Article
Chemistry, Multidisciplinary
Yixin Tian, Jiapeng Yin, Chengyao Wang, Zhenliang He, Jingyi Xie, Xiaoshan Feng, Yang Zhou, Tianyu Ma, Yang Xie, Xue Li, Tianming Yang, Chi Ren, Chengyu Li, Zhengtuo Zhao
Summary: Researchers have developed a mechanically robust ultraflexible electrode array, the MERF, for high-density, large-scale, and chronic recording of neurons in the nonhuman primate brain. The MERF array has shown promising results in basic neuroscience studies and brain-machine interface applications.
Article
Psychology, Mathematical
Anca Velisar, Natela M. Shanidze
Summary: In this study, the Pupil Core, a head-mounted video-based eye tracking device, was systematically assessed for measurement uncertainty in three eye-tracking domains. The assessment included the 2D scene camera image, eye rotation relative to the scene camera 3D space, and the projection of gaze point location onto the target plane or world coordinates. The study also explored the importance of eye camera motion during active tasks and its impact on gaze detection alignment. The findings highlighted the impact of eye camera motion, inaccurate gaze point depth estimation, and erroneous eye models on data noise and emphasized the need for consistent eye models and additional reliability assessments in experiments utilizing eye movements and gaze point measurements.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Psychology, Multidisciplinary
Chloe Callahan-Flintoft, Christian Barentine, Jonathan Touryan, Anthony J. Ries
Summary: By combining head mounted displays (HMDs) with virtual reality (VR), researchers are able to capture more naturalistic vision in an experimentally controlled setting, accurately tracking eye movements as they occur in concert with head movements. This approach allows for easier comparison between HMD studies and previous research that used monitor displays, providing insights into the strengths and weaknesses of recording and classifying eye and head tracking data in VR.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Chemistry, Analytical
Sebastian Kapp, Michael Barz, Sergey Mukhametov, Daniel Sonntag, Jochen Kuhn
Summary: An increasing number of head mounted displays for VR and AR are now equipped with integrated eye trackers, which can optimize rendering and improve user interaction. This study developed an open-source eye tracking toolkit for AR based on Unity 3D and Microsoft HoloLens 2, and evaluated its spatial accuracy and precision for fixation targets at different distances and angles.
Article
Chemistry, Multidisciplinary
Zbigniew Gomolka, Ewa Zeslawska, Boguslaw Twarog, Damian Kordos, Pawel Rzucidlo
Summary: The research proposes a smart technology to record and analyze the attention of transportation device operators during human-machine interaction. Using deep neural networks and eye trackers, the system accurately detects and tracks instruments, providing valuable insights into operator attention distribution. This study has significant implications for the education and skill training of transportation device operators.
APPLIED SCIENCES-BASEL
(2022)
Article
Behavioral Sciences
Yesol Kim, Girija Kadlaskar, Rebecca McNally Keehn, Brandon Keehn
Summary: A growing body of research suggests that the locus coeruleus-norepinephrine (LC-NE) system functions differently in individuals with autism spectrum disorder (ASD). This study investigated the dynamics of both tonic and phasic indices of LC-NE function in children with ASD and found that they exhibit increased tonic activity and reduced phasic activity compared to typically developing children. These differences may be associated with impairments in attention and arousal regulation in ASD.
Article
Chemistry, Multidisciplinary
Tomoaki Banno, Shuhei Tsuruhara, Yu Seikoba, Ryohei Tonai, Koji Yamashita, Shinnosuke Idogawa, Yuto Kita, Ko Suzuki, Yuki Yagi, Yuki Kondo, Rika Numano, Kowa Koida, Takeshi Kawano
Summary: Microscale needle-like electrodes offer high spatiotemporal resolution for in vivo extracellular recording. However, reducing the size to the nanoscale increases electrical impedance. By stacking a nanoelectrode on an amplifier module, the quality of neuronal signal recording can be improved. In experiments conducted on the mouse cortex, the nanoelectrode with amplifier could record a wider range of neural signals compared to the electrode without the amplifier.
Article
Multidisciplinary Sciences
Ryota Takamido, Satoya Kurihara, Yasushi Umeda, Hajime Asama, Seiji Kasahara, Yuichi Tanaka, Seigo Fukumoto, Toshiya Kato, Masahiro Korenaga, Misaki Hoshi, Jun Ota
Summary: This study aimed to clarify expert skills in refinery patrol inspection using data collected through a virtual reality experimental system. The results showed that expert inspectors could find more defects compared to knowledgeable novices. Additionally, the study revealed similar visual attention behavior but differences in head positioning behavior between experts and novices.
Article
Psychology, Mathematical
Bernhard Petersch, Kai Dierkes
Summary: The study focuses on potential errors in pupillometry measurement, specifically looking at eyeball rotation in relation to the recording camera and optical effects due to refraction at corneal interfaces. Through experimental data and synthetic images, a successful correction method is identified, along with discussions on the impact of errors at different levels.
BEHAVIOR RESEARCH METHODS
(2022)
Article
Psychology, Multidisciplinary
Yixiao Cui, Binghan Zheng
Summary: This study compares linguistic and extralinguistic consultations in English-Chinese translation in terms of cognitive resources allocation and information processing patterns using eye-tracking and screen-recording data. It also explores the differences among different types of translators and the effect of extralinguistic consultation on translation quality.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuecheng Zhou, Erica Liu, Yang Yang, Felix S. Alfonso, Burhan Ahmed, Kenneth Nakasone, Csaba Forro, Holger Muller, Bianxiao Cui
Summary: Optical recording based on voltage-sensitive electrochromic materials allows for long-term and sensitive measurement of bioelectrical signals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Behavioral Sciences
Zhong Zhao, Zhipeng Zhu, Xiaobin Zhang, Haiming Tang, Jiayi Xing, Xinyao Hu, Jianping Lu, Qiongling Peng, Xingda Qu
Summary: This study utilized OpenFace 2.0 to quantify head movement in children with ASD and TD, showing that children with ASD exhibited more stereotyped and greater head movement. The study suggests the widespread use of head movement tracking techniques in autism research.
Article
Materials Science, Multidisciplinary
Zhiyuan Chen, Khanh Nguyen, Grant Kowalik, Xinyu Shi, Jinbi Tian, Mitansh Doshi, Bridget R. R. Alber, Xun Guan, Xitong Liu, Xin Ning, Matthew W. W. Kay, Luyao Lu
Summary: Transparent microelectrodes have been widely studied in the biomedical field due to their advantages in simultaneous electrical and optical interrogation of cell/tissue activity. In this study, a microelectrode array (MEA) with gold-coated silver nanowires (Au-Ag NWs) was designed to achieve desirable mechanical stretchability, optical transparency, electrochemical performance, and chemical stability. The MEAs exhibited high optical transparency, low electrochemical impedance, stable chemical and electromechanical performance, and superior capability for colocalized electrophysiological and optical mapping of cardiac function.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Clinical Neurology
T. Maxwell Parker, Shervin Badihian, Ahmed Hassoon, Ali S. Saber Tehrani, Nathan Farrell, David E. Newman-Toker, Jorge Otero-Millan
Summary: Smartphone applications show promise in the assessment of neuro-ophthalmologic and vestibular disorders. The study found that the accuracy of head movements recorded using the application was better than eye movements, and the accuracy of horizontal eye movements was better than vertical movements. The precision of head movements was also better than eye movements, and variability tended to increase with eccentricity.
FRONTIERS IN NEUROLOGY
(2022)
Review
Zoology
Laura S. Lewis, Christopher Krupenye
Summary: Noninvasive, restraint-free eye-tracking research with primates has greatly advanced our understanding of primate social cognition. By comparing the cognitive capacities of different primate species, including humans, we can gain insight into the evolutionary mechanisms and selective pressures that have influenced social cognition. This review discusses the use of noninvasive behavioral methods and eye-tracking technologies in studying primate social cognition, and explores future directions for research.
AMERICAN JOURNAL OF PRIMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simona Capponi, Nadja Stoeffler, Manuel Irimia, Frederik M. A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden, H. Th Marc Timmers
Article
Anatomy & Morphology
Ryoma Morigaki, Jannifer H. Lee, Tomoko Yoshida, Christian Wuthrich, Dan Hu, Jill R. Crittenden, Alexander Friedman, Yasuo Kubota, Ann M. Graybiel
FRONTIERS IN NEUROANATOMY
(2020)
Article
Neurosciences
Jill R. Crittenden, Theresa A. Gipson, Anne C. Smith, Hilary A. Bowden, Ferah Yildirim, Kyle B. Fischer, Michael Yim, David E. Housman, Ann M. Graybiel
Summary: The study identified changes in gene expression in the striatum of mice treated with amphetamine, with abnormal plasticity occurring alongside drug-induced stereotypic behavior. Genes encoding members of the ERK cascades were found to be involved in psychomotor stimulant responses. Dysregulation of 20 genes, particularly those regulated by neuregulin 1, was observed in the sensitized group with prolonged stereotypy. These findings suggest a potential link between drug-induced sensitization of the Nrg1 signaling pathway and disorders such as schizophrenia and autism characterized by behavioral stereotypy.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Mads L. Pedersen, Maria Ironside, Ken-ichi Amemori, Callie L. McGrath, Min S. Kang, Ann M. Graybiel, Diego A. Pizzagalli, Michael J. Frank
Summary: This study utilizes a drift diffusion model to investigate how reward and aversiveness influence decision making, finding that individuals with major depressive disorder have reduced reward sensitivity, tend to avoid offers, and exhibit significant brain activity effects on behavior.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Camarin E. Rolle, Mads L. Pedersen, Noriah Johnson, Ken-Ichi Amemori, Maria Ironside, Ann M. Graybiel, Diego A. Pizzagalli, Amit Etkin
Summary: This article investigates the role of the dorsolateral prefrontal cortex (dlPFC) in approach-avoidance conflict (AAC) behavior using transcranial magnetic stimulation (TMS) and drift-diffusion modeling. It demonstrates that disrupting the dlPFC reduces reward sensitivity during conflict decision-making and identifies its network of cortical regions associated with avoidance behavior. These findings advance our understanding of the neural mechanisms underlying AAC behavior and suggest the dlPFC as a potential target for psychiatric therapeutics.
Article
Neurosciences
Satoko Amemori, Ann M. Graybiel, Ken-ichi Amemori
Summary: Clinical studies have shown coactivation of limbic cortices and basal ganglia in patients with anxiety disorders, forming a large-scale brain network with unknown mechanisms in inducing anxiety-like states. Experimental program in macaques demonstrated involvement of local striatal and frontal cortical sites in inducing pessimistic decision-making underlying anxiety. Microstimulation experiments and tracing methods identified specific brain regions and connections, suggesting a large-scale brain network regulating dopaminergic functions and influencing decision-making.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Morgane Thomsen, Jill R. Crittenden, Craig W. Lindsley, Ann M. Graybiel
Summary: Stimulation of muscarinic acetylcholine receptors M-1 and M-4 holds promise as a potential pharmacotherapy for cocaine use disorder. Previous studies have shown that M-4 stimulation can reduce the effects of cocaine, and combined M-1/M-4 stimulation or M-1 stimulation alone can lead to long-lasting reductions in cocaine taking and seeking. This research aims to determine whether M-4 approaches remain effective with repeated or chronic dosing, and the results indicate that M-4 positive allosteric modulators (PAMs) can progressively suppress cocaine choice and intake without rebound or lasting effects after treatment ends. Additionally, the effects of M-1 versus M-4 stimulation on cocaine self-administration were compared, revealing that M-4-mediated suppression of cocaine self-administration is not dependent on the CalDAG-GEFI signaling factor required for M-1-mediated suppression. These findings support the potential usefulness of M-4 PAMs as pharmacotherapy for managing cocaine use disorder, either alone or in combination with M-1-selective ligands, and suggest that M-1 and M-4 stimulation modulate cocaine-taking behavior through distinct mechanisms.
Article
Neurosciences
Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguiere, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel
Summary: CDGI is a protein highly enriched in the striatum, impacting neuronal signaling and drug self-administration. Its deletion results in a range of behavioral and learning dysfunctions.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Bernard Bloem, Rafiq Huda, Ken-ichi Amemori, Alex S. Abate, Gayathri Krishna, Anna L. Wilson, Cody W. Carter, Mriganka Sur, Ann M. Graybiel
Summary: The striatal neurons can encode associations between actions and multiple rewarding and aversive outcomes. Striosomal neurons are particularly important in action-outcome learning.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Jill R. Crittenden, Tomoko Yoshida, Samitha Venu, Ara Mahar, Ann M. Graybiel
Summary: CB1R plays a crucial role in the postnatal wiring of the brain's cannabinoid circuit, affecting the connectivity between striatal and dopaminergic neurons. Lack of CB1R expression can lead to disorganized brain connections and altered dopaminergic neuron activity.
Article
Multidisciplinary Sciences
Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriakitsa Galani, Julio Mantero, Geoffrey Tombaugh, Manolis Kellis, Myriam Heiman, Ann M. Graybiel
Summary: In human and mouse models of Huntington's disease, the two defining axes of striatal projection neurons are mixed and differentially affected. The indirect-pathway striatal projection neurons are the most depleted in human patients, while the transcriptomic distinctiveness of striosome-matrix neurons is diminished more in mouse models. The loss of striosome-matrix distinction is more prominent within the indirect-pathway neurons, suggesting the need for distinct therapeutic strategies based on the differential compromise of these two axes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Alexander Friedman, Emily Hueske, Sabrina M. Drammis, Sebastian E. Toro Arana, Erik D. Nelson, Cody W. Carter, Sebastien Delcasso, Raimundo X. Rodriguez, Hope Lutwak, Kaden S. DiMarco, Qingyang Zhang, Lara Rakocevic, Dan Hu, Joshua K. Xiong, Jiajia Zhao, Leif G. Gibb, Tomoko Yoshida, Cody A. Siciliano, Thomas J. Diefenbach, Charu Ramakrishnan, Karl Deisseroth, Ann M. Graybiel
Article
Engineering, Biomedical
Khalil B. Ramadi, Canan Dagdeviren, Preksha Bhagchandani, Carlos Nunez-Lopez, Min Jung Kim, Robert Langer, Ann M. Graybiel, Michael J. Cima
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)