Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine

(2019) Satoshi Deyama et al.   AMERICAN JOURNAL OF PSYCHIATRY

(2R,6R)-hydroxynorketamine exerts mGlu2receptor-dependent antidepressant actions

(2019) Panos Zanos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

(2019) Eric W. Lumsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine: A Paradigm Shift for Depression Research and Treatment

(2019) John H. Krystal et al.   NEURON

Role of AMPA receptor stimulation and TrkB signaling in the antidepressant-like effect of ketamine co-administered with a group II mGlu receptor antagonist, LY341495, in the forced swim test in rats

(2019) Agnieszka Pałucha-Poniewiera et al.   BEHAVIOURAL PHARMACOLOGY

Antisuicidal effect, BDNF Val66Met polymorphism, and low-dose ketamine infusion: Reanalysis of adjunctive ketamine study of Taiwanese patients with treatment-resistant depression (AKSTP-TRD)

(2019) Mu-Hong Chen et al.   JOURNAL OF AFFECTIVE DISORDERS

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats.

(2019) Taleen Hanania et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Reduced vascular endothelial growth factor levels in the cerebrospinal fluid in patients with treatment resistant major depression and the effects of electroconvulsive therapy—A pilot study

(2019) Laura Kranaster et al.   JOURNAL OF AFFECTIVE DISORDERS

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

(2019) Lace M. Riggs et al.   NEUROPSYCHOPHARMACOLOGY

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects

(2019) Manoela V. Fogaça et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

(2019) Senem Merve Fred et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Psychiatric Genomics: An Update and an Agenda

(2018) Patrick F. Sullivan et al.   AMERICAN JOURNAL OF PSYCHIATRY

AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite ( S )-Norketamine

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine

(2018) Sriparna Ghosal et al.   BIOLOGICAL PSYCHIATRY

Neurophysiological Changes Associated with Antidepressant Response to Ketamine Not Observed in a Negative Trial of Scopolamine in Major Depressive Disorder

(2018) Lawrence Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neurotrophic and Antidepressant Actions of Brain-Derived Neurotrophic Factor Require Vascular Endothelial Growth Factor

(2018) Satoshi Deyama et al.   BIOLOGICAL PSYCHIATRY

Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses

(2018) Samuel Kohtala et al.   MOLECULAR NEUROBIOLOGY

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

(2018) Kenichi Fukumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF release and signaling are required for the antidepressant actions of GLYX-13

(2017) T Kato et al.   MOLECULAR PSYCHIATRY

Effects of a ketamine metabolite on synaptic NMDAR function

(2017) Kanzo Suzuki et al.   NATURE

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

(2017) Eero Castrén et al.   NEUROBIOLOGY OF DISEASE

Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression

(2017) Tung-Ping Su et al.   NEUROPSYCHOPHARMACOLOGY

mGlu2/3 Receptor Antagonists as Novel Antidepressants

(2017) Shigeyuki Chaki   TRENDS IN PHARMACOLOGICAL SCIENCES

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

(2017) Hanna Antila et al.   Scientific Reports

Hippocampal VEGF is necessary for antidepressant-like behaviors but not sufficient for antidepressant-like effects of ketamine in rats

(2016) Miyeon Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

The Role of BDNF in the Development of Fear Learning

(2016) Iva Dincheva et al.   DEPRESSION AND ANXIETY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures

(2016) Ashley E. Lepack et al.   NEUROPHARMACOLOGY

Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling

(2016) Toshiyuki Mizui et al.   PHARMACOLOGICAL RESEARCH

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

(2016) Bangkun Yang et al.   PSYCHOPHARMACOLOGY

Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model

(2016) H-L Sun et al.   Translational Psychiatry

The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

(2015) J. Burgdorf et al.   NEUROSCIENCE

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

(2015) Manabu Fuchikami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression

(2015) Ji-chun Zhang et al.   PSYCHOPHARMACOLOGY

Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression

(2015) Wen-Xue Liu et al.   PSYCHOPHARMACOLOGY

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

BDNF Release Is Required for the Behavioral Actions of Ketamine

(2015) A. E. Lepack et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Genetics of Major Depression

(2014) Jonathan Flint et al.   NEURON

BDNF and VEGF in the pathogenesis of stress-induced affective diseases: An insight from experimental studies

(2014) Marta Nowacka et al.   Pharmacological Reports

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

(2014) E. S. Gideons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity

(2013) Elke Edelmann et al.   NEUROPHARMACOLOGY

Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures

(2013) Mi Kyoung Seo et al.   NEUROPHARMACOLOGY

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

Stress effects on BDNF expression: Effects of age, sex, and form of stress

(2013) K.G. Bath et al.   NEUROSCIENCE

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A systematic review and meta-analysis on the association between BDNF val66met and hippocampal volume-A genuine effect or a winners curse?

(2012) Marc L. Molendijk et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

(2012) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients

(2012) Gonzalo Laje et al.   BIOLOGICAL PSYCHIATRY

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

(2012) H. Yu et al.   JOURNAL OF NEUROSCIENCE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans

(2012) Thomas Frodl et al.   NEUROBIOLOGY OF DISEASE

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation

(2012) HaoSheng Sun et al.   NEUROPSYCHOPHARMACOLOGY

Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

(2012) J Isung et al.   Translational Psychiatry

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

(2011) Rong-Jian Liu et al.   BIOLOGICAL PSYCHIATRY

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

(2011) Hiroyuki Koike et al.   NEUROPHARMACOLOGY

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

(2011) Bruce S. McEwen et al.   NEUROPHARMACOLOGY

Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training

(2011) N. N. Karpova et al.   SCIENCE

VEGF in the nervous system

(2011) Jeffrey M. Rosenstein et al.   Organogenesis

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial

(2010) Wayne C. Drevets et al.   BIOLOGICAL PSYCHIATRY

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?

(2010) G MacQueen et al.   MOLECULAR PSYCHIATRY

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Brain-derived neurotrophic factor: role in depression and suicide

(2010) Yogesh Dwivedi   Neuropsychiatric Disease and Treatment

Gender differences in the enhanced vulnerability of BDNF+/− mice to mild stress

(2009) Tushar Advani et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety

(2009) J M Gatt et al.   MOLECULAR PSYCHIATRY

Stress, memory and the amygdala

(2009) Benno Roozendaal et al.   NATURE REVIEWS NEUROSCIENCE

Vascular Endothelial Growth Factor Signaling is Required for the Behavioral Actions of Antidepressant Treatment: Pharmacological and Cellular Characterization

(2009) Joshua Greene et al.   NEUROPSYCHOPHARMACOLOGY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy

(2008) R.-J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex

(2008) J. F. M. Vetencourt et al.   SCIENCE