期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 605, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120788
关键词
Drug delivery; Platinum Cancer; Nanoparticles
资金
- Argentine grant from the Universidad Nacional de La Plata [14/X041, 14/X701]
- Argentine grant from Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2016-1574, PICT2016-4596, PICT2017-0359, PICT 2019-02322]
- Argentine grant from CONICET [PIP 0340]
Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
The three main FDA-approved platinum drugs in chemotherapy such as carboplatin, cisplatin, and oxaliplatin are extensively applied in cancer treatments. Although the clinical applications of platinum-based drugs are extremely effective, their toxicity profile restricts their extensive application. Therefore, recent studies focus on developing new platinum drug formulations, expanding the therapeutic aspect. In this sense, recent advances in the development of novel drug delivery carriers will help with the increase of drug stability and biodisponibility, concomitantly with the reduction of drug efflux and undesirable secondary toxic effects of platinum compounds. The present review describes the state of the art of platinum drugs with their biological effects, pre- and clinical studies, and novel drug delivery nanodevices based on lipids, polymers, and inorganic.
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