Review
Neurosciences
Gary Jean, Joseph Carton, Kaleem Haq, Alberto E. Musto
Summary: Epilepsy is a chronic CNS disease with no known disease-modifying therapy. The generation of aberrant neuronal networks is considered a leading mechanism of epileptogenesis. Changes in dendritic spine morphology, associated with altered expression of various proteins and molecules, may contribute to the hyperexcitability and abnormal synaptic connections seen in epilepsy. Targeting dendritic spine machinery could potentially limit or reverse the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Daniel R. Kick, David J. Schulz
Summary: Central pattern generators are important for generating rhythms necessary for survival. Coordination of neurons through electrical synapses is required, but different tuning of neurons within a network can lead to uncoordinated activity. In the crab cardiac ganglion, loss of synchronous voltage signals between coupled neurons is responsible for plasticity in coupling. Understanding this mechanism can help explain how desynchronization-specific potentiation or depression of synapses is adaptive in a hybrid network.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Business, Finance
Xinzhen Feng, Gang Du
Summary: This study examines the impact of residents' financial knowledge on the scale and structure of their consumption. The findings suggest that improving financial knowledge can significantly promote consumption upgrading. The influence of financial knowledge on the scale of residents' consumption has a more significant effect in rural households compared to urban households. Additionally, the digital financial inclusion index weakens the positive impact of financial knowledge on the scale and structure of households' consumption.
FINANCE RESEARCH LETTERS
(2023)
Article
Business
Dosse Mawussi Djahini-Afawoubo, Mawuli Kodjovi Couchoro, Fambari Kokou Atchi
Summary: This paper aims to analyze the effect of mobile money on multidimensional poverty reduction using the Alkire and Foster (2011) approach to calculate the multidimensional poverty index. The results show that mobile money has a positive and statistically significant effect on multidimensional poverty reduction, particularly among rural residents, women, and illiterate individuals.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Urban Studies
Seung Kyum Kim, Soonae Park
Summary: The increasing occurrence and severity of extreme weather events are influencing people's decisions on future city living. The social impacts of heightened exposure to climate risks call for transformative measures in coastal cities. However, few studies have examined the overall effects of risk-induced household migration behavior. Using a difference-in-differences framework, this study examines hurricane-prone coastal cities in the US to understand the cumulative consequences of climate risk-related residential migration. The findings reveal that migration triggered by climate risks may contribute to climate gentrification in low-risk areas, leading to a 13.8% increase in median income in low storm intensity areas and an 18.9% decrease in non-Hispanic African American residents in low flood-risk areas. These results highlight the importance for state and local governments to promote effective climate adaptations at the local level, not only for urban sustainability in hazard-prone areas but also to address potential social inequality in low-risk areas.
Article
Multidisciplinary Sciences
Lina Sakhneny, Alona Epshtein, Limor Landsman
Summary: Pericytes produce multiple components of the pancreatic and islet BM matrices, including laminins that regulate beta-cell function. The findings suggest that pericytes play a significant role in supporting beta-cells and insulin secretion in the islets.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Yovav Eshet, Adva Margaliot
Summary: This study focuses on the relationship between personality traits, creative thinking, and academic integrity. It suggests that individuals with creative thinking and emotional stability are more likely to display higher levels of ethical behavior.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Forestry
Edyta Hewelke, Piotr T. Zaniewski, Ewa Zaniewska, Ewa Papierowska, Dariusz Gozdowski, Andrzej Lachacz, Ewa Beata Gorska
Summary: The aim of this study was to analyze the moisture content and strength of water repellency on sandy soil undergoing spontaneous afforestation or weed infestation during a warm period. Three site plots were selected in Central Poland, and the study covers the growing period in 2020. The results showed that the top layer of the Scots pine forest had extremely repellent water classes, while the birch forest had hydrophobicity for the top layer.
Article
Neurosciences
Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tang
Summary: This review summarizes the main characteristics of synapses and synaptic plasticity under physiological and pathological conditions. It elaborates on the role of microglia and the signaling pathways involved in regulating synaptic plasticity. The review also highlights the unique role of TREM2 in microglia-mediated regulation of synaptic plasticity and its relationship with AD, as well as proposing four possible ways in which TREM2 is involved in regulating synaptic plasticity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongsheng Zhu, Peng Yan, Rui Wang, Jianghua Lai, Hua Tang, Xu Xiao, Rongshan Yu, Xiaorui Bao, Feng Zhu, Kena Wang, Ye Lu, Jie Dang, Chao Zhu, Rui Zhang, Wei Dang, Bao Zhang, Quanze Fu, Qian Zhang, Chongao Kang, Yujie Chen, Xiaoyu Chen, Qing Liang, Kejia Wang
Summary: Dysregulation of the immune system is a key factor in opioid addiction. The abnormal distribution of immune cells, particularly the expansion of fragile-like regulatory T cells (Tregs), is correlated with withdrawal symptoms. Opioids increase the expression of neuron-derived Ccl2, which disrupts the blood-brain barrier (BBB) integrity and allows Tregs to infiltrate the NAc, leading to synaptic instability and withdrawal symptoms mediated by IFN-y.
Review
Neurosciences
Gesa Hartwigsen, Yoshua Bengio, Danilo Bzdok
Summary: The uniquely human cognitive faculties arise from flexible interactions between specific neural modules, with hemispheric asymmetries in functional specialization. These computational design principles support some of the most advanced cognitive operations, such as semantic understanding, logical reasoning, and language communication. The integration of dual-processing theories with the global workspace theory can explain the dynamic relay of information products between different cognitive systems.
Article
Environmental Studies
Sabri Boubaker, Anis Omri
Summary: The study shows that renewable energy can balance the relationship between emissions reduction and economic growth in emerging economies, with the potential to promote economic growth while reducing carbon emissions.
Article
Business, Finance
Jinglei Wen, Yujiao Deng
Summary: This paper investigates the impact of Intellectual Property Protection (IPP) on firm digital transformation (DT) in China using a panel dataset from 2012 to 2020. The results show a significant and robust positive relationship between IPP and firm DT, even after addressing endogeneity concerns. Mechanism analysis reveals that IPP facilitates firm DT by alleviating financing constraints and encouraging research and development (R&D) investments. This research highlights the importance of IPP in creating an environment conducive to digital transformation and provides valuable insights for policymakers and firms aiming to enhance their digital capabilities.
FINANCE RESEARCH LETTERS
(2023)
Article
Pharmacology & Pharmacy
Johanna Weiss, Kathrin Isabelle Foerster, Maria Weber, Jurgen Burhenne, Gerd Mikus, Thorsten Lehr, Walter Emil Haefeli
Summary: The metabolite of ketoconazole, N-deacetyl ketoconazole (DAK), is found to inhibit several enzymes and drug transporters in humans, which might affect the efficacy of ketoconazole.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Agriculture, Multidisciplinary
Hao-Han Sun, Zhi-Zheng Wang, Yang-Yang Gao, Ge-Fei Hao, Guang-Fu Yang
Summary: Using agrochemicals targeting protein kinases to combat pest insects, fungi, and weeds is gaining increasing attention and has potential prospects in agrochemical development. However, there is a lack of comprehensive summary and discussion on the targetability of protein kinases in this field. This study provides guidance and a quick understanding of the role of protein kinases, benefiting both agrochemical development and non-professionals' learning.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
