APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

Phosphorylation of a Tyrosine in the Amyloid-β Protein Precursor Intracellular Domain Inhibits Fe65 Binding and Signaling

(2017) Dawang Zhou et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic vesicle recycling: steps and principles

(2014) S. O. Rizzoli   EMBO JOURNAL

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss

(2013) Franco Lombino et al.   PLoS One

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Memory Deficits of British Dementia Knock-In Mice Are Prevented by A -Precursor Protein Haploinsufficiency

(2012) R. Tamayev et al.   JOURNAL OF NEUROSCIENCE

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

(2012) Robert Tamayev et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

(2011) Robert Tamayev et al.   EMBO JOURNAL

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

(2011) Manu Sharma et al.   EMBO JOURNAL

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function

(2011) Alessia P. M. Barbagallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Revisited

(2011) Qinxi Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling

(2011) C. Matrone et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Intracellular Threonine of Amyloid Precursor Protein That Is Essential for Docking of Pin1 Is Dispensable for Developmental Function

(2011) Alessia P. M. Barbagallo et al.   PLoS One

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

Synaptic Vesicle Exocytosis

(2011) T. C. Sudhof et al.   Cold Spring Harbor Perspectives in Biology

The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models

(2011) Martin Korte et al.   EXPERIMENTAL BRAIN RESEARCH

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

Identification of NEEP21 as a  -Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro

(2010) E. M. Norstrom et al.   JOURNAL OF NEUROSCIENCE

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo

(2010) Alessia P. M. Barbagallo et al.   PLoS One

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

(2010) R. Tamayev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Clathrin-Mediated Endocytosis at the Synaptic Terminal: Bridging the Gap Between Physiology and Molecules

(2010) Stephen J. Royle et al.   TRAFFIC

Modeling familial British and Danish dementia

(2009) Holly J. Garringer et al.   Brain Structure & Function

BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2

(2009) Shuji Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

(2009) Jun Xu et al.   NATURE NEUROSCIENCE

BRI2 Inhibits Amyloid  -Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the Substrate

(2008) S. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON