Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yang Zhang, Xiaofang Zhang, Benzhi Cai, Ying Li, Yuan Jiang, Xiaoyu Fu, Yue Zhao, Haiyu Gao, Ying Yang, Jiming Yang, Shangxuan Li, Hao Wu, Xuexin Jin, Genlong Xue, Jiqin Yang, Wenbo Ma, Qilong Han, Tao Tian, Yue Li, Baofeng Yang, Yanjie Lu, Zhenwei Pan
Summary: The study demonstrates that the long noncoding RNA lncRNA-CIRBIL is protective against ischemia-reperfusion injury by inhibiting the nuclear translocation of Bclaf1, indicating their potential as therapeutic targets for ischemic cardiac disease.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Simon P. Preston, Cody C. Allison, Jan Schaefer, William Clow, Stefanie M. Bader, Sophie Collard, Wasan O. Forsyth, Michelle P. Clark, Alexandra L. Garnham, Connie S. N. Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini
Summary: This study investigated the role of RIPK3 and MLKL in chronic LCMV infection and found that during the acute and early stages of infection, MLKL and RIPK3 did not affect the immune response and viral clearance. However, RIPK3 was found to promote immune dysfunction and prevent control of infection at later stages of chronic LCMV disease.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hong Hu, Xialian Wu, Guoxiang Wu, Ning Nan, Jing Zhang, Xinxin Zhu, Yu Zhang, Zhaoqian Shu, Jia Liu, Xiaoyan Liu, Junxia Lu, Huayi Wang
Summary: This study demonstrates the critical role of RIP3 amyloid formation in Necroptosis signaling, while the interaction with M45 also plays a regulatory role in cell death. The ordered inter-filament assembly of RIP3 is crucial in RIP3 amyloid-mediated kinase activation and cell necroptosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Lingmei Jin, Jiangping He, Huijian Feng, Sa Li, He Liu, Hongzhi Dong, MingLi Hu, Junju Huang, Haoyu Wu, Jiekai Chen, Ling Qi, Kaixin Wu
Summary: Deficiency of the histone H3K9 methyltransferase SETDB1 induces RIPK3-dependent necroptosis in mouse embryonic stem cells (mESCs). Reactivation of transposable elements (TEs) upon SETDB1 knockout is responsible for RIPK3 regulation through both cis and trans mechanisms. IAPLTR2_Mm and MMERVK10c-int, suppressed by SETDB1-dependent H3K9me3, act as enhancer-like cis-regulatory elements and their RIPK3 nearby members enhance RIPK3 expression when SETDB1 is knockout. Moreover, reactivated endogenous retroviruses generate excessive viral mimicry, promoting necroptosis mainly through Z-DNA-binding protein 1 (ZBP1). These results indicate the importance of TEs in regulating necroptosis.
CELL DEATH & DISEASE
(2023)
Review
Immunology
Mario Riera Romo
Summary: Regulated or programmed cell death is crucial for development, tissue organization, and immunity. Advancements in cellular and molecular research have expanded the understanding of various cell death modalities and their biochemical programs. Recent evidence points to the interconnectedness of cell death pathways and their roles in immune mechanisms.
Review
Cell Biology
Liuhua Zhou, Jiateng Sun, Lingfeng Gu, Sibo Wang, Tongtong Yang, Tianwen Wei, Tiankai Shan, Hao Wang, Liansheng Wang
Summary: Abnormalities in programmed cell death signaling cascades play a crucial role in the development and progression of cardiovascular diseases, leading to excessive cardiac remodeling and heart failure. Timely activation of cell death pathways post-injury can help in repairing cardiac structure and function. Drugs targeting key players in cell death signaling pathways may hold potential for future therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Simon Verdonck, Josephine Nemegeer, Peter Vandenabeele, Jonathan Maelfait
Summary: Cell death, including necroptosis and pyroptosis, is an important part of the antiviral immune response, eliminating virus-infected cells and promoting immune development through the release of inflammatory mediators. Viruses employ evasion mechanisms to suppress these cell death pathways and antagonize host immunity.
TRENDS IN MICROBIOLOGY
(2022)
Review
Chemistry, Physical
Qi Meng, Binbin Ding, Ping'an Ma, Jun Lin
Summary: Programmed cell death (PCD) and immunogenic cell death (ICD) are important mechanisms in cancer therapy, and understanding their relationship is significant for tumor treatments. This review describes the interrelationship between PCD and ICD using nanomedicines as examples. It provides an overview of PCD patterns, explores the link between apoptosis and ICD, introduces non-apoptotic signaling pathways and their relationship with ICD, and summarizes the potential application of PCD and ICD in the development of new nanomaterials. The review aims to deepen understanding, extend biomedical applications, and promote progress in clinical tumor therapy.
Review
Cell Biology
Yasunobu Okada, Ravshan Z. Sabirov, Kaori Sato-Numata, Tomohiro Numata
Summary: Cell volume regulation is crucial for animal cell survival and functions, with normotonic shrinkage and swelling linked to apoptotic and necrotic cell death. Various ion channels, including VSOR/VRAC, play roles in cell death induction and protection. This review focuses on the molecular properties of VSOR/VRAC and its involvement in cell volume dysregulation and cell death pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Emma C. Tovey Crutchfield, Sarah E. Garnish, Joanne M. Hildebrand
Summary: Necroptosis is an inflammatory form of cell death evolved to defend against pathogens. Small molecules targeting RIPK1 kinase activity have shown promise in disease models, triggering significant investment in necroptosis blocking drugs. Understanding the role of MLKL in murine disease models is crucial for identifying human indications for targeted drug therapies.
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Imran Khan, Abdelrahman Yousif, Mikhail Chesnokov, Linda Hong, IIana Chefetz
Summary: Programmed cell death (PCD) has been a major research interest in the past three decades. Initially, apoptosis was considered the only mechanistic pathway for PCD, but now other important pathways such as necroptosis have been discovered, which are crucial for understanding the cellular processes behind different pathological conditions. Additionally, research on triggering necroptosis in cancer cells to induce cell death and overcome chemoresistance is being discussed.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cell Biology
Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury, Michael J. Whalen
Summary: Traumatic brain injury is a major cause of death and disability, and the role of RIPK3 in the pathogenesis and functional outcomes of TBI has been demonstrated. The activation of RIPK3 contributes to inflammation and affects postinjury motor and cognitive deficits, independent of necroptosis.
CELL DEATH & DISEASE
(2021)