Review
Pharmacology & Pharmacy
Mayank Handa, Obaid Afzal, Sarwar Beg, Sachin Nashik Sanap, Ravinder K. Kaundal, Rahul K. Verma, Awanish Mishra, Rahul Shukla
Summary: Tailoring drug products to personalized medicines is challenging due to limited availability of flexible dosage strengths in the market. Inappropriate dosage strengths can lead to adverse reactions or compromised therapeutic effects, especially for drugs with narrow therapeutic windows. To overcome these challenges, data-enriched edible pharmaceuticals (DEEP) are novel concepts for designing solid oral products.
DRUG DISCOVERY TODAY
(2023)
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Mohamed Haider, Amr Elsherbeny, Valeria Pittala, Valeria Consoli, Maha Ali Alghamdi, Zahid Hussain, Ghalia Khoder, Khaled Greish
Summary: Lung cancer is a major cause of cancer occurrence and mortality worldwide. Drug resistance is a complex process in lung cancer, and nanomedicine provides promising tools for reversing resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Wang, Zhiyang Cheng, Biyu Yang, Jiahui Yu, Yi Chen, Wei Lu
Summary: The novel Mal-glu-SN38 prodrug showed selective delivery of SN38 to tumour sites and enhanced efficacy. With slower plasma clearance, increased drug exposure over time, and enhanced accumulation at the tumour site, Mal-glu-SN38 significantly delayed tumour growth after multiple doses, leading to an impressive reduction or even disappearance of tumours without observable side effects in 67% of mice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Biomaterials
Jean Felix Mukerabigwi, Yu Han, Nannan Lu, Wendong Ke, Yuheng Wang, Qinghao Zhou, Fathelrahman Mohammed, Alhadi Ibrahim, Bin Zheng, Zhishen Ge
Summary: Novel strategy utilizing vesicular nanoreactors for simultaneous cisplatin delivery and H2O2 generation can overcome drug resistance in lung cancer cells, enhancing therapeutic efficacy without obvious toxic side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Review
Biochemistry & Molecular Biology
Giovanni Tossetta
Summary: Ovarian cancer is a highly dangerous gynecologic cancer with a high fatality rate and recurrence. Chemoresistance greatly reduces the effectiveness of paclitaxel and platinum-based drugs used for treatment. Metformin, commonly used for diabetes and fatty liver disease, shows anti-tumor activity and reduces cancer risk and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuqiang Li, Yitong Jiang, Ziyan Zheng, Nan Du, Shuli Guan, Wenxuan Guo, Xiaohu Tang, Jiajunzi Cui, Lanqiong Zhang, Kunpeng Liu, Qingsong Yu, Zhihua Gan
Summary: The limited availability of anticancer drugs and drug resistance have made monotherapy-based cancer therapy challenging. Combination therapy using currently available drugs is a potential alternative, but the barrier between in vitro screening and in vivo delivery hinders its application. This study proposes a precise drug delivery strategy using engineered nanomedicine to overcome this limitation and facilitate individualized combination therapy.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Kazem Nejati, Mojgan Rastegar, Farzaneh Fathi, Mehdi Dadashpour, AmirAhmad Arabzadeh
Summary: Gastric cancer is a life-threatening disease caused by deregulated cell growth in the stomach. Multi-drug resistance in gastric cancer cells is a major challenge in chemotherapy. Nano-DDSs have emerged as a promising approach to reverse multi-drug resistance and enhance the pharmacological profile of chemotherapy drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zerrin Sezgin-Bayindir, Sonia Losada-Barreiro, Carlos Bravo-Diaz, Matej Sova, Julijana Kristl, Luciano Saso
Summary: The limitations of traditional anticancer drugs have led to the discovery of new therapeutic agents and potential drug delivery systems. Nano-sized drug delivery systems offer deep tissue penetration and specific drug targeting for effective cancer treatment. Furthermore, NRF2-based anticancer treatment approaches have garnered significant attention, but the lack of effective formulation strategies hinders their clinical application.
Article
Chemistry, Multidisciplinary
Jia Heng Teoh, Sook Muay Tay, Jerry Fuh, Chi-Hwa Wang
Summary: This study investigates the application of 3D printing to fabricate hydrogel wound dressings with customizable architectures and drug dosages. Results show that 3D printing has the ability to customize drug dosages and drug release rates through co-loading different drugs at various positions and varying the thickness of drug-free layers over drug-loaded layers in the wound dressing.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Rouba D. Al Bostami, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Cancer therapies have made significant advancements in the past decade, but there are still barriers to their success. Nanomedicines that deliver multiple drugs and genes simultaneously have shown improved effectiveness and synergistic effects. However, the development of co-delivery systems faces limitations and challenges and requires a better understanding of the therapeutic agent ratio and heterogeneity of cancer cells.
Review
Biochemistry & Molecular Biology
Belen Reig-Vano, Bartosz Tylkowski, Xavier Montane, Marta Giamberini
Summary: Alginate is considered a potential vehicle for therapeutic factors encapsulation, with its unique ability to form hydrogels that resemble natural soft tissues. This innovative approach can address systemic toxicity and tumor resistance caused by traditional therapies, while increasing the bioavailability of encapsulated compounds. Alginate-based systems show great promise in the field of cancer therapy and research, with applications in delivery systems, cell culture scaffolds, and tumor biomarkers immunosensing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Chih-Peng Lin, Shu-Hui Wu, Tzu-Yin Lin, Chia-Hui Chu, Leu-Wei Lo, Ching-Chuan Kuo, Jang-Yang Chang, Szu-Chun Hsu, Bor-Sheng Ko, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Dong-Ming Huang
Summary: This study develops a simple and versatile biological drug delivery system (bDDS) based on human red blood cell-derived vesicles (RDVs), which shows excellent biocompatibility for cancer chemotherapy. The bDDS, named Dox-gluRDVs, effectively suppress multidrug resistance in uterine sarcoma by inducing cell death through a lysosomal-mitochondrial axis-dependent mechanism.
PHARMACOLOGICAL RESEARCH
(2023)
