ADAM10 and BACE1 are localized to synaptic vesicles

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals

(2014) Jolanta L. Lundgren et al.   NEUROSCIENCE LETTERS

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Genome-wide Association Studies in Alzheimer’s Disease: A Review

(2013) Giuseppe Tosto et al.   Current Neurology and Neuroscience Reports

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

(2013) Elena Marcello et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

(2013) Sophia Schedin-Weiss et al.   PLoS One

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus

(2010) Elena Marcello et al.   NEUROBIOLOGY OF AGING

Affinity pulldown of γ-secretase and associated proteins from human and rat brain

(2009) Yasuhiro Teranishi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

(2008) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE