Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

(2021) Jinyong Choi et al.   TRENDS IN IMMUNOLOGY

Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

(2021) Marco Künzli et al.   eLife

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

(2021) Can Cui et al.   CELL

Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

(2021) Laura M. Snell et al.   NATURE IMMUNOLOGY

In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm

(2020) Mikel Ruterbusch et al.   Annual Review of Immunology

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits

(2020) Jinyong Choi et al.   NATURE IMMUNOLOGY

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

(2020) Megan S. F. Soon et al.   NATURE IMMUNOLOGY

Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire

(2020) Achia Khatun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok

(2019) Thomas Ciucci et al.   IMMUNITY

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

(2019) Kristiyan Kanev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

(2019) Wei Xu et al.   IMMUNITY

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

(2018) Michael J Moore et al.   eLife

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

(2018) Laura M. Snell et al.   IMMUNITY

Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

(2018) Gang Xin et al.   Nature Communications

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory

(2017) Hyun Mu Shin et al.   PLoS Pathogens

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

(2016) Daniel T. Utzschneider et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation

(2016) Laura A Shaw et al.   NATURE IMMUNOLOGY

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection

(2016) Laura M. Snell et al.   Cell Reports

T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX

(2015) Kevin D. Cook et al.   IMMUNITY

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection

(2015) P. Penaloza-MacMaster et al.   SCIENCE

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control

(2015) Gang Xin et al.   Cell Reports

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

(2014) Ian A. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity

(2014) Stéphane Chevrier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection

(2014) Aimee M Beaulieu et al.   NATURE IMMUNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

(2014) I. Osokine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

Kruppel-like Factors in Lymphocyte Biology

(2012) G. T. Hart et al.   JOURNAL OF IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

(2011) Heather D. Marshall et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

(2011) Laura M. Fahey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

The role of CD40 and CD154/CD40L in dendritic cells

(2009) Daphne Y. Ma et al.   SEMINARS IN IMMUNOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY

Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo

(2007) Megan M. McCausland et al.   JOURNAL OF VIROLOGICAL METHODS