Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4/MyD88/AKT/NF-κB pathway in pancreatic cancer

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice

(2020) Sydney Lavoie et al.   GASTROENTEROLOGY

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study

(2020) Michael Guenther et al.   BRITISH JOURNAL OF CANCER

Prognostic Impact of Tumor-Infiltrating Lymphocytes and Neutrophils on Survival of Patients with Upfront Resection of Pancreatic Cancer

(2019) Rainer Miksch et al.   Cancers

Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma

(2019) Eileen M. O’Reilly et al.   JAMA Oncology

A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund’s adjuvant in melanoma patients

(2019) Marit M. Melssen et al.   Journal for ImmunoTherapy of Cancer

Cell-intrinsic PD-1 promotes proliferation in pancreatic cancer by targeting CYR61/CTGF via the hippo pathway

(2019) Ning Pu et al.   CANCER LETTERS

Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer

(2019) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical role of toll-like receptor 4 (TLR4) in dextran sulfate sodium (DSS)-Induced intestinal injury and repair

(2019) Yun-Jie Shi et al.   TOXICOLOGY LETTERS

Galectin-3 activates TLR4/NF-κB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression

(2018) Wu Zhou et al.   BMC CANCER

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation

(2018) Wei Wang et al.   MEDICAL SCIENCE MONITOR

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

(2017) Suhas V Vasaikar et al.   NUCLEIC ACIDS RESEARCH

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Innate immune signaling and regulation in cancer immunotherapy

(2016) Leticia Corrales et al.   CELL RESEARCH

Bacterial Lipopolysaccharide, Lipopolysaccharide-Binding Protein, and Other Inflammatory Markers in Obesity and After Bariatric Surgery

(2016) Kathryn Tuomi et al.   Metabolic Syndrome and Related Disorders

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation

(2016) Z.Y. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

(2016) A. Gabrielson et al.   Cancer Immunology Research

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

(2013) Hongliang Fang et al.   Cellular & Molecular Immunology

Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes

(2013) B. Jayashree et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell mediated immune responses through TLR4 prevents DMBA-induced mammary carcinogenesis in mice

(2011) Mohammed Naseemuddin et al.   INTERNATIONAL JOURNAL OF CANCER

Expression and significance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma

(2010) Jian-Jun Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Lipopolysaccharide: Biosynthetic pathway and structure modification

(2009) Xiaoyuan Wang et al.   PROGRESS IN LIPID RESEARCH

Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis

(2008) N. Yusuf et al.   CANCER RESEARCH