Individual functions of the histone acetyl transferases CBP and p300 in regulating the inflammatory response of synovial fibroblasts

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Hi-JAKi-ng Synovial Fibroblasts in Inflammatory Arthritis With JAK Inhibitors

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TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis

(2019) Christopher Loh et al.   ANNALS OF THE RHEUMATIC DISEASES

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Wnt Signaling and Biological Therapy in Rheumatoid Arthritis and Spondyloarthritis

(2019) Daniela Cici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

(2018) Emmanuel Karouzakis et al.   Scientific Reports

Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment

(2018) Mengting Ding et al.   Journal of Cancer

Heterogeneity of the Type I Interferon Signature in Rheumatoid Arthritis: A Potential Limitation for Its Use As a Clinical Biomarker

(2018) Javier Rodríguez-Carrio et al.   Frontiers in Immunology

Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells

(2018) Birgit Zimmermann-Geller et al.   IMMUNOLOGY AND CELL BIOLOGY

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity

(2018) Lucas Fauquier et al.   Scientific Reports

The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance

(2017) Kerstin Klein et al.   JOURNAL OF AUTOIMMUNITY

Why location matters — site-specific factors in rheumatic diseases

(2017) Caroline Ospelt et al.   Nature Reviews Rheumatology

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors

(2016) Tobias A. Popp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

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(2015) Guangchuang Yu et al.   BIOINFORMATICS

Epigenetics in rheumatoid arthritis

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DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

(2015) Rizi Ai et al.   Arthritis & Rheumatology

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression

(2014) Lawryn H. Kasper et al.   NUCLEIC ACIDS RESEARCH

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

(2013) Jong-Sung Park et al.   ANNALS OF THE RHEUMATIC DISEASES

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(2013) Y. Liao et al.   BIOINFORMATICS

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Hox regulation of transcription: More complex(es)

(2013) Franck Ladam et al.   DEVELOPMENTAL DYNAMICS

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Target analysis by integration of transcriptome and ChIP-seq data with BETA

(2013) Su Wang et al.   Nature Protocols

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Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

(2011) Liang Zhao et al.   NUCLEIC ACIDS RESEARCH

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases

(2010) David C. Bedford et al.   Epigenetics

High frequency of copy number imbalances in Rubinstein–Taybi patients negative to CREBBP mutational analysis

(2010) Cristina Gervasini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation

(2010) Y. F. M. Ramos et al.   NUCLEIC ACIDS RESEARCH

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols