Article
Polymer Science
Tisana Kaewruethai, Chavee Laomeephol, Yue Pan, Jittima Amie Luckanagul
Summary: Research in nanoparticles as a drug delivery system has expanded to include their use as a delivery system for bioactive substances and a diagnostic or theranostic system. Nanogels, with their colloidal stability, core-shell structure, and adjustable components, offer the potential to design multifunctional nanosystems for various biomedical applications. Enhanced features of nanogels from modified polymers and metals, such as tunable amphiphilicity, biocompatibility, stimuli-responsiveness, and sensing moieties, contribute to specificity, stability, and tracking abilities.
Review
Materials Science, Multidisciplinary
Qiu-Yi Duan, Ya-Xuan Zhu, Hao-Ran Jia, Shi-Hao Wang, Fu-Gen Wu
Summary: This review introduces the history, preparation methods, properties, and applications of nanogels. It first discusses the classification and differences of nanogels from macro-sized hydrogels and other nanoparticles. Then, it focuses on the synthetic methods, properties, and applications of nanogels in drug delivery, imaging, detection, and regenerative medicine. It also raises the current problems and challenges in the field of nanogels, aiming to inspire researchers to develop more functional nanogels and promote their practical applications in various fields.
PROGRESS IN MATERIALS SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Kannan Badri Narayanan, Rakesh Bhaskar, Sung Soo Han
Summary: Nanogels (NGs), a significant nanoplatform with properties of both hydrogels and nanoparticles, have been extensively used for controlled/sustained delivery of therapeutic agents in biomedical and healthcare applications. This review summarizes the synthesis and functionalization strategies of NGs and highlights their recent advances in various biomedical fields such as cancer theranostics, immunotherapy, sensing, and tissue engineering.
Review
Pharmacology & Pharmacy
Fouad Damiri, Satish Rojekar, Yahya Bachra, Rajender S. Varma, Swetha Andra, Satheeshkumar Balu, Chandrakantsing Vijaysing Pardeshi, Paras J. Patel, Hitendra M. Patel, Ana Claudia Paiva-Santos, Mohammed Berrada, Monica C. Garcia
Summary: The biomedical, biotech, and food industries utilize polysaccharides as essential biomolecules for a wide range of applications. Polysaccharide-based nanogels have gained significant attention as carriers for different bioactive agents due to their unique versatile groups, controlled delivery capabilities, and desirable physico-chemical properties. The incorporation of hydrophilic or hydrophobic molecules, including drugs, proteins, genetic material, and nanoparticles, into the 3D polymer network of nanogels offers promising potential for drug delivery systems.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Article
Chemistry, Physical
Mehmet Can, Nurettin Sahiner
Summary: Laminarin (LAM), a marine polysaccharide with various bioactivities, shows great potential in biomedical applications. A facile method was developed to prepare poly(laminarin) (p(LAM)) particles, which exhibited excellent blood compatibility and chemical modifiability. The synthesized p(LAM) particles hold promise as natural alternative surrogates in drug delivery and other biomedical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Applied
Seid Reza Falsafi, Fuat Topuz, Hadis Rostamabadi
Summary: Dialdehyde carbohydrates (DCs) have diverse biomedical applications due to their versatile physical/chemical characteristics and biocompatibility/biodegradability. The cross-linking ability of DCs allows for the formation of versatile architectures, making them interesting matrices for applications such as drug delivery and tissue engineering. Recent progress in DCs has led to the development of advanced biomaterials in different forms, both macro and nano/micro, with potential for biomedical use. This review provides an update on the synthesis, properties, and applications of DCs, as well as addressing safety concerns and future perspectives.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Fuat Topuz, Tamer Uyar
Summary: This article summarizes the synthesis and biomedical applications of CD-based nanogels/microgels. By employing structural engineering and functional motifs of CD molecules, nanogels can adapt for the delivery of different types of drugs and significantly enhance the loading capacity and stability of lipophilic drugs.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Sachin Bhaladhare, Sulagna Bhattacharjee
Summary: The development of nanotechnology has had a significant impact on biomedical and pharmaceutical fields, particularly in the design and formulation of stimuli-responsive nano-drug delivery systems. These systems, known as smart drug delivery systems, are able to respond to various external and internal stimuli and deliver drugs to targeted sites in a controlled manner. They offer improved patient compliance, treatment efficiency, and reduced side effects on healthy tissue. Polymeric nanogels with stimuli-responsive characteristics have shown great potential in biomedical, tissue engineering, and pharmaceutical applications due to their small size, biocompatibility, stimuli-triggered drug deliverability, high payload capacity, and tailored functionality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Thi Mai Phuong Neumann-Tran, Clara Lopez-Iglesias, Lucila Navarro, Elisa Quaas, Katharina Achazi, Catalina Biglione, Daniel Klinger
Summary: Poly(N-acryloylmorpholine) (P(NAM))-based materials have been developed to prevent protein adhesion to surfaces due to their biocompatibility and protein-repellent properties. This study presents a novel approach for the synthesis of P(NAM) nanogels with controllable size. The nanogels exhibited pH-responsive swelling and redox-triggered degradation, and showed excellent protein-repellent properties. Cytotoxicity assays demonstrated the potential of these nanogels for biomedical applications.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
E. S. Anooj, M. Charumathy, Vipin Sharma, B. V. Vibala, S. T. Gopukumar, S. I. Beema Jainab, Sugumari Vallinayagam
Summary: Nanogels are considered promising materials in the biomedical field, offering high drug encapsulation capacity, stability, and stimuli responsiveness for applications in chemotherapy, diagnosis, organ targeting, and delivery of bioactive substances. Research focuses on nanogels assimilation in nanomedicine, their features and advantages, preparation techniques, and recent progress as carriers of genetic material, proteins, and vaccines. Recent developments in synthesis and experimental analysis have led to tailored microgels with specific properties and a deeper understanding of nano- and microgels behavior under external influences.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Materials Science, Multidisciplinary
Ehsan Nazarzadeh Zare, Tarun Agarwal, Atefeh Zarepour, Filippo Pinelli, Ali Zarrabi, Filippo Rossi, Milad Ashrafizadeh, Aziz Maleki, Mohammad-Ali Shahbazi, Tapas Kumar Maiti, Rajender S. Varma, Franklin R. Tay, Michael R. Hamblin, Virgilio Mattoli, Pooyan Makvandi
Summary: Polypyrrole is an electrically conductive polymer with good biocompatibility, widely used in the biomedical field. Nanocomposites prepared by blending polypyrrole with other biopolymers or nanomaterials show significant improvements in performance.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Multidisciplinary
Abuelmagd M. Abdelmonem, Antonina Lavrentieva, Nadja C. Bigall
Summary: In this study, ultra-small amphiphilic nanogels with tunable properties were successfully prepared using a combination of chemical cross-linking, hydrophobic interaction and self-assembly. These nanogels exhibited negative surface charge, small size, and high colloidal stability under a wide range of conditions. Furthermore, the nanogels were found to be non-toxic to cells. Therefore, these nanogels hold great importance in sensing and biomedical applications.
Review
Chemistry, Inorganic & Nuclear
Yu Cai, Yi Pan, Longcai Liu, Tian Zhang, Chen Liang, Xiaozhou Mou, Xiangming Ye, Wenjun Wang, Xiaochen Dong
Summary: This article provides a comprehensive review of the development of croconic acid (CA)-based near-infrared (NIR) materials in the field of biomedical applications. The rational structure design of CA molecules for excellent NIR optical properties and the formation of CA dye-based nanomaterials for improved bioavailability and stability are introduced. The biomedical applications of CA-based functional materials, including photothermal therapy, photoacoustic imaging, phototheranostics, and multimodal treatment, are summarized. The perspectives and potential drawbacks of CA-based materials for future clinical transformation are systematically discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Polymer Science
Sagar Pardeshi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Harshad Kapare, Mahendra Kumar Prajapati, Neha Munot, Mohammed Berrada, Prabhanjan S. Giram, Satish Rojekar, Faraat Ali, Md. Habibur Rahman, Hasi Rani Barai
Summary: Temperature-induced changes in the viscosity and formation of 3-D structure make thermosensitive hydrogels ideal for cell scaffolds or drug reservoirs. This review presents a comprehensive overview of the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels, and discusses their commercial potential.
