Article
Environmental Sciences
Tanmoy Mondal, Christopher A. Loffredo, Tomas Trnovec, Lubica Palkovicova Murinova, Zarish Noreen, Thomas Nnanabu, Kamil Conka, Beata Drobna, Somiranjan Ghosh
Summary: This study investigates the effects of early-life PCB exposures on gene expression in young children. The results indicate significant alterations in several pathogenetic pathways, with an overall downregulation of selected genes. The downregulation of the LEPR gene is directly correlated with exposure variables, while gender and ethnicity also influence gene expression. This research highlights the importance of biomarker-based approaches in studying the genetic susceptibility to the effects of PCBs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Environmental Sciences
Dong Li, Yan Yang, Youping Li, Xiaohua Zhu, Zeqin Li
Summary: Environmental exposure can lead to changes in epigenetic regulation, affecting gene expression. Studies have shown that histone modifications, DNA methylation, RNA modifications, and non-coding RNA expression play important roles in this process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, General & Internal
Marina Bantula, Ebymar Arismendi, Valeria Tubita, Jordi Roca-Ferrer, Joaquim Mullol, Ana de Hollanda, Joaquin Sastre, Antonio Valero, Selene Baos, Lucia Cremades-Jimeno, Blanca Cardaba, Cesar Picado
Summary: Asthma is a complex condition influenced by genes and environment, and obesity is a risk factor that can worsen asthma therapy and severity. This study aimed to determine the impact of obesity on the expression of genes associated with severe asthma. Three groups of subjects were examined: non-obese asthmatics, obese asthma patients, and non-asthmatic obese individuals. The findings showed that obesity decreased the expression of MSR1 and PHLDA1, and significantly reduced CPA3 expression, while having no effect on CD86, IL-10, SERPINB2, PI3, CHI3L1, and IL-8 expression. These results suggest that obesity can modify the expression of genes related to asthma, particularly severe asthma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Hanlin Yin, Ning Pu, Qiangda Chen, Jicheng Zhang, Guochao Zhao, Xuefeng Xu, Dansong Wang, Tiantao Kuang, Dayong Jin, Wenhui Lou, Wenchuan Wu
Summary: Lipopolysaccharide (LPS) has been shown to reshape the tumor microenvironment and synergize with PD-L1 blockade to suppress tumor growth, which may represent a promising comprehensive strategy for pancreatic ductal adenocarcinoma (PDAC).
CELL DEATH & DISEASE
(2021)
Article
Water Resources
Maxime Jeanjean, Sylvaine Goix, Marine Periot, Khaled Douib, Julien Dron, Marie-Pierre Etienne, Philippe Marchand, Annabelle Austruy, Gautier Revenko, Philippe Chamaret
Summary: Residents living near the core of an industrial zone in Fos-sur-Mer, France were found to have higher serum levels of organochlorine indicators, which was linked to behaviors involving environmental exposures. Additionally, spatial and temporal variations of pollutants were observed in the area.
EXPOSURE AND HEALTH
(2021)
Article
Multidisciplinary Sciences
Noor Ahmad Shaik, Khalidah Nasser, Arif Mohammed, Abdulrahman Mujalli, Ahmad A. Obaid, Ashraf A. El-Harouni, Ramu Elango, Babajan Banaganapalli
Summary: This study analyzed the transcriptomic data of bronchial epithelial cells from severe asthma patients and healthy controls using computational biology approaches. Differential expression of genes and miRNAs was observed, and the molecular network between miRNAs, target genes, and TFs was investigated. The results showed that the differentially expressed genes were enriched in key pathways and identified specific miRNAs, TFs, and miRNA target gene pairs associated with autoimmune reactions in bronchial epithelial cells.
Article
Environmental Sciences
Guoao Li, Jianjun Liu, Huanhuan Lu, Wenlei Hu, Mingjun Hu, Jialiu He, Wanjun Yang, Zhenyu Zhu, Jinliang Zhu, Hanshuang Zhang, Huanhuan Zhao, Fen Huang
Summary: This study aimed to explore individual air pollution exposure evaluation and the association between multiple environmental factors and obesity among adult residents in rural areas of China. The results showed that air pollution was positively associated with obesity, while green space had a protective effect on obesity. The study suggested improving air quality and increasing green space to alleviate the burden of disease caused by obesity.
Article
Biochemical Research Methods
Ravikumar Jagani, Divya Pulivarthi, Dhavalkumar Patel, Rosalind J. Wright, Robert O. Wright, Manish Arora, Mary S. Wolff, Syam S. Andra
Summary: This study developed a multi-class method for quantitating biomarkers in urine and optimized the sample preparation and analysis steps. The method can quantify 50 biomarkers of exposure in urine, belonging to 7 chemical classes and 16 sub-classes. The method has been validated in formal international proficiency testing programs and has the potential for further expansion to analyze more chemicals.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Alejandro Caceres, Natalia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Angel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Lea Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Juan R. Gonzalez
Summary: Prenatal exposures can influence the risk of obesity and neurodevelopmental delay in children, but the effect may differ between different environments. This study identified an environment characterized by low dairy consumption, low cotinine levels in blood for non-smokers, low facility richness, and the presence of green spaces during pregnancy, which can reduce the risk of obesity and neurodevelopmental delay in girls.
Article
Biochemistry & Molecular Biology
Orla Howe, Lisa White, Daniel Cullen, Grainne O'Brien, Laura Shields, Jane Bryant, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Brendan McClean, Aidan Meade, Christophe Badie, Fiona M. Lyng
Summary: Validation of a new 4-gene signature panel using G2 chromosomal radiosensitivity assay revealed significant differences in radiation response post-exposure, while some prostate cancer donors showed altered response due to Androgen Deprivation Therapy, suggesting intra-individual heterogeneity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Haotian Wu, Christina M. M. Eckhardt, Andrea A. A. Baccarelli
Summary: A substantial proportion of disease risk for common complex disorders is attributable to environmental exposures and pollutants. Recent research has shown the impact of environmental pollutants on the human genome and epigenome through epigenetic modifications. Furthermore, other molecular processes, such as the production of extracellular vesicles, epitranscriptomic changes, and mitochondrial changes, have also been identified as mechanisms through which the environment can exert its effects.
NATURE REVIEWS GENETICS
(2023)
Article
Environmental Sciences
D. Martin-Way, I. Puche-Sanz, J. M. Cozar, A. Zafra-Gomez, M. D. C. Gomez-Regalado, C. M. Morales-Alvarez, A. F. Hernandez, L. J. Martinez-Gonzalez, M. J. Alvarez-Cubero
Summary: Bladder cancer is one of the most common tumors globally, and this study aims to identify molecular markers and risk factors associated with it. The study found several genes associated with bladder cancer risk, as well as environmental exposures and dietary chemicals that contribute to the disease. The study also identified specific miRNA expression patterns that are elevated in bladder cancer cases. These findings suggest the potential use of non-invasive biomarkers and personalized medicine for bladder cancer management.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Matthew C. Cave, Christina M. Pinkston, Shesh N. Rai, Banrida Wahlang, Marian Pavuk, Kimberly Z. Head, Gleta K. Carswell, Gail M. Nelson, Carolyn M. Klinge, Douglas A. Bell, Linda S. Birnbaum, Brian N. Chorley
Summary: This study suggests that environmental exposure to PCBs is associated with liver injury in humans and provides insights into the potential modes of PCB action. MiR-derived liquid liver biopsy represents a promising new technique for environmental hepatology cohort studies.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Medicine, Research & Experimental
Xiangbo Ruan, Ping Li, Yonghe Ma, Cheng-fei Jiang, Yi Chen, Yu Shi, Nikhil Gupta, Fayaz Seifuddin, Mehdi Pirooznia, Yasuyuki Ohnishi, Nao Yoneda, Megumi Nishiwaki, Gabrijela Dumbovic, John L. Rinn, Yuichiro Higuchi, Kenji Kawai, Hiroshi Suemizu, Haiming Cao
Summary: This study established a pipeline to identify putative human lncRNA metabolic regulators that are sensitive to metabolism, relevant to disease, and applicable to the population. The researchers identified liver lncRNAs with dynamic expression in the general population and differential expression in individuals with NAFLD, and demonstrated the regulatory role of a nonconserved lncRNA in cholesterol metabolism in humanized mouse models. Through this work, disease-relevant human lncRNAs in metabolic homeostasis were efficiently identified and functionally defined, overcoming the heterogeneity of human data.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Neurosciences
Juliet Richetto, Urs Meyer
Summary: Epigenetic modifications play a role in the etiology and pathophysiology of schizophrenia and other psychiatric disorders, with contributions from both genetic and environmental factors. Recent findings suggest that these modifications can affect gene expression variability, influencing neurodevelopmental trajectories in complex ways.
BIOLOGICAL PSYCHIATRY
(2021)