Article
Immunology
Kaibiao Xu, Dongmei Wang, Yan He, Shengnan Wang, Guanghui Liu, Yue Pan, Haishan Jiang, Yu Peng, Fenliang Xiao, Yihua Huang, Qiqi Wang, Yongming Wu, Suyue Pan, Yafang Hu
Summary: This study discovered a novel anti-CRMP2 antibody associated with suspected AE and suggested its significance for the diagnosis of AE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Review
Immunology
Lawrence Steinman, Roberto Patarca, William Haseltine
Summary: Twenty years ago, a tribute was published in this journal to celebrate the 70th anniversary of an animal model known as experimental autoimmune encephalomyelitis (EAE). Recent research has helped explain how Epstein-Barr virus triggers multiple sclerosis through molecular mimicry. These observations bring us back to Rivers' first paper on EAE, published 90 years ago, and show the continued importance of this animal model in understanding disease mechanisms.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Muhammed A. Saad, Noha M. Eissa, Mohammed A. Ahmed, Aliaa N. ElMeshad, Goetz Laible, Ahmed S. Attia, Medhat A. Al-Ghobashy, Rania M. Abdelsalam, Muhammad Y. Al-Shorbagy
Summary: A nanoformulation containing rhMBP with RTX on its surface (Nano-rhMBP-RTX) was prepared and found to have potential neuro-protective effects on C57BL/6 mice after inducing experimental autoimmune encephalomyelitis (EAE), improving symptoms and histopathological findings.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Clinical Neurology
Rong Yan, Yu Mao, Huiyang Zeng, Qian Liu, Hanqiu Jiang, Jingting Peng, Qingling Yang, Shilei Cui, Lei Liu, Yanjun Guo, Jiawei Wang
Summary: This study reviewed the neuro-ophthalmic findings and outcomes in 5 patients with CRMP5-ON, and found that it often presented with optic disc edema, diffuse defects of the central field, and complications such as vitreitis, retinitis, or uveitis. MRI examination showed optic nerve or perineural optic nerve enhancement, which was associated with tumors. Cancer screening and intervention were crucial for prognosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Ellinore R. Doroshenko, Paulina C. Drohomyrecky, Annette Gower, Heather Whetstone, Lindsay S. Cahill, Milan Ganguly, Shoshana Spring, Tae Joon Yi, John G. Sled, Shannon E. Dunn
Summary: The study found that PPAR-delta plays a crucial role in microglia in limiting bystander tissue damage during neuroinflammation. Deficiency of PPAR-delta may lead to exacerbated neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jian Li, Lisen Lu, Kyle Binder, Jian Xiong, Lilin Ye, Yan H. Cheng, Sonia Majri-Morrison, Wei Lu, Jae W. Lee, Zhihong Zhang, Yu-zhang Wu, Lixin Zheng, Michael J. Lenardo
Summary: This study found that an injectable myelin-based antigen can effectively suppress autoimmune demyelinating diseases of the central nervous system without major side effects. The mechanism of action involves the uptake of the antigen by perivascular F4/80+ cells and the induction of apoptosis in encephalitogenic T cells, leading to reduced inflammation.
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Jinan Li, Chang Liu, Bo Zhao
Summary: This study investigated the expression and localization of CRMP1 in hair cells and found that it is crucial for high-frequency auditory perception.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Yuanhua Cai, Jocelyn A. A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. B. Williams, Shaoyuan Wang, Bonnie N. N. Dittel, Qizhen Shi
Summary: Targeting MOG expression to platelets using genetic engineering can prevent the development of multiple sclerosis and reduce disease severity, showing promise as a potential treatment approach.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alicia Ballester, Adriana Guijarro, Beatriz Bravo, Javier Hernandez, Rodolfo Murillas, Marta Gallego, Sara Ballester
Summary: This study investigated the role of the Hedgehog (Hh) pathway in modulating the immune response. The results showed that Hh pathway activation favored the Th2 phenotype and impaired the establishment of the Th1 phenotype. Additionally, mice with constitutive activation of the Hh pathway showed a milder response to inflammatory challenge and less spinal cord damage. These findings demonstrate the involvement of the Hh/ptch pathway in immune response modulation and highlight the potential of the ptch(+/-) mouse model for studying T-cell-mediated diseases and developing new therapeutic strategies for inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zhi-Yuan Shen, Yi Zheng, Maggie K. Pecsok, Ke Wang, Wei Li, Min-Jie Gong, Feng Wu, Lin Zhang
Summary: This study confirmed the inhibitory effect of CRP on Th17 response and elucidated the mechanism through which it mediates the regulation of Th17 responses by interacting with FcgR2B on moDCs. The study also demonstrated that CRP attenuated the antigen presenting ability of moDCs through FcgR2B, leading to a decrease in Th17 responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wen-Yuan Ju, Qing Wang, Li-Juan Song, Zhi-Bin Ding, Xiao-Hui Li, Gajendra Kumar, Yuqing Yan, Cun-Gen Ma
Summary: Microglia are resident macrophages in the central nervous system. They play a crucial role in immune surveillance and have beneficial and harmful effects in neurodegenerative diseases. Understanding the molecular mechanisms of microglia-mediated phagocytosis could provide insights for the development of novel therapeutic approaches for diseases like multiple sclerosis.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Neurosciences
Chiara Tremolanti, Chiara Cavallini, Laurence Meyer, Christian Klein, Eleonora Da Pozzo, Barbara Costa, Lorenzo Germelli, Sabrina Taliani, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Research suggests that phenylindoleglyoxylamydes (PIGAs) translocator protein (TSPO) ligands may have therapeutic potential in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) that mimics primary progressive multiple sclerosis (PPMS) in humans. Treatment with PIGA1138 significantly reduced clinical symptoms and improved motor function in MOG-EAE mice, while preserving myelin and axonal integrity. PIGA1138 also inhibited immune cell infiltration, reducing inflammation, and increased anti-inflammatory cytokine levels.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emily Van San, Angela C. C. Debruyne, Geraldine Veeckmans, Yulia Y. Y. Tyurina, Vladimir A. A. Tyurin, Hao Zheng, Sze Men Choi, Koen Augustyns, Geert van Loo, Bernhard Michalke, Vivek Venkataramani, Shinya Toyokuni, Huelya Bayir, Peter Vandenabeele, Behrouz Hassannia, Tom Vanden Berghe
Summary: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by CNS demyelination and neurological deficits. The study reveals that ferroptosis, a form of cell death, contributes to the progression of MS. Inhibiting ferroptosis can delay disease relapse and improve disease progression in a preclinical model of MS.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)