Article
Geriatrics & Gerontology
Rismah Hairu, Jacqueline C. T. Close, Stephen R. Lord, Kim Delbaere, Wei Wen, Jiyang Jiang, Morag E. Taylor
Summary: In older people with dementia, baseline white matter hyperintensities (WMHs) volume is associated with decline in executive function, sensorimotor function, and mobility over one year. The association with executive function decline remained significant even after adjusting for age and hippocampal volume. Further research is needed to confirm these findings and explore potential vascular risk reduction strategies to improve cognitive and physical impairments in this population.
AGING & MENTAL HEALTH
(2022)
Article
Clinical Neurology
Sarah K. Royse, Beth E. Snitz, James B. Hengenius, Theodore J. Huppert, Rebecca E. Roush, Rebecca E. Ehrenkranz, James D. Wilson, Marnie Bertolet, Alexandria C. Reese, Geraldine Cisneros, Katey Potopenko, James T. Becker, Ann D. Cohen, C. Elizabeth Shaaban
Summary: This study suggests that white matter hyperintensities may contribute to clinical disparities in Alzheimer's disease between Black American and non-Hispanic White populations. By measuring unhealthy white matter connectivity, researchers found that the association between white matter hyperintensities in Alzheimer's disease pathology-affected regions and cognition differs between racialized groups, which may partially explain the higher clinical burden of Alzheimer's disease in Black American populations.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hualu Han, Zihan Ning, Dandan Yang, Miaoxin Yu, Huiyu Qiao, Shuo Chen, Zhensen Chen, Dongye Li, Runhua Zhang, Gaifen Liu, Xihai Zhao
Summary: This study investigated the association between cerebral blood flow (CBF) and the progression of white matter hyperintensity (WMH) in a community-based sample of asymptomatic adults over a 2-year follow-up. The results showed that baseline WMH volume was predictive of reduced perfusion, but WMH burden was not directly associated with baseline perfusion.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman
Summary: White matter hyperintensity volume is modestly positively associated with elevated amyloid in older adults without dementia, with a stronger association observed among Black participants. However, there was no association between white matter microstructure and elevated amyloid. These findings need to be further validated in larger, multiethnic cohorts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Neuroimaging
Zilin Li, Wenxiao Wang, Feng Sang, Zhanjun Zhang, Xin Li
Summary: Hypertension is a recognized risk factor for cognitive impairment and dementia, with white matter changes playing an important role. Hypertension can induce microstructural and macrostructural changes in white matter, affecting different cognitive domains and accelerating brain aging. As a modifiable risk factor, hypertension may offer a new perspective for alleviating and delaying cognitive impairment.
NEUROIMAGE-CLINICAL
(2023)
Article
Immunology
Mitchell S. Elkind, Michelle Moon, Tatjana Rundek, Clinton B. Wright, Ken Cheung, Ralph L. Sacco, Mady Hornig
Summary: This study aimed to investigate the impact of immune markers on cognitive function and found that immune markers are associated with cognitive function, with this association having comparable effects to traditional risk factors. Further research is needed to validate these findings and determine optimal treatment targets.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Clinical Neurology
Mykyta Smirnov, Christophe Destrieux, Igor Lima Maldonado
Summary: This review provides a structured presentation of the existing knowledge of the vascularization of the human cerebral white matter from seminal historical studies to the current literature, emphasizing the transition in conceptions of white matter vascularization and the need for further research on deep white matter vascularization, especially regarding the arterial supply of white matter fibre tracts.
Article
Public, Environmental & Occupational Health
Yi-Cheng Lin, Chih-Ping Chung, Pei-Lin Lee, Kun-Hsien Chou, Li-Hung Chang, Szu-Ying Lin, Yi-Jung Lee, Ching-Po Lin, Pei-Ning Wang
Summary: The coexistence of physical and cognitive impairments in older adults can predict incident disability, dementia, and mortality. This study investigated the natural course and prevalence of these impairments and found that skeletal muscle mass/function and memory function are crucial factors associated with the progression or reversal of functional impairments.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Yuanjing Li, Gregoria Kalpouzos, Lars Backman, Chengxuan Qiu, Erika J. Laukka
Summary: This study investigated the association between the load and accumulation of white matter hyperintensities (WMHs) and the rate of cognitive decline. The results showed that higher baseline loads of WMHs were associated with a faster decline in letter fluency, perceptual speed, and global cognition. Faster accumulation of WMHs was also related to accelerated cognitive decline, primarily in perceptual speed.
NEUROBIOLOGY OF AGING
(2023)
Article
Biochemistry & Molecular Biology
Jake R. Palmer, Chenyu Wang, Dexiao Kong, Marcela Cespedes, Jonathon Pye, Ian B. Hickie, Michael Barnett, Sharon L. Naismith
Summary: The study reveals a association between altered rest-activity rhythms and increased white matter lesion burden in older adults, with participants demonstrating altered rhythms showing a higher likelihood of high WML burden.
MOLECULAR PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Jingwen Jiang, Kanmin Yao, Xiaojun Huang, Yu Zhang, Fanxia Shen, Suiqing Weng
Summary: This study aimed to investigate the factors associated with changes in white matter hyperintensity (WMH) volume and cognitive decline in patients with minor stroke. Through a 2-year longitudinal observation of a group of patients, it was found that WMH volume changes were associated with the use of antihypertensive medications and the presence of lacunes at the initial visit. The progression of WMH volume was also found to be a significant risk factor for cognitive decline.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychiatry
Yu Meng Tian, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Tong Zhu, Kar Keung Cheng, Lin Xu
Summary: The study found that compared to never or occasional drinkers, moderate and excessive alcohol users experienced greater memory decline. This association did not vary by sex and age group.
Article
Psychology, Multidisciplinary
Rostislav Brichko, Anja Soldan, Yuxin Zhu, Mei-Cheng Wang, Andreia Faria, Marilyn Albert, Corinne Pettigrew
Summary: This study found that lifetime experiences are associated with white matter microstructure, and their relationship is influenced by participant age, APOE-ε4 genetic status, and level of vascular risk. Higher cognitive reserve (CR) composite scores are associated with lower RD values and higher FA values, but the relationship differs in different age groups.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Aaron Rothstein, Yian Zhang, Anthony Q. Briggs, Mark A. Bernard, Yongzhao Shao, Christopher Favilla, Kelly Sloane, Jens Witsch, Arjun V. Masurkar
Summary: In this study, the impact of white matter hyperintensities (WMH) on subjective cognitive decline (SCD) was investigated. The results showed that moderate-to-severe WMH was associated with worse cognitive performance and higher SCD burden in executive and memory domains.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Daniel J. Tozer, Robin B. Brown, Jessica Walsh, Young T. Hong, Guy B. Williams, John T. O'Brien, Franklin I. Aigbirhio, Tim D. Fryer, Hugh S. Markus
Summary: Recent studies have found evidence of increased microglial activation, indicating inflammation, in cerebral small vessel disease. However, it is unclear whether these areas of neuroinflammation progress to tissue damage. This study showed that white matter destined to become white matter hyperintensities already exhibited signs of altered inflammation at baseline.
Article
Cardiac & Cardiovascular Systems
Hannah Gardener, Tatjana Rundek, Clinton B. Wright, Yian Gu, Nikolaos Scarmeas, Shunichi Homma, Cesare Russo, Mitchell S. V. Elkind, Ralph L. Sacco, Marco R. Di Tullio
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Clinical Neurology
Dixon Yang, Sunil Iyer, Hannah Gardener, David Della-Morte, Milita Crisby, Chuanhui Dong, Ken Cheung, Consuelo Mora-McLaughlin, Clinton B. Wright, Mitchell S. Elkind, Ralph L. Sacco, Tatjana Rundek
CEREBROVASCULAR DISEASES
(2015)
Article
Peripheral Vascular Disease
Jose Gutierrez, Mitchell S. V. Elkind, Ken Cheung, Tatjana Rundek, Ralph L. Sacco, Clinton B. Wright
JOURNAL OF HYPERTENSION
(2015)
Article
Clinical Neurology
Xiaoyan Sun, Chuanhui Dong, Bonnie Levin, Elizabeth Crocco, David Loewenstein, Henrik Zetterberg, Kaj Blennow, Clinton B. Wright
ALZHEIMERS & DEMENTIA
(2016)
Article
Multidisciplinary Sciences
Mandip S. Dhamoon, Ying-Kuen Cheung, Yeseon P. Moon, Clinton B. Wright, Ralph L. Sacco, Mitchell S. V. Elkind
Editorial Material
Clinical Neurology
Gregory Kuchcinski, Clinton B. Wright
Article
Peripheral Vascular Disease
Clinton B. Wright, Alexander P. Auchus, Alan Lerner, Walter T. Ambrosius, Hakan Ay, Jeffrey T. Bates, Jing Chen, James F. Meschia, Suchita Pancholi, Vasilios Papademetriou, Anjay Rastogi, Mary Sweeney, James J. Willard, Jerry Yee, Suzanne Oparil
Summary: The SPRINT study showed that there were no significant differences in the occurrence of strokes between the intensive blood pressure control and standard control groups. The study found similar numbers of stroke subtypes in both treatment arms, with the intensive treatment group having a lower target systolic blood pressure but no significant difference in stroke risk compared to the standard treatment group.
Editorial Material
Clinical Neurology
Francesca Bosetti, James Koenig, L. Scott Janis, Clinton B. Wright
Article
Clinical Neurology
Amol Mehta, Farid Khasiyev, Clinton B. Wright, Tatjana Rundek, Ralph L. Sacco, Mitchell S. Elkind, Jose Gutierrez
Summary: This study found an association between chronic infectious exposures, specifically herpes simplex virus 2 and cytomegalovirus, and asymptomatic intracranial large artery stenosis (ILAS) as seen on magnetic resonance angiogram imaging. This may represent an additional target for intervention in the ongoing effort to reduce the burden of stroke related to ILAS.
Article
Hematology
Victor J. Del Brutto, Farid Khasiyev, Setareh Salehi Omran, Meghan Purohit, Minghua Liu, Clinton B. Wright, Tatjana Rundek, Mitchell S. V. Elkind, Ralph L. Sacco, Jose Gutierrez
Summary: In this study of stroke-free participants, brain arterial elongation was not found to be associated with an increased risk of stroke or death. Furthermore, it did not influence the significant association between brain arterial dilation and vascular risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Dixon Yang, Minghua Liu, Joshua Z. Willey, Farid Khasiyev, Sarah E. Tom, Tatjana Rundek, Ying K. Cheung, Clinton B. Wright, Ralph L. Sacco, Mitchell S. Elkind, Jose Gutierrez
Summary: The study found that leisure time physical activity is related to extracranial carotid stenosis, but not intracranial arterial stenosis.
Editorial Material
Clinical Neurology
Clinton B. Wright, Francesca Bosetti, James I. Koenig, L. Scott Janis
Article
Immunology
Tatjana Rundek, Sabita Roy, Mady Hornig, Ying Kuen Cheung, Hannah Gardener, Janet Derosa, Bonnie Levin, Clinton B. Wright, Victor J. Del Brutto, Mitchell S. V. Elkind, Ralph L. Sacco
Summary: The study found that high levels of sCD14 were significantly associated with IL-1 pathway activation, while LPS was related to cognitive decline. These results support the hypothesis that gut microbiota dysbiosis may lead to cognitive decline.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)
Article
Clinical Neurology
J. Gutierrez, M. S. V. Elkind, C. Dong, M. Di Tullio, T. Rundek, R. L. Sacco, C. B. Wright
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)