Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery

DPP4-deficient congenic rats display blunted stress, improved fear extinction and increased central NPY

(2015) Fabio Canneva et al.   PSYCHONEUROENDOCRINOLOGY

Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function

(2014) Wenqing Zhao et al.   Neural Regeneration Research

Mapping orphan proteases by proteomics: Meprin metalloproteases deciphered as potential therapeutic targets

(2014) Christoph Becker-Pauly et al.   Proteomics Clinical Applications

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Proteomic identification of protease cleavage sites: cell-biological and biomedical applications

(2013) Hasmik Shahinian et al.   Expert Review of Proteomics

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Revealsin VivoRoles in Cellular Homeostasis and Energy Metabolism

(2013) Claire H. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absolute proteomic quantification of the activity state of proteases and proteolytic cleavages using proteolytic signature peptides and isobaric tags

(2013) Richard P. Fahlman et al.   Journal of Proteomics

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NPY and Stress 30 Years Later: The Peripheral View

(2012) Dalay Hirsch et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cardiovascular effects of the DPP-4 inhibitors

(2012) Tessey Jose et al.   Diabetes & Vascular Disease Research

NPY modulates PYY function in the regulation of energy balance and glucose homeostasis

(2012) L. Zhang et al.   DIABETES OBESITY & METABOLISM

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia

(2012) Peter Röhnert et al.   Journal of Neuroinflammation

The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus

(2012) Cornelia Walther et al.   NEUROPEPTIDES

Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α

(2011) Fiona M. Keane et al.   FEBS Journal

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells

(2011) Raquel Ferreira et al.   Journal of Neuroinflammation

Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development

(2011) Cornelia Walther et al.   JOURNAL OF PEPTIDE SCIENCE

Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet–Induced Obesity

(2011) Yan-chuan Shi et al.   Obesity

The neuropeptide Y system: Pathophysiological and therapeutic implications in obesity and cancer

(2011) Lei Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Cardiovascular effects of DPP-4 inhibition: Beyond GLP-1

(2011) Gian Paolo Fadini et al.   VASCULAR PHARMACOLOGY

Neuropeptide Y and peptide YY: important regulators of energy metabolism

(2011) Amy D Nguyen et al.   Current Opinion in Endocrinology Diabetes and Obesity

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

(2010) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Interactive Hemodynamic Effects of Dipeptidyl Peptidase-IV Inhibition and Angiotensin-Converting Enzyme Inhibition in Humans

(2010) Annis Marney et al.   HYPERTENSION

Dipeptidyl Peptidase IV Inhibition Alters the Hemodynamic Response to Angiotensin-Converting Enzyme Inhibition in Humans With the Metabolic Syndrome

(2010) Edwin K. Jackson   HYPERTENSION

Ligand-induced Internalization and Recycling of the Human Neuropeptide Y2Receptor Is Regulated by Its Carboxyl-terminal Tail

(2010) Cornelia Walther et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions

(2009) Nadine Frerker et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Kinetic Study of Neuropeptide Y (NPY) Proteolysis in Blood and Identification of NPY3–35

(2009) Karim Abid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge

(2009) Evelin Painsipp et al.   JOURNAL OF PSYCHOPHARMACOLOGY

NPY regulation of bone remodelling

(2009) Nicola J. Lee et al.   NEUROPEPTIDES

Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus☆

(2008) Ilka Böhme et al.   CELLULAR SIGNALLING

Functional role of the extracellular N-terminal domain of neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalization

(2008) D LINDNER et al.   CELLULAR SIGNALLING

Human cathepsin D.

(2008) Alina Minarowska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Sitagliptin Augments Sympathetic Enhancement of the Renovascular Effects of Angiotensin II in Genetic Hypertension

(2008) Edwin K. Jackson et al.   HYPERTENSION

Protein components of the blood–brain barrier (BBB) in the brainstem area postrema–nucleus tractus solitarius region

(2008) Nasren Maolood et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Brain-specific Proteins Decline in the Cerebrospinal Fluid of Humans with Huntington Disease

(2008) Qiaojun Fang et al.   MOLECULAR & CELLULAR PROTEOMICS

Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice

(2008) Evelin Painsipp et al.   NEUROPHARMACOLOGY

NPY and its involvement in axon guidance, neurogenesis, and feeding

(2008) Tomas Hökfelt et al.   NUTRITION

EFFECTS OF DIPEPTIDYL PEPTIDASE IV INHIBITION ON ARTERIAL BLOOD PRESSURE

(2007) Edwin K Jackson et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system

(2007) Alvin H. Schmaier   INTERNATIONAL IMMUNOPHARMACOLOGY

Upregulated expression of neuropeptide Y in hypothalamic–pituitary system of rats by chronic dexamethasone administration

(2007) Jinko Konno et al.   NEUROSCIENCE RESEARCH