Article
Oncology
Linghui Lu, Tianqi Liu, Shunni Wang, Jing Li, Feiran Zhang, Yan Ning, Yiqin Wang
Summary: This study aimed to investigate the frequency and clinicopathological characteristics of HPV-independent cervical squamous cell carcinoma (CSCC). Joint detection of multiple technologies and evaluation of clinicopathological characteristics can discriminate between HPV-independent and low-copy HPV-associated CSCC cases that present similar prognoses. Additional attention should be paid to these low-copy HPV-associated cases in clinical practice.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Dermatology
Amy R. Vandiver, Brandon J. Thomas, Mohammad Karimzada, Byron C. Knowles, Giovanni A. Botten, Roberto Spreafico, Jeremy N. Rotman, Nima M. Gharavi, Cameron Chesnut, Kevin Wesel, Serghei Mangul, Teresa Soriano, Philip O. Scumpia
Summary: RNA sequencing showed no HPV transcriptional activity in high-risk cuSCC samples, despite 64% of samples testing positive for HPV DNA, indicating that HPV transcription does not play a significant role in differentiating high-risk cuSCCs from low-risk cuSCCs or normal skin.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Oncology
Yoshikuni Inokawa, Masamichi Hayashi, Shahnaz Begum, Maartje G. Noordhuis, Daivd Sidransky, Joseph Califano, Wayne Koch, Mariana Brait, William H. Westra, Mohammad O. Hoque
Summary: AGTR1 and FHIT methylation can serve as suitable detection markers for OPSCCs derived from the HPV-infected field, showing associations with p16-positive and RB-negative phenotypes. These markers have high sensitivity and are linked to better overall survival outcomes.
Article
Oncology
Jingya Zhang, Dong Dong, Qian Wei, Li Ren
Summary: The study found that CXCL10 can serve as a serum biomarker for predicting cervical squamous cell carcinoma. CXCL10 showed good diagnostic ability in early detection, differentiating cervical intraepithelial neoplasia and SCC-Ag-negative cervical cancer, and the combination of CXCL10 and SCC-Ag improved the predictive performance.
Article
Oncology
Yuxin Bi, Junbo Hu, Ling Zeng, Gang Chen, Hongning Cai, Huang Cao, Quanfu Ma, Xufeng Wu
Summary: This study aimed to investigate the characteristics of HPV integration in cervical adenocarcinoma and cervical squamous carcinoma. The results revealed that STARD3 and ERBB2 were the hotspot genes of HPV integration in adenocarcinoma, while RNA45S rDNA and MIR3648-1 were the hotspot genes in squamous carcinoma. Additionally, the study found that the expression of the most frequently integrated genes increased after integration, suggesting the significance of integration in the development of cervical cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Tom Bradish, H. Fisher, V. Paleri, M. Robinson, D. Meikle, C. Kelly, J. O'Hara
Summary: TNM8 downstages disease and prognosticates well for stage I disease but does not differentiate between stage II and III disease when compared to TNM7. Further adaptation is required to address this to make TNM8 a more accurate prognostic tool. The survival rates at different stages showed significant differences between TNM7 and TNM8.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Davide Ciardiello, Sara Del Tufo, Paola Parente, Antonietta Gerarda Gravina, Francesco Selvaggi, Iacopo Panarese, Renato Franco, Michele Caterino, Giulia Martini, Fortunato Ciardiello, Roberto Grassi, Salvatore Cappabianca, Alfonso Reginelli, Erika Martinelli
Summary: Synchronous tumors of the rectum and anus are rare, with most cases being rectal adenocarcinomas with concomitant anal squamous cell carcinoma. This is the first reported case of synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy. Clinical-radiological evaluation showed complete tumor regression, and no evidence of recurrence was observed after 2 years of follow-up.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hong Wang, Rongxin Xiao, Biao Yang
Summary: The study revealed that in cervical squamous cell carcinoma, microRNA-101-3p is lowly expressed while KPNA2 is highly expressed, with a direct targeting relationship between the two. The microRNA-101-3p/KPNA2 axis can suppress the growth of cervical squamous cell carcinoma by targeting KPNA2.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Editorial Material
Medicine, General & Internal
Jiwon Lee, Seoyeon Shin, Jin-Hwi Kim, Su Lim Lee, Yosep Chong, Kyung Jin Seo, Kwangil Yim
Summary: In this case study, a 49-year-old female patient with menorrhagia was initially suspected to have cervical squamous cell carcinoma based on magnetic resonance imaging (MRI) findings. However, histological examination confirmed the lesion to be angioleiomyoma after hysterectomy. This is the first reported case of angioleiomyoma presenting with MRI findings suggestive of uterine SCC. Recognizing the imaging mimics of angioleiomyomas can be beneficial for accurate diagnosis and appropriate treatment strategies.
Article
Biochemistry & Molecular Biology
Can-hui Cao, Rang Liu, Xin-ran Lin, Jia-qi Luo, Li-juan Cao, Qiu-ju Zhang, Shou-ren Lin, Lan Geng, Zhong-yi Sun, Si-kang Ye, Zhi-ying Yu, Yu Shi, Xi Xia
Summary: The study showed that LRP1B mutation was associated with HPV status and poor disease outcomes in CC and HNSCC, and it was more favorable for prediction than TP53 or RB1. Additionally, LRP1B mutation led to higher mutation count and 289 co-occurrence genes in CC and HNSCC, with implications for overall survival.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shutao Zheng, Tao Liu, Lu Li, Qing Liu, Conggai Huang, Yan Liang, Yiyi Tan, Li Zhang, Xiaomei Lu
Summary: SLC1A5 expression is upregulated in various cancers, including ESCC, but its immunological involvement in the tumor microenvironment of ESCC has been poorly described. In this study, in silico analyses and experimental confirmation were performed to investigate the prognostic and clinicopathological significance of SLC1A5 expression in ESCC. The results showed that SLC1A5 expression was unrelated to prognosis but correlated with CD8+ T-cell exclusion.
Article
Oncology
S. E. Emmett, M. S. Stark, N. Pandeya, B. Panizza, D. C. Whiteman, A. Antonsson
Summary: This study found that certain miRNAs could serve as prognostic tools in patients with mucosal squamous cell carcinomas of the head and neck (HNSCC), particularly those associated with HPV status. These miRNAs have the potential to predict the clinical course of patients with HNSCC.
Review
Oncology
Yong Lu, Gary M. Clifford, Christopher K. Fairley, Andrew E. Grulich, Suzanne M. Garland, Fei Xiao, Yuan Wang, Huachun Zou
Summary: This study provides updated information on the prevalence of HPV and p16(INK4a) in oropharyngeal SCC, and highlights the importance of HPV vaccination in preventing a significant proportion of these cases.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Konrad A. Szychowski, Bartosz Skora, Monika Bar, Tomasz Piechowiak
Summary: The aim of this study was to evaluate the impact of TCS on metabolic parameters, oxidative stress, gene expression, and DNA methylation and hydroxymethylation in the SCC-15 cell line. The experiments showed that TCS was toxic to SCC-15 cells only at the highest concentrations of 50 and 100 μM. TCS increased ROS production and caspase-3 activity in a wide range of concentrations. Additionally, TCS affected SOD2 mRNA expression and SOD activity in the SCC-15 cell line at a nontoxic concentration of 10 μM, and decreased the mRNA expression of DNMT3A and DNMT3B after 6-hour treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Luisa Matos do Canto, Jenilson Mota da Silva, Patricia Valeria Castelo-Branco, Ingrid Monteiro da Silva, Leudivan Nogueira, Carlos Eduardo Fonseca-Alves, Andre Khayat, Alexander Birbrair, Silma Regina Pereira
Summary: DNA sequencing plays a crucial role in understanding cancer mutational patterns. A study on HPV-associated PSCC from Latin Americans using whole-exome sequencing revealed novel pathogenic variants and potential therapeutic targets.
Article
Infectious Diseases
Puo-Hsien Le, Cheng-Tang Chiu, Pai-Jui Yeh, Yu-Bin Pan, Cheng-Hsun Chiu
Summary: This study retrospectively evaluated the role of Clostridium innocuum (CI) infection in patients with inflammatory bowel disease (IBD). The results showed that CI infection may lead to poorer clinical remission in ulcerative colitis, which should be considered in the treatment approach.
JOURNAL OF INFECTION
(2022)
Article
Virology
Pai-Jui Yeh, Ren-Chin Wu, Cheng-Tang Chiu, Ming-Wei Lai, Chien-Ming Chen, Yu-Bin Pan, Ming-Yao Su, Chia-Jung Kuo, Wey-Ran Lin, Puo-Hsien Le
Summary: This study comprehensively analyzed the clinical manifestations and management of CMV infection in the gastrointestinal tract. The findings showed that both immunocompromised and immunocompetent hosts can be affected, and combination therapy resulted in better outcomes.
Article
Pharmacology & Pharmacy
Pang-Yun Chou, Demei Lee, Chi-Chang Weng, Ren-Chin Wu, Chien-Tun Liao, Shih-Jung Liu
Summary: The study incorporated BMP, an antimicrobial agent, and an analgesic into nanofibrous scaffolds for alveolar cleft therapy. The scaffolds demonstrated extended release of treatment drugs and favorable bone healing in animal tests. Biomolecule- and drug-incorporated nanofibrous scaffolds proved effective in alveolar cleft treatment.
Article
Medicine, General & Internal
Pei-Ching Huang, Ren-Chin Wu, Yu-Hsiang Juan, Hui-Yu Ho, Yung-Chang Lin, Yi-Ting Huang, Shu-Hang Ng, Chyong-Huey Lai, Angel Chao, Gigin Lin
Summary: This study retrospectively investigated the imaging characteristics and diagnostic accuracy of whole-body computed tomography (WBCT) for incidental ovarian tumors in breast cancer patients. The results showed that WBCT can accurately diagnose these ovarian tumors and guide disease management.
Article
Biochemistry & Molecular Biology
Chung-Ying Tsai, Hsiang-Cheng Chi, Ren-Chin Wu, Cheng-Hao Weng, Tzong-Shyuan Tai, Chan-Yu Lin, Tai-Di Chen, Ya-Hui Wang, Li-Fang Chou, Shen-Hsing Hsu, Po-Hung Lin, See-Tong Pang, Hung-Yu Yang
Summary: Compared to Western countries, Taiwan has a significantly higher incidence of urothelial carcinoma (UC). Regulatory T cells (Tregs) have an important role in controlling immune responses within the tumor microenvironment. By analyzing data from 308 UC patients, we found that the expression of CD276 or TIM-3 was positively correlated with late-stage UC and poor prognosis. Patients with high expression of both CD276 and TIM-3 had significantly lower survival rates, indicating that the mRNA levels of these immune checkpoints could serve as independent prognostic biomarkers for UC. We also observed that early-stage UC showed low infiltration of CD8+ cytotoxic T cells and Tregs, while late-stage tumors exhibited high infiltration of cytotoxic T cells with high PD-1 and FOXP3 expression, suggesting the inhibition of cytotoxic T cells in the advanced UC microenvironment. Overall, our findings suggest the potential use of combined immune checkpoint biomarkers for prognosis prediction and the need for early-stage UC treatment to convert "cold" tumors into "hot" tumors for immune checkpoint therapy.
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Tung, Ren-Chin Wu, Chiao-Yun Lin, Chyong-Huey Lai
Summary: Endometrial cancer is one of the most common gynecologic cancers worldwide, with increasing incidence rates. The latest molecular classifications have identified different subtypes, but undifferentiated/dedifferentiated EC has not been mentioned. This rare and aggressive type of cancer is resistant to conventional chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Chin-Chieh Hsu, Chih-Yang Lai, Ho-Yen Chueh, Po-Jen Cheng, Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Chyong-Huey Lai, Liang-Ming Lo, Yu-Bin Pan, Lan-Yan Yang, Yi-Hsun Yu
Summary: This retrospective cohort study aimed to report obstetric outcomes in pregnant women with previous pelvic ring injury (PRI) and investigate the correlation between residual pelvic deformity and the mode of delivery. The results showed that vaginal delivery (VD) is possible after PRI, retained trans-iliosacral implants do not affect the delivery outcome, and residual pelvic asymmetry measured by Lefaivre criteria is a potential risk factor for caesarean section (CS) after previous PRI.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Angel Chao, Huei-Jean Huang, Chiao-Yun Lin, Chia-Hwa Lee, Chien-Hsing Lin, An-Shine Chao, Chyong-Huey Lai, Ting-Chang Chang, Kai-Yun Wu, Ren-Chin Wu
Summary: This study provides the first comprehensive analysis of the genetic landscape of SCT-NOS and reveals dysregulation in the hypoxia signaling pathway as a key molecular feature of this rare tumor. Long-term follow-up with periodic measurements of androgen levels should be pursued in all cases to detect potential recurrences.
ENDOCRINE-RELATED CANCER
(2023)
Article
Polymer Science
Shuen-Yeo Chen, Fu-Ying Lee, Ren-Chin Wu, Chien-En Chao, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, hybrid resorbable 3D-printed mesh/electrospun nanofibrous biomolecule-eluting mats were developed for alveolar ridge preservation. The fabrication process involved 3D printing and coaxial electrospinning technologies. The study demonstrated the successful fabrication of resorbable drug-eluting nanofibrous mats for alveolar ridge preservation using 3D printing and coaxial electrospinning technologies.
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Puo-Hsien Le, Ren-Chin Wu, Chien-Ming Chen, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu
Summary: Vedolizumab has a good safety profile for the treatment of inflammatory bowel disease, but it also carries the risk of agranulocytosis, a rare but fatal condition.
ADVANCES IN DIGESTIVE MEDICINE
(2022)
Article
Oncology
Hsiu-Jung Tung, Chi-Yuan Chiang, Wei-Yang Chang, Ren-Chin Wu, Huei-Jean Huang, Lan-Yan Yang, Chiao-Yun Lin, Chun-Chieh Wang, Angel Chao, Chyong-Huey Lai
Summary: This study investigated the management and prognosis of UCS patients. The results showed that salvage therapy using radiotherapy, chemotherapy, or chemoradiotherapy significantly improved survival rates after recurrence (SAR), while disseminated recurrence was associated with worse SAR prognosis.
