Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Yangfan Xu, Lingrong Yi, Yangyang Lin, Suiying Peng, Weiming Wang, Wujian Lin, Peize Chen, Weichao Zhang, Yujie Deng, Suimin Guo, Le Shi, Yuling Wang, D. William Molloy, Ronan O'Caoimh
Summary: The study demonstrated that in post-stroke rehabilitation patients, the Chinese version of Qmci can accurately identify PSD patients and is comparable to MoCA-CN, with a shorter assessment time. However, it had lower accuracy in identifying PSCIND patients, warranting further research for validation.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Medicine, General & Internal
A. D. Smith, H. Refsum
Summary: Elevated concentrations of plasma total homocysteine are associated with over 100 diseases or conditions, with cardiovascular diseases and diseases of the central nervous system being the most common. Lowering total homocysteine through B vitamin treatment may prevent certain diseases, indicating the clinical importance of these associations.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Valeria Guglielmi, Davide Quaranta, Giovanna Masone Iacobucci, Salvatore Citro, Irene Scala, Danilo Genovese, Valerio Brunetti, Camillo Marra, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to assess the cognitive impairment within 1 week after mechanical thrombectomy. It was found that some patients experienced cognitive impairment after the procedure, which may lead to worse neurological and functional outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ka Young Kim, Ki Young Shin, Keun-A Chang
Summary: Stroke is a common debilitating disease with high mortality and disability rates. Post-stroke cognitive impairment is a major complication often underdiagnosed. Recent studies have shown that stroke significantly increases the risk of cognitive impairment. This study evaluated blood-derived proteins as biomarkers for post-stroke cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Ningcen Li, Hui Wang, Hang Liu, Lina Zhu, Zhongxi Lyu, Jiwen Qiu, Tianyi Zhao, Haiyan Ren, Lihong Huang, Shuangli Chen, Xiuwu Hu, Liang Zhou
Summary: Stroke is a common cause of disability and death, particularly among older adults worldwide. Post-stroke cognitive impairment (PSCI) is a common consequence of stroke, leading to long-term disability and reduced quality of life. Acupuncture has been recommended by the World Health Organization (WHO) as a complementary therapy for stroke care, and this review provides comprehensive evidence of its beneficial effects on PSCI. The mechanisms of acupuncture on PSCI involve anti-neuronal apoptosis, synaptic plasticity promotion, inflammation alleviation, and regulation of brain energy metabolism disorders. The findings of this study offer scientific support for the application of acupuncture in treating PSCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Maria Isabel Cuartero, Alicia Garcia-Culebras, Carmen Nieto-Vaquero, Enrique Fraga, Cristina Torres-Lopez, Jesus Pradillo, Ignacio Lizasoain, Maria Angeles Moro
Summary: Increasing evidence suggests that commensal microbiota may have significant effects on both health and disease, including cerebrovascular disease. Gut microbes can impact physiology by metabolizing dietary factors and host-derived substrates, leading to the creation of active compounds such as toxins. This review highlights the complex interplay between microbiota, their metabolites, and essential functions for human health, including metabolism regulation, immune system modulation, and brain development. It also discusses the role of gut dysbiosis in cerebrovascular disease, specifically in stroke phases, and the potential involvement of intestinal microbiota in post-stroke cognitive impairment and dementia, as well as potential therapeutic opportunities in targeting microbiota in this context.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Anand Veeravagu, Byung C. Yoon, Bowen Jiang, Carla M. Carvalho, Fred Rincon, Mitchell Maltenfort, Jack Jallo, John K. Ratliff
JOURNAL OF BURN CARE & RESEARCH
(2015)
Article
Critical Care Medicine
Peter A. Abdelmalik, David W. Boorman, Joseph Tracy, Jack Jallo, Fred Rincon
NEUROCRITICAL CARE
(2016)
Article
Clinical Neurology
Xiaoyan Sun, Chuanhui Dong, Bonnie Levin, Elizabeth Crocco, David Loewenstein, Henrik Zetterberg, Kaj Blennow, Clinton B. Wright
ALZHEIMERS & DEMENTIA
(2016)
Review
Medicine, General & Internal
Sebastian Sanchez, Fred Rincon
JOURNAL OF CLINICAL MEDICINE
(2016)
Article
Medicine, General & Internal
Mandip S. Dhamoon, Ying-Kuen Cheung, Yeseon Moon, Janet DeRosa, Ralph Sacco, Mitchell S. V. Elkind, Clinton B. Wright
Article
Multidisciplinary Sciences
Mandip S. Dhamoon, Ying-Kuen Cheung, Yeseon P. Moon, Clinton B. Wright, Ralph L. Sacco, Mitchell S. V. Elkind
Editorial Material
Clinical Neurology
Gregory Kuchcinski, Clinton B. Wright
Article
Peripheral Vascular Disease
Clinton B. Wright, Alexander P. Auchus, Alan Lerner, Walter T. Ambrosius, Hakan Ay, Jeffrey T. Bates, Jing Chen, James F. Meschia, Suchita Pancholi, Vasilios Papademetriou, Anjay Rastogi, Mary Sweeney, James J. Willard, Jerry Yee, Suzanne Oparil
Summary: The SPRINT study showed that there were no significant differences in the occurrence of strokes between the intensive blood pressure control and standard control groups. The study found similar numbers of stroke subtypes in both treatment arms, with the intensive treatment group having a lower target systolic blood pressure but no significant difference in stroke risk compared to the standard treatment group.
Editorial Material
Clinical Neurology
Francesca Bosetti, James Koenig, L. Scott Janis, Clinton B. Wright
Article
Clinical Neurology
Amol Mehta, Farid Khasiyev, Clinton B. Wright, Tatjana Rundek, Ralph L. Sacco, Mitchell S. Elkind, Jose Gutierrez
Summary: This study found an association between chronic infectious exposures, specifically herpes simplex virus 2 and cytomegalovirus, and asymptomatic intracranial large artery stenosis (ILAS) as seen on magnetic resonance angiogram imaging. This may represent an additional target for intervention in the ongoing effort to reduce the burden of stroke related to ILAS.
Article
Hematology
Victor J. Del Brutto, Farid Khasiyev, Setareh Salehi Omran, Meghan Purohit, Minghua Liu, Clinton B. Wright, Tatjana Rundek, Mitchell S. V. Elkind, Ralph L. Sacco, Jose Gutierrez
Summary: In this study of stroke-free participants, brain arterial elongation was not found to be associated with an increased risk of stroke or death. Furthermore, it did not influence the significant association between brain arterial dilation and vascular risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Dixon Yang, Minghua Liu, Joshua Z. Willey, Farid Khasiyev, Sarah E. Tom, Tatjana Rundek, Ying K. Cheung, Clinton B. Wright, Ralph L. Sacco, Mitchell S. Elkind, Jose Gutierrez
Summary: The study found that leisure time physical activity is related to extracranial carotid stenosis, but not intracranial arterial stenosis.
Editorial Material
Clinical Neurology
Clinton B. Wright, Francesca Bosetti, James I. Koenig, L. Scott Janis
Article
Immunology
Tatjana Rundek, Sabita Roy, Mady Hornig, Ying Kuen Cheung, Hannah Gardener, Janet Derosa, Bonnie Levin, Clinton B. Wright, Victor J. Del Brutto, Mitchell S. V. Elkind, Ralph L. Sacco
Summary: The study found that high levels of sCD14 were significantly associated with IL-1 pathway activation, while LPS was related to cognitive decline. These results support the hypothesis that gut microbiota dysbiosis may lead to cognitive decline.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)
Article
Clinical Neurology
J. Gutierrez, M. S. V. Elkind, C. Dong, M. Di Tullio, T. Rundek, R. L. Sacco, C. B. Wright
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)