Review
Cell Biology
Maria Pia Adorni, Nicoletta Ronda, Franco Bernini, Francesca Zimetti
Summary: HDL cholesterol efflux capacity (CEC) has emerged as a better predictor of cardiovascular risk compared to plasma HDL-cholesterol levels, and is often impaired in various genetic and pathological conditions associated with high cardiovascular risk.
Article
Cardiac & Cardiovascular Systems
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker-Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg
Summary: The study showed that MEDI6012 has an acceptable safety profile and can increase high-density lipoprotein cholesterol, endogenous apoA1, and non-ATP-binding cassette transporter A1 cholesterol efflux capacity in patients with stable coronary heart disease, while reducing the number of atherogenic low-density lipoprotein particles.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Chemistry, Multidisciplinary
Wenmin Yuan, Bilian Yu, Minzhi Yu, Rui Kuai, Emily E. Morin, Huilun Wang, Die Hu, Jifeng Zhang, James J. Moon, Y. Eugene Chen, Yanhong Guo, Anna Schwendeman
Summary: LXR agonists have potential anti-atherosclerotic effects by increasing cholesterol efflux, but may cause liver toxicity and hypertriglyceridemia. Encapsulating the LXR agonist in synthetic HDL nanoparticles improves drug efficacy and reduces side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Hematology
George E. G. Kluck, Alexander S. Qian, Emmanuel H. Sakarya, Henry Quach, Yak D. Deng, Bernardo L. Trigatti
Summary: Atherosclerosis is a chronic disease that affects the artery wall and is a major contributor to cardiovascular diseases. Necrotic cores, which contain debris from dead macrophages, increase the risk of plaque rupture and thrombus formation. HDL (high-density lipoprotein) has direct protective effects on different cells within atherosclerotic plaques, but its role in protecting against necroptosis and necrotic core formation is not fully understood.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tatjana Josefs, Debapriya Basu, Tomas Vaisar, Britt Arets, Jenny E. Kanter, Lesley-Ann Huggins, Yunying Hu, Jianhua Liu, Noemie Clouet-Foraison, Jay W. Heinecke, Karin E. Bornfeldt, Ira J. Goldberg, Edward A. Fisher
Summary: The study found that hypertriglyceridemia and reduced HDL-C did not affect atherosclerosis lesion size or macrophage content, suggesting that atherosclerosis regression in mice is primarily driven by LDL-C reduction and not impacted by hypertriglyceridemia and plasma HDL-C levels.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Review
Peripheral Vascular Disease
Yaling Zhang, Shiyu Luo, Yi Gao, Wenjuan Tong, Shaowei Sun
Summary: A low level of HDL-C is considered an independent biomarker of cardiovascular disease, and raising HDL-C has been recognized as a promising strategy to treat atherosclerotic cardiovascular diseases. However, increasing HDL-C levels does not necessarily reduce the risk of ASCVD, possibly due to the dysfunctional HDL particles in atherosclerotic patients that might even promote ASCVD. Therefore, it is necessary to comprehensively analyze the structure and function of HDL subfractions.
Article
Hematology
Yanni Xu, Chang Liu, Xiaowan Han, Xiaojian Jia, Yongzhen Li, Chao Liu, Ni Li, Lunming Liu, Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang, Yu Du, Yang Xu, Jian-Dong Jiang, Bin Hong, Shuyi Si
Summary: The study introduces a new small molecule, E17241, that may be used to treat atherosclerosis by promoting reverse cholesterol transport via upregulating ABCA1. E17241 shows promising potential as a drug candidate for atherosclerosis treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Plant Sciences
Xingming Hou, Clemens Malainer, Atanas G. Atanasov, Elke H. Heiss, Verena M. Dirsch, Limei Wang, KeWei Wang
Summary: The natural alkaloid evodiamine was found to lower blood lipids and reduce hepatic lipid accumulation in HFD-fed mice, likely through promoting the PPARγ-ABCG1 signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Agriculture, Multidisciplinary
Jiaheng Xia, Ping Yu, Zheling Zeng, Maomao Ma, Guohua Zhang, Dongman Wan, Deming Gong, Shuguang Deng, Jun Wang
Summary: The study revealed that high-dose lauric triglycerides affected cholesterol metabolism in obese rats by downregulating cholesterol biosynthesis and improving lipid transfer, but also accelerated LDL receptor degradation, impaired VLDL/LDL transport, ultimately leading to elevated levels of TC and LDL-c.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Michinori Matsuo
Summary: Prevention of atherosclerosis is of great importance due to its association with cardiovascular diseases globally. Recent studies have highlighted the significance of ABCA1 and ABCG1 proteins in preventing the progression of atherosclerosis by enhancing cholesterol efflux activity and suppressing inflammation in cells. These proteins have the potential to serve as therapeutic targets for preventing atherosclerosis and other related diseases.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Hematology
Jing Liu, Baiba K. Gillard, Dedipya Yelamanchili, Antonio M. Gotto, Corina Rosales, Henry J. Pownall
Summary: Mice lacking the HDL receptor Scarb1 exhibit increased bioavailability of FC in HDL, leading to elevated FC content in multiple tissue sites associated with female infertility, impaired cell maturation, cardiac dysfunction, and atherosclerosis. Sex-dependent differences in tissue-lipid composition and plasma FC clearance rates were also observed. Higher HDL-FC bioavailability may serve as a potential biomarker mechanistically linked to various pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Wenmin Yuan, Kelsey Ernst, Rui Kuai, Emily E. Morin, Minzhi Yu, Denis O. Sviridov, Jie Tang, Ling Mei, Dan Li, Rose Ackermann, Alan T. Remaley, Anna Schwendeman
Summary: Synthetic high-density lipoproteins nanomedicine (sHDL) composed of ApoA-I mimetic peptides and lipids have shown promising results for the treatment of cardiovascular diseases. However, the understanding of how ApoA-I mimetic peptides affect the properties of sHDL and their relationship with potency is limited. This study evaluated different ApoA-I mimetic peptides in terms of their physical/chemical properties, cholesterol efflux, cholesterol esterification, remodeling, and pharmacokinetics/pharmacodynamics, highlighting the importance of considering overall performance for designing and optimizing ApoA-I mimetic peptides.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Michal Vrablik, Bohumil Seifert, Alexander Parkhomenko, Maciej Banach, Jacek J. Jozwiak, Robert Gabor Kiss, Dan Gaita, Katarina Raslova, Marie Zachlederova, Sarah Bray, Kausik K. Ray
Summary: Central and Eastern Europe has high cardiovascular disease mortality but low achievement of LDL-C goals among patients receiving lipid-lowering therapy. The 2019 guidelines are harder to achieve than the 2016 guidelines, highlighting a significant gap between practice and guidelines in lipid management in the region.
Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Review
Biochemistry & Molecular Biology
Carla Borras, Aina Mercer, Sonia Sirisi, Daniel Alcolea, Joan Carles Escola-Gil, Francisco Blanco-Vaca, Mireia Tondo
Summary: This work aims to review the mechanisms of high-density lipoprotein (HDL)-mediated cholesterol trafficking in the central nervous system (CNS) in the context of Alzheimer's disease (AD). It explores the relationship between HDL-mediated cholesterol transport and Aβ peptide accumulation and apolipoprotein E (ApoE)-mediated cholesterol transport. The existing data suggest decreased cholesterol efflux and impaired cholesterol entry into neurons among patients with AD. However, most studies in this field have been performed in cells that are not physiologically relevant for CNS pathology, which is a major flaw. Further investigations are needed to clarify the role of cholesterol trafficking in AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Farras, Jonathan Richard Swann, Ian Rowland, Laura Rubio, Isaac Subirana, Ursula Catalan, Maria Jose Motilva, Rosa Sola, Maria Isabel Covas, Francisco Blanco-Vaca, Montserrat Fito, Jordi Mayneris-Perxachs
Summary: The consumption of phenol-rich oils, such as virgin olive oil, has been shown to have beneficial effects on cardiovascular health. This study aimed to explore the broader biochemical impact of phenol-enriched olive oils. The results showed that both interventions with phenol-enriched olive oils led to a favorable shift in the circulating metabolic phenotype, reducing metabolites associated with cardiometabolic diseases.
Review
Biochemistry & Molecular Biology
Marina Canyelles, Carla Borras, Noemi Rotllan, Mireia Tondo, Joan Carles Escola-Gil, Francisco Blanco-Vaca
Summary: Trimethylamine-N-oxide (TMAO), the main metabolite produced by gut microbiota, is mainly eliminated through renal excretion. Elevated levels of TMAO have been associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) and related complications. However, the causal relationship between TMAO and CVD remains inconclusive, with conflicting findings in prospective studies and potential mediating role of renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juan Pablo Munoz, Paula Sanchez-Fernandez-de-Landa, Elena Maria Goretti Diarte-Anazco, Antonio Zorzano, Francisco Blanco-Vaca, Josep Julve
Summary: FTY720 is an FDA-approved drug used in the treatment of multiple sclerosis, and it has been found to have additional benefits in glucose metabolism, metabolic diseases, and cardiac ischemia. The active form of FTY720, FTY720-P, activates mitochondrial respiration and ATP production in human cardiomyocyte cells. It also affects mitochondrial nucleoids, morphology, and activates the transcription factor STAT3, which promotes mitochondrial function. These effects are suppressed in the presence of a STAT3 inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lasse Sprankel, David Vizarraga, Jesus Martin, Sina Manger, Jakob Meier-Credo, Marina Marcos, Josep Julve, Noemi Rotllan, Margot P. Scheffer, Joan Carles Escola-Gil, Julian D. Langer, Jaume Pinol, Ignacio Fita, Achilleas S. Frangakis
Summary: This study reveals the structural and functional analysis of the previously uncharacterized protein P116. P116 plays a crucial role in extracting essential lipids from the host environment, offering a potential target for controlling Mycoplasma infection.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Joana Rossell, Marina Idalia Rojo-Lopez, Josep Julve, Didac Mauricio
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmeralda Castelblanco, Josep Julve, Nuria Villalmanzo, Erica Tellez, Anna Ramirez-Morros, Nuria Alonso, Didac Mauricio, Maria-Rosa Sarrias
Summary: The study aimed to investigate the contribution of oxLDL to the inflammatory response of macrophages under diabetic conditions. The results showed that oxLDL promoted intracellular lipid accumulation in macrophages under high glucose (HG) conditions and enhanced the production of pro-inflammatory cytokines. Moreover, HG and oxLDL upregulated the expression of the cell surface receptor TLR4 and increased the release of sCD14, which further exacerbated the inflammation.
Article
Biochemistry & Molecular Biology
Ricardo Rodriguez-Calvo, Minerva Granado-Casas, Alejandra Perez-Montes de Oca, Maria Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, German Cediel, Josep Julve, Joana Rossell, Lluis Masana, Didac Mauricio, Josep Lupon, Antoni Bayes-Genis, Nuria Alonso
Summary: This study aimed to explore the prognostic value of cardiac-specific fatty acid binding proteins (FABP3) and adipose-tissue-specific fatty acid binding proteins (FABP4) in chronic heart failure (CHF) patients, with and without type 2 diabetes mellitus (T2D). It was found that the concentrations of FABP3 and FABP4 were associated with all-cause and cardiovascular mortality, particularly in patients with T2D. The study suggests that serum FABP3 and FABP4 concentrations can serve as independent predictors for the occurrence of all-cause and cardiovascular mortality in ambulatory CHF subjects with T2D.
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Review
Nutrition & Dietetics
Julia Nino-Narvion, Marina Idalia Rojo-Lopez, Patricia Martinez-Santos, Joana Rossell, Antonio J. Ruiz-Alcaraz, Nuria Alonso, Bruno Ramos-Molina, Didac Mauricio, Josep Julve
Summary: NAD+ is crucial for cellular metabolism and plays a critical role in maintaining the integrity of the gut barrier. Its deficiency is associated with gut inflammation, leakage, and dysbiosis. NAD+-increasing therapies may protect against intestinal inflammation, potentially by modulating the composition of the intestinal microbiota. However, the mechanisms underlying these effects are not well understood.
Article
Nutrition & Dietetics
Jeimy Katherine Torres-Mendez, Julia Nino-Narvion, Patricia Martinez-Santos, Elena Maria Goretti Diarte-Anazco, Karen Alejandra Mendez-Lara, Tania Vazquez del Olmo, Noemi Rotllan, Maria Teresa Julian, Nuria Alonso, Didac Mauricio, Mercedes Camacho, Juan Pablo Munoz, Joana Rossell, Josep Julve
Summary: This study investigated the effects of nicotinamide (NAM) supplementation on brain inflammation and microglial activation in a mouse model of type 1 diabetes. The results showed that NAM supplementation prevented brain inflammation in diabetic mice through NAD+-dependent deacetylation mechanisms.
Article
Biochemistry & Molecular Biology
Giovanna Revilla, Nuseibah Al Qtaish, Pablo Caruana, Myriam Sainz-Ramos, Tania Lopez-Mendez, Francisco Rodriguez, Veronica Paez-Espinosa, Changda Li, Nuria Fucui Vallverdu, Maria Edwards, Antonio Moral, Jose Ignacio Perez, Juan Carlos Escola-Gil, Jose Luis Pedraz, Idoia Gallego, Rosa Corcoy, Maria Virtudes Cespedes, Gustavo Puras, Eugenia Mato
Summary: This study produced and assessed lenvatinib-loaded PLGA nanoparticles (NPs) as a novel therapeutic approach for aggressive thyroid tumors. The decorated NPs showed better cytotoxicity and therapeutic efficacy in vitro and in vivo compared to NPs without decoration, suggesting a promising strategy for targeted and effective administration of TKIs.
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)