Article
Radiology, Nuclear Medicine & Medical Imaging
Tzu-Pei Su, Gigin Lin, Yu-Ting Huang, Feng-Yuan Liu, Chun-Chieh Wang, Angel Chao, Hung-Hsueh Chou, Tzu-Chen Yen, Chyong-Huey Lai
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gigin Lin, Yu-Chun Lin, Ren-Chin Wu, Lan-Yan Yang, Hsin-Ying Lu, Shang-Yueh Tsai, Yu-Ting Huang, Yen-Ling Huang, Kuan-Ying Lu, Koon-Kwan Ng, Tzu-Chen Yen, Angel Chao, Chyong-Huey Lai, Ji-Hong Hong
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Genetics & Heredity
Chiao-Yun Lin, Chia-Lung Tsai, Angel Chao, Li-Yu Lee, Wei-Chun Chen, Yun-Hsin Tang, An-Shine Chao, Chyong-Huey Lai
Summary: Despite recent therapeutic breakthroughs, advanced and/or recurrent endometrial cancer remains a significant health burden globally. Our study suggests that NPM/B23-induced CD24 expression in endometrial cancer cells plays a role in immune evasion by inhibiting macrophage-mediated phagocytosis. CD24 may serve as a novel target for endometrial cancer immunotherapy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Lan-Yan Yang, Tiing Yee Siow, Yu-Chun Lin, Ren-Chin Wu, Hsin-Ying Lu, Hsin-Ju Chiang, Chih-Yi Ho, Yu-Ting Huang, Yen-Ling Huang, Yu-Bin Pan, Angel Chao, Chyong-Huey Lai, Gigin Lin
Summary: Computer-aided segmentation and machine learning using clinical and MR radiomics can predict LN metastasis in EC, with diagnostic performance surpassing conventional ADC and size criteria.
Article
Biochemistry & Molecular Biology
Chiao-Yun Lin, Chun-Chieh Wang, Ren-Chin Wu, Lan-Yan Yang, Chen-Bin Chang, Yu-Bin Pan, Angel Chao, Chyong-Huey Lai
Summary: The study identified that miR143-3p targeting BIRC2 may affect tumor recurrence and treatment response in alpha 7-HPV-related cervical SCC. High BIRC2 expression was associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Feng-Yuan Liu, Gigin Lin, Jing-Ren Tseng, Angel Chao, Huei-Jean Huang, Hung-Hsueh Chou, Yu-Chen Chang, Tzu-Chen Yen, Chyong-Huey Lai
Summary: Heterogeneity assessment using first-order and texture analysis metrics in F-18-fluorodeoxyglucose PET imaging was evaluated for classification of metastatic and benign bone lesions in cervical cancer patients. SUVsd was found to be superior to SUVmax in classification, but careful validation is required for multiple features and parameters in texture analysis.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2021)
Review
Genetics & Heredity
Yun-Hsin Tang, Chiao-Yun Lin, Chyong-Huey Lai
Summary: The Cancer Genome Atlas research network has provided molecular classifications for gynecologic cancers with the use of NGS technology, impacting clinical practice. New cancer treatments targeting pathogenic gene abnormalities, particularly PARP inhibitors, have shown breakthrough benefits in reducing hazard ratios for BRCA1/2 mutated ovarian cancer. Immune checkpoint inhibition also shows promise in cancers with mismatch repair deficiency or microsatellite instability.
Article
Oncology
Chiao-Yun Lin, Ren-Chin Wu, Chen-Yang Huang, Chyong-Huey Lai, An-Shine Chao, Hsin-Pai Li, Chia-Lung Tsai, Elizabeth Joo-Wen Kuek, Cheng-Lung Hsu, Angel Chao
Summary: Reliable animal models are crucial for studying novel treatment approaches in human malignancies. A patient-derived xenograft model termed PDX-mLung was developed for dedifferentiated endometrial carcinoma, showing high similarity and druggable genetic alterations. Combination treatment with FGFR inhibitor and cell cycle inhibitor exhibited synergistic therapeutic effects in vivo, highlighting the potential of molecularly informed therapies in difficult-to-treat cancers.
Article
Medicine, General & Internal
Yenpo Lin, Ching-Yi Hsieh, Yen-Ling Huang, Kueian Chen, Yu-Ting Huang, Ren-Chin Wu, Huei-Jean Huang, Hung-Hsueh Chou, Angel Chao, Chyong-Huey Lai, Gigin Lin
Summary: The study aimed to assess the additional value of DWI and MRS for risk stratification of sonographically indeterminate ovarian neoplasms. The results showed that MRS could play an important role in the differential diagnosis of ovarian tumors, especially for O-RADS 4 lesions or clear cell carcinomas.
Article
Medicine, General & Internal
Pei-Ching Huang, Ren-Chin Wu, Yu-Hsiang Juan, Hui-Yu Ho, Yung-Chang Lin, Yi-Ting Huang, Shu-Hang Ng, Chyong-Huey Lai, Angel Chao, Gigin Lin
Summary: This study retrospectively investigated the imaging characteristics and diagnostic accuracy of whole-body computed tomography (WBCT) for incidental ovarian tumors in breast cancer patients. The results showed that WBCT can accurately diagnose these ovarian tumors and guide disease management.
Article
Health Care Sciences & Services
Hao-Chien Hung, Po-Jung Hsu, Ting-Chang Chang, Hung-Hsueh Chou, Kuan-Gen Huang, Chyong-Huey Lai, Chao-Wei Lee, Ming-Chin Yu, Jeng-Fu You, Yu-Jen Hsu, Jun-Te Hsu, Ting-Jung Wu
Summary: This study analyzed 132 patients undergoing CRS-HIPEC and found that patients in the MDT group had higher PCI scores and more complete CRS than those in the non-MDT group, with similar post-operative complication rates. Independent prognostic factors for survival included older age, ECOG score, and completeness of cytoreduction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Tung, Ren-Chin Wu, Chiao-Yun Lin, Chyong-Huey Lai
Summary: Endometrial cancer is one of the most common gynecologic cancers worldwide, with increasing incidence rates. The latest molecular classifications have identified different subtypes, but undifferentiated/dedifferentiated EC has not been mentioned. This rare and aggressive type of cancer is resistant to conventional chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Chyong-Huey Lai, Elizabeth Vallikad, Hao Lin, Lan-Yan Yang, Shih-Ming Jung, Hsueh-Erh Liu, Yu-Che Ou, Hung-Hsueh Chou, Cheng-Tao Lin, Huei-Jean Huang, Kuan-Gen Huang, Jiantai Qiu, Yao-Ching Hung, Tzu- Wu, Wei-Yang Chang, Kien-Thiam Tan, Chiao-Yun Lin, Angel Chao, Chee-Jen Chang
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2020)