Article
Biochemistry & Molecular Biology
Evgeniya V. Pushchina, Anatoly A. Varaksin, Dmitry K. Obukhov
Summary: In this study, the distribution of different cell types and molecular markers in the brain of rainbow trout was investigated. Radial glial cells and neural stem cells were found in the telencephalon and tectum, indicating their importance in adult neurogenesis in rainbow trout.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sheng-Jun Wen, Xi-Min Zheng, Li-Fen Liu, Na-Na Li, Hai-An Mao, Liang Huang, Qiong-Lan Yuan
Summary: This study found that microglia were conducive to neurosphere formation, while astrocytes and mixed glial cells were conducive to neurosphere differentiation. Co-transplantation of neural stem cells and astrocytes showed better improvement of neurological deficits in rat models of ischemic stroke compared to neural stem cell only transplantation.
NEURAL REGENERATION RESEARCH
(2021)
Review
Physiology
Chia-Yu Yeh, Kuan-Yu Wu, Guo-Jen Huang, Alexei Verkhratsky
Summary: Adult neurogenesis is an important process that contributes to adaptive network remodelling in the brain. This review focuses on the cellular characteristics and roles of radial astrocytes (RSA) and parenchymal astrocytes in adult neurogenesis in different brain regions. The potential therapeutic applications of RSA and astrocytes in cell replacement and regeneration strategies are also discussed.
Article
Biochemistry & Molecular Biology
Julia Schneider, Johannes Weigel, Marie-Theres Wittmann, Pavel Svehla, Sebastian Ehrt, Fang Zheng, Tarek Elmzzahi, Julian Karpf, Lucia Paniagua-Herranz, Onur Basak, Arif Ekici, Andre Reis, Christian Alzheimer, Felipe Ortega de la O, Sabine Liebscher, Ruth Beckervordersandforth
Summary: Astrocytes play a vital role in the development and function of the central nervous system. This study comprehensively assessed the generation and proliferation of astrocytes in the mouse dentate gyrus throughout the lifespan, revealing their plasticity in response to environmental and behavioral stimuli.
Article
Biochemistry & Molecular Biology
Younghee Seo, Sangheon Han, Byeong-Wook Song, Jin Woo Chang, Young Cheol Na, Won Seok Chang
Summary: This study investigated the activation of eNSCs and adult neurogenesis after low-intensity focused ultrasound (LIFUS) treatment, and found that LIFUS could activate eNSCs and promote the generation of adult neurons, suggesting its potential as a treatment for neurological damage and disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Hailiang Tang, Yao Li, Weijun Tang, Jianhong Zhu, Graham C. Parker, John H. Zhang
Summary: Ischemic stroke is a common cerebrovascular accident that occurs in adults and increases the risk of neural deficits. Stem cell therapy is currently the most promising approach for inducing neurogenesis and repairing neural damage after ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Cell Biology
Shuzo Matsubara, Taito Matsuda, Kinichi Nakashima
Summary: Tissue-specific stem cells generate new functional cells to maintain tissue homeostasis and repair damaged tissue. Neurogenesis of endogenous NSCs alone is insufficient for complete brain repair, leading to exploration of direct reprogramming as an innovative approach. This review discusses the control of NSCs and neurogenesis in the adult brain, as well as the potential of direct neuronal reprogramming for future clinical applications.
Article
Neurosciences
Priya Prakash, Hediye Erdjument-Bromage, Michael R. O'Dea, Christy N. Munson, David Labib, Valentina Fossati, Thomas A. Neubert, Shane A. Liddelow
Summary: This study identifies a reactive astrocyte sub-state called interferon-responsive reactive astrocytes (IRRAs) and characterizes their proteomic changes. The researchers found that IRRAs have distinct features from neurotoxic reactive astrocytes (NRAs), including unique protein expressions. This study lays the foundation for future investigations of the functional roles of IRRAs in neurodegenerative disorders.
Article
Cell & Tissue Engineering
Hong Fan, Jialei Yang, Kun Zhang, Junling Xing, Baolin Guo, Honghui Mao, Wenting Wang, Yingzhou Hu, Wei Lin, Ying Huang, Jian Ding, Caiyong Yu, Fanfan Fu, Li Sun, Jing Wu, Youyi Zhao, Wenbin Deng, Chengji Zhou, Mengsheng Qiu, Shengxi Wu, Yu-Qiang Ding, Yazhou Wang
Summary: Reactive astrogliosis is enhanced by the activation of Wnt signaling and dedifferentiation of astrocytes following ischemic injury. Apoptotic neurons up-regulate Wnt2 protein via internal ribosome entry site (IRES)-mediated translation, leading to the activation of Wnt signaling and astrocyte dedifferentiation. This apoptosis-initiated Wnt-activating mechanism promotes neuronal regeneration.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiaoyu Wei, Sulei Fu, Hanbo Li, Yang Liu, Shuai Wang, Weimin Feng, Yunzhi Yang, Xiawei Liu, Yan-Yun Zeng, Mengnan Cheng, Yiwei Lai, Xiaojie Qiu, Liang Wu, Nannan Zhang, Yujia Jiang, Jiangshan Xu, Xiaoshan Su, Cheng Peng, Lei Han, Wilson Pak-Kin Lou, Chuanyu Liu, Yue Yuan, Kailong Ma, Tao Yang, Xiangyu Pan, Shang Gao, Ao Chen, Miguel A. Esteban, Huanming Yang, Jian Wang, Guangyi Fan, Longqi Liu, Liang Chen, Xun Xu, Ji-Feng Fei, Ying Gu
Summary: This study used Stereo-seq technology to analyze spatial distribution and molecular features of axolotl brain during development and regeneration. The researchers identified an injury-induced ependymoglial cell cluster as a potential progenitor cell population for replenishing lost neurons. They also discovered regressed neurons and provided evidence for the involvement of resident ependymoglial cells in neurogenesis.
Article
Multidisciplinary Sciences
Yueyang Liu, Jingyu Yang, Xiaohang Che, Jianhua Huang, Xianyang Zhang, Xiaoxiao Fu, Jialing Cai, Yang Yao, Haotian Zhang, Ruiping Cai, Xiaomin Su, Qian Xu, Fu Ren, Renzhi Cai, Andrew Schally, Ming-Sheng Zhou
Summary: The GHRH agonist MR-409 has remarkable neuroprotective effects in ischemic stroke mice by enhancing endogenous neurogenesis. It reduces mortality, ischemic insult, and hippocampal atrophy while improving neurological functional recovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Materials Science, Multidisciplinary
Hongfei Ge, Quan Hu, Tunan Chen, Yang Yang, Chao Zhang, Jun Zhong, Yi Yin, Xuheng Jiang, Xin Zhou, Shuhong Wang, Rong Hu, Wenyan Li, Hua Feng
Summary: A feasible method for modifying grafted neural stem cells (NSCs) using layer-by-layer (LbL) assembly has been developed, which enhances their regenerative ability and survival rate, showing potential application in the treatment of ischemic stroke.
APPLIED MATERIALS TODAY
(2022)
Article
Biochemistry & Molecular Biology
Hakan Kayir, Bryan W. Jenkins, Begum Alural, Jibran Y. Khokhar
Summary: The study found that clozapine enhanced hippocampal Nestin concentration in a schizophrenia model, while MK-801 did not affect Nestin concentration. MK-801 induced schizophrenia-like PPI disruptions, some of which were reversed by clozapine, but social interaction deficits were not detected in the model. Future studies will explore the impact of neurodevelopmental Nestin concentration on symptom onset and antipsychotic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Michael R. Williamson, Stephanie P. Le, Ronald L. Franzen, Nicole A. Donlan, Jill L. Rosow, Mathilda S. Nicot-Cartsonis, Alexis Cervantes, Benjamin Deneen, Andrew K. Dunn, Theresa A. Jones, Michael R. Drew
Summary: This study reveals that cells migrating from the subventricular zone after stroke promote brain repair and functional recovery in mice.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ming Hou, Suji Wang, Dandan Yu, Xinyi Lu, Xiansen Zhao, Zhangpeng Chen, Chao Yan
Summary: Chronic stress hinders neural stem cell differentiation and hippocampal neurogenesis, while CBD administration can alleviate depressive symptoms and modulate neural differentiation and AHN through signaling pathway modulation.
FRONTIERS OF MEDICINE
(2022)
Article
Clinical Neurology
Meei-Ling Sheu, Chiung-Chyi Shen, Hsi-Kai Tsou, Meng Yin Yang, Hong-Lin Su, Jason Sheehan, Ming-Hong Chang, Hong-Shiu Chen, Hung-Chuan Pan
Summary: This study aimed to investigate the outcomes of administering isolated mitochondria into denervated muscle after nerve injury. Results showed that local infusion of mitochondria can successfully prevent denervated muscle atrophy and augment nerve regeneration by reducing oxidative stress in denervated muscle.
Article
Biochemistry & Molecular Biology
Huey-Shan Hung, Kai-Bo Chang, Cheng-Ming Tang, Tian-Ren Ku, Mei-Lang Kung, Alex Yang-Hao Yu, Chiung-Chyi Shen, Yi-Chin Yang, Hsien-Hsu Hsieh, Shan-hui Hsu
Summary: A novel nanocomposite composed of fibronectin and silver nanoparticles was developed, with 30.2 ppm silver nanoparticles showing the best biocompatibility and anti-inflammatory response. This nanocomposite may facilitate MSC migration and proliferation, induce endothelial cell differentiation, and attenuate immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Chih-Wei Huang, Meng-Yin Yang, Wen-Yu Cheng, Szu-Yen Pan, Chia-Lin Wang, Wei-Yi Lai, Tzu-Wei Lin, Szu-Yuan Liu, Yu-Fen Huang, Chin-Ming Lai, Chiung-Chyi Shen
Summary: This study aimed to identify the predictive and prognostic factors of microvascular decompression (MVD) surgery for trigeminal neuralgia (TN). The study found that atypical TN and severe venous compression were associated with poor outcomes. The preoperative BNI score could serve as an effective predictive tool for the outcome of MVD surgery.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Cell Biology
I-Lun Hsin, Huang-Pin Shen, Hui-Yi Chang, Jiunn-Liang Ko, Po-Hui Wang
Summary: The study revealed a novel mechanism of the PI3K/mTOR dual inhibitor, PQR309, in lowering cell viability in endometrial cancer cells by disrupting the PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop.
Article
Pediatrics
Jih-Chin Chang, Jeng-Yuan Chiou, Jiunn-Liang Ko, Jing-Yang Huang, Ko-Huang Lue
Summary: Bronchiolitis in children under one year of age has predictive value for the development of preschool asthma, especially in children with bronchiolitis hospitalizations.
Article
Environmental Sciences
Yuan-Ting Yang, Chung-Hao Hsu, Yu-Fen Wang, Yu-Jun Chang, Hui-Ju Yang, Jiunn-Liang Ko, Kuo-Chia Yang
Summary: This study investigated the quality of life (QoL) and factors influencing QoL in Taiwanese vitiligo patients. The results showed no significant difference in QoL between vitiligo patients and controls. Among vitiligo patients, adults, married females, those with higher education, shorter disease history, and generalized type of vitiligo experienced poorer QoL. This highlights the importance of tailored psychological counseling and treatment for vitiligo patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Surgery
Mao-Shih Lin, Chung-Hsin Lee, Se-Yi Chen, Chiung-Chyi Shen
Summary: This case report presents an intracranial collision tumor composed of atypical meningioma and glioblastoma. The mechanism behind collision brain tumors remains unclear, and one-stage surgical treatment seems feasible.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Article
Geriatrics & Gerontology
Shuo-Chun Weng, Chiann-Yi Hsu, Chiung-Chyi Shen, Jin-An Huang, Po-Lin Chen, Shih-Yi Lin
Summary: This study investigated stroke patients in a post-acute care network in central Taiwan and found that improvements in physical and cognitive functions were significantly associated with reduced hospital readmission and lower mortality. The combination of multiple assessment parameters better predicted clinical outcomes, providing valuable rehabilitation information for acute stroke patients receiving post-acute care.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Huey-Shan Hung, Yi-Chin Yang, Chih-Hsuan Chang, Kai-Bo Chang, Chiung-Chyi Shen, Chien-Lun Tang, Szu-Yuan Liu, Chung-Hsin Lee, Chun-Ming Yen, Meng-Yin Yang
Summary: The study demonstrates that the composite material of chitosan and gold nanoparticles can enhance the neural differentiation of mesenchymal stem cells and has the potential as a biosafe nanomaterial for neural tissue engineering.
Article
Biology
Chiung-Chyi Shen, Yuang-Seng Tsuei, Meng-Yin Yang, Weir-Chiang You, Ming-His Sun, Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Hung-Chuan Pan
Summary: This study evaluated the ophthalmological outcomes and complications of gamma knife radiosurgery (GKRS) in treating carotid cavernous sinus fistula. The results showed that GKRS can effectively obliterate the fistula and preserve the cavernous sinus vascular structure. However, there may be some complications during the treatment, such as residual chemosis, cataract, and cranial nerve palsy.
Article
Surgery
Chun -Pi Chang, Cheng-Siu Chang, Meng-Yin Yang, Chiung-Chyi Shen
Summary: This case report presents a rare case of a meningioma of Meckel's cave with a typical dumbbell-shaped, schwannoma-like presentation on MRI, leading to a misleading differential diagnosis. The authors discuss the characteristics observed on MRI and their surgical approach to this condition.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Correction
Chemistry, Physical
Kai-Bo Chang, Chiung-Chyi Shen, Shan-hui Hsu, Chang Ming Tang, Yi-Chin Yang, Sin-Ying Liu, Tian Ren Ku, Mei-Lang Kung, Hsien-Hsu Hsieh, Huey-Shan Hung
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Surgery
Chia-Fang Shen, Szu-Yuan Liu, Chung-Hsin Lee, Szu-Yen Pan, Chiung-Chyi Shen
Summary: Pituicytomas are low-grade glial tumors in the sellar and suprasellar region that can be easily confused with non-functional pituitary adenomas. Gross total resection through surgery is the best chance of successful treatment.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Letter
Surgery
Cheng-Ying Lee, Mao-Shih Lin, Chien-Lun Tang, Chiung-Chyi Shen
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Chien-Lun Tang, Chiung-Chyi Shen
Summary: Vertebral osteomyelitis is a rare condition that poses challenges to surgeons, with most cases successfully treated by conservative methods but surgical intervention necessary in cases with neurological deficits, spinal deformities, or instability.
FORMOSAN JOURNAL OF SURGERY
(2021)