Review
Biochemistry & Molecular Biology
Chang Youn Lee, In Soo Ryu, Jin-Hyeob Ryu, Hyun-Jeong Cho
Summary: Alzheimer's disease is a progressive neurodegenerative disorder, with miRNAs playing a crucial role in its pathological processes. Limitations of current pharmaceutical therapies have led to research on miRNA-based next-generation therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xu Wang, Yuxin Tong, Jiayu Zhang, Nazia Khan, Kaili Zhang, Huihui Bai, Qianqian Zhang, Yue Chen
Summary: This study investigates neuroinflammation under different periodontal statuses. Both the Lig group and Lps group showed notable microgliosis and astrogliosis, with a positive correlation between periodontal inflammation and the number of glial cells. Furthermore, expressions of IL-1 beta and TNF-alpha were significantly increased in the Lps group.
Review
Neurosciences
Guimei Zhang, Zicheng Wang, Huiling Hu, Meng Zhao, Li Sun
Summary: Alzheimer's disease is a common type of age-related dementia, where dysregulated microglia activity can lead to chronic neuroinflammation, promote pathological protein accumulation, and impair mitophagy. Targeting microglia may offer new therapeutic interventions for the disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Yuehua Huang, Xiaoyu Li, Guifei Luo, Junli Wang, Ranhui Li, Chuyi Zhou, Teng Wan, Fenglian Yang
Summary: This paper reviews the recent research progress on pyroptosis and focuses on the pathogenic roles of pyroptosis in Alzheimer's disease (AD) and the potential of targeted inhibition of inflammasome-dependent pyroptosis for AD treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Benjamin R. Troutwine, Laylan Hamid, Colton R. Lysaker, Taylor A. Strope, Heather M. Wilkins
Summary: Genetic variation in the APOE gene is associated with the risk of Alzheimer's disease. The APOE epsilon 4 alleles are the strongest genetic risk factor for late onset sporadic AD, while the APOE epsilon 2 alleles have lower risk and the APOE epsilon 3 alleles have neutral risk.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Giorgia Menegoni, Luca Steardo, Caterina Scuderi
Summary: Alzheimer's disease treatments are not curative, new approaches are needed. Astrocytes are targeted as a specific method. Studies suggest that palmitoylethanolamide may have a potential therapeutic effect by modulating astrocytes.
Article
Plant Sciences
Caixia Zang, Hui Liu, Junmei Shang, Hanyu Yang, Lu Wang, Chanjuan Sheng, Zihong Zhang, Xiuqi Bao, Yang Yu, Xinsheng Yao, Dan Zhang
Summary: The study demonstrates that GJ-4 improves cognitive deficits in APP/PS1 transgenic mice by reducing A beta levels, inhibiting tau protein phosphorylation, and suppressing neuroinflammatory responses. These findings provide a basis for further development of GJ-4 as a potential treatment for AD.
Article
Neurosciences
Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree, Xianlin Han
Summary: This study investigated the impact of CNS sulfatide deficiency on AD pathology using different mouse models. The results showed that mild sulfatide losses within myelinating cells can activate disease-associated microglia and astrocytes, leading to chronic AD-like neuroinflammation and mild cognitive impairment, with gender differences. Additionally, sulfatide deficiency was found to be an important contributor to neuroinflammation and cognitive impairment in AD.
MOLECULAR NEURODEGENERATION
(2021)
Article
Clinical Neurology
Kaitlin B. Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie Schneider, Judy Pa
Summary: Females with Alzheimer's disease are more susceptible than males, and microglial activation plays an important mediating role in females but not males. This finding is crucial for understanding the pathogenesis of Alzheimer's disease and providing precision health care.
Review
Biochemistry & Molecular Biology
Ziyad M. Althafar
Summary: This study summarizes the molecular pathogenesis of Alzheimer's disease (AD), the activities of microglia in the adult brain, the role of microglia in the aging brain, and the significance of targeting microglia for the treatment of AD.
Review
Immunology
Nobufumi Sekino, Magdy Selim, Amjad Shehadah
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It induces cerebral dysfunction, disruption of the blood-brain barrier, neuroinflammation, hypoperfusion, and accumulation of amyloid beta and tau protein in the brain. However, there is currently no specific treatment for cognitive impairments in sepsis. Antibiotics, targeting proinflammatory cytokines, and preventing ischemic injuries and hypoperfusion are suggested for the acute phase, while targeting neuroinflammation, blood-brain barrier dysfunction, protein phosphorylation, and specific receptors are suggested for the late phase of sepsis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Geriatrics & Gerontology
Qing-Qing Tao, Rong-Rong Lin, Yi-He Chen, Zhi-Ying Wu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the accumulation of Aβ and tau in the brain. The dysfunction of the blood brain barrier (BBB) is increasingly recognized as a causative factor of cognitive impairment, but its role in the pathogenesis of AD is still not fully understood. Additional research is needed to determine the underlying mechanisms between BBB dysfunction and AD, as well as explore new therapies for BBB regulation to treat AD in the future.
Article
Cell Biology
Raly James Perez Custodio, Zaynab Hobloss, Maiju Myllys, Reham Hassan, Daniela Gonzalez, Joerg Reinders, Julia Bornhorst, Ann-Kathrin Weishaupt, Abdel-latif Seddek, Tahany Abbas, Adrian Friebel, Stefan Hoehme, Stephan Getzmann, Jan G. Hengstler, Christoph van Thriel, Ahmed Ghallab
Summary: Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the most common chronic liver disease in Western countries. This study found that MASLD has an effect on brain histology, cognitive functions, and neurotransmitters.
Review
Behavioral Sciences
RuoLan Cai, YangYang Wang, ZhenTing Huang, Qian Zou, YinShuang Pu, Changyin Yu, Zhiyou Cai
Summary: ROCK activation can promote the occurrence of Alzheimer's disease and may involve a positive feedback loop between Aβ and ROCK. Additionally, ROCK can also promote the formation of neurofibrillary tangles and exacerbate neuroinflammatory responses.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Haidy Abbas, Nesrine S. El Sayed, Nancy Abdel Hamid Abou Youssef, Passent M. E. Gaafar, Mohamed R. Mousa, Ahmed M. Fayez, Manal A. Elsheikh
Summary: In this study, a non-invasive intranasal delivery system using novel chitosan decorated nanoparticles was developed and evaluated for the treatment of cognitive dysfunction in Alzheimer's disease. The results showed that the chitosan decorated nanoparticles improved cognitive function in an animal model of Alzheimer's disease, indicating their potential as a safe and effective therapeutic approach.
Article
Neurosciences
Cong Hu, Yuanyuan Huang, Lingzhi Wu, Hailin Zhao, Chen Pac Soo, Qingquan Lian, Daqing Ma
Summary: This study found that apoptosis and necroptosis occur in different brain regions of hippocampus in a model of HIE, suggesting the development of strategies to prevent each form of neuronal death is valuable.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
C. L. Shovlin, M. P. Vizcaychipi
Summary: COVID-19 presents more systemic complications and severe pulmonary vasculopathy compared to other respiratory viruses, which may be related to the sustained downregulation of ACE2 protein expression after SARS-CoV-2 infection. Research has shown that the ACE2 gene is located in a novel cluster on the X chromosome that is co-regulated with other genes. Failure to rapidly suppress viral replication in patients predicts delayed responses that may contribute to deteriorations.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Masae Iwasaki, Junichi Saito, Hailin Zhao, Atsuhiro Sakamoto, Kazuyoshi Hirota, Daqing Ma
Summary: The widespread occurrence of SARS-CoV-2 has led to a pandemic of COVID-19. The S spike protein of SARS-CoV-2 binds with ACE2, entering host cells and causing multi-organ damage by inducing inflammation.
Article
Surgery
Yangzi Zhu, Meiyan Zhou, Xiuqin Jia, Wei Zhang, Yibing Shi, Shengjie Bai, Sanketh Rampes, Marcela P. Vizcaychipi, Congyou Wu, Kai Wang, Daqing Ma, Qi Yang, Liwei Wang
Summary: The goal of this study was to investigate the changes in functional connectivity (FC) after cardiac surgery and its relationship with cognitive deficits and systemic inflammation. Seventeen patients who underwent cardiac valve replacement and age-matched healthy controls were included in the study. Results showed that executive function was significantly impaired after cardiac surgery. The surgical patients demonstrated decreased FC within the executive control network and attenuated negative connectivity in the default mode network, which were related to increased tumor necrosis factor-a levels and decreased executive function up to day 7 after surgery.
Article
Medicine, General & Internal
Bernhard Wernly, Michael Beil, Raphael Romano Bruno, Stephan Binneboessel, Malte Kelm, Sviri Sigal, Peter Vernon van Heerden, Ariane Boumendil, Antonio Artigas, Maurizio Cecconi, Brian Marsh, Rui Moreno, Sandra Oeyen, Bernardo Bollen Pinto, Wojciech Szczeklik, Susannah Leaver, Sten Mikael Walther, Joerg C. Schefold, Michael Joannidis, Jesper Fjolner, Tilemachos Zafeiridis, Dylan de Lange, Bertrand Guidet, Hans Flaatten, Christian Jung
Summary: In Europe, there are two different healthcare organisation systems: tax-based healthcare system (THS) and social health insurance system (SHI). The characteristics, treatment, and mortality of critically ill older patients in the intensive care unit (ICU) differ between THS and SHI. Patients in SHI are older, sicker, and frailer, with higher ICU mortality but similar 30-day mortality compared to THS. The trend towards ICU excess mortality in SHI may result from a more liberal admission policy and increased treatment limitations.
Article
Surgery
Azeem Alam, Daqing Ma
Article
Pharmacology & Pharmacy
Yumo Li, Binbin Wu, Cong Hu, Jie Hu, Qingquan Lian, Jun Li, Daqing Ma
Summary: This study found that Dexmedetomidine plays a role in protecting the lungs by increasing vagal nerve tone. The indirect anti-inflammatory effects and direct cytoprotective effects of Dexmedetomidine are likely achieved through increased vagal nerve tone and activation of alpha 2-adrenoceptors, respectively.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jiaxiang Duan, Lunli Xiang, Zhen Yang, Li Chen, Jianteng Gu, Kaizhi Lu, Daqing Ma, Hailin Zhao, Bin Yi, Hongwen Zhao, Jiaolin Ning
Summary: This study found that methionine restriction (MR) can attenuate lipopolysaccharide (LPS)-induced lung injury by regulating cystathionine-gamma-lyase (CSE) expression and hydrogen sulfide (H2S). MR inhibits the activation of TLR4/NF-kappa B/NOD-like receptor protein 3 (NLRP3) pathway, reducing the release of inflammatory mediators and immune cell infiltration.
Article
Cell Biology
Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia Li, Daqing Ma
Summary: Perioperative risk factors, including the choice of anesthetics, may influence ovarian cancer recurrence after surgery. This study investigated the effects of inhalational anesthetic sevoflurane and intravenous agent propofol on ovarian cancer cell biology and metabolism. The results showed that sevoflurane increased malignancy-related factors while propofol decreased them, suggesting different impacts of the two anesthetics on ovarian cancer cells.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zilong Yang, Xiaoyan Pan, Xiaoxia Wu, Qiuyun Lin, Yongxia Chen, Shuting Cai, Yuanli Zhang, Zhenhua Mai, Niall Ahmad, Daqing Ma, Liehua Deng
Summary: This study found that TREM-1 plays a critical role in inducing cardiomyocyte pyroptosis in septic conditions. Inhibiting TREM-1 can alleviate the upregulation of NLRP3 and decrease cell death, leading to improved cardiac function and prolonged survival in septic patients.
Review
Medicine, Research & Experimental
Ryan Wong, Yiwen Zhang, Hailin Zhao, Daqing Ma
Summary: circRNAs play important regulatory roles in many critical biological pathways and disease pathologies, and studies have shown their significant involvement in organ injuries with therapeutic implications.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Junichi Saito, Hailin Zao, Lingzhi Wu, Masae Iwasaki, Qizhe Sun, Cong Hu, Masashi Ishikawa, Kazuyoshi Hirota, Daqing Ma
Summary: Ketamine has inhibiting effects on neuroglioma and lung cancer cells in vitro by suppressing cell proliferation and migration, inducing apoptosis, and increasing ROS and cleaved caspase-3 expression. The anti-cancer effect of ketamine is more pronounced in lung cancer cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Anesthesiology
Qian Zhai, Ying Zhang, Mao Ye, Shan Zhu, Jianyu Sun, Yue Wang, Bin Deng, Daqing Ma, Qiang Wang
Summary: This study found that sleep deprivation leads to cognitive decline, associated with synapse elimination and complement pathway activation, and dexmedetomidine can protect against these effects. These findings provide a basis for further research on the role of dexmedetomidine in preventing cognitive deficits caused by sleep deprivation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Emergency Medicine
Lexin Liu, Qizhe Sun, Frank Davis, Jianhua Mao, Hailin Zhao, Daqing Ma
Summary: Organ fibrosis is a process of excessive extracellular matrix deposition which can lead to vital organ failure. Despite the hypothesis that epithelial-mesenchymal transition (EMT) may be a key mechanism, the underlying mechanisms of fibrosis are still largely unknown.