Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Monika Pieniawska, Katarzyna Izykowska
Summary: Histone deacetylases (HDACs) are enzymes that alter chromatin structure, affecting gene expression. They play important roles in T-cell development and function. This review summarizes the current understanding of the role of HDACs in early T-cell development and mature lymphocyte function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nisha Nair, Anthony G. Wilson
Summary: Although there are gold-standard diagnostic guidelines and effective treatments for rheumatoid arthritis (RA), a significant number of patients do not respond adequately to their initial treatment. Epigenetic biomarkers, specifically DNA methylation and histone modifications, have shown promise in improving diagnosis and treatment response in RA. However, there are challenges in their clinical application and the need for validation in diverse populations.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo
Summary: This article describes the epigenetic changes that occur in the pathogen Mycobacterium tuberculosis and its host during infection, including DNA methylation, histone modification, and microRNA. It summarizes the research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat drug-resistant tuberculosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Farzin Zobdeh, Ivan I. Eremenko, Mikail A. Akan, Vadim V. Tarasov, Vladimir N. Chubarev, Helgi B. Schioeth, Jessica Mwinyi
Summary: Migraine is a complex neurological disorder and current drug treatments have limited success rates. Understanding the epigenetic changes associated with migraine may help to improve treatment strategies and identify new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Heena Khan, Palak Tiwari, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Sirtuins, as a class III of histone deacetylases dependent on nicotinamide adenine dinucleotide, play a significant role in influencing the progression of neurodegenerative disorders by switching between deacetylation and acetylation processes. Pharmacological modulation of sirtuin activity has shown promising effects on various neurodegenerative disorders, and sirtuins may serve as a potential therapeutic target for the treatment of these diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Physiology
Moez Eid, Valentina Dzreyan, Svetlana Demyanenko
Summary: SIRT1 and SIRT2 exhibit changes in expression and localization in response to photothrombotic stroke in brain cells, but these changes are not related to the regulation of cell apoptosis. The selectivity and non-selectivity of their inhibitors did not have any impact on stroke outcomes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Xingrui He, Zi Hui, Li Xu, Renren Bai, Yuan Gao, Zongcheng Wang, Tian Xie, Xiang-Yang Ye
Summary: Histone deacetylases (HDACs) are important enzymes involved in the removal of acetyl groups from lysine residues, and have shown potential therapeutic applications in cancer and various diseases. There are currently numerous HDAC inhibitors under clinical investigation, aiming to provide up-to-date information for drug discovery programs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Bryan McClarty, Guadalupe Rodriguez, Hongxin Dong
Summary: The study showed that the HDAC inhibitor CI-994 at different doses could reduce motor and memory side effects induced by haloperidol in aged mice. A dose of 20 mg/kg was effective in improving motor coordination and mitigating memory impairment in aged mice. Biochemical analyses indicated an increase in histone acetylation and expression of the dopamine 2 receptor gene in aged mice after administration of CI-994 at 20 mg/kg.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Genetics & Heredity
Nisha Nair, Anne Barton, Anthony G. Wilson
Summary: The review highlights the key epigenetic modifications in different cell types associated with rheumatoid arthritis and discusses potential therapeutic targets focusing on epigenetic markers. It emphasizes the importance of altered epigenetic regulation in promoting the destructive behavior underlying disease pathogenesis.
Review
Cell Biology
Xiaomin Ma, Xin Wang, Guangbing Zheng, Guiqin Tan, Fangyu Zhou, Wenwen Wei, Dan Tian, Hongsong Yu
Summary: Behçet's disease is a chronic multisystem autoimmune disease with complex pathogenesis involving genetics, environmental factors, and gut microbiota. Previous studies have indicated that external environmental factors and abnormalities in epigenetic modification may impact the development of BD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Antonio Julia, Antonio Gomez, Maria Lopez-Lasanta, Francisco Blanco, Alba Erra, Antonio Fernandez-Nebro, Antonio Juan Mas, Carolina Perez-Garcia, Ma Luz Garcia Vivar, Simon Sanchez-Fernandez, Mercedes Alperi-Lopez, Raimon Sanmarti, Ana Maria Ortiz, Carlos Marras Fernandez-Cid, Cesar Diaz-Torne, Estefania Moreno, Tianlu Li, Sergio H. Martinez-Mateu, Devin M. Absher, Richard M. Myers, Jesus Tornero Molina, Sara Marsal
Summary: This study found that treatment with TNFi can restore homeostatic blood methylation in RA patients, and the clinical response is closely related to methylation variation in specific biological pathways.
Review
Environmental Sciences
Sherihan G. AbdelHamid, Aya A. Refaat, Anthony M. Benjamin, Laila A. Elmawardy, Lougine A. Elgendy, Mark M. Manolly, Nada Abd Elmaksoud, Nourhan Sherif, Nadia M. Hamdy
Summary: The COVID-19 pandemic has led to drastic postinfection complications with interindividual variations, prompting research on the impact of epigenetic modulation on infection susceptibility and outcome. Studies suggest that viral microRNAs and host DNA methylation and chromatin remodeling may play crucial roles in influencing the severity and outcome of the disease.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Claudia Colussi, Giuseppe Aceto, Cristian Ripoli, Alessia Bertozzi, Domenica Donatella Li Puma, Elena Paccosi, Marcello D'Ascenzo, Claudio Grassi
Summary: This study reveals that the abnormal localization of HDAC4 may contribute to synaptic dysfunction in AD, leading to impaired synaptic transmission and cognitive deficits.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Biology
Thibaut Renard, Baptiste Martinet, Natalia De Souza Araujo, Serge Aron
Summary: Epigenetic alterations are a primary hallmark of aging, and this study found that such changes occur not only in mammals but also play a crucial role in insects. By using a hypomethylating agent, the researchers extended the average lifespan of bumblebees and induced differential methylation of genes associated with aging. Additionally, they discovered that the overexpression of the longevity gene sirt1 was positively correlated with lifespan.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Margot Crucet, Branko Simic, Simon Kraler, Nicole R. Bonetti, Caroline Ospelt, Oliver Distler, Adrian Ciurea, Luca Liberale, Matti Jauhiainen, Jari Metso, Melroy Miranda, Rose Cydecian, Lena Schwarz, Vera Fehr, Rita Zilinyi, Mohammad Amrollahi-Sharifabadi, Lydia Ntari, Niki Karagianni, Frank Ruschitzka, Reijo Laaksonen, Paul M. Vanhoutte, George Kollias, Giovanni G. Camici, Thomas F. Luescher
Summary: This study aimed to identify the molecular mechanism of endothelial dysfunction in a mouse model of rheumatoid arthritis (RA) and in patients with RA. The results showed that increased TNF alpha levels contribute to RA and endothelial dysfunction by increasing vascular oxLDL content and activation of the LOX-1/NF kappa B/Arg2 pathway, resulting in reduced NO bioavailability and decreased cGMP levels. Anti-TNF alpha treatment improved both articular symptoms and endothelial function by reducing LOX-1, vascular oxLDL, and Arg2 levels.
CARDIOVASCULAR RESEARCH
(2022)
Correction
Rheumatology
Christopher D. Buckley, Caroline Ospelt, Steffen Gay, Kim S. Midwood
Summary: A correction to this paper has been published and can be found at the provided link.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Rheumatology
Christopher D. Buckley, Caroline Ospelt, Steffen Gay, Kim S. Midwood
Summary: This review discusses the role of synovial extracellular matrix in rheumatoid arthritis and how better understanding of it can improve disease diagnosis and new therapies. Current treatments for rheumatoid arthritis are not effective for many patients and cannot cure or prevent the disease. Lack of complete understanding of the pathogenesis of inflammatory joint disease is a major obstacle to developing better drugs.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
M. Houtman, X. Ge, A. Mcgovern, K. Klein, G. Orozco, M. Frank Bertoncelj, M. Marks, O. Distler, P. Martin, S. Eyre, C. Ospelt
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
M. Mirrahimi, K. Klein, M. Houtman, M. Maciukiewicz, M. Frank Bertoncelj, A. Juengel, M. Berli, M. Marks, O. Distler, C. Ospelt
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Monika Krosel, Marcel Gabathuler, Malgorzata Maciukiewicz, Larissa Moser, Gideon Isaac Lee, Miriam Marks, Matija Tomsic, Oliver Distler, Caroline Ospelt, Kerstin Klein
Summary: In rheumatoid arthritis, chromatin remodeling and histone 3 lysine 27 acetylation are associated with sustained inflammatory responses in synovial fibroblasts. Writer proteins CBP and p300 have overlapping but distinct regulatory functions in controlling gene expression, with p300 being the major HAT for H3K27ac. Inhibition of CBP/p300 mirrors effects seen with p300 silencing, suggesting that inhibitors targeting these proteins may not be sufficient as anti-inflammatory drugs.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Octavio Morante-Palacios, Laura Ciudad, Raphael Micheroli, Carlos de la Calle-Fabregat, Tianlu Li, Gisela Barbisan, Miranda Houtman, Sam G. Edalat, Mojca Frank-Bertoncelj, Caroline Ospelt, Esteban Ballestar
Summary: The study revealed that MAFB plays a critical role in the acquisition of tolerogenic properties in DCs in synergy with GR. MAFB interacts with TET2 and binds to genomic loci involved in the demethylation process in tolDCs. Knockdown of MAFB abolishes the tolerogenic properties of tolDCs, reversing the specific DNA demethylation and gene upregulation.
NUCLEIC ACIDS RESEARCH
(2022)
Editorial Material
Rheumatology
Alessia Alunno, Felice Rivellese, Kim Lauper, Daniel Aletaha, Maya H. Buch, Laure Gossec, Peter Mandl, Pedro M. Machado, Caroline Ospelt, Anna Molto, Sofia Ramiro, Elena Nikiphorou, Alexandre Sepriano
Article
Immunology
Caroline Ospelt
Summary: In the past 70 years, the study of epigenetics has transitioned from being a research curiosity to being one of the most hyped biological concepts. Today, the modulation of epigenetics through behavioral changes is promoted as a cure for diseases. The concept that environmental influences can cause stable and heritable changes in gene expression has been enthusiastically embraced in the field of medical biology.
IMMUNOLOGY LETTERS
(2022)
Letter
Rheumatology
Raphael Micheroli, Chantal Pauli, Kristina Buerki, Philipp Rossbach, Oliver Distler, Caroline Ospelt, Adrian Ciurea
Editorial Material
Immunology
Caroline Ospelt
Summary: ETS1 regulates tissue-remodeling properties of specific fibroblast subtypes in synovium, gut, and cancer, making it a novel therapeutic target for modulating pathogenic fibroblast activation.
Review
Rheumatology
Caroline Ospelt
Summary: New analytical methods and the increasing availability of synovial biopsies have shed light on the role of synovial fibroblasts (SFs) in rheumatoid arthritis (RA). Recent studies have revealed heterogeneity and propagation of SFs in RA, expanding our understanding of their active involvement in the invasion of synovium into cartilage. This review provides an overview of the processes occurring at sites of invasive synovial tissue growth in RA by integrating old and new evidence.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Monika Krosel, Larissa Moser, Miranda Houtman, Jasna Friscic, Matija Tomsic, Oliver Distler, Markus H. Hoffmann, Caroline Ospelt, Kerstin Klein
Summary: BET proteins regulate gene transcription by binding to acetylated histone side chains. The BET inhibitor I-BET151 not only prevents the reading of acetylated histones, but also influences overall chromatin organization.
Letter
Rheumatology
Larissa Moser, Katerina Laskari, Caroline Ospelt, Miranda Houtman
Article
Biotechnology & Applied Microbiology
Xiangyu Ge, Mojca Frank-Bertoncelj, Kerstin Klein, Amanda McGovern, Tadeja Kuret, Miranda Houtman, Blaz Burja, Raphael Micheroli, Chenfu Shi, Miriam Marks, Andrew Filer, Christopher D. Buckley, Gisela Orozco, Oliver Distler, Andrew P. Morris, Paul Martin, Stephen Eyre, Caroline Ospelt
Summary: The study reveals the potential causal role of fibroblast-like synoviocytes (FLS) in the genetic susceptibility for rheumatoid arthritis (RA), accounting for up to a quarter of RA heritability. Activation of FLS may impact the expression of genes like TNFAIP3 and cellular proliferation.