Article
Biochemistry & Molecular Biology
Tuo Wang, Chi Jin, Peng Yang, Zhihao Chen, Jiangzhou Ji, Qingyang Sun, Sheng Yang, Yifei Feng, Junwei Tang, Yueming Sun
Summary: The expression of Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) is suppressed by DNA hypermethylation of its promoter in colorectal cancer (CRC) tissues and cell lines, and decreased UBE2J1 is associated with poor prognosis. As a suppressor gene, UBE2J1 inhibits the proliferation and metastasis of CRC cells. Mechanistically, UBE2J1-TRIM25 forms an E2-E3 complex, physically interacts with and targets RPS3 for ubiquitination and degradation at the K214 residue. The downregulated RPS3 restrains NF-kappa B translocation into the nucleus, leading to inactivation of the NF-kappa B signaling pathway. These findings suggest that UBE2J1-mediated RPS3 poly-ubiquitination and degradation may serve as a novel biomarker and therapeutic target for CRC.
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Article
Biochemistry & Molecular Biology
Zhen-xing Liang, Hua-shan Liu, Li Xiong, Xin Yang, Feng-wei Wang, Zi-wei Zeng, Xiao-wen He, Xian-rui Wu, Ping Lan
Summary: In this study, a novel protein circPLCE1-411 was identified as a key player in NF-kappa B activation in CRC. It inhibits NF-kappa B nuclear translocation by promoting the degradation of RPS3, leading to suppression of tumor proliferation and metastasis in CRC. Additionally, downregulation of circPLCE1 in CRC tissues is associated with poor patient survival.
Review
Chemistry, Medicinal
Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat
Summary: Nuclear factor-kappa B (NF-kappa B) is a transcription factor that controls gene expression and plays a crucial role in regulating cell signaling. The constitutive activity of NF-kappa B signaling has been reported in various cancer cells, making it a desirable target for cancer treatment. Plant-derived compounds, such as flavonoids and polyphenols, have been evaluated as potential inhibitors of NF-kappa B signaling and have shown promising anticancer effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Mao Li, Markus W. Schweiger, Daniel J. Ryan, Ichiro Nakano, Litia A. Carvalho, Bakhos A. Tannous
Summary: The study found that in breast cancer metastasis, OR5B21 showed increased transcript abundance in distant metastatic sites, and its knockdown significantly reduced invasion and migration of cancer cells. OR5B21 expression was associated with epithelial to mesenchymal transition through the STAT3/NF-kappa B/CEBPb signaling axis.
Article
Immunology
Jichun Lin, Wenshuo Fang, Zhuo Xiang, Qingqing Wang, Huapeng Cheng, Shimin Chen, Jing Fang, Jia Liu, Qiang Wang, Zhimin Lu, Leina Ma
Summary: It has been found that glycolytic enzyme hexokinase 2 (HK2) plays a crucial role in upregulating PD-L1 expression in breast cancer cells. Under high glucose conditions, HK2 acts as a protein kinase and phosphorylates IκBa at T291, leading to the degradation of IκBa and activation of NF-κB, resulting in the promotion of PD-L1 expression. Correlation analysis shows that HK2 and PD-L1 expression levels are positively correlated with immune cell infiltration and survival time of breast cancer patients. These findings highlight the potential of targeting the protein kinase activity of HK2 for breast cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Maria Magdalena Barreca, Riccardo Alessandro, Chiara Corrado
Summary: Flavonoids, phytochemical compounds found in plants, have various medicinal properties including anti-inflammatory, antioxidative, antiviral, and anticarcinogenic effects. They also offer neuroprotective and cardioprotective benefits. Recently, their effects have been shown to be mediated through the inhibition of the NF-κB signaling pathway. This review summarizes the effects of flavonoids on common diseases such as cancer, cardiovascular, and neurodegenerative diseases, with a focus on their action on the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Johanna Wolfsberger, Habib A. M. Sakil, Leilei Zhou, Niek van Bree, Elena Baldisseri, Sabrina de Souza Ferreira, Veronica Zubillaga, Marina Stantic, Nicolas Fritz, Johan Hartman, Charlotte Rolny, Margareta T. Wilhelm
Summary: Low levels of TAp73 are correlated with an increased NF-kappa B-regulated inflammatory signature in breast cancer, leading to hyperactivation of NF-kappa B pathway and secretion of Ccl2, which results in accumulation and phenotype transformation of pro-tumoral macrophages. These findings suggest that TAp73 regulates macrophage accumulation and phenotype in breast cancer through inhibition of the NF-kappa B pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju
Summary: NF-kappa B is a major regulator of the biological characteristics of tumor cells, and antioxidants or protease inhibitors may suppress colorectal cancer. Computational studies suggest NF-kappa B could be a potential target for anti-cancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Oncology
Yen-Yun Wang, Amos C. Hung, Steven Lo, Shyng-Shiou F. Yuan
Summary: Obesity is a major modifiable risk factor for breast cancer, with adipocytokines like visfatin and resistin playing important roles in tumor-stromal interactions and breast cancer development. Therapeutic strategies targeting these adipocytokines hold promise for novel breast cancer therapies.
Article
Biochemistry & Molecular Biology
Shenglan Liu, Liangmei He, Junhong Wu, Xinqiang Wu, Lu Xie, Wei Dai, Lingxia Chen, Fuhua Xie, Zhiping Liu
Summary: DHX9 plays a crucial role in promoting proliferation and metastasis in colorectal cancer, making it a potential therapeutic target for prevention and treatment of CRC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qun Wang, Yun Huang, Min Jia, Dong Lu, Hong-Wei Zhang, Dan Huang, San-Hong Liu, Chao Lv
Summary: SPS-1, an active fraction from safflower polysaccharide, demonstrated strong antitumor effects in a mouse model of colorectal cancer by regulating the immune pathway and changing macrophage phenotype. It inhibited tumor growth, suppressed cell proliferation, induced apoptosis in CRC cells, and could potentially be used as a therapeutic option for CRC prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
