Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

NAFLD 2020: The State of the Disease

(2020) Thomas G. Cotter et al.   GASTROENTEROLOGY

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

(2020) Vlad Ratziu et al.   HEPATOLOGY

Ceramides ‐ a cause of insulin resistance in NAFLD in both murine models and humans

(2020) Hannele Yki‐Järvinen   HEPATOLOGY

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver‐Targeting Acetyl‐CoA Carboxylase Inhibitor (PF‐05221304): A Three‐Part Randomized Phase 1 Study

(2020) Arthur Bergman et al.   Clinical Pharmacology in Drug Development

Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development

(2020) Simona-Rebeca Ignat et al.   Cells

Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes

(2020) Mark L. Hartman et al.   DIABETES CARE

Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges

(2020) Jean-François Dufour et al.   GUT

Thyroid Hormone Signaling and the Liver

(2020) Megan J. Ritter et al.   HEPATOLOGY

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

(2020) Kristin Schwerbel et al.   JOURNAL OF HEPATOLOGY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2020) Qing Ye et al.   Lancet Gastroenterology & Hepatology

Role of Patatin-Like Phospholipase Domain–Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes

(2020) Oana P. Zaharia et al.   DIABETES CARE

Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis

(2020) Mishghan Zehra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): A United Kingdom population-based cohort study using the health improvement network (THIN)

(2020) A. Vusirikala et al.   BMC Endocrine Disorders

Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance

(2020) Theresia Sarabhai et al.   JCI Insight

Effect of Empagliflozin on Liver Steatosis and Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease Without Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

(2020) Hoda Taheri et al.   ADVANCES IN THERAPY

Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease

(2019) Carolina M. Perdomo et al.   Nutrients

NGM 282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients with Nonalcoholic Steatohepatitis

(2019) Stephen A. Harrison et al.   HEPATOLOGY

Fat and Fibrosis: Does Empagliflozin Impair the Progression of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus?

(2019) Reenam S. Khan et al.   DIGESTIVE DISEASES AND SCIENCES

The SGLT2 Inhibitor Dapagliflozin Reduces Liver Fat but Does Not Affect Tissue Insulin Sensitivity: A Randomized, Double-Blind, Placebo Controlled Study With 8-Week Treatment in Type 2 Diabetes Patients

(2019) Aino Latva-Rasku et al.   DIABETES CARE

Yogurt improves insulin resistance and liver fat in obese women with nonalcoholic fatty liver disease and metabolic syndrome: a randomized controlled trial

(2019) Yang Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PS-110-Ketohexokinase inhibitor PF-06835919 administered for 6 weeks reduces whole liver fat as measured by magnetic resonance imaging-proton density fat fraction in subjects with non-alcoholic fatty liver disease

(2019) Roberto Calle et al.   JOURNAL OF HEPATOLOGY

A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial

(2019) Mads J. Skytte et al.   DIABETOLOGIA

Sodium-glucose cotransporter-2 inhibitors in type 2 diabetes: a magic potion to reduce heart failure?

(2019) K. Pafili et al.   Expert Review of Clinical Pharmacology

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

(2019) Oana P Zaharia et al.   Lancet Diabetes & Endocrinology

Clinical Use of DPP-4 Inhibitors

(2019) Baptist Gallwitz   Frontiers in Endocrinology

Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial

(2019) Sabine Kahl et al.   DIABETES CARE

Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation

(2019) Fei Chen et al.   HEPATOLOGY

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

(2019) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes

(2019) Fernando Bril et al.   DIABETES CARE

Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation

(2019) Maurice B. Bizino et al.   DIABETOLOGIA

The Prevalence of Lean/Nonobese Nonalcoholic Fatty Liver Disease

(2019) Yiwen Shi et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients

(2019) Kenichiro Enooku et al.   JOURNAL OF GASTROENTEROLOGY

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Stephen A Harrison et al.   LANCET

Are Lifestyle Therapies Effective for NAFLD Treatment?

(2019) Nermeen N. El-Agroudy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dynamic changes of muscle insulin sensitivity after metabolic surgery

(2019) Sofiya Gancheva et al.   Nature Communications

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism

(2019) Joost Boeckmans et al.   Cells

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

(2018) Maria Apostolopoulou et al.   DIABETES CARE

Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study

(2018) Jan W. Eriksson et al.   DIABETOLOGIA

Ad libitum Mediterranean and Low Fat Diets both Significantly Reduce Hepatic Steatosis: a Randomized Controlled Trial

(2018) Catherine Properzi et al.   HEPATOLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients

(2018) Michiharu Komatsu et al.   HEPATOLOGY RESEARCH

High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance

(2018) Shira Zelber-Sagi et al.   JOURNAL OF HEPATOLOGY

Determinants of fibrosis progression and regression in NASH

(2018) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement

(2018) Frédéric Brioude et al.   Nature Reviews Endocrinology

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver Fat Scores Moderately Reflect Interventional Changes in Liver Fat Content by a Low-Fat Diet but Not by a Low-Carb Diet

(2018) Stefan Kabisch et al.   Nutrients

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

(2018) Kavita Jadhav et al.   Molecular Metabolism

Critical appraisal for low-carbohydrate diet in nonalcoholic fatty liver disease: Review and meta-analyses

(2018) Jaehee Ahn et al.   CLINICAL NUTRITION

Evaluation of the effects of dapagliflozin, an SGLT2 inhibitor, on hepatic steatosis and fibrosis by transient elastography in patients with type 2 diabetes and non-alcoholic fatty liver disease

(2018) Masanori Shimizu et al.   DIABETES OBESITY & METABOLISM

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

(2018) Linda Lorenz et al.   NATURE

Complete Resolution of Nonalcoholic Fatty Liver Disease After Bariatric Surgery: A Systematic Review and Meta-Analysis

(2018) Yung Lee et al.   Clinical Gastroenterology and Hepatology

Effect of canagliflozin treatment on hepatic triglyceride content and glucose metabolism in patients with type 2 diabetes

(2018) Kenneth Cusi et al.   DIABETES OBESITY & METABOLISM

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

(2018) Rohit Loomba et al.   GASTROENTEROLOGY

Liraglutide, sitagliptin and insulin glargine added to metformin: the effect on body weight and intrahepatic lipid in patients with type 2 diabetes mellitus and NAFLD

(2018) Jinhua Yan et al.   HEPATOLOGY

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

(2018) Mayada Metwally et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial

(2018) Arun Sanyal et al.   LANCET

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Validity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults

(2018) Emanuella De Lucia Rolfe et al.   PLoS One

Short article

(2017) Xiao-Long Deng et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Ipragliflozin and sodium glucose transporter 2 inhibitors to reduce liver fat: will the prize we sought be won?

(2017) Kalliopi Pafili et al.   EXPERT OPINION ON PHARMACOTHERAPY

Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes

(2017) Mariya Markova et al.   GASTROENTEROLOGY

Effect of PNPLA3 I148M polymorphism on histologically proven non-alcoholic fatty liver disease in liver transplant recipients

(2017) Hyeyoung Kim et al.   HEPATOLOGY RESEARCH

MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat

(2017) Giovanni Musso et al.   HUMAN MOLECULAR GENETICS

Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2017) Salvatore Petta et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

(2017) Elisa Álvarez Hernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment of NAFLD with diet, physical activity and exercise

(2017) Manuel Romero-Gómez et al.   JOURNAL OF HEPATOLOGY

Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness

(2017) Yong-ho Lee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Ultra-high-field magnetic resonance spectroscopy in non-alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non-alcoholic steatohepatitis and advanced fibrosis

(2017) Stefan Traussnigg et al.   LIVER INTERNATIONAL

Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

(2017) Aki Juhani Käräjämäki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis

(2017) Christina N Katsagoni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial

(2017) Tisha R Joy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction

(2017) Irene Cantero et al.   Nutrients

Effect of Mediterranean Diet and Antioxidant Formulation in Non-Alcoholic Fatty Liver Disease: A Randomized Study

(2017) Ludovico Abenavoli et al.   Nutrients

PNPLA3 variant and portal/periportal histological pattern in patients with biopsy-proven non-alcoholic fatty liver disease: a possible role for oxidative stress

(2017) Guido Carpino et al.   Scientific Reports

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study

(2017) Arash Etemadi et al.   BMJ-British Medical Journal

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

(2017) Kasper W. ter Horst et al.   Cell Reports

New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2017) Xu Zhang et al.   Protein & Cell

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study

(2017) Arash Etemadi et al.   BMJ-British Medical Journal

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

(2016) Monize Aydar Nogueira et al.   CLINICAL NUTRITION

Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy

(2016) A. Dutour et al.   DIABETES OBESITY & METABOLISM

Twelve week liraglutide or sitagliptin does not affect hepatic fat in type 2 diabetes: a randomised placebo-controlled trial

(2016) Mark M. Smits et al.   DIABETOLOGIA

The potential of SGLT2 inhibitors in phase II clinical development for treating type 2 diabetes

(2016) K. Pafili et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity

(2016) Pierre Bedossa et al.   GUT

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage

(2016) Benedetta Donati et al.   HEPATOLOGY

Inactivation ofTm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

(2016) Eriks Smagris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease

(2016) Salvatore Petta et al.   JOURNAL OF HEPATOLOGY

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

(2016) Matthew J. Armstrong et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

(2016) Jeffrey Cui et al.   JOURNAL OF HEPATOLOGY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

(2016) Marcin Krawczyk et al.   JOURNAL OF LIPID RESEARCH

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Adipokines in nonalcoholic fatty liver disease

(2016) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function

(2015) Andrew J. Ford et al.   Acta Biomaterialia

A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease

(2015) Ilkay S Idilman et al.   ACTA RADIOLOGICA

Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients

(2015) Maria Fritsch et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

NADPH Oxidase–Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment

(2015) Suvarthi Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Glucokinase regulatory protein

(2015) Anne Raimondo et al.   CURRENT OPINION IN LIPIDOLOGY

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study

(2015) Rohit Loomba et al.   GASTROENTEROLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Effect of Vildagliptin on Hepatic Steatosis

(2015) Mavin Macauley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals

(2015) Kenichi Nishioji et al.   PLoS One

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance

(2015) Hannele Yki-Järvinen   Nutrients

Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts

(2015) Norifumi Kawada   Frontiers in Physiology

Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis

(2014) Mei Chung et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors

(2014) B. Omar et al.   DIABETES

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

(2014) F. Rosqvist et al.   DIABETES

Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial

(2014) Bettina Nowotny et al.   DIABETOLOGIA

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans

(2014) Andreas Peter et al.   DIABETOLOGIA

Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials

(2014) S Chiu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial

(2014) Arun J. Sanyal et al.   GASTROENTEROLOGY

Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: A randomized controlled trial

(2014) Karin E. Koopman et al.   HEPATOLOGY

TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

(2014) Roberta Fares et al.   LIVER INTERNATIONAL

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease

(2014) Sarah C. Ferrante et al.   PEDIATRIC RESEARCH

Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

(2014) Salvatore Petta et al.   PLoS One

Comparison of Liver Fat Indices for the Diagnosis of Hepatic Steatosis and Insulin Resistance

(2014) Sabine Kahl et al.   PLoS One

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

(2013) Daniel F. Vatner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men

(2013) Richard D. Johnston et al.   GASTROENTEROLOGY

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

(2013) Kento Imajo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene

(2013) Hwa-Li Tan et al.   JOURNAL OF GASTROENTEROLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease

(2013) Marno C. Ryan et al.   JOURNAL OF HEPATOLOGY

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

(2013) April D. Lake et al.   TOXICOLOGICAL SCIENCES

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

(2012) Fanny Theytaz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial

(2012) Helena Bjermo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Effects of Dapagliflozin on Body Weight, Total Fat Mass, and Regional Adipose Tissue Distribution in Patients with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Metformin

(2012) Jan Bolinder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study

(2011) Maria Maersk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes

(2011) A. I. Schmid et al.   DIABETES CARE

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss

(2011) K. Hallsworth et al.   GUT

Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects

(2011) Sven Haufe et al.   HEPATOLOGY

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

(2011) Nicola Santoro et al.   HEPATOLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Three Weeks on a High-Fat Diet Increases Intrahepatic Lipid Accumulation and Decreases Metabolic Flexibility in Healthy Overweight Men

(2011) Noud A. van Herpen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

(2011) Ahmad Al-Serri et al.   JOURNAL OF HEPATOLOGY

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease

(2011) NOBITO HIGUCHI et al.   Experimental and Therapeutic Medicine

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Exenatide in the Treatment of Diabetic Patients With Non-Alcoholic Steatohepatitis: A Case Series

(2010) Patrick R Kenny et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

(2010) P. Dongiovanni et al.   GUT

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Combination of acarbose and ezetimibe prevents non-alcoholic fatty liver disease: A break of intestinal insulin resistance?

(2010) Natalia N. Rudovich et al.   JOURNAL OF HEPATOLOGY

Down-regulation of SREBP-1c is associated with the development of burned-out NASH

(2010) Tadanobu Nagaya et al.   JOURNAL OF HEPATOLOGY

Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis

(2010) Lixin Zhu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

(2010) Kitt Falk Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

NAFLD and Insulin Resistance Do Not Increase the Risk of Postoperative Complications Among Patients Undergoing Bariatric Surgery—A Prospective Analysis

(2010) Tarsila Ribeireiro et al.   OBESITY SURGERY

Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes

(2009) Kim-Anne Lê et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High protein intake reduces intrahepatocellular lipid deposition in humans

(2009) Murielle Bortolotti et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of a short-term overfeeding with fructose or glucose in healthy young males

(2009) Emilienne Tudor Ngo Sock et al.   BRITISH JOURNAL OF NUTRITION

Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

(2009) Hella Wobser et al.   CELL RESEARCH

Metformin: diamonds are forever

(2009) N Papanas et al.   EXPERT OPINION ON PHARMACOTHERAPY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

(2009) Koji Fujita et al.   HEPATOLOGY

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease

(2009) Yuichi Nozaki et al.   JOURNAL OF HEPATOLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial

(2009) John Willy Haukeland et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis

(2008) Guruprasad P. Aithal et al.   GASTROENTEROLOGY

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease

(2008) Xiao-Dong Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY