4.7 Article

A facile one-pot synthesis of microgels and nanogels of laminarin for biomedical applications

期刊

JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 588, 期 -, 页码 40-49

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2020.12.053

关键词

Laminarin; Seaweed polysaccharide; Laminarin microgel and nanogel; Blood compatible

资金

  1. Scientific Research Commission of Canakkale Onsekiz Mart University [COMU FYL-2020-3258]

向作者/读者索取更多资源

Laminarin (LAM), a marine polysaccharide with various bioactivities, shows great potential in biomedical applications. A facile method was developed to prepare poly(laminarin) (p(LAM)) particles, which exhibited excellent blood compatibility and chemical modifiability. The synthesized p(LAM) particles hold promise as natural alternative surrogates in drug delivery and other biomedical applications.
Hypothesis: Laminarin (LAM) as a nontoxic, biodegradable, and biocompatible marine polysaccharide, has been reported for its ingenious bioactivities such as antioxidant, antitumor antiapoptotic antiinflammatory, immunomodulatory and dietary fiber activities, and distinct physicochemical structure possess a remarkably promising potential in biomaterial science. Synthesis of LAM-based microgels and bulk hydrogels have been reported in two stages: modification of LAM polysaccharide with polymerizable functional groups and subsequent crosslinking reaction. Therefore, here an easier and more effortless methods to prepare poly(laminarin) (p(LAM)) particles were tackled. Experimental: A direct and facile single step fabrication of micro/nanogels of p(LAM) for the first time by means of reverse micelle microemulsion system were illustrated. Preparation of p(LAM) particles were achieved by the well-known Oxa-Michael addition reaction mechanism using divinyl sulfone as the crosslinker. Findings: P(LAM) particles in 0.3-10 mm size range in spherical morphologies were prepared with 93 +/- 7% yield and functionalized with chlorosulfonic acid (CSA) demonstrating their chemical modifiability for variety of agents e.g., targeting ligands. The bare and modified p(LAM) particles showed excellent blood compatibility with hemolytic indices of <1% and blood clotting indices higher than 90%. The reported p(LAM) particles hold great promise as natural alternative surrogates in biomedical applications including drug delivery. (c) 2020 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Chemistry, Physical

Crosslinked poly(Lactose) microgels and nanogels for biomedical applications

Mehmet Can, Ramesh S. Ayyala, Nurettin Sahiner

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

Article Chemistry, Applied

An amino acid, L-Glutamic acid-based metal-organic frameworks and their antibacterial, blood compatibility, biocompatibility, and sensor properties

Mehmet Can, Sahin Demirci, Aydin K. Sunol, Nurettin Sahiner

MICROPOROUS AND MESOPOROUS MATERIALS (2020)

Article Chemistry, Analytical

Graphene Aerogels for In Situ Synthesis of Conductive Poly(para-phenylenediamine) Polymers, and Their Sensor Application

Sahin Demirci, Mehmet Can, Nurettin Sahiner

MICROMACHINES (2020)

Article Chemistry, Multidisciplinary

Natural Celluloses as Catalysts in Dehydrogenation of NaBH4 in Methanol for H2 Production

Mehmet Can, Sahin Demirci, Aydin K. Sunol, George Philippidis, Nurettin Sahiner

ACS OMEGA (2020)

Article Energy & Fuels

PEI modifiednatural sands of Florida as catalysts for hydrogen production from sodium borohydride dehydrogenation in methanol

Erk Inger, Sahin Demirci, Mehmet Can, Aydin K. Sunol, George Philippidis, Nurettin Sahiner

Summary: Experimental results demonstrate that treated T and P sand samples show higher capability in catalyzing hydrogen generation, with a more significant effect observed after PEI modification.

INTERNATIONAL JOURNAL OF ENERGY RESEARCH (2021)

Article Polymer Science

HA particles as resourceful cancer, steroidal and antibiotic drug delivery device with sustainable and multiple drug release capability

Nurettin Sahiner, Selin S. Suner, Saliha B. Kurt, Mehmet Can, Ramesh S. Ayyala

Summary: Hyaluronic acid particles crosslinked with divinyl sulfone at a 10% mole ratio were prepared as versatile drug carriers for cancer drugs, corticosteroids, and antibiotics, with two different methods of drug loading utilized. These particles demonstrated good blood compatibility and the ability to release drugs gradually over long periods of time, depending on the type of drug, in both linear and dual release patterns.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY (2021)

Article Materials Science, Multidisciplinary

Modification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicity

Mehmet Can, Sahin Demirci, Yildiz Yildrim, Canan Cakir coban, Mustafa Turk, Nurettin Sahiner

Summary: The modification of Halloysite nanotubes (HNTs) clay with alkyl halides resulted in changes in physical and chemical properties, including increased surface charge and surface area. HNT-BrOD clays showed slight hemolytic activity at certain concentrations, while both base-activated HNT and HNT-BrOD clays exhibited antithrombotic characteristics.

MATERIALS CHEMISTRY AND PHYSICS (2021)

Article Polymer Science

Colloidal bioactive nanospheres prepared from natural biomolecules, catechin and L-lysine

Mehmet Can, Mehtap Sahiner, Nurettin Sahiner

Summary: This study focuses on exploring the biomedical applications of catechins by incorporating them into nano-vehicles. The synthesized CAT-LYS particles exhibited antioxidant, chelation, and reducing capabilities, as well as improved blood compatibility and inhibition activity.

JOURNAL OF POLYMER RESEARCH (2022)

Article Materials Science, Multidisciplinary

Chemically Cross-Linked Poly(β-Cyclodextrin) Particles as Promising Drug Delivery Materials

Sahin Demirci, Dawin Khiev, Mehmet Can, Mehtap Sahiner, Manas R. Biswal, Ramesh S. Ayyala, Nurettin Sahiner

Summary: The one-pot synthesis of poly(beta-cyclodextrin) (p(beta-CD)) micro/nanoparticles using different cross-linkers proved to have good physicochemical properties, including biocompatibility, blood compatibility, and sustained drug release capabilities.

ACS APPLIED POLYMER MATERIALS (2021)

Article Engineering, Environmental

Dichromate and arsenate anion removal by PEI microgel, cryogel, and bulkgel

Senol Kubilay, Sahin Demirci, Mehmet Can, Nahit Aktas, Nurettin Sahiner

Summary: In this study, PEI-based hydrogels were utilized to remove dichromate and arsenate anions from aqueous media successfully with a time-dependent adsorption capacity, fitting well with pseudo-second-order kinetic and nonlinear Langmuir isotherm models.

JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2021)

Article Chemistry, Physical

Mechanistic exploration of Co doping in optimizing the electrochemical performance of 2H-MoS2/N-doped carbon anode for potassium-ion battery

Panpan Zhang, Xu Wang, Yangyang Yang, Haifeng Yang, Chunsheng Lu, Mingru Su, Yu Zhou, Aichun Dou, Xiaowei Li, Xiaochuan Hou, Yunjian Liu

Summary: In this study, the influence of transition metal doping on the electronic and mechanical properties and electrochemical performance of 2HMoS2/NC was investigated using Cobalt (Co) as an example. Co doping was found to effectively improve the electronic conductivity and active site areas of 2H-MoS2/NC at different positions, optimizing the adsorption and diffusion capability of potassium ions. Furthermore, the study revealed the optimal roles of different types of nitrogen atoms in kinetic adsorption, diffusion, and interfacial stability of potassium ions. These findings provide guidance for the experimental design of high rate 2H-MoS2/NC electrode materials and the optimal design of other functional composite materials.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Addressing the synchronized impact of a novel strontium titanium over copolymerized carbon nitride for proficient solar-driven hydrogen evolution

Zeeshan Ajmal, Mahmood Ul Haq, Shahid Zaman, M. K. Al-Muhanna, Anuj Kumar, Mohammed M. Fadhali, Siwar Ben Hadj Hassine, Muhammas Qasim, K. F. Alshammari, Ghulam Abbas Ashraf, Abdul Qadeer, Adil Murtaza, Sulaiman Al-Sulaimi, Huaqiang Zeng

Summary: This study presents a novel heterojunction structure (SrTiO3/CN-TAL10.0) for enhanced photocatalytic water splitting (PWS). The incorporation of thiophenedicarboxaldehyde (TAL) through copolymerization significantly improves the photocatalytic activity of carbon nitride (CN) while maintaining its photostability performance. The optimized composition allows efficient isolation of photoinduced charge carriers and enhanced charge transport, resulting in a remarkable increase in overall photocatalytic efficiency.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Magnetic-driven Interleukin-4 internalization promotes magnetic nanoparticle morphology and size-dependent macrophage polarization

Angela Arnosa-Prieto, Patricia Diaz-Rodriguez, Manuel A. Gonzalez-Gomez, Pelayo Garcia-Acevedo, Lisandra de Castro-Alves, Yolanda Pineiro, Jose Rivas

Summary: Macrophages can exhibit different phenotypes depending on the microenvironment and the characteristics of magnetic iron oxide nanoparticles (MNPs). This study demonstrates that the concentration and morphology of MNPs can influence the polarization of macrophages. The findings have implications for therapeutics targeting tissue regeneration and tumor progression.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Polyamide nanofiltration membranes by vacuum-assisted interfacial polymerization: Broad universality of Substrate, wide window of monomer concentration and high reproducibility of performance

Yu Fang, Cheng-Ye Zhu, Hao-Cheng Yang, Chao Zhang, Zhi-Kang Xu

Summary: This study demonstrates the advantages of vacuum-assisted interfacial polymerization (VAIP) in fabricating polyimide nanofiltration membranes. By using vacuum filtration, aqueous solutions of PIP can be evenly distributed on different microfiltration substrates, leading to the fabrication of uniform and ultra-thin polyamide layers with excellent performance. The membranes exhibit high rejection rates and water permeance, as well as satisfactory long-term stability.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Comparing polymer-surfactant complexes to polyelectrolytes

Isaac J. Gresham, Edwin C. Johnson, Hayden Robertson, Joshua D. Willott, Grant B. Webber, Erica J. Wanless, Andrew R. J. Nelson, Stuart W. Prescott

Summary: Understanding the interactions between polymers and surfactants is crucial for optimizing commercial systems. This study tested the behavior of polymer-surfactant systems, revealing that they do not behave like polyelectrolytes in the presence of salt. Additionally, the structure of polymer-surfactant complexes under confinement differs from that of polyelectrolytes.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Crosslinking alginate at water-in-water Pickering emulsions interface to control the interface structure and enhance the stress resistance of the encapsulated probiotics

Yunxiao Xie, Cui Liu, Jie Zhang, Yan Li, Bin Li, Shilin Liu

Summary: This study aimed to improve the microstructure and rheological properties of W/W Pickering emulsions by crosslinking sodium alginate at the water-water interface, thereby enhancing the activity of encapsulated probiotics in simulated gastrointestinal digestion.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Multi-layering of carbon conductivity enhancers for boosting rapid recharging performance of high mass loading lithium ion battery electrodes

Sang Ho Lee, Yige Sun, Patrick S. Grant

Summary: This research developed an effective approach to enhance the charging rates of lithium ion batteries (LIBs) by strategically incorporating carbon nanotube (CNT) conductivity boosters into Li4Ti5O12 (LTO) electrodes. Multi-layer architectures comprising CNT-rich and CNT-free LTO electrode layers were manufactured using a layer-by-layer spray coating method to promote charge transfer kinetics of high mass loading electrodes. The best performing multi-layer was paired with a spray-coated LiFePO4 (LFP) positive electrode, resulting in attractive power performance that outperformed conventional LTO || LFP combinations.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Defect engineering induces Mo-regulated Co9Se8/FeNiSe heterostructures with selenium vacancy for enhanced electrocatalytic overall water splitting in alkaline

Jingwei Liang, Shaobin Li, Fengbo Li, Li Zhang, Yufeng Jiang, Huiyuan Ma, Kun Cheng, Liang Qing

Summary: A molybdenum-regulated self-supporting electrode material with rich vacancy defects has been successfully synthesized and shows exceptional catalytic activities and stability for electrocatalytic overall water splitting. This study provides a new perspective for the design and synthesis of non-precious metal bifunctional electrocatalysts.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Surfactant-free microemulsions (SFMEs) as a template for porous polymer synthesis

Jonas Blahnik, Jennifer Schuster, Rainer Mueller, Eva Mueller, Werner Kunz

Summary: This study investigates the relationship between the morphology of PMMA monopolymers and PMMA-PHEMA copolymers with the expected nature of surfactant-free microemulsions (SFMEs) before polymerization. It is found that previously mesostructured, surfactant-free mixtures can produce porous polymers of different morphologies, while unstructured, oil-rich regions lead to solid, transparent polymers without nanostructured morphologies. Additionally, a surfactant-based reference system shows similar phase behavior and polymer morphologies as the comparable surfactant-free system, indicating the importance of the hydrotropic behavior of HEMA in this system.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Morphology regulation of isomeric covalent organic frameworks for high selective light scattering detection of lead

Zheng-Fen Pu, Wen-Zhi She, Rong Sheng Li, Qiu-Lin Wen, Bi-Chao Wu, Chun-Hua Li, Jian Ling, Qiue Cao

Summary: This study synthesized two framework-isomeric covalent organic frameworks (COFs) and discovered that the light scattering signal of COFs can be used for the analytical detection of lead ions. By controlling synthesis conditions and introducing regulators, the morphology of COFs could be controlled and framework-isomeric COFs could be precisely synthesized.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Preparation and dynamic color-changing study of fluorescent polymer nanoparticles for individualized and customized anti-counterfeiting application

Yuchen Weng, Ying Hong, Jingyu Deng, Sicheng Cao, Li-Juan Fan

Summary: This paper reports the preparation of dynamic color-changing fluorescent polymer nanoparticles (PNPs) by constructing a fluorescence resonance energy transfer (FRET) pair. The PNPs show excellent anti-counterfeiting effects and reproducibility. The study demonstrates a promising encryption strategy that can achieve multiple outputs with simple operation.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Employing polyaniline/viologen complementarity to enhance coloration and charge dissipation in multicolor electrochromic display with wide modulation range

Guodong Liu, Zijian Wang, Jianing Wang, Hanbin Liu, Zhijian Li

Summary: This study investigates the combination of multicolor switchable polyaniline (PANI) electrode and 1-methyl-4,4'-bipyridyl iodide (MBI), which demonstrates superior optical properties in visible and near-infrared light modulation, as well as excellent electrochemical performances. This combination can be used to develop novel electrochromic devices for applications in smart packaging, smart labels, and flexible smart windows.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Facile constructing Ti3C2Tx/TiO2@C heterostructures for excellent microwave absorption properties

Huying Yan, Yang Guo, Xingzhi Bai, Jiawei Qi, Haipeng Lu

Summary: By modifying Ti3C2Tx through heterogeneous interface engineering, optimized impedance matching is achieved, leading to enhanced electromagnetic wave absorption performance.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Reversible crowdedness of pH-responsive and host-guest active polymersomes: Mimicking μm-sized cell structures

Kehu Zhang, Yang Zhou, Silvia Moreno, Simona Schwarz, Susanne Boye, Brigitte Voit, Dietmar Appelhans

Summary: This article presents an advanced crosslinking strategy to fabricate clustered polymersomes using host-guest interactions. By controlling the input of crosslinker and environmental conditions, reversible aggregation and disassembly of these polymersomes can be achieved. The size and structure of these clustered polymersomes can be regulated and visualized through a fluorescent enzymatic cascade reaction.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)

Article Chemistry, Physical

Potassium regulating electronic state of zirconia supported palladium catalyst and hydrogen spillover for improved acetylene hydrogenation

Junjie Xu, Weixiong Huang, Ruiling Li, Li Li, Jinjin Ma, Jiaou Qi, Haiyan Ma, Min Ruan, Lilin Lu

Summary: In this study, a potassium doped palladium catalyst was developed for acetylene hydrogenation, showing excellent catalytic performance and durability. The doping of potassium effectively weakened the adsorption of ethylene, improved ethylene selectivity, and lowered the barriers of hydrogen activation and transfer reactions.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2024)