Article
Biochemistry & Molecular Biology
Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci
Summary: Prostate cancer is the second most common cancer in men. Higher intake of polyphenols, curcumin, and quercetin has been associated with lower prostate cancer risk. In this study, the combination of curcumin and quercetin showed synergic anticancer and anti-inflammatory effects, inhibiting proliferation, inducing apoptosis, and modulating inflammation-mediated signaling pathways.
Review
Biochemistry & Molecular Biology
Kanchan Gairola, Shriya Gururani, Ananya Bahuguna, Vaishali Garia, Rohit Pujari, Shiv K. Dubey
Summary: Cancer is a major global challenge and targeting cancer stem cells may be a novel strategy for elimination of the chronic disease. Natural products have shown potential in inhibiting tumorigenesis and modulating signaling pathways related to CSC self-renewal and differentiation, with minimal toxicity compared to traditional therapies.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Clementina Sansone, Luigi Pistelli, Luana Calabrone, Angelo Del Mondo, Angelo Fontana, Marco Festa, Douglas M. Noonan, Adriana Albini, Christophe Brunet
Summary: This study investigates the potential of diatoxanthin (Dt), a photoprotective xanthophyll, in intercepting prostate cancer progression. The results demonstrate the chemopreventive effect of Dt even at low concentration, and suggest that Dt-induced cancer cell death is mediated by oxidative stress mechanisms. Furthermore, Dt also exhibits anti-angiogenic properties, providing a potential therapeutic approach for prostate cancer.
Review
Biochemistry & Molecular Biology
Rituparna Ghosh, Priya Samanta, Rupali Sarkar, Souradeep Biswas, Prosenjit Saha, Subhadip Hajra, Arijit Bhowmik
Summary: Advancement in novel target detection using improved molecular cancer biology has opened up new avenues for promising anti-cancer drug development. HIF-1 alpha, a major transcriptional regulator, plays a crucial role in tumor adaptation to hypoxia and regulates various biological processes involved in tumorigenesis. Inhibitors targeting HIF-1 alpha have been considered as a novel cancer therapeutic strategy, holding potential for accelerated anticancer drug discovery.
Review
Nutrition & Dietetics
Asma Ismail Mahmod, Shatha Khaled Haif, Ayah Kamal, Israa A. Al-ataby, Wamidh H. Talib
Summary: This review aims to explore the anti-inflammatory and anti-colorectal cancer potential of natural bioactive compounds derived from the main foods in the Mediterranean diet.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Yeqin Yuan, Huizhi Long, Ziwei Zhou, Yuting Fu, Binyuan Jiang
Summary: Breast cancer is the most common cancer in women, with a rising incidence that poses significant challenges for treatment. The PI3K-AKT pathway and its targets play crucial roles in breast cancer development, and natural products and drugs targeting this pathway show potential for treatment. This review discusses the role of the PI3K-AKT signaling pathway in breast cancer and highlights the use of natural products and drugs targeting this pathway in clinical trials.
Article
Plant Sciences
Yinan Zhao, Xuke Zhang, Ying Li, Yeling Li, Han Zhang, Ziteng Song, Jing Xu, Yuanqiang Guo
Summary: A new compound, Xipsxanthone H, was extracted from Garcinia xipshuanbannaensis and found to have inhibitory effects on the proliferation and metastasis of nonsmall-cell lung cancer by targeting STAT3 and FAK signaling pathways. This discovery provides a potential candidate for developing new therapeutic agents for lung cancer.
Review
Pharmacology & Pharmacy
Chuchu Xu, Yian Chen, Qinghong Yu, Jiaqing Song, Ying Jin, Xiufei Gao
Summary: This comprehensive review examines the compounds that target ferroptosis in breast cancer and elucidates their potential mechanisms of action. It also discusses the challenges associated with the clinical application of ferroptosis-inducing drugs, providing valuable insights for the development of novel treatment strategies for breast cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Man Chu, Cheng Zheng, Cheng Chen, Gendi Song, Xiaoli Hu, Zhi-wei Wang
Summary: Accumulating evidence suggests that cancer stem cells (CSCs) play a crucial role in tumor progression and drug resistance. Numerous chemopreventive compounds, known as nutraceuticals, have been found to eliminate CSCs by regulating signaling pathways. These nutraceuticals, including soy isoflavone, curcumin, resveratrol, etc., may offer a promising strategy for treating cancer by targeting CSCs.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Immunology
Matteo Gallazzi, Denisa Baci, Lorenzo Mortara, Annalisa Bosi, Giuseppe Buono, Angelo Naselli, Andrea Guarneri, Federico Deho, Paolo Capogrosso, Adriana Albini, Douglas M. Noonan, Antonino Bruno
Summary: This study characterized the phenotype and function of peripheral blood NK cells in prostate cancer patients, finding that they promote inflammatory angiogenesis in endothelial cells and modulate monocytes and macrophages towards an M2-like phenotype. These findings suggest a potential use of peripheral blood NK cell profiling in prostate cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jared Sivinski, Donna D. Zhang, Eli Chapman
Summary: NRF2 is a crucial transcription factor that regulates redox homeostasis. While being activated can protect normal cells, abnormal upregulation of NRF2 may facilitate the growth and spread of cancer cells. Researchers are therefore interested in discovering both NRF2 activators and inhibitors to better understand and control its dual role in health and disease.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Nutrition & Dietetics
Chandra K. Singh, Gagan Chhabra, Arth Patel, Hao Chang, Nihal Ahmad
Summary: Studies have shown the importance of zinc in prostate biology and functions, with high concentrations in healthy prostates and decreased levels in prostate cancer. Zinc supplementation may not effectively increase zinc concentrations in PCa, possibly due to dysregulation of zinc transporters. Natural dietary phytochemicals may modulate zinc levels and combined with zinc, could potentially inhibit prostate cancer.
Article
Medicine, Research & Experimental
Yvonne H. W. Derks, Mark Rijpkema, Helene I. Amatdjais-Groenen, Annemarie Kip, Gerben M. Franssen, J. P. Michiel Sedelaar, Diederik M. Somford, Michiel Simons, Peter Laverman, Martin Gotthardt, Dennis W. P. M. Lowik, Susanne Luetje, Sandra Heskamp
Summary: A novel PSMA-targeting ligand was developed and optimized for multimodal image-guided prostate cancer surgery combined with targeted photodynamic therapy, showing increased uptake in PSMA-expressing tumors and specificity in human samples.
Article
Oncology
Haseeb Zubair, Mohammad Aslam Khan, Shashi Anand, Sanjeev Kumar Srivastava, Seema Singh, Ajay Pratap Singh
Summary: The development of cancer involves the coevolution of tumor cells with their surrounding environment, and the interactions between tumor cells and stromal cells play a crucial role in tumor growth, metastasis, and therapy resistance. Natural compounds have significant potential in targeting the tumor microenvironment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Food Science & Technology
Shilpi Singh, Akhilesh Kumar Maurya, Abha Meena, Nidhi Mishra, Suaib Luqman
Summary: Narirutin, a compound found in lemon, orange, passion fruit, bergamot, and grapefruit, has potential as an anti-allergic, cardioprotective, neuroprotective, and hepatoprotective agent. It can suppress the growth of prostate cancer cells, but its chemopreventive potential against hormone-refractory prostate cancer cells (PC-3) and its mode of action are not yet known. In this study, the chemopreventive possibility of narirutin was explored in PC-3 cells, and it was found that narirutin reduced cell viability, induced G0/G1 phase arrest, and increased the generation of reactive oxygen species (ROS). Narirutin also inhibited the activity of hyaluronidase and showed a strong binding interaction with the enzyme. Molecular dynamics simulation analysis supported the idea that narirutin binding enhanced the compactness and stability of the enzyme. Additionally, narirutin was predicted to be non-toxic and non-CYPs inhibitor. These results suggest that narirutin may be a potential chemopreventive agent for hormone-resistant prostate cancer cells and provide data supporting the use of diet-based nutraceutical agents to prevent prostate cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
