Editorial Material
Neurosciences
Xinyi Jenny He, Matthew R. Banghart
Summary: Mahn et al. and Copits et al. recently described how light-activated inhibitory GPCRs eOPN3 and PPO can reversibly suppress synaptic transmission in mice in a Neuron paper.
Article
Multidisciplinary Sciences
Mitsuharu Midorikawa, Mariko Miyata
Summary: This study revealed that in the maturation of neuronal circuits in the brain, necessary synapses enlarge the number of releasable vesicles and establish an experience-dependent coupling of calcium channels and fast-releasing synaptic vesicles, while the transmitter release mechanisms of synapses fated for elimination do not mature regardless of sensory experience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Shankar Ramachandran, Shelagh Rodgriguez, Mariana Potcoava, Simon Alford
Summary: This study investigates the number, subtypes, and locations of Ca2+ channels involved in neurotransmitter release at central synapses. By using single channel analysis and lattice light-sheet microscopy, the researchers discovered that a small pool of Ca2+ channels, comprising N-, P/Q-, and R-subtypes, are available to gate neurotransmitter release. They also found that as few as one channel may trigger neurotransmitter release. These findings provide important insights into the understanding of Ca2+ channel and synaptic dysfunction.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Minji Kang, DoEun Lee, Jae-man Song, Sunha Park, Da-ha Park, Sanghyeon Lee, Young Ho Suh
Summary: Neddylation plays a crucial role in the maturation and activity of nerve endings known as pre-synapses, with the specific receptor protein mGlu7 being identified as a target of neddylation. The process of neddylation is necessary for synaptic function, facilitating the clustering of mGlu7 in the presynaptic active zone and stabilizing protein expression.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Carolina Gomis Perez, Natasha R. Dudzinski, Mason Rouches, Ane Landajuela, Benjamin Machta, David Zenisek, Erdem Karatekin
Summary: Membrane tension gradients play a crucial role in cellular activities such as cell migration, division, phagocytosis, and exo-endocytosis. The speed at which membrane tension equilibrates can vary significantly depending on the cell type. Rapid synaptic vesicle turnover in neuronal terminals leads to quick membrane tension equilibration, while neuroendocrine adrenal chromaffin cells have slower recovery rates.
Article
Multidisciplinary Sciences
Abhijith Radhakrishnan, Xia Li, Kirill Grushin, Shyam S. Krishnakumar, Jun Liu, James E. Rothman
Summary: The controlled release of neurotransmitters stored in synaptic vesicles is essential for information processing in the brain, relying on the fusion of vesicles with presynaptic Ca2+ influx. Through cryoelectron tomography analysis, it was found that vesicles are initially tethered to the plasma membrane by protein densities under native conditions. During the process of priming for release, a highly cooperative framework is formed between the primed vesicles and the membrane, facilitating rapid neurotransmitter release following Ca2+ influx.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Beyenech Binotti, Momchil Ninov, Andreia P. Cepeda, Marcelo Ganzella, Ulf Matti, Dietmar Riedel, Henning Urlaub, Sivakumar Sambandan, Reinhard Jahn
Summary: The study shows that ATG9-containing vesicles are enriched in synapses and resemble synaptic vesicles in size and density. These vesicles represent a distinct population with limited overlap with synaptic vesicles and other membranes of the secretory pathway, revealing surprising heterogeneity in their membrane composition. ATG9-containing vesicles may function as lipid shuttles that scavenge membrane lipids from various intracellular membranes to support autophagosome biogenesis.
Article
Multidisciplinary Sciences
Rou-Gang Xie, Wen-Guang Chu, Da-Lu Liu, Xu Wang, Sui-Bin Ma, Fei Wang, Fu-Dong Wang, Zhen Lin, Wen-Bin Wu, Na Lu, Ying-Ying Liu, Wen-Juan Han, Hui Zhang, Zhan-Tao Bai, San-Jue Hu, Hui-Ren Tao, Thomas Kuner, Xu Zhang, Rohini Kuner, Sheng-Xi Wu, Ceng Luo
Summary: This study reveals the regulatory role of presynaptic NMDARs in spinal nociceptor terminals in pain transmission. It also uncovers the state-dependent modulation mechanism of presynaptic NMDARs on presynaptic plasticity and pain sensitivity.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Anna Pittaluga
Summary: This review summarizes the results from synaptosome studies over the past 40 years, supporting the existence of auto and hetero NMDA receptors controlling the release of transmitters in the CNS of mammals. Additionally, immunochemical studies in isolated nerve endings confirm these functional observations.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Rylie B. Walsh, Erica C. Dresselhaus, Agata N. Becalska, Matthew J. Zunitch, Cassandra R. Blanchette, Amy L. Scalera, Tania Lemos, So Min Lee, Julia Apiki, ShiYu Wang, Berith Isaac, Anna Yeh, Kate Koles, Avital A. Rodal
Summary: The loss of the endosomal retromer complex in Drosophila motor neurons leads to accumulation of cargoes in neuronal extracellular vesicles (EVs), while mutations in regulators of endosome-plasma membrane recycling such as rab11 and rab4 cause reduced EV cargo levels. The study suggests that EV traffic is influenced by a balance between Rab4/Rab11 recycling and retromer-dependent removal from EV precursor compartments, shedding light on competing pathways in Alzheimer's disease and the potential role of misregulated EV traffic as an underlying defect.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Neurosciences
Emily Church, Edaeni Hamid, Zack Zurawski, Mariana Potcoava, Eden Flores-Barrera, Adriana Caballero, Kuei Y. Tseng, Simon Alford
Summary: Presynaptic inhibition plays a crucial role in presynaptic terminals, with GABAB receptors inhibiting Ca2+ entry and 5-HT1B receptors targeting SNARE complexes. The colocalization of these receptors provides synaptic integration and allows for complex presynaptic integration.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Aline Delva, Koen Van Laere, Wim Vandenberghe
Summary: This study used PET imaging to longitudinally assess presynaptic terminal loss in early Parkinson's disease (PD). The results showed that F-18-FE-PE2I PET was able to detect a significant decline over 2 years in early PD, while C-11-UCB-J PET did not show any changes. However, the changes in F-18-FE-PE2I binding did not correlate with clinical motor progression.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Hannah R. Monday, Shivani C. Kharod, Young J. Yoon, Robert H. Singer, Pablo E. Castillo
Summary: Learning and memory rely on long-lasting, synapse-specific modifications. This study found that presynaptic FMRP and protein synthesis dynamically control presynaptic structure and function in the mature mammalian brain.
Article
Clinical Neurology
Hatice Kurucu, Marti Colom-Cadena, Caitlin Davies, Lewis Wilkins, Declan King, Jamie Rose, Makis Tzioras, Jane H. Tulloch, Colin Smith, Tara L. Spires-Jones
Summary: In Alzheimer's disease, loss of inhibitory neurons and synapses may contribute to disrupted excitatory/inhibitory balance and cognitive decline.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Miriam Garcia-Avila, Ximena Torres, Montserrat G. Cercos, Citlali Trueta
Summary: Mechanisms regulating electrical activity and secretion in serotonergic neurons vary at different compartments, with a chloride-mediated auto-inhibitory mechanism exclusively localized at presynaptic terminals. Serotonin released from peri-synaptic dense-core vesicles contributes to this auto-inhibition, highlighting the unique regulation mechanisms in nerve terminals compared to soma, expanding the potential functions of a single neuron in the nervous system.
Article
Biochemistry & Molecular Biology
Y. Akwa, E. Gondard, A. Mann, E. Capetillo-Zarate, E. Alberdi, C. Matute, S. Marty, T. Vaccari, A. M. Lozano, E. E. Baulieu, D. Tampellini
MOLECULAR PSYCHIATRY
(2018)
Article
Clinical Neurology
Alexandre Androuin, Brigitte Potier, U. Valentin Naegerl, Daniel Cattaert, Lydia Danglot, Manon Thierry, Ihsen Youssef, Antoine Triller, Charles Duyckaerts, Khalid Hamid El Hachimi, Patrick Dutar, Benoit Delatour, Serge Marty
ACTA NEUROPATHOLOGICA
(2018)
Article
Nanoscience & Nanotechnology
Omri Bar-Elli, Dan Steinitz, Gaoling Yang, Ron Tenne, Anastasia Ludwig, Yung Kuo, Antoine Triller, Shimon Weiss, Dan Oron
Article
Biochemistry & Molecular Biology
Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes-Hamon, Audrey Coens, Luc Buee, Philippe Hantraye, Antoine Triller, Ronald Melki
Review
Neurosciences
Amulya Nidhi Shrivastava, Antoine Triller, Ronald Melki
Article
Neurosciences
Farah Chali, Giampaolo Milior, Serge Marty, Melanie Morin-Brureau, Caroline Le Duigou, Etienne Savary, Corinne Blugeon, Laurent Jourdren, Richard Miles
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biophysics
Xianan Qin, Lei Liu, Sang Kwon Lee, Adolfo Alsina, Teng Liu, Chao Wu, Hojeong Park, Chenglong Yu, Hajin Kim, Jun Chu, Antoine Triller, Ben Zhong Tang, Changbong Hyeon, Chan Young Park, Hyokeun Park
BIOPHYSICAL JOURNAL
(2020)
Article
Anatomy & Morphology
John F. Wesseling, Sebastien Phan, Eric A. Bushong, Lea Siksou, Serge Marty, Isabel Perez-Otano, Mark Ellisman
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Clinical Neurology
P. Codron, F. Letournel, S. Marty, L. Renaud, A. Bodin, M. Duchesne, C. Verny, G. Lenaers, C. Duyckaerts, J-P Julien, J. Cassereau, A. Chevrollier
Summary: This study used STORM super-resolution imaging technique to analyze human brain tissue samples, successfully imaging pathological aggregates in the central nervous system of patients with neurodegenerative diseases, providing a more comprehensive understanding of common neurological disorders.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Clinical Neurology
David Wallon, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, Antoine Bonnevalle, Marie Sarazin, Michel Bottlaender, Mathieu Mula, Serge Marty, Natsuko Nakamura, Catherine Schramm, Francois Sellal, Therese Jonveaux, Camille Heitz, Isabelle Le Ber, Stephane Epelbaum, Eloi Magnin, Aline Zarea, Stephane Rousseau, Olivier Quenez, Didier Hannequin, Florence Clavaguera, Dominique Campion, Charles Duyckaerts, Gael Nicolas
Summary: Microduplications of the 17q21.31 chromosomal region containing the MAPT gene have been found in patients with a progressive disorder characterized by memory impairment, behavioral changes, and atypical extrapyramidal syndrome. Neuropathological examination shows Tau protein deposits with a spectrum of 3R- and 4R-tau aggregates.
ACTA NEUROPATHOLOGICA
(2021)
Article
Neurosciences
Alexandre Androuin, Manon Thierry, Susana Boluda, Asha Baskaran, Dominique Langui, Charles Duyckaerts, Marie-Claude Potier, Khalid Hamid El Hachimi, Benoit Delatour, Serge Marty
Summary: This study investigates the subcellular localization of Aβ fibrils in transgenic mouse models and human brain tissue of Alzheimer's disease (AD). Results show the accumulation of Aβ fibrils in intralysosomal lipofuscin granules in mice and undigested material in enlarged lipofuscin granules in human cortical biopsies. However, no intraneuronal accumulations of Aβ fibrils were detected in the examined samples.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Fumihiro Niwa, Angela Patrizio, Antoine Triller, Christian G. Specht
Article
Neurosciences
Nora Gruenewald, Audric Jan, Charlotte Salvatico, Vanessa Kress, Marianne Renner, Antoine Triller, Christian G. Specht, Guenter Schwarz
Article
Biophysics
Marianne Renner, Lili Wang, Sabine Levi, Laetitia Hennekinne, Antoine Triller
BIOPHYSICAL JOURNAL
(2017)