Article
Oncology
Takahiro Maeno, Rio Arimatsu, Koichi Ojima, Yuki Yamaya, Hikaru Imakyure, Naruha Watanabe, Yusuke Komiya, Ken Kobayashi, Mako Nakamura, Takanori Nishimura, Ryuichi Tatsumi, Takahiro Suzuki
Summary: Satellite cells play a crucial role in skeletal muscle regeneration and hypertrophy through the formation of nascent myofibers. This study investigated the role of netrin-4, a multi-potent modulator, in regulating myofiber type commitment and myotube formation. The findings suggest that satellite cells synthesize netrin-4 during the initiation stage of myogenic differentiation to promote their own fusion through the MyoD-Myomixer signaling axis.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Physiology
Madhura Chakraborty, Athul Sivan, Arikta Biswas, Bidisha Sinha
Summary: In this study, we investigated the regulation of fluctuation-tension during myogenesis and the role of the fusogen myomerger. Our findings suggest that low tension and clustered surface-myomerger at the early phase are crucial for fusion and can be disrupted by cholesterol-reducing molecules.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Chengchuang Song, Qi Wang, Qi Qi, Xi Chen, Yanhong Wang, Chunlei Zhang, Fang Xintang
Summary: The study revealed that miR-495-3p inhibits proliferation and promotes differentiation in muscle cells by targeting CDH2. This finding sheds light on the crucial regulatory role of miR-495-3p in skeletal muscle development.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tiantian Zhao, Rui Zhao, Xudong Yi, Rui Cai, Weijun Pang
Summary: METTL3 plays an important role in skeletal muscle development by regulating cell proliferation and myogenic differentiation through m6A RNA methylation.
Article
Endocrinology & Metabolism
Duyen Tran, Stephen Myers, Courtney McGowan, Darren Henstridge, Rajaraman Eri, Sabrina Sonda, Vanni Caruso
Summary: 1-DSL disrupts the functionality of skeletal muscle cells, likely contributing to the muscle dysfunction detected in patients with Type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Developmental Biology
Sunny Trivedi, Mallika Bhattacharya, Michelle Starz-Gaiano
Summary: Cell migration is essential in animal development and diseases. The E3 ubiquitin ligase Mib2 is found to play a crucial role in promoting epithelial stability and collective cell migration. Mib2 stabilizes E-cadherin-based adhesion complexes and promotes a robust actin cytoskeletal network to maintain epithelial integrity, and its interaction with other cytoskeletal regulators contributes to collective cell migration.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kai Shi, Yingling Lu, Xiaolu Chen, Dongfeng Li, Wenxing Du, Minli Yu
Summary: Tet2 plays a crucial role in chicken myogenesis by regulating the demethylation of genomic DNA and histones to control the expression of MRFs, thus contributing to myoblast differentiation. The expression of Tet2 is significantly elevated during myoblast differentiation, leading to an increase in 5hmC levels and a decrease in H3K9me2 and H3K27me3 levels. Knockdown of Tet2 inhibits the formation of multinucleated myotubes and reduces pivotal MRFs expression.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kumar Vishal, Elizabeth Barajas Alonso, Ashley A. DeAguero, Jennifer A. Waters, Maria B. Chechenova, Richard M. Cripps
Summary: The activity of MEF2, a myogenic regulatory protein, is modulated by post-translational modification. By investigating the phosphorylation of Drosophila MEF2 in vivo, the authors identified that serine 98 is a phosphorylated residue. The study shows that blocking phosphorylation at S98 enhances MEF2 function in myoblasts, but attenuates its function in differentiating muscles.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Article
Biology
Maxime R. F. Gosselin, Virginie Mournetas, Malgorzata Borczyk, Suraj Verma, Annalisa Occhipinti, Justyna Rog, Lukasz Bozycki, Michal Korostynski, Samuel C. Robson, Claudio Angione, Christian Pinset, Dariusz C. Gorecki
Summary: In Duchenne muscular dystrophy (DMD), myoblasts are affected, leading to muscle degeneration and repair defects. These cells show abnormalities in gene expression and function, impacting muscle regeneration. Therefore, myoblasts can be a novel therapeutic target for the treatment of DMD.
Article
Biochemistry & Molecular Biology
Yixuan Liu, Nanqi Liu, Yang Yu, Difei Wang
Summary: Nr4a1 regulates myoblast adhesion via Zeb1 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Suting Li, Zhi Wang, Mao Chen, Ya Xiao, Jie Min, Ming Hu, Jianming Tang, Li Hong
Summary: In this study, ArfGAP3 was found to be expressed during skeletal muscle injury and myoblast differentiation, and positively correlated with COPI-related genes. In vitro experiments showed that ArfGAP3 regulates COPI-associated vesicle and GLUT4 transport, impacting myoblast proliferation and differentiation by influencing glucose uptake. These findings provide insight into the repair process after skeletal muscle injury.
CELLULAR SIGNALLING
(2023)
Article
Biology
Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano
Summary: The E3 ligase MIB2 ubiquitylates apoptosis-inhibitor cFLIP, suppressing RIPK1 kinase activity-dependent and -independent apoptosis. Deletion of MIB2 enhances RIPK1 kinase activity and impairs ubiquitylation of cFLIP(L), resulting in increased apoptosis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarina Gros, Urska Matkovic, Giulia Parato, Katarina Mis, Elisa Luin, Annalisa Bernareggi, Marina Sciancalepore, Tomaz Mars, Paola Lorenzon, Sergej Pirkmajer
Summary: Neuronal agrin has an age-dependent role in promoting the proliferation of human myoblasts by binding to Lrp4 and activating MuSK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Liyi Wang, Tizhong Shan
Summary: Fat infiltration in skeletal muscle is associated with various diseases and meat quality, understanding its origin and regulation is crucial for developing therapies against human myopathies and improving meat quality. Various factors, including age, sarcopenia, oxidative stress, and nutrition, can induce transdifferentiation of myoblasts into adipocytes, affecting fat accumulation in skeletal muscle. Regulatory roles and mechanisms of these factors during the transdifferentiation process are also important to consider.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Jeong Ho Lim, Mirza Masroor Ali Beg, Khurshid Ahmad, Sibhghatulla Shaikh, Syed Sayeed Ahmad, Hee Jin Chun, Dukhwan Choi, Woo-Jong Lee, Jun-O Jin, Jihoe Kim, Arif Tasleem Jan, Eun Ju Lee, Inho Choi
Summary: The study shows that IgLON5 plays a crucial role in myogenesis and muscle regeneration by interacting with extracellular matrix and cell membrane proteins, creating an essential microenvironment for muscle stem cell survival.
Article
Developmental Biology
Marta Carrasco-Rando, Alexandra Atienza-Manuel, Paloma Martin, Richard Burke, Mar Ruiz-Gomez
Article
Developmental Biology
Antonio S. Tutor, Silvia Prieto-Sanchez, Mar Ruiz-Gomez
Article
Multidisciplinary Sciences
Helen Weavers, Silvia Prieto-Sanchez, Ferdinand Grawe, Amparo Garcia-Lopez, Ruben Artero, Michaela Wilsch-Braeuninger, Mar Ruiz-Gomez, Helen Skaer, Barry Denholm
Article
Multidisciplinary Sciences
K. G. Guruharsha, Mar Ruiz-Gomez, H. A. Ranganath, Rahul Siddharthan, K. VijayRaghavan
Article
Cell Biology
Lucia Garcia-Guerra, Rocio Vila-Bedmar, Marta Carrasco-Rando, Marta Cruces-Sande, Mercedes Martin, Ana Ruiz-Gomez, Mar Ruiz-Gomez, Margarita Lorenzo, Sonia Fernandez-Veledo, Federico Mayor, Cristina Murga, Iria Nieto-Vazquez
JOURNAL OF MOLECULAR CELL BIOLOGY
(2014)
Article
Genetics & Heredity
Marta Carrasco-Rando, Antonio S. Tutor, Silvia Prieto-Sanchez, Esther Gonzalez-Perez, Natalia Barrios, Annalisa Letizia, Paloma Martin, Sonsoles Campuzano, Mar Ruiz-Gomez
Article
Cell Biology
Marta Carrasco-Rando, Silvia Prieto-Sanchez, Joaquim Culi, Antonio S. Tutor, Mar Ruiz-Gomez
JOURNAL OF CELL BIOLOGY
(2019)
Article
Developmental Biology
Alexandra Atienza-Manuel, Vicente Castillo-Mancho, Stefano De Renzis, Joaquim Culi, Mar Ruiz-Gomez
Summary: The complex composed of Amnionless, Cubilin, and Cubilin2 is crucial for nephrocyte slit diaphragm (SD) dynamics in Drosophila. Loss of CUBAM-mediated endocytosis leads to dramatic morphological changes in nephrocytes and mislocalisation of SD, likely due to an imbalance between endocytosis and exocytosis. While rescuing receptor-mediated endocytosis can partially restore SD positioning in CUBAM mutants, suggesting a specific requirement of CUBAM in SD degradation and recycling.
Biographical-Item
Developmental Biology
Mar Ruiz-Gomez, Sonsoles Campuzano
Article
Developmental Biology
Marta Carrasco-Rando, Joaquim Culi, Sonsoles Campuzano, Mar Ruiz-Gomez
Summary: The assembly of slit diaphragms in Drosophila embryonic garland nephrocytes is facilitated by a cell division that breaks membrane symmetry and generates PIP2-enriched domains at the equator. This allows for the recruitment and assembly of slit diaphragm proteins, leading to the formation of functional nephrocytes.