Article
Endocrinology & Metabolism
Christopher E. Shannon, Aurora Merovci, Marcel Fourcaudot, Devjit Tripathy, Muhammad Abdul-Ghani, Hu Wang, Xianlin Han, Luke Norton, Ralph A. DeFronzo
Summary: This study demonstrates that the major lipid pools in skeletal muscle are not affected by increased glucose availability, suggesting that glucotoxicity and lipotoxicity promote insulin resistance through distinct mechanistic pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Physiology
Peter O. Isesele, Vera C. Mazurak
Summary: Skeletal muscle is primarily composed of myofibers, with their size and muscle mass being influenced by various pathological and physiological conditions. Satellite cells play a crucial role in muscle regeneration, but a reduced number and impaired myogenic function may lead to muscle disorders. The function of satellite cells is affected by mitochondrial function, inflammation, and Omega-3 PUFAs.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Bulbul Ahmed, Rifat Sultana, Michael W. Greene
Summary: This review discusses the potential mechanisms behind obesity-associated insulin resistance, such as dysfunctional adipose tissue, excessive release of free fatty acids, and the impact of lipotoxicity on cellular dysfunction leading to systemic inflammation and disruption of the insulin signaling pathway. It highlights that hepatic insulin resistance is the primary event that triggers peripheral tissue insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Katarzyna Lipke, Adriana Kubis-Kubiak, Agnieszka Piwowar
Summary: Free fatty acids (FFAs) play vital roles in the organism but disturbances in fatty acid homeostasis can lead to lipotoxicity, contributing to the development of diseases such as insulin resistance and diabetes. Lipotoxic effects primarily affect organs such as the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys.
Review
Endocrinology & Metabolism
Kalliopi Pafili, Michael Roden
Summary: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic alterations with increased lipid accumulation, mainly influenced by global obesity and diabetes epidemics. Recent studies have suggested that certain conditions, such as severe insulin-resistant diabetes (SIRD) subgroup and an increasing number of gene variants, predispose individuals to a higher risk of NAFLD and its accelerated progression.
MOLECULAR METABOLISM
(2021)
Review
Chemistry, Medicinal
Atiporn Therdyothin, Nacharin Phiphopthatsanee, Masoud Isanejad
Summary: Sarcopenia, a disease that affects the aging population worldwide, can be prevented by nutritional strategies such as omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation. This review examines the effect and mechanism of n-3 PUFA on muscle health. Despite conflicting evidence, n-3 PUFA is suggested to benefit muscle mass, strength, physical performance, and muscle protein synthesis. Proposed mechanisms include anti-inflammatory properties, increased expression of mTORC1 pathway, decreased protein breakdown, improved mitochondrial function, enhanced amino acid transport, and modulation of neuromuscular junction activity. However, the interpretation of findings is limited by small sample sizes, heterogeneity of supplementation regimens, and different measuring protocols.
Article
Gastroenterology & Hepatology
Irma Garcia-Martinez, Rosa Alen, Laura Pereira, Adrian Povo-Retana, Alma M. Astudillo, Ana B. Hitos, Isabel Gomez-Hurtado, Eduardo Lopez-Collazo, Lisardo Bosca, Ruben Frances, Ignacio Lizasoain, Maria Angeles Moro, Jesus Balsinde, Manuel Izquierdo, Angela M. Valverde
Summary: This study reveals that small extracellular vesicles (sEV) released by hepatocytes under NAFLD conditions induce liver inflammation and insulin resistance in hepatocytes through paracrine hepatocyte-macrophage-hepatocyte crosstalk. These sEV act as transporters of saturated fatty acids (SFAs) and potent inducers of liver inflammation. Liver inflammation mediated by sEV can be attenuated by inhibiting Toll-like receptor-4 (TLR4). Evidence of macrophage-hepatocyte interactome was also found in patients with NAFLD, highlighting the relevance of sEV in SFAs-mediated lipotoxicity in NAFLD.
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Article
Endocrinology & Metabolism
Kirsten M. Jansen, Norma Dahdah, Pau Gama-Perez, Pauke C. Schots, Terje S. Larsen, Pablo M. Garcia-Roves
Summary: This study aimed to compare the effects of exenatide and Calanus oil on obesity-induced alterations in mitochondrial respiration. The results showed that exenatide increased hepatic mitochondrial respiration in high-fat fed mice, while Calanus oil had no negative effect on respiratory activity in skeletal muscle and adipose tissue, suggesting its potential as a dietary supplement.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Napapan Kangwan, Wasana Pratchayasakul, Aphisek Kongkaew, Komsak Pintha, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that PSO and metformin can effectively improve gut dysbiosis, inflammation, and metabolic disturbance in HFD-fed rats, with metformin showing greater benefits.
Article
Nutrition & Dietetics
Gabrielle Farley, Daniel W. Riggs, Aruni Bhatnagar, Jason Hellmann
Summary: This study demonstrates the role of omega-3 polyunsaturated fatty acids as effect modifiers for the inverse relationship between cardiovascular fitness and inflammation, highlighting the anti-inflammatory benefits associated with increasing cardiovascular fitness. Factors such as gender, race, and BMI influence the sensitivity of individuals to the effects of omega-3 PUFAs, while high saturated fatty acid levels attenuate the benefits.
CLINICAL NUTRITION
(2021)
Article
Immunology
Akira Shikuma, Daisuke Kami, Ryotaro Maeda, Yosuke Suzuki, Arata Sano, Toshihiko Taya, Takehiro Ogata, Anne Konkel, Satoaki Matoba, Wolf-Hagen Schunck, Satoshi Gojo
Summary: EEQ-A exhibits potent anti-inflammatory and immunomodulatory properties, improving survival rate and reducing organ damage in sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Carmen Rodriguez-Garcia, Cristina Sanchez-Quesada, Maria Jose Martinez-Ramirez, Jose J. Gaforio
Summary: Lipodystrophy syndromes are rare diseases that result in dysfunction of adipose tissue and abnormal accumulation of triglycerides. Both genetic and acquired factors may contribute to the development of lipodystrophy, and dietary fats can modulate gene activity. This article summarizes the main genes involved in lipodystrophy and reviews the effects of dietary fats on its development.
Review
Endocrinology & Metabolism
Somaya Albhaisi, Arun J. Sanyal
Summary: NAFLD has become a leading cause of chronic liver disease globally, closely linked to metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. Metabolic inflexibility is considered a key factor in the progression of NAFLD to NASH and cirrhosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
William T. Festuccia
Summary: Evidence suggests that lipotoxicity and inflammation are key factors linking adipose tissue dysfunction to metabolic diseases, with mTOR playing a crucial role in regulating adipocyte and macrophage function. Studies reviewed here show that optimal levels of mTORC1 activity are necessary for lipogenic actions in adipocytes, while mTORC1 also regulates polarization in macrophages. On the other hand, mTORC2 promotes glucose uptake and lipogenesis in adipocytes while dampening macrophage inflammatory response.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Infectious Diseases
Paul Loubet, Linda Wittkop, Laetitia Ninove, Mathieu Chalouni, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Eric Thouvenot, Martine Laville, Bruno Laviolle, Jean-Daniel Lelievre, Jacques Morel, Stephanie Nguyen Quoc, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, Francois Vrtovsnik, Sophie Circosta, Laure Esterle, Axel Levier, Philippe Vanhems, Eric Tartour, Beatrice Parfait, Xavier de Lamballerie, Odile Launay
Summary: This study aimed to investigate the 1-month humoral response to two or three doses of mRNA COVID-19 vaccine in specific populations compared with healthy adults. The results showed a lower humoral response in the specific populations. However, the third dose of the vaccine had a positive effect on the immune response.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Critical Care Medicine
Justyna A. Karolak, Carrie L. Welch, Christian Mosimann, Katarzyna Bzdega, James D. West, David Montani, Melanie Eyries, Mary P. Mullen, Steven H. Abman, Matina Prapa, Stefan Graf, Nicholas W. Morrell, Anna R. Hemnes, Frederic Perros, Rizwan Hamid, Malcolm P. O. Logan, Jeffrey Whitsett, Csaba Galambos, Pawel Stankiewicz, Wendy K. Chung, Eric D. Austin
Summary: Over the past decade, the significance of the TBX4 gene in respiratory diseases has been recognized. TBX4 is associated with congenital disorders involving respiratory and skeletal structures, but its exact role in human development is not fully understood. Through human and animal studies, we discuss the developmental, tissue-specific, and pathological functions of TBX4, as well as review the published TBX4 variants that result in different disease phenotypes. We also outline future research directions to enhance our understanding of TBX4 function and the impact of TBX4 disruption on development.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Nutrition & Dietetics
Giorgina Barbara Piccoli, Tommy Cederholm, Carla Maria Avesani, Stephan J. L. Bakker, Vincenzo Bellizzi, Cristina Cuerda, Adamasco Cupisti, Alice Sabatino, Stephane Schneider, Massimo Torreggiani, Denis Fouque, Juan Jesus Carrero, Rocco Barazzoni
Summary: Increased life expectancy presents significant challenges to healthcare systems globally, including the rise in chronic kidney disease (CKD) and malnutrition-protein-energy wasting (PEW) in older adults, leading to poor clinical outcomes. A critical review paper by ESPEN and ERN-ERA aims to summarize key concepts in preventing and treating CKD progression and impaired nutritional status, and provide guidance on defining optimal protein and energy intake in varying CKD severity. Careful assessment and individualized approach are necessary, considering malnutrition-PEW status, kidney function, and patient preferences. Greater awareness and research are needed to improve nutritional care for this growing patient subgroup.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Benedicte Gaborit, Sara Fernandes, Paul Loubet, Laetitia Ninove, Anne Dutour, Bertrand Cariou, Muriel Coupaye, Karine Clement, Sebastien Czernichow, Claire Carette, Noemie Resseguier, Laure Esterle, Sabrina Kali, Marie Houssays, Xavier de Lamballerie, Linda Wittkop, Odile Launay, Martine Laville
Summary: Patients with diabetes and obesity have weaker immune responses to COVID-19 vaccines, especially one month after the second dose. Post-vaccination serological checks are necessary for these high-risk populations.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Urology & Nephrology
Maxime Espi, Xavier Charmetant, Cyrille Mathieu, Alexandre Lalande, Didier Decimo, Laetitia Koppe, Caroline Pelletier, Anne Ovize, Alexia Barbry, Emmanuel Morelon, Emilie Kalbacher, Denis Fouque, Olivier Thaunat
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nathan Mewton, Erwan Donal, Francois Picard, Francois Derimay, Daniel Grinberg, Delphine Maucort Boulch, Thomas Bochaton, Nicolas Piriou, Amelie De Lorgeril, Geraldine Samson, Frederic Rouleau, Benjamin Riche, Jean Noel Trochu
Summary: The study aimed to assess the distribution of primary and secondary heart failure events in a severe heart failure population and their association with 2-year all-cause mortality. The results showed that primary heart failure decompensations were three times more frequent than secondary decompensations, but both types had a similar impact on mortality risk. Patients with only primary or only secondary decompensation had a significantly increased risk of death.
AMERICAN HEART JOURNAL
(2023)
Article
Physiology
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurelle Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frederic Perros
Summary: Hereditary pulmonary veno-occlusive disease (hPVOD) is a severe autosomal recessive pulmonary hypertension caused by loss of function of the EIF2AK4 gene. Researchers generated rat models with biallelic Gcn2 mutation to study the molecular and cellular response of the lungs under amino acid deprivation. The study revealed that Gcn2-/- rats displayed increased apoptosis, overexpression of proinflammatory genes, and infiltration of inflammatory cells, suggesting a potential role of Gcn2 in immune homeostasis and hPVOD development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kossi D. Abalo, Sophie Malekzadeh-Milani, Sebastien Hascoet, Serge Dreuil, Tiphaine Feuillet, Cecilia Damon, Helene Bouvaist, Ivan Bouzguenda, Sarah Cohen, Claire Dauphin, Sylvie Di Filippo, Stephanie Douchin, Francois Godart, Patrice Guerin, Pauline Helms, Clement Karsenty, Bruno Lefort, Pierre Mauran, Caroline Ovaert, Jean-Francois Piechaud, Jean-Benoit Thambo, Choonsik Lee, Mark P. Little, Damien Bonnet, Marie-Odile Bernier, Estelle Rage
Summary: Pediatric patients with congenital heart disease who undergo cardiac catheterization (CC) may be exposed to low dose ionizing radiation (LDIR). However, this study found no increased risk of lympho-hematopoietic malignancies and lymphoma associated with LDIR in these patients.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Clinical Neurology
Paul Clottes, Nicolas Benech, Chloe Dumot, Sophie Jarraud, Hubert Vidal, Laura Mechtouff
Summary: Despite recent advances in stroke therapy, it remains a leading cause of disability and death, necessitating the identification of new therapeutic targets. Increasingly, dysbiosis of gut microbiota has been recognized as playing a detrimental role in cardiovascular diseases, including stroke. The metabolites produced by gut microbiota, such as trimethylamine-N-oxide, short chain fatty acids, and tryptophan, have been found to be key players. There is evidence linking gut microbiota alteration to cardiovascular risk factors, supported by preclinical studies. Additionally, observational studies have shown that stroke patients with altered gut microbiota experience more complications, larger infarct sizes, and worse clinical outcomes. Various microbiota-targeted strategies, including prebiotics/probiotics and inhibitors of metabolites, have been developed. However, the timing and endpoints of these studies have varied, resulting in different outcomes. Based on available evidence, it is believed that further research on microbiota-targeted strategies, in conjunction with conventional stroke care, should be conducted within three therapeutic time windows: primary prevention or secondary prevention to control cardiovascular risk factors, acute phase to minimize infarct size and systemic complications, and subacute phase to prevent recurrence and promote neurological recovery.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Emma Wischlen, Noemie Laverdure, Domitille Erard, Barbara Rohmer, Olivier Boillot, Remi Dubois, Alain Lachaux, Sophie Collardeau-Frachon, Valerie Hervieu, Jerome Dumortier
Summary: Post-transplantation evolution of progressive familial intrahepatic cholestasis type 2 patients can be complicated by antibody-induced bile salt export pump deficiency (AIBD). There is no consensus on its management. We describe a patient who presented two episodes, 9 years apart. The first episode was refractory to plasmapheresis and intravenous immunoglobulin (IVIG) started 2 months after AIBD onset, leading to graft loss. The second episode responded to plasmapheresis, IVIG and rituximab initiated less than 2 weeks after the beginning of symptoms, allowing for long-term recovery. This case suggests that intensive treatment with minimum delay after symptoms onset could sponsor a better evolution.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Bochaton, Nathan Mewton
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Gastroenterology & Hepatology
Sarah Duponchel, Lea Monnier, Jennifer Molle, Nadia Bendridi, Muhammad Rizwan Alam, Ahmed Gaballah, Boyan Grigorov, Alexander Ivanov, Marcel Schmiel, Margarete Odenthal, Michel Ovize, Jennifer Rieusset, Fabien Zoulim, Birke Bartosch
Summary: Chronic HCV infection causes cellular stress, fibrosis, and predisposes to hepatocarcinogenesis. Mitochondria play key roles in orchestrating stress responses. The study revealed that HCV proteins associate with mitochondria and alter the composition of mitochondrial subdomains, which are crucial for efficient viral replication.
Article
Medicine, Research & Experimental
Thibault Leger, Aurelien Brun, Kassandra Lanchais, Jean-Paul Rigaudiere, Arnaud Briat, Yann Guitton, Fabien Marchand, Anne Tournadre, Frederic Capel
Summary: This study found that nutritional supplementation with omega 3 fatty acids can alleviate symptoms of rheumatoid arthritis and be an effective preventive treatment for patients who do not need pharmacological therapy.
Article
Critical Care Medicine
Pierre-Edouard Bollaert, Alexandra Monnier, Francis Schneider, Laurent Argaud, Julio Badie, Claire Charpentier, Ferhat Meziani, Michel Bemer, Jean-Pierre Quenot, Marie Buzzi, Herve Outin, Cedric Bruel, Laurent Ziegler, Sebastien Gibot, Jean-Marc Virion, Camille Alleyrat, Guillaume Louis, Nelly Agrinier
Summary: The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. However, the conservative strategy did not reduce mortality in these patients.
Article
Pediatrics
Tania Perrin, Pierre Pradat, Julie Larcade, Marion Masclef-Imbert, Blandine Pastor-Diez, Jean-Charles Picaud
Summary: This cohort study aimed to evaluate the impact of an individualised nutritional care approach combining standardised fortification with adjustable fortification on postnatal growth and body composition in extremely low birth weight (ELBW) infants. The study found that the individualised nutritional care approach prevented postnatal weight loss in most infants, limited length growth deficit, and supported excellent head circumference growth.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
