Review
Endocrinology & Metabolism
Xiaohui Du, Le Yang, Ling Kong, Ye Sun, Kunshuang Shen, Ying Cai, Hui Sun, Bo Zhang, Sifan Guo, Aihua Zhang, Xijun Wang
Summary: This article reviews the application of metabolomics in diabetic retinopathy (DR) and introduces potential biomarkers such as alanine, lactate, and glutamine that may be related to the pathogenesis of DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Daniela D. Weber, Maheshwor Thapa, Sepideh Aminzadeh-Gohari, Anna-Sophia Redtenbacher, Luca Catalano, Rene G. Feichtinger, Peter Koelblinger, Guido Dallmann, Michael Emberger, Barbara Kofler, Roland Lang
Summary: Metabolomic analysis revealed significant differences in the metabolism of melanoma subtypes, with potential biomarkers identified for melanoma screening. This highlights the metabolic heterogeneity of melanomas and suggests a diagnostic biomarker signature for potential screening of melanoma.
Article
Pharmacology & Pharmacy
Gaelle Magliocco, Jules Desmeules, Alain Matthey, Luis M. Quiros-Guerrero, Nasim Bararpour, Timothee Joye, Laurence Marcourt, Emerson F. Queiroz, Jean-Luc Wolfender, Yvonne Gloor, Aurelien Thomas, Youssef Daali
Summary: The study identified potential novel markers of the CYP2D6 enzyme using a metabolomic approach in human biofluids, which could contribute significantly to personalized medicine.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ibukun Ogunade, Adeoye Oyebade, Bremansu Osa-Andrews, Sunday Peters
Summary: In this study, the plasma carboxyl-metabolome in beef steers with different average daily gain (ADG) was analyzed. Differences in short chain fatty acids and long chain fatty acids were observed between beef steers with higher and lower ADG. Pathway analysis revealed alterations in enzymes involved in fatty acid metabolism in the liver.
Article
Veterinary Sciences
Yuqiong Li, Zhengwei Zhao, Yang Yu, Xiaojun Liang, Shengyi Wang, Lei Wang, Dongan Cui, Meizhou Huang
Summary: This study investigated the pathogenesis of retained placenta (RP) in dairy cows using plasma metabolomics, revealing imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and disrupted biomarkers in RP cows. These potential biomarkers may contribute to the imbalanced antioxidants, cytokine ratios, and hormonal dysregulation in cows with RP, providing a promising therapeutic strategy for the condition.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Ding Wang, Jing Zhu, Na Li, Hongyang Lu, Yun Gao, Lei Zhuang, Zhongjian Chen, Weimin Mao
Summary: This study analyzed the plasma metabolic profile of patients with malignant mesothelioma and identified differential metabolites and disrupted metabolic pathways. Five potential plasma biomarkers were identified, which could be critical for the diagnosis of malignant mesothelioma.
Article
Pharmacology & Pharmacy
Donghui Lao, Rong Liu, Jianying Liang
Summary: By applying metabolomics, potential biomarkers for AIDS patients have been identified and verified, suggesting their potential role in the diagnosis of HIV/AIDS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yali Xu, Bin Zhao, Zhu Xu, Xiaogang Li, Qiang Sun
Summary: This study conducted a wide range of targeted metabolomics profiling to investigate plasma signatures of breast cancer. The analysis identified 716 metabolites, with serotonin as the main metabolic pathway. By combining the changes in these metabolites, differentiation between benign abnormalities and breast cancer was achieved. This study provides new insights into plasma biomarkers for the differential diagnosis of breast cancer.
FRONTIERS IN MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Haitao Shi, Jing Peng, Jingjing Hao, Xi Wang, Meng Xu, Shengli Li
Summary: This study investigated the effects of AFB(1) exposure on the digestibility and performance of Saanen goats. It found that AFB(1) exposure decreased nutrient digestibilities, weight gain, and average daily gain of the goats in a dose-dependent manner. Untargeted metabolomic analysis revealed alterations in the plasma metabolome, with significant effects on choline metabolism, glycerophospholipid metabolism, and amino acid metabolism. These findings provide new insights into the toxicity of AFB(1) in ruminants.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Oncology
Victor Ruiz-Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Dorela Shuboni-Mulligan, Christel Herold-Mende, Terri S. Armstrong, Mark R. Gilbert, Kevin Camphausen, Mioara Larion
Summary: This study provides plasma and tissue metabolic biomarkers of treatment response in a mouse model of astrocytoma that was subjected to radiotherapy. The plasma metabolome varied in mice undergoing radiotherapy compared to controls, with fumarate as the best discriminatory feature. Additionally, changes in metabolic rewiring were observed in tumor tissue after radiotherapy, suggesting potential metabolic imaging approaches for treatment monitoring using blood draws.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physiology
Byungwhi Kong, Bhuwan Khatri, Seong Kang, Stephanie Shouse, Hakeem Kadhim, Michael Kidd, Kentu Lassiter, Joseph Hiltz, Barbara Mallmann, Sara Orlowski, Nicholas Anthony, Walter Bottje, Wayne Kuenzel, Casey Owens
Summary: The study on Woody Breast Myopathy aims to improve prediction or early diagnosis by using body fluids like blood as potential biomarkers. Specific plasma proteins and metabolites such as FRA10A associated CGG repeat 1, MYH9, 3-hydroxybutyric acid, and raffinose are found to be differentially abundant in WB broilers, indicating their potential as early-age biomarkers for WB onset.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Lucia Pinilla, Ivan D. Benitez, Fernando Santamaria-Martos, Adriano Targa, Anna Moncusi-Moix, Mireia Dalmases, Olga Minguez, Maria Aguila, Mariona Jove, Joaquim Sol, Reinald Pamplona, Ferran Barbe, Manuel Sanchez-de-la-Torre
Summary: The study investigated the plasma metabolome and lipidome of patients with suspected OSA to identify potential biomarkers for diagnosis and understand the underlying mechanisms of the disease. Results showed a plasma profile comprising 33 metabolites in OSA patients, with a specific 4-metabolite signature providing high accuracy for OSA detection. CPAP treatment led to changes in 5 plasma metabolites affected by OSA, indicating a potential for personalized OSA management using blood-based biomarkers and suggesting adaptive mechanisms in response to OSA-induced hypoxia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hagen M. Gegner, Thomas Naake, Aurelien Dugourd, Torsten Mueller, Felix Czernilofsky, Georg Kliewer, Evelyn Jaeger, Barbara Helm, Nina Kunze-Rohrbach, Ursula Klingmueller, Carsten Hopf, Carsten Mueller-Tidow, Sascha Dietrich, Julio Saez-Rodriguez, Wolfgang Huber, Rudiger Hell, Gernot Poschet, Jeroen Krijgsveld
Summary: Metabolomic and proteomic analyses of human plasma and serum samples have the potential to advance our understanding of disease biology. However, pre-analytical factors such as temperature and time can impact the integrity of the samples and there is a need for standardized operating procedures to ensure reliable data.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Kwang Seob Lee, Yong-ho Lee, Sang-Guk Lee
Summary: This study aimed to evaluate the predictive value of metabolite ratios for the clinical incidence or remission of type 2 diabetes mellitus (T2D). The study found that the alanine/glycine ratio was the most significant marker for T2D incidence, while the hydroxy sphingomyelin C22:2 ratio was most specific for T2D remission. The study also validated the effectiveness of alanine/glycine as a risk marker for T2D.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Qian-Yi Wang, Liang-Hui You, Lan-Lan Xiang, Yi-Tian Zhu, Yu Zeng
Summary: GDM is a common metabolic disorder during pregnancy with unclear etiology and pathogenesis. Metabolomics can be utilized to discover diagnostic biomarkers, evaluate prognosis, guide treatment, and explore mechanisms in GDM research.
WORLD JOURNAL OF DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Nikul Soni, Alastair B. Ross, Nathalie Scheers, Intawat Nookaew, Britt G. Gabrielsson, Ann-Sofie Sandberg
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Swarnim Gupta, Edwin Habeych, Nathalie Scheers, Sylvie Merinat, Brigitte Rey, Nicola Galaffu, Ann-Sofie Sandberg
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Malin Barman, Hardis Rabe, Bill Hesselmar, Susanne Johansen, Ann-Sofie Sandberg, Agnes E. Wold
Article
Multidisciplinary Sciences
Alastair B. Ross, Malin Barman, Olle Hartvigsson, Anna-Carin Lundell, Otto Savolainen, Bill Hesselmar, Agnes E. Wold, Ann-Sofie Sandberg
Summary: Metabolites in umbilical cord blood may be related to childhood allergy development, while perinatal factors such as birth order, sex and mode of delivery impact energy and biosynthetic pathways. Maternal diet is also associated with metabolites linked to allergy.
Article
Nutrition & Dietetics
Mia Stravik, Malin Barman, Bill Hesselmar, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg
Article
Food Science & Technology
Fionnuala Murphy, Jessica Gathercole, Erin Lee, Ines Homewood, Alastair B. Ross, Stefan Clerens, Evelyne Maes
Summary: High-throughput protocols such as REIMS and MALDI-TOF MS are effective in quickly discriminating the peptide and small molecular fingerprints of fermented milk products with different flavour characteristics. These techniques can aid in cost-effective fingerprinting to screen for new fermented products and bacterial cultures, and REIMS has been shown to be suitable for measuring liquid dairy samples for the first time.
INTERNATIONAL DAIRY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Linda Englund Ogge, Fiona Murray, Dominika Modzelewska, Robert Lundqvist, Staffan Nilsson, Helena Carre, Maria Kippler, Agnes E. Wold, Ann-Sofie Sandberg, Anna Sandin, Bo Jacobsson, Malin Barman
Summary: This study investigates the potential bias due to self-selection in the NICE birth cohort in Sweden and finds that self-selection has minimal impact on the study's outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Malin Barman, Mia Stravik, Karin Broberg, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg
Summary: Higher proportions of n-6 polyunsaturated fatty acids (including arachidonic acid) but lower proportions of n-3 polyunsaturated fatty acids (including DPA) in the infant's phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.
Article
Biochemistry & Molecular Biology
Olle Hartvigsson, Malin Barman, Otto Savolainen, Alastair B. Ross, Anna Sandin, Bo Jacobsson, Agnes E. Wold, Ann-Sofie Sandberg, Carl Brunius
Summary: The proportion of arterial and venous cord blood affects the monitoring results of neonate health. Metabolomics analysis reveals differences in the metabolomes of arterial and venous blood, mainly related to amino acid and energy metabolism. Venous cord metabolites related to energy metabolism are positively associated with multiple pregnancies.
Article
Nutrition & Dietetics
Inger-Cecilia Mayer Labba, Michael Hoppe, Elisabeth Gramatkovski, Martin Hjellstrom, Mehdi Abdollahi, Ingrid Undeland, Lena Hulthen, Ann-Sofie Sandberg
Summary: This study compared the absorption of non-heme iron from meals containing texturized fava bean protein, beef protein, and cod protein. The results showed that iron absorption from fava bean protein meal was significantly lower compared to beef protein meal and cod protein meal. Therefore, a dietary shift from meat and fish protein to fava bean protein may increase the risk of iron deficiency.
Article
Chemistry, Applied
Alastair B. Ross, Evelyne Maes, Erin J. Lee, Ines Homewood, Jennifer M. Marsh, Stephanie L. Davis, Robert J. Willicut
Summary: This study used lipidomics to investigate the impact of UV light on hair lipids. The results showed that UV exposure decreased several lipid classes and increased others.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2022)
Letter
Nutrition & Dietetics
Alastair B. Ross, Nicola M. McKeown, Eleanor J. Beck, Jan-Willem van der Kamp, Kevin B. Miller, Chris J. Seal
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Environmental Sciences
Mia Stravik, Klara Gustin, Malin Barman, Michael Levi, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg, Maria Kippler, Marie Vahter
Summary: This study assessed biomarkers in the blood and urine of 549 pregnant women to investigate the effects of fish and seafood intake on fetal development. The results showed that erythrocyte mercury and urinary arsenobetaine are reliable indicators of seafood intake.
ENVIRONMENTAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Alastair B. Ross, Shruti P. Shertukde, Kara Livingston Staffier, Mei Chung, Paul F. Jacques, Nicola M. McKeown
Summary: Greater intake of whole grains is associated with reduced risk of cardiovascular disease and type 2 diabetes, but the evidence regarding its effects on cognition is inconclusive. Limited evidence suggests that higher whole-grain intake is linked to better mood and anxiety-related scores. However, more well-designed studies are needed to further investigate the relationship between whole-grain intake and cognitive outcomes.
ADVANCES IN NUTRITION
(2023)
Article
Environmental Sciences
Mariza Kampouri, Klara Gustin, Mia Stravik, Malin Barman, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Marie Vahter, Maria Kippler
Summary: Studies suggest that early-life exposure to toxic metals and fluoride may affect the immune system and contribute to allergic diseases. This study investigated the relationship between exposure to these compounds in pregnant women and their infants with food allergy and atopic eczema. The results showed that gestational cadmium exposure was associated with an increased risk of food allergy in infants, while gestational and infant fluoride exposure had a weak association with atopic eczema. Further research is needed to establish causality.
ENVIRONMENT INTERNATIONAL
(2023)