Review
Neurosciences
Jacob Starkey, Eric J. Horstick, Sarah D. Ackerman
Summary: Animal behavior relies on the accurate wiring of neurons into neural circuits, which undergo significant remodeling during critical periods. Environmental experiences during these periods can have lasting effects on circuit function and behavior. Understanding the mechanisms that regulate critical period timing is crucial for studying neurodevelopmental disorders, and glial cells may play a role in this process.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwen
Summary: Neuronal death and neuroinflammation are important factors in the progression of traumatic brain injury (TBI). This study reveals that a protein called TRAF7 plays a critical role in TBI by regulating cell death and inflammation. The interaction between TRAF7 and MEKK3 is a key step in the development of TBI, suggesting that TRAF7 could be a potential therapeutic target for TBI treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Binbin Wu, Lei He, Yutong Xiao, Juan Du, Xiaoxiao Wang, Zhangwu Zhao
Summary: This study demonstrates the importance of the JH receptor, Methoprene-tolerant (Met), in controlling neurite development and sleep behavior in Drosophila. Met negatively controls the fusion of MB beta lobes and positively maintains pruning of pigment-dispersing factor sLNvs projections, while also regulating nighttime sleep in a development-independent manner through the alpha/beta lobe of MB. By combining analyses of neuronal morphology and entomological behavior, this study advances our understanding of how JH receptor regulates the nervous system.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Biology
Anadika R. Prasad, Ines Lago-Baldaia, Matthew P. Bostock, Zaynab Housseini, Vilaiwan M. Fernandes
Summary: Research in the Drosophila visual system has uncovered the intricate interplay between glial signals and neuronal differentiation, leading to the determination of neuronal numbers and programmed cell death.
Article
Physiology
Guibin Liang, Wenhua Wang, Zhihui He
Summary: This study explores the literature of sepsis associated with acute lung injury (ALI) from a bibliometric perspective. The research has made significant progress in the past decade, with China being the largest contributor and articles from the United States being the most cited. Shanghai Jiao Tong University, University of California System, and Huazhong University of Science Technology were the main contributing institutions. Articles in International Immunopharmacology, Inflammation, Shock and Critical Care were cited the most. The focus of future research may be on programmed cell death, including apoptosis, necroptosis, and pyroptosis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Matthew J. Moulton, Scott Barish, Isha Ralhan, Jinlan Chang, Lindsey D. Goodman, Jake G. Harland, Paul C. Marcogliese, Jan O. Johansson, Maria S. Ioannou, Hugo J. Bellen
Summary: The study reveals that the increasing genetic risk factors for Alzheimer's disease have unclear contributions to the disease mechanism, but the neuron-to-glia lipid transfer pathway induced by ROS plays a key role in protecting against neurotoxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Eloise de Tredern, Yasmine Rabah, Laure Pasquer, Julia Minatchy, Pierre-Yves Placais, Thomas Preat
Summary: The research finds a mechanism of glucose transport from cortex glia to neurons in Drosophila, which plays a role in the formation of olfactory long-term memory. Real-time imaging experiments show that insulin signaling increases glucose concentration in glia, promoting the transport of glucose to neuronal somata in the olfactory memory center.
Article
Immunology
Jingyi Wang, Xi Zheng, Yijia Jiang, Huimiao Jia, Xiaocui Shi, Yue Han, Qingping Li, Wenxiong Li
Summary: The study revealed increased expressions of PD-1 and PD-L1 in kidneys after renal ischemia-reperfusion injury, suggesting their essential roles in acute kidney injury (AKI) development. sPD-1 and sPD-L1 can indirectly reflect the expressions of PD-1 and PD-L1 in kidneys, showing excellent predictive abilities for AKI in high-risk patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan J. Fraire-Zamora, Sebastien Tosi, Jerome Solon, Jordi Casanova
Summary: This study investigates how hormone-driven extracellular matrix remodeling controls tissue shortening and apoptotic cell removal through the transcriptional activity of Yki, leading to organ disassembly during animal development.
Article
Neurosciences
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Taisuke Tomita, Vilmante Borutaite
Summary: Recent experimental models have shown a link between extracellular tau and neurodegeneration, but the exact mechanisms by which extracellular tau induces neuronal death remain unclear. This study found that extracellular phosphorylated tau(2N4R) is the most toxic form, causing neuronal loss at low nanomolar concentrations, and the neurotoxicity of tau(1N4R) depends on its aggregation state.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
A. Dziedziech, U. Theopold
Summary: This study provides evidence for the ancient origin of pyroptosis in Drosophila melanogaster, showing that the inflammatory based programmed cell death mechanism fits the features of pyroptosis and relies on ancient apoptotic machinery.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhongmin Fan, Hongwei Ma, Yi Li, You Wu, Jiajia Wang, Lize Xiong, Zongping Fang, Xijing Zhang
Summary: Sepsis-associated encephalopathy (SAE) is a complication of sepsis that leads to long-term mental health issues. This study found that neuronal apoptosis and necroptosis are related to the mental impairments in SAE, and inhibiting neuronal MD2 can alleviate these issues.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Olena Odnokoz, Kyle Nakatsuka, Corbin Wright, Jovelyn Castellanos, Vladimir Klichko, Doris Kretzschmar, William C. Orr, Svetlana N. Radyuk
Summary: Mitochondrial dysfunction is closely related to oxidative stress and is considered a major factor in the development of neurological disorders. The under-expression of mitochondrial Prxs in flies may lead to behavioral changes associated with neural function and affect lifespan and motor activity, suggesting a causal link between mitochondrial Prx activity and the development of neurological disorders and premature aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chaoqun Yu, Peng Chen, Longyu Miao, Guohu Di
Summary: Acute liver injury (ALI) is a significant global public health issue, which can rapidly progress to acute liver failure and pose a serious threat to patient's life safety. The activation of NLRP3 inflammasome and programmed cell death (PCD) play crucial roles in various types of ALI. This review provides a comprehensive summary of the involvement of NLRP3 inflammasome activation and PCD in different types of ALI, offering a valuable reference for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mehmet Neset Ozel, Claudia Skok Gibbs, Isabel Holguera, Mennah Soliman, Richard Bonneau, Claude Desplan
Summary: The study reveals that the Drosophila visual system contains nearly 200 distinct types of neurons, each defined by unique combinations of about 10 continuously expressed transcription factors. Modifying the terminal selector code can predictably convert neuronal fates and these conversions are morphologically and transcriptionally complete. Additionally, the study identifies one gene that is linked to an upstream patterning factor, which specifies neuronal fates in stem cells.
Article
Biochemistry & Molecular Biology
Qingzhong Ren, Takeshi Awasaki, Yu-Fen Huang, Zhiyong Liu, Tzumin Lee
Editorial Material
Multidisciplinary Sciences
Takeshi Awasaki, Kei Ito
Article
Biochemistry & Molecular Biology
Ayumi Kudo, Takeshi Awasaki, Yukio Ishikawa, Takashi Matsuo
GENES & GENETIC SYSTEMS
(2017)
Article
Developmental Biology
Qingzhong Ren, Takeshi Awasaki, Yu-Chun Wang, Yu-Fen Huang, Tzumin Lee
Article
Genetics & Heredity
Kazuyuki Hirai, Zhuo Wang, Kohei Miura, Takaaki Hayashi, Takeshi Awasaki, Moe Wada, Yoko Keira, Hiroyuki O. Ishikawa, Kyoichi Sawamura
G3-GENES GENOMES GENETICS
(2018)
Article
Biochemistry & Molecular Biology
Hung-Hsiang Yu, Takeshi Awasaki, Mark David Schroeder, Fuhui Long, Jacob S. Yang, Yisheng He, Peng Ding, Jui-Chun Kao, Gloria Yueh-Yi Wu, Hanchuan Peng, Gene Myers, Tzumin Lee
Article
Anatomy & Morphology
Thomas Brody, Amarendra S. Yavatkar, Alexander Kuzin, Mukta Kundu, Leonard J. Tyson, Jermaine Ross, Tzu-Yang Lin, Chi-Hon Lee, Takeshi Awasaki, Tzumin Lee, Ward F. Odenwald
DEVELOPMENTAL DYNAMICS
(2012)
Article
Neurosciences
Jacob S. Yang, Takeshi Awasaki, Hung-Hsiang Yu, Yisheng He, Peng Ding, Jui-Chun Kao, Tzumin Lee
JOURNAL OF COMPARATIVE NEUROLOGY
(2013)
Editorial Material
Neurosciences
Takeshi Awasaki, Tzumin Lee
NATURE NEUROSCIENCE
(2011)
Article
Neurosciences
Takeshi Awasaki, Chih-Fei Kao, Ying-Jou Lee, Ching-Po Yang, Yaling Huang, Barret D. Pfeiffer, Haojiang Luan, Xiaotang Jing, Yu-Fen Huang, Yisheng He, Mark David Schroeder, Alexander Kuzin, Thomas Brody, Christopher T. Zugates, Ward F. Odenwald, Tzumin Lee
NATURE NEUROSCIENCE
(2014)
Article
Neurosciences
Liria M. Masuda-Nakagawa, Kei Ito, Takeshi Awasaki, Cahir J. O'Kane
FRONTIERS IN NEURAL CIRCUITS
(2014)
Article
Developmental Biology
Kentaro Kato, Minako Orihara-Ono, Takeshi Awasaki
Meeting Abstract
Biochemistry & Molecular Biology
Kyoichi Sawamura, Zhuo Wang, Kohei Miura, Takaaki Hayashi, Kazuyuki Hirai, Takeshi Awasaki, Moe Wada, Yoko Keira, Hiroyuki O. Ishikawa
GENES & GENETIC SYSTEMS
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Takeshi Awasaki, Kentaro Kato
GENES & GENETIC SYSTEMS
(2015)
Meeting Abstract
Genetics & Heredity
L. Masuda-Nakagawa, T. Awasaki, K. Ito, R. Stocker, C. O'kane, N. Gendre
JOURNAL OF NEUROGENETICS
(2012)