Article
Neurosciences
Dobromila Pekala, Peter Wenner
Summary: Neurons regulate synaptic strength through synaptic scaling, which can be uniform or nonuniform. Our study in chick embryo motoneurons identified slow and rapid forms of scaling, with nonuniform patterns observed. The changes in miniature postsynaptic current (mPSC) amplitudes did not affect the probability of release.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Chengyun Cai, Lifeng Wang, Shixin Li, Shengchun Lou, Jia-lie Luo, Ding-Yi Fu, Tingting Chen
Summary: This study found that lonafarnib can improve the synaptic structure and function in Alzheimer's disease (AD) mice, leading to improved spatial cognition. This improvement may be related to lonafarnib increasing the levels of brain-derived neurotrophic factor (BDNF) through the H-Ras-alpha 7nAChR-dependent CaMKII-CREB pathway.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Juanxian Cheng, Zhe Zhao, Liping Chen, Ying Li, Ruijing Du, Yan Wu, Qian Zhu, Ming Fan, Xiaotao Duan, Haitao Wu
Summary: This study demonstrated that the dynamic modification of MeCP2 by O-GlcNAc at threonine 203 plays a critical role in neural development and synaptic transmission potentially via brain-derived neurotrophic factor. Disruption of this modification impaired dendrite development, spine maturation, and synaptic transmission in both cultured neurons and mouse cerebral cortex.
NEUROSCIENCE BULLETIN
(2022)
Article
Medicine, Research & Experimental
Lan Li, Jie-hong Yang, Chang Li, Hui-fen Zhou, Li Yu, Xiao-long Wu, Yi-hang Lu, Yu He, Hai-tong Wan
Summary: This study aimed to investigate the effect of Danhong injection (DHI) on long-term neurological function recovery after cerebral ischemia and explore the underlying mechanisms. The results showed that DHI treatment significantly reduced the infarct volume, promoted neurological recovery, and reversed brain pathological changes. DHI also promoted neurogenesis by increasing the migration and proliferation of neural stem cells and enhancing synaptic plasticity. Furthermore, the pro-neurogenic effects of DHI were related to increased brain-derived neurotrophic factor (BDNF) expression and the activation of the BDNF/AKT/CREB signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Xing-Lei Song, Di-Shi Liu, Min Qiang, Qian Li, Ming-Gang Liu, Wei-Guang Li, Xin Qi, Nan-Jie Xu, Guang Yang, Michael Xi Zhu, Tian-Le Xu
Summary: ASIC1a, a key subunit in the central nervous system, plays important roles in synaptic functions by dynamically trafficking and localizing on the surface of excitatory synapses in response to extracellular pH fluctuations and synaptic activity, supported by novel techniques and tools.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero, Tony Wyss-Coray
Summary: Recent understanding of how the systemic environment impacts lifelong brain development has led to interventions aimed at slowing brain ageing. This study discovered that infusing young cerebrospinal fluid (CSF) into aged brains improves memory function and promotes the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs). The researchers identified serum response factor (SRF) as a mediator of OPC proliferation in response to young CSF, and fibroblast growth factor 17 (Fgf17) as a key target for restoring oligodendrocyte function in the ageing brain.
Review
Neurosciences
Ronald S. Duman, Satoshi Deyama, Manoela Viar Fogaca
Summary: Depression is associated with neuronal atrophy and reduced synaptic connectivity in brain regions like the hippocampus and prefrontal cortex. Antidepressant treatments can reverse these deficits by up-regulating factors like BDNF, which plays a key role in synaptic plasticity. Rapid-acting antidepressants, such as ketamine, rely on the activity-dependent release of BDNF and other growth factors for their effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Tara L. Henechowicz, Joyce L. Chen, Leonardo G. Cohen, Michael H. Thaut
Summary: The study compared the prevalence of the Val66Met BDNF polymorphism between musicians and the general population, finding no significant difference in distribution between the two groups.
Article
Neurosciences
Wei Wei, Yinghua Liu, Chun-Ling Dai, Narjes Baazaoui, Yunn Chyn Tung, Fei Liu, Khalid Iqbal
Summary: Alzheimer's disease is characterized by cognitive impairment and loss of synaptic plasticity, and early treatment with P021 during development can prevent cognitive dysfunction and ameliorate synaptic protein deficit in AD mouse models.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Hernan H. Dieguez, Juan S. Calanni, Horacio E. Romeo, Agustina Alaimo, Maria F. Gonzalez Fleitas, Agustina Iaquinandi, Monica S. Chianelli, Maria Keller Sarmiento, Pablo H. Sande, Ruth E. Rosenstein, Damian Dorfman
Summary: The study found that exposure to enriched environment (EE) and visual stimulation (VS) helps protect damage to the retinal pigment epithelium and outer retina, and reduce oxidative stress caused by NE-AMD. These results suggest that housing in an enriched environment and visual stimulation could become a promising therapeutic strategy for NE-AMD.
CELL DEATH & DISEASE
(2021)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Carlos B. Mantilla, Leonid G. Ermilov, Sarah M. Greising, Heather M. Gransee, Wen-Zhi Zhan, Gary C. Sieck
Summary: Our study found that the neurotrophin brain-derived neurotrophic factor (BDNF) can enhance neuromuscular transmission by activating the tropomyosin-related kinase receptor B (TrkB). BDNF not only increases quantal release in all fiber types, but also enhances synaptic vesicle replenishment. We concluded that BDNF/TrkB signaling can mitigate synaptic depression and maintain neuromuscular transmission.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Physics, Multidisciplinary
Francesco Randi, Andrew M. Leifer
Summary: This paper investigates the time-dependent functional connectivity between neurons in the brain, using nonequilibrium Green's functions to describe the dynamic behavior of neuron networks. Through numerical calculations and examples inspired by Caenorhabditis elegans, the relationship between connectivity and response functions is demonstrated.
PHYSICAL REVIEW LETTERS
(2021)
Article
Multidisciplinary Sciences
Noam D. Peer, Hagar G. Yamin, Dana Cohen
Summary: The basal ganglia are vital for animal survival, processing information from different brain areas and encoding it through direct and indirect pathways. In this study, we focused on how the globus pallidus encodes motor and cognitive input. Our findings show that GP neurons exhibit multidimensional responses to movement and contextual information.
Article
Biology
Abagael M. Lasseigne, Fabio A. Echeverry, Sundas Ijaz, Jennifer Carlisle Michel, E. Anne Martin, Audrey J. Marsh, Elisa Trujillo, Kurt C. Marsden, Alberto E. Pereda, Adam C. Miller
Summary: This study investigated the functional relationship between neuronal Connexins and ZO1, revealing that ZO1 is crucial for the localization of synaptic Connexins, while Connexins are not necessary for ZO1 localization. Disruption of this hierarchical ZO1/Connexin relationship abolishes electrical transmission and disrupts Mauthner cell-initiated escape responses.