Article
Pharmacology & Pharmacy
Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang Hu
Summary: Continual deletion of microglia using pexidartinib reduces the production of collagen I and reforms the astrocyte scar, allowing for axon regeneration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Zhan-Shan Gao, Chuan-Jie Zhang, Nan Xia, He Tian, Dao-Yong Li, Jia-Quan Lin, Xi-Fan Mei, Chao Wu
Summary: This study successfully designed berberine carried by M2-type macrophage-derived exosomes, which efficiently delivered the drug to the injured spinal cord, showing good anti-inflammatory and anti-apoptotic effects. The treatment significantly improved motor function in SCI mice, indicating that Exos-Ber is a potential therapeutic agent for SCI.
ACTA BIOMATERIALIA
(2021)
Review
Cell Biology
Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Summary: Spinal cord injury is a devastating disease causing loss of sensory and motor functions, with a pathological process involving mechanical primary injury and secondary injury. Macrophages play a crucial role in the pathology of SCI, and can be divided into different types. Hematogenous macrophages may have various roles in SCI but their specific function remains controversial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Jian Wu, Bing Lu, Riyun Yang, Ying Chen, Xue Chen, Yi Li
Summary: Targeting EphB2 can effectively inhibit the formation of astroglial-fibrotic scars at the beginning of SCI, promoting nerve regeneration.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Dunja Bijelic, Marija Adzic, Mina Peric, Igor Jakovcevski, Eckart Foerster, Melitta Schachner, Pavle R. Andjus
Summary: The study found that different fragments of TnC can affect astrocyte proliferation and GFAP expression levels after spinal cord injury. These results may explain the delayed reaction of astrocytes and their localization to the injury site border to allow microglia/macrophages to form a lesion core during the initial stages of glial scar formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shingo Yoshizaki, Tetsuya Tamaru, Masamitsu Hara, Ken Kijima, Masatake Tanaka, Dai-jiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Summary: The study demonstrated that beta 1Ab treatment could suppress the expression of TNF alpha in microglia and glial scars within the glial scar after SCI, and this alteration was associated with the role of fibronectin.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Shao-Ming Wang, Jung-Yu C. Hsu, Chiung-Yuan Ko, Hsiang-En Wu, Yu-Wei Hsiao, Ju-Ming Wang
Summary: Fibrotic scars caused by spinal cord injury hinder neuronal regeneration, resulting in paralysis. The role of astrocytes in fibrotic scar formation is not well understood. This study showed that astrocytic Cebpd promotes fibroblast migration and fibrotic scar formation through the Ptx3/NF kappa B/Mmp3 axis pathway. The RI37 peptide was identified as a potential therapeutic agent to inhibit fibrotic scar formation.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Sheng-Ping Fu, Xiang-Chong Wu, Rui-Lin Yang, De-Zhi Zhao, Jie Cheng, Hu Qian, Jun Ao, Qian Zhang, Tao Zhang
Summary: Spinal Cord Injury (SCI) is a devastating neurological disorder with no effective treatment. Secondary inflammatory responses contribute to the difficulties in neurological recovery. Mesenchymal Stem Cells (MSCs) have shown therapeutic potential by regulating macrophage balance and facilitating tissue repair and regeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Neurosciences
Ziyu Li, Shuisheng Yu, Xuyang Hu, Yiteng Li, Xingyu You, Dasheng Tian, Li Cheng, Meige Zheng, Juehua Jing
Summary: This study reviews recent advances in fibrotic scar formation after SCI, exploring its interactions with other main cellular components and its potential role as a treatment target for SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Tobias Zrzavy, Carmen Schwaiger, Isabella Wimmer, Thomas Berger, Jan Bauer, Oleg Butovsky, Jan M. Schwab, Hans Lassmann, Romana Hoeftberger
Summary: This study provides a detailed characterization of inflammatory responses and oxidative tissue injury in human traumatic spinal cord injury lesions. It reveals that ongoing inflammatory responses and neurotoxicity could lead to sustained neuronal damage long after the initial trauma, potentially impacting the response to rehabilitation and recovery in patients.
Review
Cell & Tissue Engineering
Yuanliang Xia, Ruohan Yang, Hengyi Wang, Yulin Hou, Yuehong Li, Jianshu Zhu, Feng Xu, Changfeng Fu
Summary: Spinal cord injury (SCI) causes significant harm to patients' physical, mental, and financial health. Inflammation is an important factor affecting SCI recovery, and the modulation of macrophage phenotypes appears to be a meaningful therapeutic target. Biomaterials, with their targeting and bio-compatibility properties, hold potential in modulating macrophage phenotypes for SCI recovery.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Zipeng Zhou, Dan Li, Xiangyi Fan, Yajiang Yuan, Hongyu Wang, Dahao Wang, Xifan Mei
Summary: Excessive activation of M1 phenotype macrophages/microglia leads to poor prognosis of spinal cord injury (SCI), while selective activation of M2 phenotype macrophages/microglia promotes SCI recovery. Berberine-loaded gold nanoclusters (BRB-AuNCs) were used to inhibit M1 phenotype activation and reduce inflammation, resulting in reduced neuronal apoptosis after SCI. In vitro and in vivo experiments demonstrated the anti-inflammatory and anti-apoptotic effects of BRB-AuNCs by inducing macrophages/microglia polarization from M1 to M2 phenotype. Treatment with BRB-AuNCs significantly improved motor function in SCI rats.
REGENERATIVE BIOMATERIALS
(2022)
Article
Neurosciences
Kathryn M. Madalena, Faith H. Brennan, Phillip G. Popovich
Summary: Glucocorticoid receptors in myeloid cells play a role in regulating inflammation and functional recovery after spinal cord injury. Contrary to expectations, deleting these receptors in mice actually reduced the macrophage response at the site of injury and improved hindlimb motor recovery, myelin and axon protection/regeneration, and microvascular plasticity.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Ziyu Li, Meige Zheng, Shuisheng Yu, Fei Yao, Yang Luo, Yanchang Liu, Dasheng Tian, Li Cheng, Juehua Jing
Summary: The study reveals that macrophages M2 polarization can secrete PDGFB to act on PDGFR beta, promoting the migration of PDGFR beta(+) pericytes, providing a promising new target for the treatment of SCI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Bianca Kuehl, Martin Beyerbach, Wolfgang Baumgaertner, Ingo Gerhauser
Summary: In this study, the phenotype of microglia/macrophages during acute and subacute spinal cord injury (SCI) in dogs was characterized. The expression of certain markers related to antigen recognition, processing, presentation, cell migration, and phagocytosis was found to increase in the gray matter of the spinal cord during subacute SCI. Interestingly, only CD204-positive cells were upregulated in the white matter. These findings contribute to our understanding of the immunological processes during SCI and could potentially serve as targets for future therapeutic strategies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Neurosciences
Y. Zhu, C. Soderblom, V. Krishnan, J. Ashbaugh, J. R. Bethea, J. K. Lee
NEUROBIOLOGY OF DISEASE
(2015)
Article
Neurosciences
Y. Zhu, K. Lyapichev, D. H. Lee, D. Motti, N. M. Ferraro, Y. Zhang, S. Yahn, C. Soderblom, J. Zha, J. R. Bethea, K. L. Spiller, V. P. Lemmon, J. K. Lee
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Yunjiao Zhu, Oscar G. Vidaurre, Kadidia P. Adula, Nebojsa Kezunovic, Maureen Wentling, George W. Huntley, Patrizia Casaccia
JOURNAL OF NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Egle Cekanaviciute, Bryan B. Yoo, Tessel F. Runia, Justine W. Debelius, Sneha Singh, Charlotte A. Nelson, Rachel Kanner, Yadira Bencosme, Yun Kyung Lee, Stephen L. Hauser, Elizabeth Crabtree-Hartman, Ilana Katz Sand, Mar Gacias, Yungjiao Zhu, Patrizia Casaccia, Bruce A. C. Cree, Rob Knight, Sarkis K. Mazmanian, Sergio E. Baranzini
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Clinical Neurology
Achilles Ntranos, Vasilis Ntranos, Valentina Bonnefil, Jia Liu, Seunghee Kim-Schulze, Ye He, Yunjiao Zhu, Rachel Brandstadter, Corey T. Watson, Andrew J. Sharp, Ilana Katz Sand, Patrizia Casaccia
Article
Clinical Neurology
Ilana Katz Sand, Yunjiao Zhu, Achilles Ntranos, Jose C. Clemente, Egle Cekanaviciute, Rachel Brandstadter, Elizabeth Crabtree-Hartman, Sneha Singh, Yadira Bencosme, Justine Debelius, Rob Knight, Bruce A. C. Cree, Sergio E. Baranzini, Patrizia Casaccia
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2019)