p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

(2020) Arianna Fumagalli et al.   Cell Stem Cell

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

(2020) Clara Morral et al.   Cell Stem Cell

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

(2020) Hae-Ock Lee et al.   NATURE GENETICS

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

(2020) Priscilla Cheung et al.   Cell Stem Cell

Integrating Old and New Paradigms of G1/S Control

(2020) Seth M. Rubin et al.   MOLECULAR CELL

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

(2020) Yong-Hee Cho et al.   Nature Communications

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

(2019) Carlota Colomer et al.   MOLECULAR CELL

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

YAP/TAZ Activation as a Target for Treating Metastatic Cancer

(2018) Janine Warren et al.   Cancers

CANCERTOOL: a visualization and representation interface to exploit cancer datasets

(2018) Ana R Cortazar et al.   CANCER RESEARCH

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

(2018) Isabel Puig et al.   JOURNAL OF CLINICAL INVESTIGATION

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

(2018) Ysbrand M. Nusse et al.   NATURE

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

(2016) Dafni-Eleftheria Pefani et al.   MOLECULAR CELL

Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress

(2016) Yafei Dai et al.   Oncotarget

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

(2014) Yuki Kagoya et al.   JOURNAL OF CLINICAL INVESTIGATION

p53 Promotes Cell Survival due to the Reversibility of Its Cell-Cycle Checkpoints

(2014) Dana J. Lukin et al.   MOLECULAR CANCER RESEARCH

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Identification of Lgr5-Independent Spheroid-Generating Progenitors of the Mouse Fetal Intestinal Epithelium

(2013) Roxana C. Mustata et al.   Cell Reports

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Vascular Permeability and Drug Delivery in Cancers

(2013) Sandy Azzi et al.   Frontiers in Oncology

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

(2011) Vinagolu K. Rajasekhar et al.   Nature Communications

The Canonical NF- B Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

(2010) M. Liu et al.   CANCER RESEARCH

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

(2009) R. N. Jorissen et al.   CLINICAL CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL