☆ 4.4 Article

Making a Difference: Monocyte Heterogeneity in Cardiovascular Disease

CURRENT ATHEROSCLEROSIS REPORTS (2012)

期刊

CURRENT ATHEROSCLEROSIS REPORTS

卷 14, 期 5, 页码 450-459

出版社

CURRENT MEDICINE GROUP

DOI: 10.1007/s11883-012-0274-8

关键词

Monocyte subsets; Monocyte heterogeneity; Ly-6C; CD14; CD16; Macrophage; Dendritic cells; Atherosclerosis; Myocardial infarction; Cardiovascular disease; Extramedullary hematopoeisis; Inflammation

类别

Peripheral Vascular Disease

资金

NHLBI NIH HHS [R01 HL095612] Funding Source: Medline

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Reagent

摘要

Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 C-high/low) and humans (CD14(+/dim/-) CD16(+/-)) in the context of atherosclerosis and its complications.

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