Progranulin induces adipose insulin resistance and autophagic imbalance via TNFR1 in mice

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+regulatory T cells

(2014) Ya Hu et al.   IMMUNOLOGY

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism

(2013) Bo Zhou et al.   CELL CYCLE

Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-Induced Obesity Through Nuclear Factor-κB Signaling Pathway

(2013) Bo Zhou et al.   ENDOCRINOLOGY

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

(2013) Jinlong Jian et al.   FEBS LETTERS

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

(2012) Toshiya Matsubara et al.   Cell Metabolism

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

(2012) Hans Wils et al.   JOURNAL OF PATHOLOGY

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

IRS-2, but not IRS-1, can sustain proliferation and rescue UBF stabilization in InR or InR defective signaling of 32D myeloid cells

(2011) Shufang Wu et al.   CELL CYCLE

Progranulin: A growth factor, a novel TNFR ligand and a drug target

(2011) Chuan-ju Liu et al.   PHARMACOLOGY & THERAPEUTICS

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

(2011) Tania O. Crişan et al.   PLoS One

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

(2010) Stephan Blüml et al.   ARTHRITIS AND RHEUMATISM

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate

(2009) Hasan Tanak et al.   JOURNAL OF MOLECULAR MODELING

Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance

(2009) L. Zhou et al.   MOLECULAR PHARMACOLOGY

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

(2008) B.-S. Youn et al.   DIABETES

Blockade of Tumor Necrosis Factor (TNF) Receptor Type 1-Mediated TNF-α Signaling Protected Wistar Rats from Diet-Induced Obesity and Insulin Resistance

(2008) Huifang Liang et al.   ENDOCRINOLOGY

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

(2008) Kai Kessenbrock et al.   JOURNAL OF CLINICAL INVESTIGATION