Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration

Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

(2020) Satish Bodakuntla et al.   JOURNAL OF CELL SCIENCE

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic microtubules at the synapse

(2020) Erik W Dent   CURRENT OPINION IN NEUROBIOLOGY

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

(2020) Kishore K. Mahalingan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

(2020) Verena Henrichs et al.   Nature Communications

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

(2020) C. K. Deniston et al.   NATURE

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

(2019) Valerie Siahaan et al.   NATURE CELL BIOLOGY

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Cytoskeleton dynamics in axon regeneration

(2018) Oriane Blanquie et al.   CURRENT OPINION IN NEUROBIOLOGY

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration

(2018) Vandana Shashi et al.   EMBO JOURNAL

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

(2018) Maria M Magiera et al.   EMBO JOURNAL

CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice

(2018) Stephen Gilmore-Hall et al.   JOURNAL OF CELL BIOLOGY

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

(2017) Scott T. Brady et al.   NEUROBIOLOGY OF DISEASE

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

(2017) Chrystelle Aillaud et al.   SCIENCE

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

(2017) Wenting Guo et al.   Nature Communications

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease

(2016) Dennis Klein et al.   BRAIN RESEARCH

Microtubules in health and degenerative disease of the nervous system

(2016) Andrew J. Matamoros et al.   BRAIN RESEARCH BULLETIN

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

Neuronal polarity: remodeling microtubule organization

(2016) Sam FB van Beuningen et al.   CURRENT OPINION IN NEUROBIOLOGY

Stability properties of neuronal microtubules

(2016) Peter W. Baas et al.   Cytoskeleton

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

(2016) Amy E. Ghiretti et al.   NEURON

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

(2014) Olivia Tort et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

(2014) Catherine Diamante Sorbara et al.   NEURON

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

β-Tubulin mutations that cause severe neuropathies disrupt axonal transport

(2013) Shinsuke Niwa et al.   EMBO JOURNAL

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X

(2011) Janos Groh et al.   BRAIN

Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background

(2011) Marie-Christine Birling et al.   GENESIS

Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin

(2011) Iryna Berezniuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE