Article
Biochemical Research Methods
Yuhao Piao, Kun Yu, Thomas B. Jones, Weiqiang Wang
Summary: This paper introduces an electrical actuation scheme of dielectric droplets through negative liquid dielectrophoresis, establishing a general model for evaluating the electromechanical force acting on the droplets. By comparing actuation forces for different liquid combinations in parallel-plate geometry, the low voltage actuation of dielectric droplets by negative dielectrophoresis is predicted. The experimental results demonstrate successful manipulations of dielectric droplets at voltages < 100 V-rms.
Article
Materials Science, Multidisciplinary
Sebastian von der Ecken, Alexandros A. Sklavounos, Aaron R. Wheeler
Summary: Digital microfluidics (DMF) has become a key technology in the fields of microfluidics and microelectromechanical systems, with increasing demand for larger and more complex devices. This work introduces a new method, VAPE-DMF, using vertical addressing techniques to facilitate the manufacture of DMF devices with large driving electrode arrays. Demonstrating the capability to handle multiple samples and reactions in parallel, VAPE-DMF represents a significant advancement in the field of digital microfluidics.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Mechanics
Penghao Tian, Mulin Li, Jie Tan, Mingyang Sun, Guijun Chen, Dongyue Jiang
Summary: This study proposes a concave curvature capillary-wave propeller (CWP) to enlarge the capillary-wave amplitude. Experimental and theoretical analysis reveals that the concave curvature increases the wave amplitude, velocity vector, and wave intensity. It is also found that 20 Hz electrical signals are favorable for pursuing large wave energy density. This research is important for increasing the propulsion speed of small-scale floating objects and improving the performance of CWPs in other applications.
Article
Chemistry, Analytical
Kuan-Lun Ho, Hong-Yu Liao, Helene Minyi Liu, Yen-Wen Lu, Pin-Kuan Yeh, Justin Yu Chang, Shih-Kang Fan
Summary: This study developed a disposable POC cartridge that detects the SARS-CoV-2 N gene with high accuracy and efficiency through digital microfluidics technology. The cartridge has multiple droplet tracks, allowing for multiple tests and controls at once.
Article
Chemistry, Analytical
Kailiang Zhang, Fangyuan Xing, Jiuqing Liu, Zhijie Xie
Summary: This paper presents a method for effective on-chip droplet generation, splitting, and switching using controllable hydrodynamics. A two-dimensional simulation model based on the phase-field method is established to analyze the hydrodynamic droplet manipulation behaviors. The numerical results show that the droplets can be generated with controlled sizes and can realize on-demand splitting and switching.
ANALYTICA CHIMICA ACTA
(2022)
Article
Computer Science, Information Systems
Lixia Tian, Hu Zhang, Zichuan Yi, Bingsong Zhang, Rui Zhou, Guofu Zhou, Jianlong Gong
Summary: This paper proposes a power function driving waveform for electrowetting displays (EWDs) to address their defects such as reduced aperture ratio and unstable grayscale. By optimizing the oil splitting suppression stage, DC driving stage, and oil stabilization stage, the proposed waveform effectively improves the aperture ratio and oil stability of EWDs, shortens the response time, and increases the luminance value.
Article
Materials Science, Multidisciplinary
Shubhi Bansal, Sriram Subramanian
Summary: While acoustic metamaterials face challenges with limited tunability and narrow operational frequency range, integrating liquids with active actuation mechanisms in metamaterials opens up new design possibilities. The use of active microfluidic techniques enables active tunability in liquid-embedded metamaterial designs, leading to the development of a novel class of microfluidic acoustic metamaterials (MAM) with deep-subwavelength ultra-compact tunable features and multi-stable characteristics. MAM demonstrates active acoustic switching, amplitude modulation, and phase modulation with high transmission efficiency and broadband operations, paving the way for automation, tuning, and miniaturization of metamaterials using microelectromechanical (MEMS) and microfluidic concepts.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Engineering, Electrical & Electronic
Seungmin Lee, Daeyoung Lee, Minsuk Choi, Sang Kug Chung
Summary: This paper presents a method for efficiently manipulating droplets on a 2-D plane using low-frequency electrowetting-on-dielectric (EWOD) and asymmetric oscillation characteristic of droplets. The study investigates the behavior of droplets actuated by low-frequency EWOD and their horizontal transportation. It also demonstrates droplet transference to adjacent electrodes and successfully manipulates droplets using a limited number of patterned electrodes.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Multidisciplinary
Shreyank Goel, Dipin S. Pillai
Summary: This paper investigates the electrowetting behavior of a charge-carrying droplet and develops a reduced-order electrokinetic model. The dependence of droplet deformation and wetting alteration on electric field parameters is studied numerically. The research findings are important for applications such as biomedical diagnostics.
Article
Nanoscience & Nanotechnology
Ali Reza Bahari, Mobin Abdar Esfahani, Mojtaba Taghipoor
Summary: Transparent electrowetting is a branch of EWOD devices that use transparent electrodes for optical applications. This paper introduces a transparent EWOD with permanent liquid electrodes. Liquid electrodes were used instead of conventional solid-state ones. The concept of Liquid Electrode EWOD (LEWOD) is successfully implemented on both rigid and flexible substrates. Results show promising performance similar to PCBs, indicating potential future applications of liquid electrodes in EWOD systems.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Review
Chemistry, Analytical
Ren Shen, A'man Lv, Shuhong Yi, Ping Wang, Pui-In Mak, Rui P. Martins, Yanwei Jia
Summary: Since the identification of DNA/RNA as the genetic material, nucleic acid analysis has played a crucial role in molecular diagnostics, disease prediction, prognosis, and basic biological research. Among various platforms, electrowetting-based digital microfluidics (DMF) has emerged as a promising tool, allowing for the manipulation of individual droplets using electrical signals. This review highlights the technical principles supporting nucleic acid analysis on DMF platforms, recent advances in applications including extraction, amplification, and sequencing, as well as the commercialization status and future prospects of DMF for nucleic acid analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Man Ho, Aaron Au, Robert Flick, Thu V. Vuong, Alexandros A. Sklavounos, Ian Swyer, Christopher M. Yip, Aaron R. Wheeler
Summary: Fouling at liquid-solid interfaces is a severe problem for digital microfluidics (DMF) and can be combatted by including amphiphilic surfactant additives in the droplets. This study evaluated 19 different Pluronic and Tetronic additives to determine their antifouling performance, structural similarities, and mechanism of action. The analysis showed that Pluronic and Tetronic additives with specific characteristics can provide exceptional antifouling performance in DMF. The results and their implications are important progress for the DMF community and can guide the selection of surfactants for manipulating biological matrices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Juhwan Park, Kyoung G. Lee, Dong Hyun Han, Ji-Soo Lee, Seok Jae Lee, Je-Kyun Park
Summary: The study introduces a portable microfluidic device, PAMD, for generating and dispensing droplets for ddPCR with a simple pushbutton operation. PAMD can control multiple droplet generation units simultaneously with a single pushbutton, and the size of droplets can be adjusted by changing the geometry of the droplet generation channel.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Johannes Strassner, Christoph Doering, Emerson Oliveira, Henning Fouckhardt
Summary: This article discusses the phenomena and techniques of electrowetting on dielectric (EWOD) and optoelectrowetting (OEW), and explores the operating points of OEW through discussion and modification.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Review
Polymer Science
Mohamad Orabi, Joe F. Lo
Summary: Hydrogel droplets are biodegradable and biocompatible materials with promising applications in tissue engineering and clinical treatments. Microfluidic techniques provide precise control over the generation of hydrogel droplets, resulting in tight distributions of particle size, shape, matrix, and mechanical properties. This review focuses on recent advances in microfluidic hydrogel droplet generation and the applications of hydrogels in cell and tissue engineering.
Article
Physics, Applied
Ehsan Samiei, Hojatollah Rezaei Nejad, Mina Hoorfar
APPLIED PHYSICS LETTERS
(2015)
Article
Chemistry, Multidisciplinary
Hojatollah Rezaei Nejad, Ehsan Samiei, Ali Ahmadi, Mina Hoorfar
Article
Biophysics
Ehsan Samiei, George S. Luka, Homayoun Najjaran, Mina Hoorfar
BIOSENSORS & BIOELECTRONICS
(2016)
Review
Biochemical Research Methods
Ehsan Samiei, Maryam Tabrizian, Mina Hoorfar
Article
Chemistry, Multidisciplinary
B. A. Nestor, E. Samiei, R. Samanipour, A. Gupta, A. Van den Berg, M. Diaz de Leon Derby, Z. Wang, H. Rezaei Nejad, K. Kim, M. Hoorfar
Article
Biochemical Research Methods
Ehsan Samiei, Maria Diaz de Leon Derby, Andre Van den Berg, Mina Hoorfar
Article
Chemistry, Analytical
George Luka, Ehsan Samiei, Soroush Dehghani, Thomas Johnson, Homayoun Najjaran, Mina Hoorfar
Article
Nanoscience & Nanotechnology
Amir Seyfoori, S. A. Seyyed Ebrahimi, Ehsan Samiei, Mohsen Akbari
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Analytical
Maryam Jahanshahi, David Hamdi, Brent Godau, Ehsan Samiei, Carla Liria Sanchez-Lafuente, Katie J. Neale, Zhina Hadisi, Seyed Mohammad Hossein Dabiri, Erik Pagan, Brian R. Christie, Mohsen Akbari
Article
Biochemistry & Molecular Biology
Ehsan Samiei, Amir Seyfoori, Brian Toyota, Saeid Ghavami, Mohsen Akbari
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Chemistry, Analytical
Arash Dalili, Ehsan Samiei, Mina Hoorfar
Article
Cell Biology
Adel Rezaei Moghadam, Simone C. da Silva Rosa, Ehsan Samiei, Javad Alizadeh, Jared Field, Philip Kawalec, James Thliveris, Mohsen Akbari, Saeid Ghavami, Joseph W. Gordan
CELL DEATH DISCOVERY
(2018)
Article
Biochemical Research Methods
Amir Seyfoori, Ehsan Samiei, Neda Jalili, Brent Godau, Mehdi Rahmanian, Leila Farahmand, Keivan Majidzadeh-A, Mohsen Akbari
Proceedings Paper
Engineering, Electrical & Electronic
Ehsan Samiei, Hojatollah Rezaei Nejad, Mina Hoorfar
2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015)
(2015)