Article
Chemistry, Inorganic & Nuclear
Roberta Panebianco, Maurizio Viale, Nadia Bertola, Francesco Bellia, Graziella Vecchio
Summary: Multi-metal and multi-cavity systems based on terpyridine functionalized cyclodextrin polymers were synthesized and exhibited high antiproliferative activity in tumor cells through metal coordination with terpyridine derivatives.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Xue-Lian Li, Li-Zhen Zeng, Rong Yang, Xu-Dan Bi, Yang Zhang, Ruo-Bing Cui, Xin-Xi Wu, Feng Gao
Summary: In this study, a highly active cyclometalated iridium(III) complex was discovered through systematic structure regulation, showing potential application in antitumor photodynamic therapy.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Anna Wieczorek-Blauz, Karolina Kowalczyk, Andrzej Blauz, Anna Makal, Sylwia Pawledzio, Chatchakorn Eurtivong, Homayon J. Arabshahi, Johannes Reynisson, Christian G. Hartinger, Blazej Rychlik, Damian Plazuk
Summary: Incorporating the ferrocenyl moiety into a bioactive molecule can significantly alter the activity of the resulting conjugate. By applying this strategy, ferrocenyl analogs of monastrol were designed with higher antiproliferative activity and KSP modulatory activity, attributed to the presence of the ferrocenyl group.
DALTON TRANSACTIONS
(2022)
Article
Multidisciplinary Sciences
Huihui Zhang, Chang Xu, Xiaowen Zhan, Yu Yu, Kaifu Zhang, Qiquan Luo, Shan Gao, Jinlong Yang, Yi Xie
Summary: The use of a carbon-supported copper bis-(terpyridine) complex enables a baton relay-like active site transfer mechanism during CO2 reduction, leading to high CO selectivity and stability. It is expected to accelerate future studies on next-generation CO2 electrocatalysts.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shadia A. Elsayed, Hagar E. Badr, Armando di Biase, Ahmed M. El-Hendawy
Summary: Four new transition metal complexes were synthesized and characterized, showing good antioxidant activity and in vitro cytotoxicity against breast cancer and colon cancer cells. These complexes exhibit potential as effective anticancer agents and may warrant further studies for clinical application.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Meysam Khosravifarsani, Samia Ait-Mohand, Benoit Paquette, Leon Sanche, Brigitte Guerin
Summary: The study presents a novel TP conjugate combined with Cu-64, which emits beta(-) and Auger electrons for radiotherapy and beta(+) particles for PET imaging, showing stable and selective killing of cancer cells. The antitumor activity of this combination is significantly higher compared to traditional treatments, indicating a promising potential for cancer therapy and PET imaging.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Matthew P. P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. D. Herbert, Kelvin K. H. Tong, Jonathan W. W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. C. Goldstone, Christian G. G. Hartinger
Summary: Pt(terpyridine) complexes are known for their ability to intercalate with DNA. The addition of an NHC co-ligand significantly increased the anticancer activity of the complex compared to its chlorido derivative. While the compound showed high efficacy, it was well-tolerated by zebrafish embryos, especially when compared to cisplatin. DNA interaction studies suggest that the mode of action is related to intercalation.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Moritz Nau, Larissa A. A. Casper, Gernot Haug, Michael Linseis, Serhiy Demeshko, Rainer F. F. Winter
Summary: Permethylation of the phenylene linker increases the valence tautomer of the diradical ferrocenium thioxanthyl radical and inhibits dimerization of the latter and the one-electron reduced neutral radical.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Lucia M. Balsa, Veronica Ferraresi-Curotto, Martin J. Lavecchia, Gustavo A. Echeverria, Oscar E. Piro, Javier Garcia-Tojal, Reinaldo Pis-Diez, Ana C. Gonzalez-Baro, Ignacio E. Leon
Summary: The study presents a copper-hydrazone complex with anticancer activity against human breast cancer cells on 2D and 3D models, showing higher efficacy than cisplatin. Molecular docking and dynamics simulations revealed CuHL's interaction with DNA, inducing cell programmed death and genotoxic effects. The compound also decreased breast cancer stem cell population and overcame cisplatin's efficacy on multicellular spheroids.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
P. Jyothi, V. Sumalatha, D. Rajitha
Summary: Three Co(II) complexes were synthesized and characterized, showing good DNA binding, antimicrobial, and anticancer activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Chemistry, Inorganic & Nuclear
Ramakrishnan Abhijnakrishna, Kuppan Magesh, Agarwal Ayushi, Sivan Velmathi
Summary: The compound 2,2';6,2'' terpyridine has unique properties that have attracted significant interest in various fields. It exhibits intense non-radiative relaxation and low quantum yields, making it valuable in electrochemistry, biochemistry, and photophysical chemistry. Metal-terpyridine complexes have shown great potential in biological activity, acting as anti-tumor and cell imaging agents, as well as effective sensors for recognizing vital biological targets.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Bin Liu, Chun Wai Tang, Wei Wei, Cheng Zhang, Guochen Jia, Tianshou Zhao
Summary: This paper describes the design and synthesis of terpyridine-based complexes of Cr, Mn, Fe, and Co for non-aqueous redox flow batteries. The electrochemical studies show that these complexes can undergo multi-electron transfer reactions. The Mn and Fe-based complexes exhibit low negative and high positive redox potentials, allowing them to serve as a bipolar electrolyte for symmetric RFBs with a cell voltage of over 2 V. The solubility of these complexes can be improved by incorporating a polyether substituent and optimizing the counter anion. The iron complex [Fe(tpy-O(CH2CH2O)3CH3)2][TFSI]2 has a high solubility of 0.76 M in MeCN. The iron-based NARFB demonstrates superior battery performance with a high cell voltage, columbic efficiency, energy efficiency, and stable charge-discharge capacity retention.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Karampal Singh, Joshua Northcote-Smith, Kuldip Singh, Kogularamanan Suntharalingam
Summary: This study reports the synthesis, characterisation, and anti-breast cancer stem cell (CSC) properties of a series of copper(ii)-terpyridine complexes containing aryl sulfonamide groups. One of these complexes, with p-toluene sulfonamide, is more potent than established anti-CSC drug salinomycin and anticancer drug cisplatin. The complexes enter breast CSCs, generate intracellular reactive oxygen species (ROS), induce endoplasmic reticulum stress, and trigger apoptosis.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Gabriel H. Ribeiro, Analu R. Costa, Aparecido R. de Souza, Fabiana V. da Silva, Felipe T. Martins, Ana M. Plutin, Alzir A. Batista
Summary: This review discusses the development of ruthenium complexes with acylthiourea ligands for potential antitumor activity. It highlights the increased biological activity of the coordination products compared to their precursor complexes and free ligands. The structure-activity relationships of different structure scaffolds of ruthenium complexes with N-mono- and disubstituted acylthiourea ligands are discussed in relation to their cytotoxic properties and antitumor activity. The mode of binding of Ru-acylthiourea complexes to DNA is also explored to understand their cytotoxic action.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossio Cuartero, Andres Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Perez-Ojeda, Andriy Mokhir
Summary: The drug FeC 2 induces endoplasmic reticulum stress and increases ROS levels in cancer cells without affecting normal cells. It exhibits low micromolar toxicity towards various cancer cells and shows potential in suppressing primary tumor growth and metastases in murine models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Cell Biology
Sudarshan Gadadhar, Hala Dadi, Satish Bodakuntla, Anne Schnitzler, Ivan Bieche, Filippo Rusconi, Carsten Janke
JOURNAL OF CELL BIOLOGY
(2017)
Article
Cell Biology
Montserrat Bosch Grau, Christel Masson, Sudarshan Gadadhar, Cecilia Rocha, Olivia Tort, Patricia Marques Sousa, Sophie Vacher, Ivan Bieche, Carsten Janke
JOURNAL OF CELL SCIENCE
(2017)
Article
Cell Biology
Sudarshan Gadadhar, Satish Bodakuntla, Kathiresan Natarajan, Carsten Janke
JOURNAL OF CELL SCIENCE
(2017)
Review
Biochemistry & Molecular Biology
Maria M. Magiera, Puja Singh, Sudarshan Gadadhar, Carsten Janke
Article
Biochemistry & Molecular Biology
Sudarshan Gadadhar, Namrata Bora, Vinita Tiwari, Anjali A. Karande
BIOCHEMICAL JOURNAL
(2014)
Article
Chemistry, Inorganic & Nuclear
Tridib K. Goswami, Sudarshan Gadadhar, Babu Balaji, Bappaditya Gole, Anjali A. Karande, Akhil R. Chakravarty
DALTON TRANSACTIONS
(2014)
Article
Multidisciplinary Sciences
Sudarshan Gadadhar, Anjali A. Karande
Article
Chemistry, Inorganic & Nuclear
Tridib K. Goswami, Sudarshan Gadadhar, Anjali A. Karande, Akhil R. Chakravarty
Article
Cell Biology
Tiziana Giordano, Sudarshan Gadadhar, Satish Bodakuntla, Jonas Straub, Sophie Leboucher, Guillaume Martinez, Walid Chemlali, Christophe Bosc, Annie Andrieux, Ivan Bieche, Christophe Arnoult, Stefan Geimer, Carsten Janke
JOURNAL OF CELL SCIENCE
(2019)
Correction
Cell Biology
Montserrat Bosch Grau, Christel Masson, Sudarshan Gadadhar, Cecilia Rocha, Olivia Tort, Patricia Marques Sousa, Sophie Vacher, Ivan Bieche, Carsten Janke
JOURNAL OF CELL SCIENCE
(2020)
Article
Multidisciplinary Sciences
Sudarshan Gadadhar, Gonzalo Alvarez Viar, Jan Niklas Hansen, An Gong, Aleksandr Kostarev, Come Ialy-Radio, Sophie Leboucher, Marjorie Whitfield, Ahmed Ziyyat, Aminata Toure, Luis Alvarez, Gaia Pigino, Carsten Janke
Summary: This study demonstrates the importance of tubulin glycylation for controlled flagellar beating, directional sperm swimming, and male fertility by utilizing a mouse model lacking this modification. The lack of glycylation led to abnormal dynein arm conformations in sperm axonemes, resulting in subfertility in male mice due to aberrant beat patterns of sperm flagella.
Article
Biochemistry & Molecular Biology
Satish Bodakuntla, Xidi Yuan, Mariya Genova, Sudarshan Gadadhar, Sophie Leboucher, Marie-Christine Birling, Dennis Klein, Rudolf Martini, Carsten Janke, Maria M. Magiera
Summary: The research reveals that the glutamylases TTLL1 and TTLL7 generate unique and distinct glutamylation patterns on neuronal microtubules, affecting microtubule function and neuronal degeneration in different ways. This demonstrates the importance of specific patterns of tubulin glutamylation in maintaining physiological homeostasis.
Review
Cell Biology
Sudarshan Gadadhar, Tatjana Hirschmugl, Carsten Janke
Summary: Microtubules are crucial for sperm development and function, particularly in sperm motility and the swimming towards the oocyte. Tubulin posttranslational modifications, which control microtubule functions, have been found to be key players in sperm development, and their aberrations can lead to male infertility. The understanding of the tubulin code and its implications in sperm functionality is important for male fertility.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Satish Bodakuntla, Xidi Yuan, Mariya Genova, Sudarshan Gadadhar, Sophie Leboucher, Marie-Christine Birling, Dennis Klein, Rudolf Martini, Carsten Janke, Maria M. Magiera
Article
Biochemistry & Molecular Biology
Kathiresan Natarajan, Sudarshan Gadadhar, Judith Souphron, Maria M. Magiera, Carsten Janke
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)