Article
Food Science & Technology
Weixin Wang, Shengmin Sang
Summary: This study investigates the metabolism of p-coumaroylagmatine (pCAA) in mice and by human gut microbiota, and measures the concentrations of its main metabolites. The results show that pCAA is metabolized through four different pathways, generating nine major metabolites. Furthermore, there are interindividual differences in the formation of dihydro-pCAA in human in vitro intestinal microbial conversion. Additionally, significant amounts of pCAA are detected in mice, making it a potential exposure biomarker for whole grain barley intake.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Agriculture, Multidisciplinary
Janeth Sanabria, Siobhon Egan, Reika Masuda, Alex J. Lee, Glenn R. Gibson, Jeremy K. Nicholson, Julien Wist, Elaine Holmes
Summary: The evolution of complex in vitro models of the human gastrointestinal system has enhanced our understanding of the role of the gut microbiome in human physiology and pathology. A cross-field bibliometric search and mapping of human gastrointestinal in vitro research has been conducted to better understand the capabilities of bioreactors and the development in this field.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Jungen Tang, Xin Zhou, Xuefen Wu, Shengyan Lin, Bingxia Ming, Jixin Zhong, Baoju Wang, Lingli Dong
Summary: Systemic sclerosis (SSc) is an immune-mediated systemic autoimmune disease with high morbidity and mortality. Establishing appropriate animal models to explore the role of gut microbiota in the pathogenesis of SSc is essential. Through 16S rRNA gene sequencing, similar gut microbiota aberration was found in SSc patients and BLM-induced mice, providing a potential platform for studying gut microbiota aberration in SSc patients and developing disease-modifying treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Food Science & Technology
Kunal Pratap, Marwan E. Majzoub, Aya C. Taki, Socorro Miranda Hernandez, Marie Magnusson, Christopher R. K. Glasson, Rocky de Nys, Torsten Thomas, Andreas L. Lopata, Sandip D. Kamath
Summary: The intestinal microbial community is crucial for gut health, and dietary components like algal polysaccharides and carotenoids can modulate its structure. This study found that ulvan and astaxanthin can promote significant changes in the gut microbiota of mice, highlighting their potential to improve gut health conditions.
Article
Biochemistry & Molecular Biology
Laura Moles, Ander Egimendia, Inaki Osorio-Querejeta, Leire Iparraguirre, Ainhoa Alberro, Jose Suarez, Lucia Sepulveda, Tamara Castillo-Trivino, Maider Munoz-Culla, Pedro Ramos-Cabrer, David Otaegui
Summary: This study characterized microbial changes in murine demyelinating models and found correlations with disease progression, resembling characteristics of dysbiosis in multiple sclerosis (MS) patients. The findings provide insights into the interplay between microbiota and demyelination processes, highlighting the potential for modulating microbiota as a therapeutic strategy for MS.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Peripheral Vascular Disease
Ryohei Shinohara, Hitomi Nakashima, Takuo Emoto, Tomoya Yamashita, Yoshihiro Saito, Naofumi Yoshida, Taishi Inoue, Katsuhiro Yamanaka, Kenji Okada, Ken-ichi Hirata
Summary: This study found that the gut microbiota plays a critical role in the development of abdominal aortic aneurysm (AAA), and inhibiting the microbiota could be a therapeutic approach for AAA.
Review
Biotechnology & Applied Microbiology
Namiko Hoshi, Jun Inoue, Daisuke Sasaki, Kengo Sasaki
Summary: The human gut microbiome plays a crucial role in metabolic, physiological, and immunological functions, with dysbiosis potentially leading to gastrointestinal and extra-intestinal disorders. The newly developed KUHIMM serves as an in vitro model capable of hosting human gut microbial species and detecting metabolites in real time, allowing for analysis of interventions like diet, drugs, probiotics, and prebiotics on intestinal bacteria, as well as applications in disease models such as ulcerative colitis and precision medicine.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Oncology
Yanshan Ge, Xinhui Wang, Yali Guo, Junting Yan, Aliya Abuduwaili, Kasimujiang Aximujiang, Jie Yan, Minghua Wu
Summary: Recent scientific advances have shown the complex relationship between the gut microbiome and cancer. Changes in gut microbiota composition can lead to immune dysregulation, promoting chronic inflammation and tumor development. Gut microorganisms and their metabolites can affect inflammation and tumorigenesis in specific organs through various axes of interaction.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Food Science & Technology
Yuxiao Liao, Zhao Peng, Shiyin Xu, Zitong Meng, Dan Li, Xiaolei Zhou, Rui Zhang, Shaojun Shi, Liping Hao, Liegang Liu, Wei Yang
Summary: This study investigates whether deoxynivalenol (DON) can induce intestinal damage through gut microbiota in mice. The results show that DON exposure causes colon tissue damage, disruption of tight junction protein expression, increased oxidative stress and apoptosis in mice. DON exposure also alters the composition and diversity of the gut microbiota as well as the contents of fecal metabolites. Only a decrease in specific gene expression levels in the colon is observed after fecal microbiota transplantation. Additionally, depleting the gut microbiota in mice also results in histological damage and disrupted tight junction protein expression in the colon after DON exposure.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhang
Summary: The therapeutic effect of Clostridium butyricum (CB) on ICV-STZ-induced mice was investigated in this study. The results showed that CB improved cognitive dysfunction, restored neuron structure, and regulated TLR4 signaling pathway and intestinal microbiota. This study supports the potential anti-AD effect of CB and provides a theoretical basis for further clinical application.
Article
Immunology
Jiuxi Liu, Jiapei Cai, Naisheng Zhang, Jiandong Tai, Peng Fan, Xue Dong, Yongguo Cao
Summary: Salidroside, a plant compound, can ameliorate high-fat diet-induced obesity by modulating gut microbiota. It reduces body weight and fat accumulation, decreases liver inflammation and metabolic endotoxemia, and repairs intestinal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Chiara Tarracchini, Federico Fontana, Leonardo Mancabelli, Gabriele Andrea Lugli, Giulia Alessandri, Francesca Turroni, Marco Ventura, Christian Milani
Summary: This study explored the age-related development of the human gut microbiome and the impact of feeding types on the metabolic functionality of the microbiome. The results showed that the gut microbial communities begin to metabolically evolve as early as 1 month after birth, but still appear functionally underdeveloped compared to adults at the age of 4 years. Breastfed infants showed enrichment in microbial metabolic functions related to specific low-concentration amino acids present in human milk.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yishan Wang, Xiaodi Zhang, Jiawei Li, Ying Zhang, Yingjie Guo, Qing Chang, Li Chen, Yiwei Wang, Siyao Wang, Yu Song, Yongkun Zhao, Zhihong Wang
Summary: Sini Decoction (SND) has been clinically proven effective in cardiomyopathy and inflammatory bowel diseases, but its role in colitis-associated cancer remains unclear. This study found that SND extract can reduce tumor number and size, decrease CRC biomarkers, upregulate beneficial bacteria, and modulate gut microbial community in mice. SND effectively intervenes in colorectal cancer development by regulating intestinal immunity and changing intestinal microbiota composition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Hongru Wang, Shangjun Ren, Hailing Lv, Lili Cao
Summary: Research indicates that gut microbiota from mice with cerebral ischemia-reperfusion injury can significantly affect animal behavior, brain functional connectivity, hippocampal neuronal plasticity, and neuroinflammation, shedding light on the role of gut microbiome in the pathobiology of cerebrovascular diseases.
Article
Food Science & Technology
Teresa Requena, Ya Song, Carmen Pelaez, M. Carmen Martinez-Cuesta
Summary: The study used a simulator to culture the gut microbiota from obese individuals, finding differences in the microbiota composition compared to normal-weight individuals, with key bacterial species missing and other changes occurring when high-fermented carbohydrates and fructose beverages were consumed by the obese individuals. These findings suggest potential strategies for targeted production of propionate by the human gut microbiota in relation to obesity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)