Article
Chemistry, Physical
Beata Korchowiec, Monika Orlof-Naturalna, Jacek Korchowiec, Jean-Bernard Regnouf de Vains, Maxime Mourer, Ewa Rogalska
Summary: The calixarene derivative tetra-p-guanidinoethylcalix[4]arene exhibited in vitro activity against various Gram-positive and Gram-negative bacteria. The study investigated the interaction between bacterial cell membranes and the water-soluble calixarene using model lipids as monomolecular films. The structure of phosphatidylglycerols influenced the affinity of the calixarene for the monolayer, suggesting potential for developing new antibiotics.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Biochemistry & Molecular Biology
Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, David A. Gewirtz, Sujit Kumar Bhutia
Summary: Lysosomes are crucial organelles responsible for degrading cellular cargo and maintaining cellular homeostasis, playing a critical role in the connection between autophagy and endocytosis. Damage to the lysosomal membrane can lead to selective lysosomal degradation pathway and trigger lysophagy in severe cases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Man Huo, Xian-Yin Dai, Yu Liu
Summary: This study presents a high-efficiency room temperature phosphorescence (RTP) capturing system through secondary assembly strategy, allowing the capture and transfer of light at different wavelengths, suitable for cellular imaging purposes.
Review
Biochemistry & Molecular Biology
Ge Yu, Daniel J. Klionsky
Summary: Autophagy is a conserved process in cell survival and cell death, enabling the degradation of cytoplasmic components. It has the primary role of delivering cytoplasmic components to vacuoles or lysosomes for degradation and can also regulate cell death in certain ways, with complex crosstalk between different pathways.
Article
Biochemistry & Molecular Biology
Yui Jin, Natsuko Jin, Yu Oikawa, Ron Benyair, Michiko Koizumi, Thomas E. Wilson, Yoshinori Ohsumi, Lois S. Weisman
Summary: The vacuole/lysosome plays a crucial role in cell growth and cell cycle progression via the TORC1 pathway. Bur1, an essential cyclin-dependent kinase, cooperates with TORC1 to regulate cell cycle progression, with mutations in BUR1 showing synthetic growth defects and high sensitivity to rapamycin. Together, Bur1 and TORC1 are required for the activation of Sch9 to promote cell cycle progression.
Article
Materials Science, Multidisciplinary
Gayathri Ravichandran, Dinesh Harijan, Nagarajan Ganapathy, Ganesan Prabusankar, Abhijit De, Aravind Kumar Rengan
Summary: In this study, we have uncovered the potential therapeutic role of cobalt nanoparticles by elucidating their interaction with oxygen and amino acids. This discovery has led to the design of a novel combinatorial targeted therapy that induces cell death through starvation and acidification, as well as the identification of autophagy and cellular degradation.
ACS MATERIALS LETTERS
(2023)
Article
Cell Biology
Mateus Milani, Philippe Pihan, Claudio Hetz
Summary: Calcium is a crucial messenger in regulating cellular processes and interorganelle communication. Lysosomal function is dependent on calcium, and ion channels on the lysosomal membrane regulate lysosomal properties such as pH. Lysosome-dependent cell death (LDCD) is a specific type of cell death involving lysosomes that plays important roles in tissue homeostasis, development, and pathology. This article focuses on recent advances in understanding the role of calcium signaling in LDCD.
Article
Chemistry, Analytical
Min Wang, Xiao Zhang, Le Wang, Jingyi Zhang, Na Liu, Di Zhang
Summary: A novel fluorescent probe (FAP1) with lysosomal localization group was designed and synthesized for the detection of formaldehyde. The probe showed good fluorescence recognition performances for formaldehyde, including large Stokes shift (130 nm), specific selectivity, good anti-interference ability, and low minimum detection limit (16 nM). It is notable that the probe exhibited good biocompatibility and could be applied to the imaging detection of formaldehyde in lysosome.
MICROCHEMICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Shi Tai, Jiaxing Sun, Yuying Zhou, Zhaowei Zhu, Yuhu He, Mingxian Chen, Hui Yang, Yichao Xiao, Tao Tu, Liang Tang, Xuping Li, Jianping Zeng, Xilong Zheng, Shenghua Zhou
Summary: In this study, it was found that metformin prevents VSMC and vascular senescence by promoting autolysosome formation. Specifically, metformin enhanced the autophagic flux at the autophagosome-lysosome fusion level, thereby inhibiting Ang II-induced cellular and vascular senescence.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sara Aly Attia, Anh Tan Truong, Alvin Phan, Shin-Jae Lee, Manal Abanmai, Marinella Markanovic, Hugo Avila, Haozhong Luo, Atham Ali, Parameswaran G. Sreekumar, Ram Kannan, J. Andrew MacKay
Summary: This study successfully extended the activity of the anti-apoptotic mini-cry peptide in the retina by fusing it with two temperature-sensitive elastin-like polypeptides (ELP). The results suggest that the ELP architecture is critical for optimizing the delivery of therapeutic peptides, and enhancing lysosomal membrane permeabilization can further enhance the protection of mini-cry.
Review
Chemistry, Multidisciplinary
Wen Zhou, Xiaoyue Ni, Chen Xie, Quli Fan, Dingbin Liu
Summary: Cells are inherently heterogeneous, and understanding the protein machinery underlying their functions is crucial. While genome and transcriptome sequencing have advanced at the single-cell level, comprehensive proteomic profiling remains challenging. Advanced imaging and spectroscopy techniques are being developed for single-cell proteomic imaging to overcome these challenges and enable better analysis.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Bing Hu, Juan-Juan Li, Yan-Bin Ren, Tian-Xing Zhang, Li-Bin Chen, Xiao-Liu Li, Dong-Sheng Guo, Ke-Rang Wang
Summary: The development and study of five calixarene-based cryoprotectants in this research demonstrated their excellent cryoprotective effects, especially for those with specific functional groups. This provides a supramolecular principle for the development of novel cryoprotectants.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Hao Wang, Guangxu Bai, Jianwei Chen, Wen Han, Ran Guo, Na Cui
Summary: The study found that during sepsis, the mTOR pathway modulates CD4 + T cell autophagy and apoptosis by regulating the transcription of A-L fusion-related proteins. Further experiments demonstrated that deletion of mTOR could alleviate fusion dysfunction between autophagosomes and lysosomes in CD4 + T cells, improving cell apoptosis.
Article
Multidisciplinary Sciences
Xiwang Yang, Ya Wen, Shaomin Liu, Liqiang Duan, Tongfeng Liu, Zhou Tong, Zhuo Wang, Yinmin Gu, Yibo Xi, Xiaodong Wang, Dingsan Luo, Ruobing Zhang, Yajuan Liu, Yang Wang, Tianyou Cheng, Siyuan Jiang, Xiaofeng Zhu, Xiaohui Yang, Yongbo Pan, Shuwen Cheng, Qinong Ye, Jinfei Chen, Xiaoding Xu, Shan Gao
Summary: The study revealed the critical role of a long noncoding RNA LCDR in regulating lysosome function, which affects lung cancer cell survival. LCDR interacts with hnRNP K to maintain lysosomal membrane integrity, leading to lysosomal cell death and apoptosis. Targeting LCDR/hnRNP K/LAPTM5 axis may provide potential therapeutic targets for cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Paolo Lo Meo, Samuele Terranova, Antonella Di Vincenzo, Delia Chillura Martino, Pellegrino Conte
Summary: This study introduces a new analysis method for evaluating NMRD curves, based on the inverse integral transform, which provides a true heuristic approach to identifying dynamic domains in systems without introducing subjective elements. Analysis of real sample data sets suggests that the results obtained with this heuristic method may actually be attributed to distinct physical/chemical features of the systems.
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
[Anonymous]
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Multidisciplinary
Kevin Buffet, Iwona Nierengarten, Nicolas Galanos, Emilie Gillon, Michel Holler, Anne Imberty, Susan E. Matthews, Sebastien Vidal, Stephane P. Vincent, Jean-Francois Nierengarten
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Multidisciplinary
James P. Buttress, David P. Day, James M. Courtney, Elliot J. Lawrence, David L. Hughes, Robin J. Blagg, Alison Crossley, Susan E. Matthews, Carl Redshaw, Philip C. Bulman Page, Gregory G. Wildgoose
Article
Chemistry, Organic
Marco M. D. Cominetti, David L. Hughes, Susan E. Matthews
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Chemistry, Organic
Qiran Sheng, Joseph C. Neaverson, Tasnim Mahmoud, Clare E. M. Stevenson, Susan E. Matthews, Zoe A. E. Waller
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Cell Biology
Shirley C. Mills, Lesley Howell, Andrew Beekman, Leanne Stokes, Anja Mueller
CELLULAR SIGNALLING
(2018)
Article
Chemistry, Multidisciplinary
Susan E. Matthews, Samy Cecioni, John E. O'Brien, Colin J. MacDonald, David L. Hughes, Garth A. Jones, Stephen H. Ashworth, Sebastien Vidal
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Multidisciplinary Sciences
James M. Fox, Fahima Kausar, Amy Day, Michael Osborne, Khansa Hussain, Anja Mueller, Jessica Lin, Tomoko Tsuchiya, Shiro Kanegasaki, James E. Pease
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
I Hamshaw, M. Ajdarirad, A. Mueller
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Wing Yee Lai, Anja Mueller
Summary: The chemokine system plays a crucial role in various physiological processes, with dysregulation linked to inflammatory diseases and cancer. Despite the development of 45 drugs targeting chemokine receptors in the past two decades, only three have been clinically approved, highlighting challenges including limited understanding, high system redundancy, and non-specific binding issues.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Chemistry, Medicinal
Jean-Jacques Helesbeux, Laura Carro, Florence O. McCarthy, Vania M. Moreira, Francesca Giuntini, Niamh O'Boyle, Susan E. Matthews, Guelsah Bayraktar, Samuel Bertrand, Christophe Rochais, Pascal Marchand
Summary: The 29th Annual GP(2)A Conference was held virtually this year due to the COVID-19 pandemic, spanning three days and attracting an international delegation of researchers. Keynote lectures, young researcher talks, and flash presentation posters were included in the report, showcasing high-level scientific discussions on cutting-edge advances in pharmaceutical chemistry.
Article
Pharmacology & Pharmacy
Isabel Hamshaw, Marco M. D. Cominetti, Wing-Yee Lai, Mark Searcey, Anja Mueller
Summary: Cancer metastasis is a major cause of cancer-related death. The CXCR4 receptor and its ligand CXCL12 play important roles in promoting metastasis, making them attractive therapeutic targets. In this study, a novel CXCR4 antagonist was developed and used for CXCR4-based imaging. The results showed that these antagonists were non-toxic and effectively inhibited cancer cell migration and calcium release.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Isabel Hamshaw, Youssef Ellahouny, Artur Malusickis, Lia Newman, Dante Ortiz-Jacobs, Anja Mueller
Summary: Cancer metastasis is the leading cause of cancer related mortality. This study investigated the role of protein kinase C (PKC) and protein kinase D (PKD) in cell migration stimulated by CXCL12 and CXCL13 in different types of cancer cells. The findings suggest that PKC inhibitors could be a potential therapeutic for preventing migration in both CXCL12 and CXCL13 stimulated cancers, while PKD inhibitors may be effective in preventing migration in CXCL12 stimulated malignant melanoma.
CELLULAR SIGNALLING
(2024)
Article
Pharmacology & Pharmacy
Enana Alassaf, Anja Mueller
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Michael D. Threadgill, Susan E. Matthews, Francesca Giuntini
