期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 9, 页码 2362-2376出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2751-16.2017
关键词
axon regeneration; fibrotic scar; foamy macrophages; glial scar; myelin laden macrophages; neuroinflammation
资金
- NINDS [R01NS081040, R21NS082835, R01HD057632]
- U.S. Army Grant [W81XWH131007715]
- Miami Project to Cure Paralysis
- Buoniconti Fund
- Walter G. Ross Foundation
Although infiltrating macrophages influence many pathological processes after spinal cord injury (SCI), the intrinsic molecular mechanisms that regulate their function are poorly understood. A major hurdle has been dissecting macrophage-specific functions from those in other cell types as well as understanding how their functions change over time. Therefore, we used the RiboTag method to obtain macrophage-specific mRNA directly from the injured spinal cord in mice and performed RNA sequencing to investigate their transcriptional profile. Our data show that at 7 d after SCI, macrophages are best described as foam cells, with lipid catabolism representing the main biological process, and canonical nuclear receptor pathways as their potential mediators. Genetic deletion of a lipoprotein receptor, CD36, reduces macrophage lipid content and improves lesion size and locomotor recovery. Therefore, we report the first macrophage-specific transcriptional profile after SCI and highlight the lipid catabolic pathway as an important macrophage function that can be therapeutically targeted after SCI.
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