Depolarizing GABA and Developmental Epilepsies

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

(2014) Kathrin Töllner et al.   ANNALS OF NEUROLOGY

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

(2014) Martin Puskarjov et al.   EPILEPSIA

Local Impermeant Anions Establish the Neuronal Chloride Concentration

(2014) J. Glykys et al.   SCIENCE

Bumetanide, an Inhibitor of Cation-chloride Cotransporter Isoform 1, Inhibits γ-Aminobutyric Acidergic Excitatory Actions and Enhances Sedative Actions of Midazolam in Neonatal Rats

(2013) Yukihide Koyama et al.   ANESTHESIOLOGY

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

The Paradox of the Paroxysm

(2013) Gilles Huberfeld et al.   NEUROSCIENTIST

Excitatory actions of GABA in the intact neonatal rodent hippocampus in vitro

(2013) Guzel Valeeva et al.   Frontiers in Cellular Neuroscience

Cell-attached recordings of responses evoked by photorelease of GABA in the immature cortical neurons

(2013) Marat Minlebaev et al.   Frontiers in Cellular Neuroscience

Anion transport and GABA signaling

(2013) Christian A. Hübner et al.   Frontiers in Cellular Neuroscience

Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport

(2013) Arjun Khanna et al.   Frontiers in Neurology

Comparison of Brain Maturation among Species: An Example in Translational Research Suggesting the Possible Use of Bumetanide in Newborn

(2013) Ronit Pressler et al.   Frontiers in Neurology

Phasic GABAA-receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus

(2012) Sergey N. Kolbaev et al.   EPILEPSIA

Traumatic Alterations in GABA Signaling Disrupt Hippocampal Network Activity in the Developing Brain

(2012) V. Dzhala et al.   JOURNAL OF NEUROSCIENCE

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

(2012) Ivan Pavlov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

How inhibition influences seizure propagation

(2012) Andrew J. Trevelyan et al.   NEUROPHARMACOLOGY

GABAergic Transmission and Chloride Equilibrium Potential Are Not Modulated by Pyruvate in the Developing Optic Tectum of Xenopus laevis Tadpoles

(2012) Arseny S. Khakhalin et al.   PLoS One

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

(2012) R. Bos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

(2012) Yehezkel Ben-Ari et al.   Frontiers in Cellular Neuroscience

Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact

(2012) Piotr Bregestovski et al.   Frontiers in Pharmacology

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

Diuretics and epilepsy: Will the past and present meet?

(2011) Edward H. Maa et al.   EPILEPSIA

GABAergic depolarization during early cortical development and implications for anticonvulsive therapy in neonates

(2011) Knut Kirmse et al.   EPILEPSIA

Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats

(2011) Marat Minlebaev et al.   EPILEPSY RESEARCH

Primary Afferent Terminals Acting as Excitatory Interneurons Contribute to Spontaneous Motor Activities in the Immature Spinal Cord

(2011) R. Bos et al.   JOURNAL OF NEUROSCIENCE

GABA Regulates the Multidirectional Tangential Migration of GABAergic Interneurons in Living Neonatal Mice

(2011) Hiroyuki Inada et al.   PLoS One

Early Gamma Oscillations Synchronize Developing Thalamus and Cortex

(2011) M. Minlebaev et al.   SCIENCE

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

(2010) Doris D. Wang et al.   CEREBRAL CORTEX

Age- and region-specific effects of anticonvulsants and bumetanide on 4-aminopyridine-induced seizure-like events in immature rat hippocampal-entorhinal cortex slices

(2010) Abdul Wahab et al.   EPILEPSIA

Prototypic Seizure Activity Driven by Mature Hippocampal Fast-Spiking Interneurons

(2010) Y. Fujiwara-Tsukamoto et al.   JOURNAL OF NEUROSCIENCE

Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

(2010) V. I. Dzhala et al.   JOURNAL OF NEUROSCIENCE

Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome

(2009) Roman Tyzio et al.   ANNALS OF NEUROLOGY

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Bumetanide, an NKCC1 Antagonist, Does Not Prevent Formation of Epileptogenic Focus but Blocks Epileptic Focus Seizures in Immature Rat Hippocampus

(2009) Romain Nardou et al.   JOURNAL OF NEUROPHYSIOLOGY

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

(2009) C. K. Pfeffer et al.   JOURNAL OF NEUROSCIENCE

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Compensatory changes in cellular excitability, not synaptic scaling, contribute to homeostatic recovery of embryonic network activity

(2009) J. C. Wilhelm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks

(2009) P. Bonifazi et al.   SCIENCE

Postnatal changes in somatic γ-aminobutyric acid signalling in the rat hippocampus

(2008) Roman Tyzio et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Layer-Specific Generation and Propagation of Seizures in Slices of Developing Neocortex: Role of Excitatory GABAergic Synapses

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

Excitatory GABA in Rodent Developing Neocortex In Vitro

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

NKCC1 and AE3 Appear to Accumulate Chloride in Embryonic Motoneurons

(2008) Carlos Gonzalez-Islas et al.   JOURNAL OF NEUROPHYSIOLOGY

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

(2008) Kristopher T. Kahle et al.   Neurosurgical Focus

Does Plasticity of the GABAAReversal Potential Contribute to Epileptogenesis?

(2008)   Epilepsy Currents

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

(2007) Volodymyr I. Dzhala et al.   ANNALS OF NEUROLOGY