Article
Pharmacology & Pharmacy
Mehdi Najar, Makram Merimi, Wissam H. Faour, Catherine A. Lombard, Douaa Moussa Agha, Yassine Ouhaddi, Etienne M. Sokal, Laurence Lagneaux, Hassan Fahmi
Summary: This study explored the application of Foreskin-derived mesenchymal stromal/stem cells (FSK-MSCs) in immunotherapy. It was found that FSK-MSCs can interact with T cells and inflammatory signals, modulating the T cell response accordingly.
Article
Oncology
Gabrielle Leclercq, Helene Haegel, Alberto Toso, Tina Zimmermann, Luke Green, Nathalie Steinhoff, Johannes Sam, Vesna Pulko, Anneliese Schneider, Anna Maria Giusti, John Challier, Anne Freimoser-Grundschober, Laurent Lariviere, Alex Odermatt, Martin Stern, Pablo Umana, Marina Bacac, Christian Klein
Summary: This study aimed to identify small molecules that can reduce cytokine release while maintaining T cell-mediated tumor killing. By screening a library of FDA-approved kinase inhibitors, mTOR, JAK, and Src kinase inhibitors were found to modulate cytokine release. Further in vitro and in vivo experiments confirmed these findings and supported the evaluation of these inhibitors as a treatment to prevent cytokine release syndrome (CRS).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Rosemina Merchant, Carole Galligan, Manjunatha Ankathatti Munegowda, L. Bruce Pearce, Peter Lloyd, Paul Smith, Fahar Merchant, Minh D. To
Summary: MDNA11 is a next generation long-acting IL-2 immunotherapeutic that overcomes the limitations of current treatments by modifying receptor selectivity and extending the pharmacokinetic profile. It has been shown to control tumor growth and induce durable tumor clearance when used as a monotherapy or in combination with immune checkpoint inhibitors. Evaluation of MDNA11 in non-human primates demonstrates its good tolerability and the ability to stimulate a strong and durable immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Constance Renault, Nicolas Veyrenche, Franck Mennechet, Anne-Sophie Bedin, Jean-Pierre Routy, Philippe Van de Perre, Jacques Reynes, Edouard Tuaillon
Summary: Th17 cells play a crucial role in defending against pathogens at mucosal barriers, but they are also vulnerable to HIV-1 infection and depletion from gut mucosal sites. The imbalance caused by the loss of Th17 cells impairs cytokine production and leads to damage in the gut mucosal barrier, promoting HIV-1 disease progression. The expression of specific receptors by Th17 cells contributes to their susceptibility to HIV infection. Moreover, Th17 cells serve as long-lived viral reservoirs in HIV patients receiving antiretroviral therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Florent Lemaitre, Negar Farzam-Kia, Ana Carmena Moratalla, Yves Carpentier Solorio, Marie-Laure Clenet, Olivier Tastet, Aurelie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Pierre Duquette, J. Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Summary: IL-27 alters immune functions of human astrocytes and shapes the profile and motility of encountered T lymphocytes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Kathryne E. Marks, Stephanie Flaherty, Kristen M. Patterson, Matthew Stratton, Gustavo J. Martinez, Joseph M. Reynolds
Summary: The study shows that activation of TLR2 increases the pathogenicity and migratory capacity of Th17 cells, comparable to IL-23. RNA sequencing revealed differential expression of genes associated with Th17 pathogenicity through the TLR2 pathway, including Ipcef1.
Article
Oncology
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E. Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E. Lopes, Heather C. Losey, Raymond J. Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong
Summary: The study demonstrated that mNemvaleukin significantly inhibited SCLC tumor growth, with the most significant survival benefit observed when combined with chemotherapy. mNemvaleukin expanded tumor-infiltrating NK cells and CD8(+) T cells, and promoted their activation and proliferation. Combining mNemvaleukin with chemotherapy had the strongest effects in activating effector and cytotoxic CD8(+) T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Hye-Soo Park, Seunga Choi, Yong-Woo Back, Kang-In Lee, Han-Gyu Choi, Hwa-Jung Kim
Summary: The study found that PGE2 produced by RpfE-activated dendritic cells via the MAPK and cyclooxygenase 2 signaling pathways induces Th1 and Th17 cell responses mainly via the EP4 receptor, contributing to defense against Mycobacterium tuberculosis infection. Moreover, adding optimal amount of PGE2 to IL-2-IL-6-IL-23p19-IL-1 beta is essential for promoting differentiation into Th1/Th17 cells with strong bactericidal activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Robert Nechanitzky, Duygu Nechanitzky, Parameswaran Ramachandran, Gordon S. Duncan, Chunxing Zheng, Christoph Gobl, Kyle T. Gill, Jillian Haight, Andrew C. Wakeham, Bryan E. Snow, Vivian Bradaschia-Correa, Milan Ganguly, Zhibin Lu, Mary E. Saunders, Richard A. Flavell, Tak W. Mak
Summary: Choline acetyltransferase (ChAT) plays a critical role in the pathogenicity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). ChAT-deficient Th17 cells in mice resist disease progression and show reduced brain-infiltrating immune cells. ChAT expression in Th17 cells is associated with TCR signaling, Bhlhe40 transcription factor, and increased mRNA levels of Il2, Il17, Il22, and Il23r.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nidhi Medara, Jason C. Lenzo, Katrina A. Walsh, Neil M. O'Brien-Simpson, Eric C. Reynolds, Ivan B. Darby
Summary: This study evaluated the longitudinal variation in peripheral T helper cells in periodontitis patients undergoing management, indicating potential roles of IFN-gamma(+) and Foxp3(+) cells in the systemic compartment of periodontitis. Treatment outcomes were associated with changes in the expression of IFN-gamma and Foxp3 cells. Periodontal management has local and systemic effects, highlighting the importance of assessing and managing periodontitis for overall systemic health.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Immunology
Fernanda Tereza Bovi Frozza, Tiago Fazolo, Priscila Oliveira de Souza, Karina Lima, Julia Crispim da Fontoura, Theo Souza Borba, Marcia Polese-Bonatto, Luciane Beatriz Kern, Renato T. Stein, Graham Pawelec, Cristina Bonorino
Summary: Human cytomegalovirus (CMV) is a persistent virus that requires lifelong immune surveillance. Long-term interactions with the immune system may have negative effects. This study investigated the influence of CMV-specific cellular and humoral activity on immune responses and disease severity in COVID-19 patients. Results showed that high frequencies of CMV-specific T cells were associated with a SARS-CoV-2-reactive profile skewed toward Th17-dominated immunity.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Review
Cell Biology
Hafid Ait-Oufella, Jean-Remi Lavillegrand, Alain Tedgui
Summary: Research shows that chronic inflammation triggered by cholesterol-rich lipoproteins is crucial in atherosclerosis development. Effector Th1 cells are proatherogenic, while regulatory T cells (Tregs) protect against atherosclerosis. Understanding how Tregs affect atherosclerosis could lead to new targeted therapies against cardiovascular disease.
Article
Biotechnology & Applied Microbiology
Hongtao Wang, Yan Li, Zhang Yue, Yang Liu, Qiaohua Chen, Dahai Hu, Juntao Han
Summary: This study investigates the role of ADCS-Exos in the secretion of inflammatory factors, Th17 and Treg cell differentiation in hypertrophic scar formation and maturation. The results show that hypertrophic scars have increased levels of IL-6, IL-10, IL-17A, TNF-alpha, ROR ut, and Foxp3. Naive CD4(+) T cells treated with ADCS-Exos exhibit decreased production of IL-6, IL-17A, TNF-alpha, and ROR ut, and increased production of IL-10 and Foxp3. Mice treated with ADCS-Exos also show reduced collagen deposition and increased production of IL-10 and Foxp3.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Patrick J. Quinn, Maria C. Ramello, Meena Malipatlolla, Bence Daniel, Katalin Sandor, Dorota Klysz, Jeremy Bjelajac, Peng Xu, Kylie A. Burdsall, Victor Tieu, Vandon T. Duong, Micah G. Donovan, Evan W. Weber, Howard Y. Chang, Robbie G. Majzner, Joaquin M. Espinosa, Ansuman T. Satpathy, Crystal L. Mackall
Summary: This research identified MED12 and CCNC as key genes controlling T cell function through CRISPR knockout screening. Knockout of MED12 gene enhances antitumor activity, prolongs the effector phenotype of CAR-T and TCR-T cells, and promotes the expansion of non-engineered T cells. The study reveals the importance of Mediator in T cell effector programming and provides a new target to enhance the potency of antitumor T cell responses.
Article
Biochemistry & Molecular Biology
Taru Goyal, Prasenjit Mitra, Preeti Singh, Raghumoy Ghosh, Malavika Lingeswaran, Shailja Sharma, Praveen Sharma
Summary: Occupational exposure to lead has a significant impact on workers' immune system and parameters, leading to immune cell dysfunction and increased pro-inflammatory response.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Mathematical & Computational Biology
Jukka Intosalmi, Helena Ahlfors, Sini Rautio, Henrik Mannerstom, Zhi Jane Chen, Riitta Lahesmaa, Brigitta Stockinger, Harri Lahdesmaki
BMC SYSTEMS BIOLOGY
(2015)
Article
Oncology
Soile Tuomela, Sini Rautio, Helena Ahlfors, Viveka Oling, Verna Salo, Ubaid Ullah, Zhi Chen, Saara Hamalisto, Subhash K. Tripathi, Tarmo Aijo, Omid Rasool, Hayssam Soueidan, Lodewyk Wessels, Brigitta Stockinger, Harri Lahdesmaki, Riitta Lahesmaa
Article
Cell Biology
Subhash K. Tripathi, Zhi Chen, Antti Larjo, Kartiek Kanduri, Kari Nousiainen, Tarmo Aijo, Isis Ricano-Ponce, Barbara Hrdlickova, Soile Tuomela, Essi Laajala, Verna Salo, Vinod Kumar, Cisca Wijmenga, Harri Lahdesmaki, Riitta Lahesmaa
Article
Biochemistry & Molecular Biology
Imran Mohammad, Inna Starskaia, Tamas Nagy, Jitao Guo, Emrah Yatkin, Kalervo Vaananen, Wendy T. Watford, Zhi Chen
Article
Biochemistry & Molecular Biology
Imran Mohammad, Kari Nousiainen, Santosh D. Bhosale, Inna Starskaia, Robert Moulder, Anne Rokka, Fang Cheng, Ponnuswamy Mohanasundaram, John E. Eriksson, David R. Goodlett, Harri Lahdesmaki, Zhi Chen
Article
Biochemistry & Molecular Biology
Imran Mohammad, Inna Starskaia, Tamas Nagy, Jitao Guo, Emrah Yatkin, Kalervo Vaananen, Wendy T. Watford, Zhi Chen
Article
Biochemistry & Molecular Biology
Tiina Kelkka, Deborah Kienhoefer, Markus Hoffmann, Marjo Linja, Kajsa Wing, Outi Sareila, Malin Hultqvist, Essi Laajala, Zhi Chen, Julia Vasconcelos, Esmeralda Neves, Margarida Guedes, Laura Marques, Gerhard Kroenke, Merja Helminen, Leena Kainulainen, Peter Olofsson, Sirpa Jalkanen, Riitta Lahesmaa, M. Margarida Souto-Carneiro, Rikard Holmdahl
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Immunology
Romain Roncagalli, Simon Hauri, Frederic Fiore, Yinming Liang, Zhi Chen, Amandine Sansoni, Kartiek Kanduri, Rachel Joly, Aurelie Malzac, Harri Lahdesmaki, Riitta Lahesmaa, Sho Yamasaki, Takashi Saito, Marie Malissen, Ruedi Aebersold, Matthias Gstaiger, Bernard Malissen
Article
Multidisciplinary Sciences
Christophe Come, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimentel, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck
Article
Immunology
Satyajeet P. Khare, Ankitha Shetty, Rahul Biradar, Indumathi Patta, Zhi Jane Chen, Ameya Sathe, Puli Chandramouli Reddy, Riitta Lahesmaa, Sanjeev Galande
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Linglu Wang, Ponnuswamy Mohanasundaram, Michelle Lindstrom, Muhammad Nadeem Asghar, Giulia Sultana, Julia O. Misiorek, Yaming Jiu, Hongbo Chen, Zhi Chen, Diana M. Toivola, Fang Cheng, John E. Eriksson
Summary: Vimentin plays an important role in intestinal diseases, particularly in the injury and repair processes of colonic epithelial cells. Vim(-/-) mice showed more severe colitis and higher production of reactive oxygen and nitrogen species than wild-type mice when exposed to DSS. CD11b(+) macrophages were identified as the main cellular source of reactive oxygen species production. Additionally, Vim(-/-) mice did not spontaneously develop colitis-associated cancer model upon DSS treatment, but exhibited increased tumor numbers and size in the distal colon in the azoxymethane/DSS model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Victor Urbiola-Salvador, Dominika Miroszewska, Agnieszka Jablonska, Talha Qureshi, Zhi Chen
Summary: This review discusses the application of proteomics studies in characterizing immune responses and tumor immune microenvironment heterogeneity in cancer. Proteomics studies have gained considerable attention in recent years for decoding immune responses, and they are proven to be more accurate in reflecting cell state compared to genomics or transcriptomics studies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Victor Urbiola-Salvador, Suiane Lima de Souza, Peter Gresner, Talha Qureshi, Zhi Chen
Summary: Using a proximity extension assay, the study quantified 1387 proteins in plasma samples from 28 Finnish patients with COVID-19 and their controls to determine the protein profile changes caused by SARS-CoV-2 infection. The findings revealed altered immune signatures in patients with comorbidities and the identification of novel elevated proteins, anti-microbial activity proteins, and extracellular matrix remodeling proteins. Additionally, downregulation of RNF41 was observed in patients compared to healthy controls. These plasma protein changes provide insights into SARS-CoV-2 infection and potential biomarkers for diagnosis, prognosis, and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mohd Moin Khan, Ubaid Ullah, Meraj H. Khan, Lingjia Kong, Robert Moulder, Tommi Valikangas, Santosh Dilip Bhosale, Elina Komsi, Omid Rasool, Zhi Chen, Laura L. Elo, Jukka Westermarck, Riitta Lahesmaa
Article
Immunology
Zhilin Li, Mohd Moin Khan, Juha Kuja-Panula, Hongyun Wang, Yu Chen, Deyin Guo, Zhi Jane Chen, Riitta Lahesmaa, Heikki Rauvala, Li Tian
BRAIN BEHAVIOR AND IMMUNITY
(2017)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.