Article
Environmental Sciences
Ioanna Efthimiou, Georgios Kalamaras, Katerina Papavasileiou, Natalia Anastasi-Papathanasi, Yiannis Georgiou, Stefanos Dailianis, Yiannis Deligiannakis, Dimitris Vlastos
Summary: The study investigated the cytotoxic and oxidative effects of custom-made nanoparticles on hemocytes of Mytilus galloprovincialis using hemolymph serum as exposure medium. Results showed that Ag NPs were more cytotoxic than ZnO-Ag NPs and/or ZnO NPs, with high levels of superoxide anion and malondialdehyde detected in cells treated with Ag NPs. Further studies are needed to understand the oxidative mode of action of NP metal ions in complex NP mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Ilef Romdhani, Giuseppe De Marco, Tiziana Cappello, Samira Ibala, Nesrine Zitouni, Iteb Boughattas, Mohamed Banni
Summary: This study assessed the impact of environmental microplastics combined with other pollutants on mussels. The results showed that microplastics accumulated in the mussels and could transfer to other marine organisms, potentially having adverse effects on their health status.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Teresa Balbi, Francesco Trenti, Anastasija Panevska, Gregor Bajc, Graziano Guella, Caterina Ciacci, Barbara Canonico, Laura Canesi, Kristina Sepcic
Summary: OlyA6, a protein produced by oyster mushroom, shows potent insecticidal activity against coleopteran plant pests. It can form transmembrane pores in membranes containing ceramide phosphoethanolamine (CPE). In addition, CAEP is identified as a novel high-affinity receptor for OlyA6 and a target for cytolytic OlyA6/PlyB complexes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Physiology
Francesca Cima, Roberta Varello
Summary: Edible bivalves are economically important bioresources, and understanding their immune responses to environmental pollutants is crucial for biodiversity preservation and economic reasons. This study examined the immunotoxicity of two different bivalves (clam and mussel) after exposure to CuCl, a pollutant found in antifouling paints. The results showed that both species exhibited toxic effects on their immune responses, with the clam being more sensitive to certain biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Environmental Sciences
Elena-Daniela Pantea, Valentina Coatu, Nicoleta-Alexandra Damir, Andra Oros, Luminita Lazar, Natalia Rosoiu
Summary: The study tested the lysosomal membrane stability (LMS) of hemocytes in wild mussels (Mytilus galloprovincialis) as a biomarker of cellular stress for chemical pollution through neutral red retention time (NRRT) assays. Seawater quality and pollutant bioaccumulation in the mussels' soft tissue were investigated to assess environmental contamination. The results showed that LMS, observed through reduced NRRT values, was significantly affected by contaminant exposure, particularly in port areas where elevated bioaccumulation of pesticides and biphenyls was observed, indicating cellular stress induced by contaminants.
Article
Chemistry, Multidisciplinary
Yiru Shi, Zan Dai, Yue Wang, Jiangqi Luo, Larry Cai, Jie Tang, Chengzhong Yu, Yannan Yang
Summary: The study introduces a crystallinity gradient-based selective etching strategy to control the structure and composition of CaO2 nanoparticles. This strategy not only reduces the production of harmful substances and enhances anticancer activity, but also inhibits tumor growth through the lysosome-dependent cell death pathway.
Article
Engineering, Chemical
Ziyue Wang, Jingyao Qi, Xiaohui Lu, Haicheng Jiang, Panpan Wang, Mingrui He, Jun Ma
Summary: In this study, an antifouling MOF membrane was developed by growing MAF-4 and epitaxially growing MAF-7 on PES substrates, leading to exceptional salt rejection, high permeability, and nearly 100% bactericidal rate. The synergistic effect of MAF-4 and MAF-7 enhanced photocatalytic activity, with the main bactericidal mechanism being the generation of reactive oxygen species under visible light. The membrane also showed a significant reduction in flux loss and inhibition of biofilm formation, indicating potential for desalination applications.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Environmental Sciences
Young-Seon Ko, SungJun Park, GwangPyo Ko, Kyoungja Woo
Summary: This study investigates the antibacterial activity of silica substrate particles of different sizes and their hybrid counterparts with silver nanoparticles. The results show that particle size plays a significant role in bactericidal activity, while effective total surface area (ETSA) is considered a crucial factor influencing the antibacterial performance. Further research with various silica substrate sizes is needed to fully understand the impact of silica substrate on the antibacterial activity of immobilized silver nanoparticles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
QiMing Tian, SiMin Wei, HongRui Su, ShuMei Zheng, ShuYa Xu, MingJiang Liu, RuoNan Bo, JinGui Li
Summary: Gallic acid (GA), a natural ingredient in traditional Chinese medicine, possesses antibacterial properties by enhancing antibiotic activity, disrupting bacterial membrane structure, and improving protection against bacterial infection.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Justyna Roszkowiak, Siobhan McClean, Aleksandra M. M. Mironczuk, Daria Augustyniak
Summary: Neutrophil elastase (NE) plays a role in innate antibacterial defense. This study found that M. catarrhalis can survive and replicate in the presence of NE, despite NE destabilizing the outer membrane. NE cleaves virulent surface proteins in outer membrane vesicles of M. catarrhalis. The cleavage of OMP CD decreases resistance to serum complement, while the cleavage of McaP has no effect on erythromycin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Qi Feng Lim, Ray Chin Chong Yap, Choon Peng Teng, Jayven Chee Chuan Yeo, Ming Yan Tan, Jessica Pei Wen Toh, Qiang Zhu, Warintorn Thitsartarn, Chaobin He, Songlin Liu, Junhua Kong
Summary: The increasing emergence of infectious diseases like COVID-19 has created an urgent need for filtration/purification materials with multifunctional features. Polymer membranes and metal-organic frameworks (MOFs) have shown high effectiveness in air filtration and purification. In this work, an electrospray-on-electrospinning in situ process was used to integrate MOF nanoparticles into a nanofibrous membrane, resulting in advanced properties such as high mechanical strength, flexibility, breathability, particle filtration, and antimicrobial performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Polymer Science
Silvana Alfei, Gabriella Piatti, Debora Caviglia, Anna Maria Schito
Summary: The resistance of bacteria to current chemotherapy is a growing global concern, and new antimicrobial agents like the cationic polymer P5 are urgently needed. P5 showed remarkable antibacterial activity against multi-drug-resistant clinical isolates, making it a promising novel agent to overcome severe infections caused by antibiotic-resistant bacteria.
Article
Biochemistry & Molecular Biology
Yu-Jeong Choi, Youn Kyung Choi, Seong-Gyu Ko, Chunhoo Cheon, Tai Young Kim
Summary: Costunolide (CTL) induces apoptosis by increasing reactive oxygen species (ROS) generation in cancer cells. It has a stronger cytotoxic effect on SK-BR-3 cells compared to MCF-7 cells. This difference is due to the activation of mitochondrial-dependent intrinsic apoptosis pathway in SK-BR-3 cells and PINK1/Parkin-dependent mitophagy pathway in MCF-7 cells in response to CTL treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Ceramics
Xiang He, Bowei Liu, Yong Liu, Qianli Huang
Summary: This study aimed to enhance the mechanical strength and bactericidal activity of macro-porous ceramics by incorporating copper. The results showed that increasing the sintering temperature and copper content led to improved bending strength and reduced porosity. The bactericidal activity against Escherichia coli and Staphylococcus aureus also increased with higher copper content. The Cu-containing Al2O3 porous ceramic with 8 wt% Cu and sintered at 1500 degrees C exhibited the highest performance.
CERAMICS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Niluni M. Wijesundara, Song F. Lee, Zhenyu Cheng, Ross Davidson, David N. Langelaan, H. P. Vasantha Rupasinghe
Summary: This study investigated the bactericidal mechanism of carvacrol on Streptococcus pyogenes. It was found that carvacrol primarily killed the bacteria by disrupting membrane integrity and increasing permeability. Carvacrol also showed affinity with specific membrane phospholipids. This research provides insight for the development of natural health products for managing streptococcal pharyngitis or other therapeutic applications.
Review
Genetics & Heredity
Angelica Miglioli, Laura Canesi, Isa D. L. Gomes, Michael Schubert, Remi Dumollard
Summary: Nuclear Receptors (NRs) are transcription factors specific to metazoans that directly translate signaling molecule information. They play crucial roles in vertebrate and marine invertebrate development. Marine invertebrates are important for understanding NR superfamily evolution and ancestral states of NR-ligand interactions.
Article
Biochemistry & Molecular Biology
Gianmarco Mangiaterra, Elisa Carotti, Salvatore Vaiasicca, Nicholas Cedraro, Barbara Citterio, Anna La Teana, Francesca Biavasco
Summary: This study investigated the role of subinhibitory concentrations of different anti-pseudomonas antibiotics in maintaining persistent Pseudomonas aeruginosa (PA) cells in vitro biofilms. Tobramycin and bacterial cell wall-targeting antibiotics were found to play a major role in the resilience of VBNC forms, while ciprofloxacin and ceftazidime/avibactam led to their complete loss. The results could provide a deeper understanding of bacterial population dynamics during the treatment of recurrent PA infections within the CF lung.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zeinab El Rashed, Giulio Lupidi, Hussein Kanaan, Elena Grasselli, Laura Canesi, Hala Khalifeh, Ilaria Demori
Summary: Fucoidan, a sulfated polysaccharide with antioxidant properties, was extracted from the roots of the terrestrial shrub Ferula hermonis for the first time in this study. The extracted fraction, termed FUFe, showed high radical scavenging capacity in vitro cellular models and exhibited potential as a bioactive compound against fatty liver disease and related vascular damage.
Article
Biochemistry & Molecular Biology
Barbara Canonico, Luca Giorgi, Maria Gemma Nasoni, Mariele Montanari, Gianluca Ambrosi, Mauro Formica, Caterina Ciacci, Patrizia Ambrogini, Stefano Papa, Vieri Fusi, Francesca Luchetti
Summary: Fluorescent probes are essential tools in biological studies, and AJ2NBD has been shown to be a non-toxic and efficient probe for labeling living cells, making it suitable for organelle research. However, further specific tests are required to ensure the accurate tracing of vesicles/vacuoles by this new probe.
BIOLOGICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Maria Gemma Nasoni, Silvia Carloni, Barbara Canonico, Sabrina Burattini, Erica Cesarini, Stefano Papa, Marica Pagliarini, Patrizia Ambrogini, Walter Balduini, Francesca Luchetti
Summary: The study showed that melatonin treatment during reoxygenation phase can reduce mitochondrial ROS production, improve cell viability, promote mitochondrial dynamics, and enhance mitochondrial biogenesis. Additionally, melatonin can also foster mitochondrial transfer between injured cells through TNT connections.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Barbara Canonico, Michela Cangiotti, Mariele Montanari, Stefano Papa, Vieri Fusi, Luca Giorgi, Caterina Ciacci, Maria Francesca Ottaviani, Desislava Staneva, Ivo Grabchev
Summary: The study investigated the activity and interaction of a PAMAM dendrimer modified with 4-N-methylpiperazine-1,8-naphthalimide units and complexed by Cu(ii) ions towards healthy and cancer cells. Results showed that the metallodendrimer exhibited cytotoxic effects on U937 tumor cells while sparing healthy PBMC, indicating its potential as an anticancer drug.
BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Federica Sola, Mariele Montanari, Mara Fiorani, Chiara Barattini, Caterina Ciacci, Sabrina Burattini, Daniele Lopez, Alfredo Ventola, Loris Zamai, Claudio Ortolani, Stefano Papa, Barbara Canonico
Summary: This study investigates the preferential mitochondrial targeting of fluorescent silica nanoparticles in myeloid cells and their conjugation with the anticancer drug doxorubicin. The functionalized nanoparticles show reduced cytotoxicity and specific ability to release extracellular vesicles involved in tumor progression. This research highlights the importance of modulating signaling pathways in cancer cells using targeted nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Serena Benedetti, Simona Catalani, Barbara Canonico, Maria Gemma Nasoni, Francesca Luchetti, Stefano Papa, Lucia Potenza, Francesco Palma
Summary: The antiviral drug Acyclovir may induce anticancer effects by inhibiting cancer cell growth and inducing apoptosis, even without detecting human herpesviruses in the cells. Furthermore, the drug also causes mitochondrial damage and an increase in intracellular reactive oxygen species levels.
TOXICOLOGY IN VITRO
(2022)
Article
Biochemistry & Molecular Biology
Mariele Montanari, Sabrina Burattini, Caterina Ciacci, Patrizia Ambrogini, Silvia Carloni, Walter Balduini, Daniele Lopez, Giovanna Panza, Stefano Papa, Barbara Canonico
Summary: This study compared the automated-mechanical and enzymatic disaggregation methods for obtaining cell suspensions from various rat tissues. The results showed that these methods worked similarly in some tissues, but the enzyme-free Medimachine II protocol preserved lysosome and mitochondria labeling better, while the enzymatic gentle dissociation consistently induced a lower amount of intracellular ROS.
Article
Biochemistry & Molecular Biology
Simone Vespa, Pietro Del Biondo, Pasquale Simeone, Enrico Cavallucci, Giulia Catitti, Raffaella Auciello, Domenico De Bellis, Isotta Altomare, Laura Pierdomenico, Barbara Canonico, Ilaria Cicalini, Ilaria Angilletta, Piero Del Boccio, Damiana Pieragostino, Francesca Santilli, Andrea Urbani, Vincenzo De Laurenzi, Liborio Stuppia, Paola Lanuti
Summary: Allergic reactions to COVID-19 vaccine components are rare but should be considered. Skin tests combined with the basophil activation test (BAT) using PEG2000, PEG4000, and DMG-PEG2000 can help evaluate allergic reactions to the vaccine. The study suggests that even when the BAT is negative, a high stimulation index (SI) in basophil activation may indicate a low-grade reaction to PEG.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Giulia Catitti, Domenico De Bellis, Simone Vespa, Pasquale Simeone, Barbara Canonico, Paola Lanuti
Summary: Extracellular Vesicles (EVs) are circulating particles that carry proteins, lipids, RNAs, and DNA fragments, playing important roles in intercellular communication. EVs can regulate host immune response and exhibit both pro- and anti-inflammatory functions. Physical exercise has anti-inflammatory effects on the host's immune response. This review highlights the role of circulating EVs in the anti-inflammatory events associated with the regulation of the host's immune response during physical exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Francesca Luchetti, Maria G. Nasoni, Sabrina Burattini, Atefeh Mohammadi, Marica Pagliarini, Barbara Canonico, Patrizia Ambrogini, Walter Balduini, Russel J. Reiter, Silvia Carloni
Summary: This study found that melatonin plays a neuroprotective role against ischemic injury by modulating the Sirt1/FoxO1/Rab7 axis in cells and hippocampal cultures. Melatonin restores the physiological levels of autophagy, enhances autophagosome maturation, and increases lysosomal activity. This research provides new insights into the protective effects of melatonin in ischemic injury through the activation of the Sirt1/FoxO1/Rab7 axis.
Review
Pharmacology & Pharmacy
Sara Biagiotti, Faiza Abbas, Mariele Montanari, Chiara Barattini, Luigia Rossi, Mauro Magnani, Stefano Papa, Barbara Canonico
Summary: This article provides an overview of extracellular vesicles (EVs) nature, features, methodologies for isolation/preparation, and characterization/visualization. EVs have extensive applications in nanomedical-drug delivery and regenerative medicine, offering advantages over synthetic vehicles or nanoparticles. The article particularly focuses on red blood cell-derived extracellular vesicles (RBCEVs), discussing their biogenesis, isolation/production methods, and therapeutic applications. RBCEVs show promise as a versatile platform for clinical applications and pharmaceutical exploitations.
Article
Environmental Sciences
Teresa Balbi, Angelica Miglioli, Michele Montagna, Davide Piazza, Beatrice Risso, Remi Dumollard, Laura Canesi
Summary: The widely used biocide triclosan (TCS) is detected at high concentrations in water compartments, and it has been found to disrupt the biomineralization process in early mussel larvae.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Federica Sola, Barbara Canonico, Mariele Montanari, Angela Volpe, Chiara Barattini, Chiara Pellegrino, Erica Cesarini, Michele Guescini, Michela Battistelli, Claudio Ortolani, Alfredo Ventola, Stefano Papa
Summary: The study on NT(B)700 NPs showed efficient uptake process in cells with the involvement of mitochondria and lysosome pathways, without inducing significant cytotoxic effects. The NPs did not show a preferred internalization route, and despite localizing mainly in mitochondria, they did not significantly increase intracellular ROS levels, which are known inducers of apoptosis. Lymphoid and myeloid cells were able to release the NPs, indicating their biosafety.
NANOTECHNOLOGY SCIENCE AND APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Fuqiang Ge, Qiaoling Yu, Jun Zhang, Yaoyao Han, Dongfa Zhu, Xi Xie
Summary: The E93 gene was identified and found to be widely distributed in adult tissues of the swimming crab. The expression levels of PtE93 mRNA in Y-organ and epidermis fluctuated during the molt cycle, suggesting its involvement in juvenile molting. Treatment with 20E induced PtE93 expression, while treatment with MF showed the opposite effect. The study also observed a negative correlation between PtE93 and ecdysteroid biosynthesis genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Manuel Marrero, Oscar Monroig, Jose A. Perez, Monica B. Betancor, Ana Galindo, Ana Bolanos, N. Guadalupe Acosta, Covadonga Rodriguez
Summary: This study investigated the combined effects of partial dietary replacement of fish oil (FO) by vegetable oil (VO) and reduced ambient salinity on the fatty acid composition of C. labrosus juveniles. The results showed that C. labrosus is able to biosynthesise EPA and DHA from ALA, and low salinity conditions can upregulate the gene expression related to fatty acid metabolism. Fish reared on FO20 diet showed the highest amount of n-3 LC-PUFA in muscle.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Davide Degli Esposti, Aureline Lalouette, Karen Gaget, Louveline Lepeule, Zineb Chaabi, Maxime Lepretre, Anabelle Espeyte, Nicolas Delorme, Herve Queau, Laura Garnero, Federica Calevro, Arnaud Chaumot, Olivier Geffard
Summary: Metal pollution has significant effects on aquatic environments, and metallothioneins play important roles in maintaining metal homeostasis and detoxification. This study identified two metallothionein-coding transcripts in Gammarus fossarum and investigated their organ-specific expression patterns. The results showed that mt1 was more strongly induced after cadmium exposure, and mt1 was more highly induced in the caeca compared to the gills for any metal exposure. Additionally, mt2 was more inducible in the gills than in the caeca for cadmium and zinc exposure at the individual level.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cuihong You, Shuangshuang Miao, Zhiyong Xie, Siyuan Lin, Shuqi Wang, Cuiying Chen, Li Lin, Yanhua Huang, Meng Zhou, Yewei Dong, Yuanyou Li, Ping Zhuang
Summary: The rabbitfish S. guttatus was found to have the capability for LC-PUFA biosynthesis, with the expression of related genes varying temporally and spatially during embryogenesis and being influenced by ambient salinity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Saydur Rahman, Mohammad Maruf Billah, Victor Rangel, Esmirna Cantu
Summary: Global warming has severe impacts on the reproductive fitness of marine invertebrates. In this study, the researchers used various techniques to investigate the effects of high temperatures on global DNA methylation, cellular apoptosis, and nitrative stress in the gonads of Atlantic sea urchins.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
E. S. Kladchenko, A. A. Tkachuk, M. S. Podolskaya, A. Yu. Andreyeva
Summary: This study investigated the osmotic stability and cellular responses of hemocytes in Mediterranean mussel and Pacific oyster. The results revealed that both species showed cellular volume changes and alterations in mitochondrial membrane potential upon hypoosmotic swelling. These findings provide insights into the cellular responses of bivalve mollusks to osmotic stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yuya Ohhara, Chiemi Sagisaka, Kimiko Yamakawa-Kobayashi
Summary: This study investigated the biosynthetic capacity of n-3 PUFAs in the terrestrial invertebrate Sinella dubiosa, and found that it can metabolize oleic, linolenic, and arachidonic acids to produce EPA, suggesting that it may serve as an EPA source in soil ecosystems.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
N. Perales-Garcia, D. Tovar-Ramirez, M. G. Martinez-Morales, B. P. Ceballos-Vazquez, D. A. Corona-Rojas, M. A. Salcedo-Meza, A. Garrido-Mora, F. Vega-Villasante, H. Nolasco-Soria
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
N. Perales-Garcia, D. Tovar-Ramirez, M. G. Martinez-Morales, B. P. Ceballos-Vazquez, D. A. Corona-Rojas, M. A. Salcedo-Meza, A. Garrido-Mora, F. Vega-Villasante, H. Nolasco-Soria
Summary: This study provides the first report on the digestive tract pH of the pygmy octopus. The pH of the digestive tract regions was found to be lower than 7.0 and did not differ significantly between wild and captive octopuses. The digestive gland had the lowest pH values, but they were still above 5.0.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Carlos Espirito-Santo, Carmen Alburquerque, Francisco A. Guardiola, Rodrigo O. A. Ozorio, Leonardo J. Magnoni
Summary: Swimming has physiological effects on farmed fish, but the potential link between swimming and oxidative stress is still poorly understood. This study investigated the impact of different moderate swimming conditions on the antioxidant status of gilthead seabream, revealing that swimming modulated the activity of antioxidant enzymes in the liver and skeletal muscle. Adequate swimming conditions were found to minimize oxidative stress in gilthead seabream.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingxin Zhang, Chaobin Qin, Junli Wang, Liping Yang, Xiao Yan, Shaoyang Zhi, Guoxing Nie
Summary: The study focuses on the expression patterns of PFK genes in response to glucose, insulin, and glucagon stimuli in grass carp. The findings suggest that PFK family genes have different or even opposite expression patterns in various tissues, which may contribute to glucose intolerance in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jianshuang Li, Likang Lyu, Haishen Wen, Yun Li, Xiaojie Wang, Yijia Yao, Xin Qi
Summary: This study investigated the transcriptional regulation of estrogen receptors (ESRs) on isotocin receptors (itrs) in guppies, and found that estrogen can regulate oxytocin receptor expression in ovoviviparous teleosts. The study also demonstrated that ESR1 represses itr2 promoter activity in an estrogen-dependent manner, while overexpression of ESR2a or ESR2b enhances itr2 promoter activity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Wan-Xin Li, Li-Ting Cai, Yan-Ping Huang, Yuan-Qing Huang, Shu-Hui Pan, Zhi-Long Liu, Charles Brighton Ndandala, Gang Shi, Si-Ping Deng, Hong-Juan Shi, Guang-Li Li, Dong-Neng Jiang
Summary: In this study, it was found that S. argus has two lep genes, with lepa highly expressed in the liver and lepb not detected in any tissue. lepa was found to play a role in regulating female reproduction in S. argus.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Xiang Wu, Xiao-Ying Tan, Yi-Chuang Xu, Hua Zheng, Xiao-Lei Wei, Wu-Hong Lv, Zhi Luo
Summary: This study investigates the mechanisms underlying the activation of lipophagy in yellow catfish under high glucose-induced lipid deposition. The SIRT1-NRF2-TFEB pathway is proposed to mediate lipophagy activation, and lipophagy helps alleviate high glucose-induced lipid deposition. This study provides insights into the control of lipophagy in response to metabolic stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)