri Adolfs, Thomas E. Sieburgh, Roland E. van Dijk, Kyoko Watanabe, Nicky C. H. van Kronenburg, Mark H. Broekhoven, Danielle Posthuma, Frank J. Meye, Onur Basak, R. Jeroen Pasterkamp
Summary: This study reveals the cellular and molecular trajectories of habenular neuron development and organization into subtypes, as well as their distinctive functional properties and projection targets. It also links specific developing habenular subtypes to psychiatric disease, providing a framework for further investigation of habenular development in normal and disease states.
Article
Biochemical Research Methods
Lianshun Xie, Hengxin Liu, Zhiwen You, Luyue Wang, Yiwen Li, Xinyue Zhang, Xiaoshan Ji, Hui He, Tingli Yuan, Wenping Zheng, Ziyan Wu, Man Xiong, Wu Wei, Yuejun Chen
Summary: A fundamental interest in developmental neuroscience is mapping single-cell lineages in the brain. Researchers developed a CRISPR editing-based lineage-specific tracing method called CREST and used it to map single-cell lineages in the developing mouse ventral midbrain (vMB). They identified different progenitor types and clonal lineages using the CREST method and associated progenitor cell transcriptomes with their differentiation potentials using pandaCREST. This comprehensive single-cell lineage analysis provides new insights into neural specification and offers a dual-recorder single-cell lineage tracing method for the mouse brain called CREST.
Article
Neurosciences
Jon-Ruben Van Rhijn, Yan Shi, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun Klein Gunnewiek, Chantal Schoenmaker, Elizabeth Palmer, Laurence Faivre, Sarah Kittel-Schneider, Dirk Schubert, Han Brunner, Barbara Franke, Nael Nadif Kasri
Summary: Monoamine oxidase A (MAOA) mutations in Brunner syndrome lead to hyperactivity in dopaminergic neurons and abnormal neuronal network function. We found reduced synaptic density but hyperactive network activity in dopaminergic neurons of individuals with Brunner syndrome. The hyperactivity is mediated by upregulation of NMDA receptor subunits GRIN2A and GRIN2B due to MAOA mutations. By restoring the mutated MAOA gene, we normalized neuronal function.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemical Research Methods
Jennifer Hammelman, David K. Gifford
Summary: Discovering sequence features that guide cells to different fates is crucial for understanding cellular development and disease-related mutations. The Expected Pattern Effect and Differential Expected Pattern Effect methods can interpret genome regulatory sequences to identify cell type-specific or condition-specific patterns. These methods identify relevant transcription factor motifs and spacings that predict cell state-specific chromatin accessibility.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Han -Sol Lee, Jin-Hee Han
Summary: The hippocampus is essential for retrieving contextual memories, and the activation of a specific group of neurons in the dorsal CA1 is necessary for memory retrieval. Individual neurons and synchronous activity patterns in the dCA1 neuronal network play a critical role in representing contextual memory recall.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Kira Mitchel, Jenna M. Bergmann, Ava E. Brent, Tova M. Finkelstein, Kyra A. Schindler, Miriam A. Holzman, Lucie Jeannotte, Jennifer H. Mansfield
Summary: The skeletal system originates from multiple embryonic sources and must develop in coordination, particularly across the lateral somitic frontier. Hox genes play a regulatory role in skeletal pattern, but there are still questions about the genetic control of this coordination, especially in structures like the sternum. The embryology of the presternum, a recently identified structure, is not well described in mouse models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yvette Akwa, Chiara Di Malta, Fatima Zallo, Elise Gondard, Adele Lunati, Lara Z. Diaz-de-Grenu, Angela Zampelli, Anne Boiret, Sara Santamaria, Maialen Martinez-Preciado, Katia Cortese, Jeffrey H. Kordower, Carlos Matute, Andres M. Lozano, Estibaliz Capetillo-Zarate, Thomas Vaccari, Carmine Settembre, Etienne E. Baulieu, Davide Tampellini
Summary: Synaptic stimulation promotes TFEB-mediated clearance of pathological MAPT/Tau, which provides neuroprotection. Deep brain stimulation activates TFEB and reduces MAPT/Tau levels in Parkinson disease patients, leading to neuroprotection.
Article
Neurosciences
Marcia C. L. Pereira, Austin C. Boese, Rabi Murad, Jun Yin, Milton H. Hamblin, Jean-Pyo Lee
Summary: This study investigated the therapeutic effects of transplanting human neural stem cells (hNSCs) during the early stages of Parkinson's disease (PD) development. The results showed that early hNSC engraftment mitigated motor symptoms induced by PD and reduced loss of dopaminergic neurons. The comprehensive analysis of PD mouse brains post-hNSC transplantation revealed changes in gene expressions associated with mitochondrial bioenergetics, proteostasis, and other signaling pathways related to improved PD outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siwei Zhou, Xiaofang Zhou, Zewen Jiang, Jinrong Ma, Yuanmei Li, Zhiyong Qian, Hua Li
Summary: The long non-coding RNA SNHG8 plays a vital role in Parkinson's disease by regulating miR-421-3p and SNX8 to alleviate rotenone-induced dopaminergic neuron injury.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Yidong Deng, Yuangao Liao, Peijian Huang, Yujian Yao, Weihua Liu, Yong Gu, Guohu Weng
Summary: This study aims to investigate the role of IRAK-M as a negative regulator of innate immunity in the pathological progression of Parkinson's disease. The results suggest that IRAK-M can reduce dopaminergic neuron damage in sub-acute Parkinson's disease by suppressing inflammation, providing a potential therapeutic target for Parkinson's disease treatment.
Article
Biochemistry & Molecular Biology
Gerardo Zapata, Keqin Yan, David J. Picketts
Summary: Heterozygous variants in the BPTF gene lead to a neurodevelopmental disorder characterized by intellectual disability, speech delay, and microcephaly. A mouse model for this syndrome was created, and it exhibited smaller size and severe cortical hypoplasia. The study also identified changes in gene expression related to neural development, apoptotic signaling, and amino acid biosynthesis. This research provides a valuable model for further understanding the NEDDFL syndrome.
HUMAN MOLECULAR GENETICS
(2022)
Article
Developmental Biology
Tomoya Nakatani, Minoru Kumai, Eri Mizuhara, Yasuko Minaki, Yuichi Ono
DEVELOPMENTAL BIOLOGY
(2010)
Article
Developmental Biology
Eri Mizuhara, Yasuko Minaki, Tomoya Nakatani, Minoru Kumai, Takeshi Inoue, Keiko Muguruma, Yoshiki Sasai, Yuichi Ono
DEVELOPMENTAL BIOLOGY
(2010)
Article
Developmental Biology
Tomoya Nakatani, Yasuko Minaki, Minoru Kumai, Chiemi Nitta, Yuichi Ono
DEVELOPMENTAL BIOLOGY
(2014)
Article
Developmental Biology
Yasuko Minaki, Tornoya Nakatani, Eri Mizuhara, Takeshi Inoue, Yuichi Ono
GENE EXPRESSION PATTERNS
(2008)
Article
Oncology
Soo Ki Kim, Akihiro Nasu, Junji Komori, Takahiro Shimizu, Yuko Matsumoto, Yasuko Minaki, Kenji Kohno, Kazuharu Shimizu, Shinji Uemoto, Tsutomu Chiba, Hiroyuki Marusawa
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Multidisciplinary Sciences
Yusuke Seto, Tomoya Nakatani, Norihisa Masuyama, Shinichiro Taya, Minoru Kumai, Yasuko Minaki, Akiko Hamaguchi, Yukiko U. Inoue, Takayoshi Inoue, Satoshi Miyashita, Tomoyuki Fujiyama, Mayumi Yamada, Heather Chapman, Kenneth Campbell, Mark A. Magnuson, Christopher V. Wright, Yoshiya Kawaguchi, Kazuhiro Ikenaka, Hirohide Takebayashi, Shin'ichi Ishiwata, Yuichi Ono, Mikio Hoshino
NATURE COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Koji Hirata, Sota Kodama, Yasuhiro Nakano, Yasuko Minaki-Nakagawa, Yoshiki Aoyama, Morito Sakikubo, Toshihiko Goto, Masahiro Yoshida, Toshihiko Masui, Takuya Yamamoto, Shinji Uemoto, Yoshiya Kawaguchi
SCIENTIFIC REPORTS
(2019)
Article
Critical Care Medicine
Michiharu Sakamoto, Yasuko Minaki, Takashi Nakano, Itaru Tsuge, Hiroki Yamanaka, Yoshihiro Sowa, Yoshihiro Shimizu, Masukazu Inoie, Susumu Saito, Naoki Morimoto
Summary: A prospective clinical study was conducted to confirm the safety and efficacy of dried allogeneic cultured epidermis (CE) for wound treatment. The results showed that treatment with dried CE was effective in promoting wound healing and had a low incidence of severe adverse events.
Article
Developmental Biology
Yuichi Ono, Tomoya Nakatani, Yoshimasa Sakamoto, Eri Mizuhara, Yasuko Minaki, Minoru Kumai, Akiko Hamaguchi, Miyuki Nishimura, Yoko Inoue, Hideki HayashiO, Jun Takahashi, Toshio Imai
Article
Developmental Biology
Tomoya Nakatani, Yasuko Minaki, Minoru Kumai, Yuichi Ono
Article
Biochemistry & Molecular Biology
E Mizuhara, T Nakatani, Y Minaki, Y Sakamoto, Y Ono, Y Takai
JOURNAL OF BIOLOGICAL CHEMISTRY
(2005)
Article
Neurosciences
Y Minaki, E Mizuhara, K Morimoto, T Nakatani, Y Sakamoto, A Inoue, K Satoh, T Imai, Y Takai, Y Ono
NEUROSCIENCE RESEARCH
(2005)
Article
Biochemistry & Molecular Biology
E Mizuhara, T Nakatani, Y Minaki, Y Sakamoto, Y Ono
JOURNAL OF BIOLOGICAL CHEMISTRY
(2005)
Article
Biochemistry & Molecular Biology
T Nakatani, E Mizuhara, Y Minaki, Y Sakamoto, Y Ono
JOURNAL OF BIOLOGICAL CHEMISTRY
(2004)